KEGG T01001: 7137

Homo sapiens (human): 7137

Entry

7137              CDS       T01001

Symbol

TNNI3, CMD1FF, CMD2A, CMH7, RCM1, TNNC1, cTnI

Name

(RefSeq) troponin I3, cardiac type

K12044

troponin I, cardiac muscle

Organism

hsa Homo sapiens (human)

Pathway

hsa04024

cAMP signaling pathway

hsa04260

Cardiac muscle contraction

hsa04261

Adrenergic signaling in cardiomyocytes

hsa04814

Motor proteins

hsa04820

Cytoskeleton in muscle cells

hsa05410

Hypertrophic cardiomyopathy

hsa05414

Dilated cardiomyopathy

hsa05415

Diabetic cardiomyopathy

Network

nt06539 Cytoskeleton in muscle cells

Element

N01818

Actin thin filament, muscle contraction

Disease

H00292

Hypertrophic cardiomyopathy

H00294

Dilated cardiomyopathy

H01219

Restrictive cardiomyopathy

Drug target

Nelutroctiv:

D12804

Brite

KEGG Orthology (KO) [BR:hsa00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04024 cAMP signaling pathway
    7137 (TNNI3)
09140 Cellular Processes
  09142 Cell motility
   04814 Motor proteins
    7137 (TNNI3)
   04820 Cytoskeleton in muscle cells
    7137 (TNNI3)
09150 Organismal Systems
  09153 Circulatory system
   04260 Cardiac muscle contraction
    7137 (TNNI3)
   04261 Adrenergic signaling in cardiomyocytes
    7137 (TNNI3)
09160 Human Diseases
  09166 Cardiovascular disease
   05410 Hypertrophic cardiomyopathy
    7137 (TNNI3)
   05414 Dilated cardiomyopathy
    7137 (TNNI3)
   05415 Diabetic cardiomyopathy
    7137 (TNNI3)
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04812 Cytoskeleton proteins [BR:hsa04812]
    7137 (TNNI3)
Cytoskeleton proteins [BR:hsa04812]
Eukaryotic cytoskeleton proteins
  Actin filaments / Microfilaments
   Actin-binding proteins
    Troponins
     7137 (TNNI3)

SSDB

Motif

Pfam:

Troponin Troponin-I_N Tup_N DUF919 DUF3738 CorA

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

UniProt:

Structure

LinkDB

Position

19:complement(55151767..55157732)

AA seq 210 aa
MADGSSDAAREPRPAPAPIRRRSSNYRAYATEPHAKKKSKISASRKLQLKTLLLQIAKQE
LEREAEERRGEKGRALSTRCQPLELAGLGFAELQDLCRQLHARVDKVDEERYDIEAKVTK
NITEIADLTQKIFDLRGKFKRPTLRRVRISADAMMQALLGARAKESLDLRAHLKQVKKED
TEKENREVGDWRKNIDALSGMEGRKKKFES

NT seq 633 nt +upstreamnt +downstreamnt
atggcggatgggagcagcgatgcggctagggaacctcgccctgcaccagccccaatcaga
cgccgctcctccaactaccgcgcttatgccacggagccgcacgccaagaaaaaatctaag
atctccgcctcgagaaaattgcagctgaagactctgctgctgcagattgcaaagcaagag
ctggagcgagaggcggaggagcggcgcggagagaaggggcgcgctctgagcacccgctgc
cagccgctggagttggccgggctgggcttcgcggagctgcaggacttgtgccgacagctc
cacgcccgtgtggacaaggtggatgaagagagatacgacatagaggcaaaagtcaccaag
aacatcacggagattgcagatctgactcagaagatctttgaccttcgaggcaagtttaag
cggcccaccctgcggagagtgaggatctctgcagatgccatgatgcaggcgctgctgggg
gcccgggctaaggagtccctggacctgcgggcccacctcaagcaggtgaagaaggaggac
accgagaaggaaaaccgggaggtgggagactggcgcaagaacatcgatgcactgagtgga
atggagggccgcaagaaaaagtttgagagctga

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