KEGG   Homo sapiens (human): 7064
Entry
7064              CDS       T01001                                 

Gene name
THOP1, EP24.15, MEPD_HUMAN, MP78, TOP
Definition
(RefSeq) thimet oligopeptidase 1
  KO
K01392  thimet oligopeptidase [EC:3.4.24.15]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04614  Renin-angiotensin system
hsa05143  African trypanosomiasis
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09152 Endocrine system
   04614 Renin-angiotensin system
    7064 (THOP1)
 09160 Human Diseases
  09174 Infectious disease: parasitic
   05143 African trypanosomiasis
    7064 (THOP1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:hsa01002]
    7064 (THOP1)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.24  Metalloendopeptidases
    3.4.24.15  thimet oligopeptidase
     7064 (THOP1)
Peptidases and inhibitors [BR:hsa01002]
 Metallo peptidases
  Family M3
   7064 (THOP1)
SSDB
Motif
Pfam: Peptidase_M3
Other DBs
NCBI-GeneID: 7064
NCBI-ProteinID: NP_003240
OMIM: 601117
HGNC: 11793
Ensembl: ENSG00000172009
Vega: OTTHUMG00000180492
Pharos: P52888(Tbio)
UniProt: P52888
LinkDB
Structure
PDB: 
2O36 1S4B

Position
19p13.3
AA seq 689 aa
MKPPAACAGDMADAASPCSVVNDLRWDLSAQQIEERTRELIEQTKRVYDQVGTQEFEDVS
YESTLKALADVEVTYTVQRNILDFPQHVSPSKDIRTASTEADKKLSEFDVEMSMREDVYQ
RIVWLQEKVQKDSLRPEAARYLERLIKLGRRNGLHLPRETQENIKRIKKKLSLLCIDFNK
NLNEDTTFLPFTLQELGGLPEDFLNSLEKMEDGKLKVTLKYPHYFPLLKKCHVPETRRKV
EEAFNCRCKEENCAILKELVTLRAQKSRLLGFHTHADYVLEMNMAKTSQTVATFLDELAQ
KLKPLGEQERAVILELKRAECERRGLPFDGRIRAWDMRYYMNQVEETRYCVDQNLLKEYF
PVQVVTHGLLGIYQELLGLAFHHEEGASAWHEDVRLYTARDAASGEVVGKFYLDLYPREG
KYGHAACFGLQPGCLRQDGSRQIAIAAMVANFTKPTADAPSLLQHDEVETYFHEFGHVMH
QLCSQAEFAMFSGTHVERDFVEAPSQMLENWVWEQEPLLRMSRHYRTGSAVPRELLEKLI
ESRQANTGLFNLRQIVLAKVDQALHTQTDADPAEEYARLCQEILGVPATPGTNMPATFGH
LAGGYDAQYYGYLWSEVYSMDMFHTRFKQEGVLNSKVGMDYRSCILRPGGSEDASAMLRR
FLGRDPKQDAFLLSKGLQVGGCEPEPQVC
NT seq 2070 nt   +upstreamnt  +downstreamnt
atgaagccccccgcagcctgtgcaggagacatggcggacgcagcatctccgtgctctgtg
gtaaacgacctgcggtgggacctgagtgcccagcagatagaggagcgcaccagggagctc
atcgagcagaccaagcgcgtgtatgaccaggttggcacccaggagtttgaggacgtgtcc
tacgagagcacgctcaaggcgctggccgatgtggaggtcacctacacagttcagaggaat
atccttgacttcccccagcatgtttccccctccaaggacatccggacagccagcacagag
gccgacaagaagctctctgagttcgacgtggagatgagcatgagggaggacgtgtaccag
aggatcgtgtggctccaggagaaagttcagaaggactcactgaggcccgaggctgcgcgg
tacctggagcggctaatcaagctgggccggagaaatgggcttcacctccccagagagact
caggaaaacatcaaacgcatcaagaagaagctgagccttctgtgcatcgacttcaacaag
aacctgaacgaggacacgaccttcctgcccttcacgctccaggagctaggagggctcccc
gaggactttctgaactccctggagaagatggaggacggcaagttgaaggtcaccctcaag
tacccccattacttccccctcctgaagaaatgccacgtgcctgagaccaggaggaaagtg
gaggaggccttcaactgccggtgcaaggaggagaactgcgctatcctcaaggagctggtg
acgctgcgggcccagaagtcccgcctgctggggttccacacgcacgccgactatgtcctg
gagatgaacatggccaagaccagccagaccgtggccaccttcctagatgagctggcgcag
aagctgaagcccctgggggagcaggagcgtgcggtgattctggagctgaagcgtgcggag
tgcgagcgccggggcctgcccttcgacggccgcatccgtgcctgggacatgcgctactac
atgaaccaggtggaggagacgcgctactgcgtggaccagaacctgctcaaggagtacttc
cccgtgcaggtggtcacgcacgggctgctgggcatctaccaggagctcctggggctggcc
ttccaccacgaggagggcgccagtgcctggcatgaggacgtgcggctctacaccgcgagg
gacgcggcctcgggggaggtggtcggcaagttctacctggacctgtacccgcgggaagga
aagtacgggcacgcggcctgctttggcctgcagcccggctgcctgcggcaggatgggagc
cgccagatcgccatcgcggccatggtggccaacttcaccaagcccacagccgacgcgccc
tcgctgctgcagcatgacgaggtggagacctacttccatgagtttggccacgtgatgcac
cagctctgctcccaggcggagttcgccatgttcagcgggacccacgtggagcgggacttt
gtggaggcgccgtcgcagatgctggagaactgggtgtgggagcaggagccgctgctgcgg
atgtcgcggcactaccgcacaggcagcgccgtgccccgggagctcctggagaagctcatt
gagtcccggcaggccaacacaggcctcttcaacctgcgccagatcgtcctcgccaaggtg
gaccaggccctgcacacgcagacggacgcagaccccgccgaggagtatgcgcggctctgc
caggagatcctcggggtcccggccacgccaggaaccaacatgcctgcaaccttcggccat
ctggcaggtggctacgacgcccagtactacgggtacctgtggagcgaggtgtattccatg
gacatgttccacacgcgcttcaagcaggagggtgtcctgaacagcaaggttggcatggat
tacagaagctgcatcctgagacccggcggttccgaggatgccagcgccatgctgaggcgc
ttcctgggccgtgaccccaagcaggacgccttcctcctgagcaaggggctgcaggtcggg
ggctgcgagcccgagccgcaggtctgctga

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