Homo sapiens (human): 6550
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Entry
6550 CDS
T01001
Symbol
SLC9A3, DIAR8, NHE-3, NHE3
Name
(RefSeq) solute carrier family 9 member A3
KO
K12040
solute carrier family 9 (sodium/hydrogen exchanger), member 3
Organism
hsa
Homo sapiens (human)
Pathway
hsa04964
Proximal tubule bicarbonate reclamation
hsa04974
Protein digestion and absorption
hsa04976
Bile secretion
hsa04978
Mineral absorption
Disease
H01174
Congenital diarrhea
Drug target
Tenapanor (
DG03072
):
D11652
D11653
<JP/US>
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09150 Organismal Systems
09154 Digestive system
04976 Bile secretion
6550 (SLC9A3)
04974 Protein digestion and absorption
6550 (SLC9A3)
04978 Mineral absorption
6550 (SLC9A3)
09155 Excretory system
04964 Proximal tubule bicarbonate reclamation
6550 (SLC9A3)
09180 Brite Hierarchies
09183 Protein families: signaling and cellular processes
02000 Transporters [BR:
hsa02000
]
6550 (SLC9A3)
Transporters [BR:
hsa02000
]
Solute carrier family (SLC)
SLC9: Na+/H+ exchanger
6550 (SLC9A3)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Na_H_Exchanger
NEXCaM_BD
Motif
Other DBs
NCBI-GeneID:
6550
NCBI-ProteinID:
NP_004165
OMIM:
182307
HGNC:
11073
Ensembl:
ENSG00000066230
Pharos:
P48764
(Tbio)
UniProt:
P48764
Structure
PDB
PDBj
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All DBs
Position
5:complement(470456..524449)
Genome browser
AA seq
834 aa
AA seq
DB search
MWGLGARGPDRGLLLALALGGLARAGGVEVEPGGAHGESGGFQVVTFEWAHVQDPYVIAL
WILVASLAKIGFHLSHKVTSVVPESALLIVLGLVLGGIVWAADHIASFTLTPTVFFFYLL
PPIVLDAGYFMPNRLFFGNLGTILLYAVVGTVWNAATTGLSLYGVFLSGLMGDLQIGLLD
FLLFGSLMAAVDPVAVLAVFEEVHVNEVLFIIVFGESLLNDAVTVVLYNVFESFVALGGD
NVTGVDCVKGIVSFFVVSLGGTLVGVVFAFLLSLVTRFTKHVRIIEPGFVFIISYLSYLT
SEMLSLSAILAITFCGICCQKYVKANISEQSATTVRYTMKMLASSAETIIFMFLGISAVN
PFIWTWNTAFVLLTLVFISVYRAIGVVLQTWLLNRYRMVQLEPIDQVVLSYGGLRGAVAF
ALVVLLDGDKVKEKNLFVSTTIIVVFFTVIFQGLTIKPLVQWLKVKRSEHREPRLNEKLH
GRAFDHILSAIEDISGQIGHNYLRDKWSHFDRKFLSRVLMRRSAQKSRDRILNVFHELNL
KDAISYVAEGERRGSLAFIRSPSTDNVVNVDFTPRSSTVEASVSYLLRENVSAVCLDMQS
LEQRRRSIRDAEDMVTHHTLQQYLYKPRQEYKHLYSRHELTPTEDEKQDREIFHRTMRKR
LESFKSTKLGLNQNKKAAKLYKRERAQKRRNSSIPNGKLPMESPAQNFTIKEKDLELSDT
EEPPNYDEEMSGGIEFLASVTKDTASDSPAGIDNPVFSPDEALDRSLLARLPPWLSPGET
VVPSQRARTQIPYSPGTFCRLMPFRLSSKSVDSFLQADGPEERPPAALPESTHM
NT seq
2505 nt
NT seq
+upstream
nt +downstream
nt
atgtggggactcggggcccggggccccgaccgggggctgctgctggcgctggcgctgggc
gggctggcgcgggccgggggcgtcgaggtggagcccggcggcgcgcacggcgagagcggg
