Homo sapiens (human): 6675
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Entry
6675 CDS
T01001
Symbol
UAP1, AGX, AGX1, AGX2, SPAG2
Name
(RefSeq) UDP-N-acetylglucosamine pyrophosphorylase 1
KO
K00972
UDP-N-acetylglucosamine/UDP-N-acetylgalactosamine diphosphorylase [EC:
2.7.7.23
2.7.7.83
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa00520
Amino sugar and nucleotide sugar metabolism
hsa00541
Biosynthesis of various nucleotide sugars
hsa01100
Metabolic pathways
hsa01250
Biosynthesis of nucleotide sugars
Module
hsa_M00892
UDP-GlcNAc biosynthesis, eukaryotes, Fru-6P => UDP-GlcNAc
hsa_M01003
UDP-GlcNAc biosynthesis, GlcNAc => UDP-GlcNAc
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09100 Metabolism
09107 Glycan biosynthesis and metabolism
00520 Amino sugar and nucleotide sugar metabolism
6675 (UAP1)
00541 Biosynthesis of various nucleotide sugars
6675 (UAP1)
Enzymes [BR:
hsa01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.7 Nucleotidyltransferases
2.7.7.23 UDP-N-acetylglucosamine diphosphorylase
6675 (UAP1)
2.7.7.83 UDP-N-acetylgalactosamine diphosphorylase
6675 (UAP1)
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Gene cluster
GFIT
Motif
Pfam:
UDPGP
NTP_transf_3
Motif
Other DBs
NCBI-GeneID:
6675
NCBI-ProteinID:
NP_001311045
OMIM:
602862
HGNC:
12457
Ensembl:
ENSG00000117143
UniProt:
Q16222
Structure
PDB
PDBj
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Position
1:162561531..162601240
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AA seq
522 aa
AA seq
DB search
MNINDLKLTLSKAGQEHLLRFWNELEEAQQVELYAELQAMNFEELNFFFQKAIEGFNQSS
HQKNVDARMEPVPREVLGSATRDQDQLQAWESEGLFQISQNKVAVLLLAGGQGTRLGVAY
PKGMYDVGLPSRKTLFQIQAERILKLQQVAEKYYGNKCIIPWYIMTSGRTMESTKEFFTK
HKYFGLKKENVIFFQQGMLPAMSFDGKIILEEKNKVSMAPDGNGGLYRALAAQNIVEDME
QRGIWSIHVYCVDNILVKVADPRFIGFCIQKGADCGAKVVEKTNPTEPVGVVCRVDGVYQ
VVEYSEISLATAQKRSSDGRLLFNAGNIANHFFTVPFLRDVVNVYEPQLQHHVAQKKIPY
VDTQGQLIKPDKPNGIKMEKFVFDIFQFAKKFVVYEVLREDEFSPLKNADSQNGKDNPTT
ARHALMSLHHCWVLNAGGHFIDENGSRLPAIPRSATNGKSETITADVNHNLKDANDVPIQ
CEISPLISYAGEGLESYVADKEFHAPLIIDENGVHELVKNGI
NT seq
1569 nt
NT seq
+upstream
nt +downstream
nt
atgaacattaatgacctcaaactcacgttgtccaaagctgggcaagagcacctactacgt
ttctggaatgagcttgaagaagcccaacaggtagaactttatgcagagctccaggccatg
aactttgaggagctgaacttctttttccaaaaggccattgaaggttttaaccagtcttct
caccaaaagaatgtggatgcacgaatggaacctgtgcctcgagaggtattaggcagtgct
acaagggatcaagatcagctccaggcctgggaaagtgaaggacttttccagatttctcag
aataaagtagcagttcttcttctagctggtgggcaggggacaagactcggcgttgcatat
cctaaggggatgtatgatgttggtttgccatcccgtaagacactttttcagattcaagca
gagcgtatcctgaagctacagcaggttgctgaaaaatattatggcaacaaatgcattatt
ccatggtatataatgaccagtggcagaacaatggaatctacaaaggagttcttcaccaag
cacaagtactttggtttaaaaaaagagaatgtaatcttttttcagcaaggaatgctcccc
gccatgagttttgatgggaaaattattttggaagagaagaacaaagtttctatggctcca
gatgggaatggtggtctttatcgggcacttgcagcccagaatattgtggaggatatggag
caaagaggcatttggagcattcatgtctattgtgttgacaacatattagtaaaagtggca
gacccacggttcattggattttgcattcagaaaggagcagactgtggagcaaaggtggta
gagaaaacgaaccctacagaaccagttggagtggtttgccgagtggatggagtttaccag
gtggtagaatatagtgagatttccctggcaacagctcaaaaacgaagctcagacggacga
ctgctgttcaatgcggggaacattgccaaccatttcttcactgtaccatttctgagagat
gttgtcaatgtttatgaacctcagttgcagcaccatgtggctcaaaagaagattccttat
gtggatacccaaggacagttaattaagccagacaaacccaatggaataaagatggaaaaa
tttgtctttgacatcttccagtttgcaaagaagtttgtggtatatgaagtattgcgagaa
gatgagttttccccactaaagaatgctgatagtcagaatgggaaagacaaccctactact
gcaaggcatgctttgatgtcccttcatcattgctgggtcctcaatgcagggggccatttc
atagatgaaaatggctctcgccttccagcaattccccgcagtgctacaaatgggaagtca
gagaccatcacagctgatgtcaatcacaacttgaaggatgccaatgatgtaccaatccaa
tgtgaaatctctcctcttatctcctatgctggagaaggattagaaagttatgtggcagat
aaagaattccatgcacctctaatcatcgatgagaatggagttcatgagctggtgaaaaat
ggtatttga
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