ggcttccaggtggtcaccttcgagtgggcccacgtgcaggatccctacgtcatcgcgctc
tggatcctcgtggccagcttggccaagatcgggttccacctgtcccacaaggtcaccagc
gtggttcccgagagcgccctgctcatcgtgctgggcctggtgctgggcggcatcgtctgg
gcggccgaccacatcgcgtccttcacactgacgcccaccgtcttcttcttctacctgctg
ccccccatcgtgctggacgccggctacttcatgcccaaccgcctcttcttcggcaacctg
gggaccatcctgttgtacgccgtcgtgggtaccgtgtggaacgcggccaccaccgggctg
tccctctacggcgtcttcctcagtgggctcatgggcgacctgcagattgggctgctggac
ttcctcctgtttggcagcctcatggcggctgtggacccggtggccgtcctggccgtgttt
gaggaggtccatgtcaacgaggtcctgttcatcatcgtcttcggggagtcgctgctgaac
gacgcagtcaccgtggttctgtacaatgtgtttgaatctttcgtggcgctgggaggtgac
aacgtgactggcgtggactgcgtgaagggcatagtgtccttcttcgtggtgagcctgggg
ggcacgctggtgggggtggtcttcgccttcctgctgtcgctggtgacgcgcttcaccaag
catgtgcgtatcatcgagcccggcttcgtgttcatcatctcctacctgtcctacctgacg
tccgagatgctgtcgctgtcggccatcctcgccatcaccttctgtggcatctgctgtcag
aagtatgtgaaggccaacatctcggagcagtcggccaccaccgtgcgctacaccatgaag
atgctggccagcagcgccgagaccatcatcttcatgttcctgggtatctcggccgtgaac
ccgttcatctggacctggaacacggccttcgtgctcctgacgctggtcttcatctccgtg
taccgggccatcggtgtggtcctgcagacctggcttctgaaccgctaccgcatggtgcag
ctggagcccattgaccaggtggtcctgtcctacgggggcctgcgcggggccgtggccttt
gccctggtggtgcttctggatggagacaaggtcaaggagaagaacctgttcgtcagcacc
accatcatcgtagtgttcttcaccgtcatcttccagggcctgaccatcaagcctctggtg
cagtggctgaaggtgaagaggagcgagcaccgggaacctcggctcaacgagaagctgcac
gggcgcgctttcgaccacatcctctcggccatcgaggacatatccggacagatcgggcac
aattatctcagagacaagtggtcccacttcgacaggaagttcctcagcagggtcctcatg
agacggtcggcccagaagtctcgagaccggatcctgaatgtcttccacgagctgaacctg
aaggatgccatcagctacgtggctgagggagagcgccgcgggtccctggccttcatccgc
tcccccagcaccgacaacgtggtcaacgtggacttcacgccacgatcgtccaccgtggag
gcctctgtctcctacctcctgagagaaaatgtcagcgctgtctgcctggacatgcagtct
ctggagcagcgacggcggagcatccgggacgcggaggacatggtcacgcaccacacgcta
cagcagtacctgtacaagccgcggcaggagtacaagcatctgtacagccgacacgagctc
acgcccacggaggacgagaaacaggaccgggaaatcttccacaggaccatgcggaagcgc
ctggagtccttcaagtcgaccaagctggggctcaaccagaacaagaaggcggccaagctg
tacaagcgggagcgtgcccagaagcggagaaacagcagcatccccaatgggaagctgccc
atggagagccctgcgcagaatttcaccatcaaggagaaagacttggaactttcagacacc
gaggagccccccaactatgatgaggagatgagtggggggatcgagttcctggctagtgtc
accaaggacacagcgtccgactcccctgcaggaattgacaaccctgtgttttctccggac
gaggccctggaccgcagcctcctggccaggctgccgccctggctgtctcccggggagacg
gtggtcccctcgcagagggcccgcacgcagattccctactctcccggcaccttctgccgc
ctgatgcccttccgcctcagcagcaagtccgtggactccttcctgcaggcagacggcccc
gaggagcggccccccgccgccctccccgagtccacacacatgtga
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