Homo sapiens (human): 7156 Help Entry 7156              CDS       T01001                                  Symbol TOP3A, MGRISCE2, PEOB5, TOP3, ZGRF7 Name (RefSeq) DNA topoisomerase III alpha   KO K03165   DNA topoisomerase III [EC:5.6.2.1] Organism hsa  Homo sapiens (human) Pathway hsa03440   Homologous recombination hsa03460   Fanconi anemia pathway Network nt06506  Double-strand break repair   Element N01447   Double Holliday junction dissolution Disease H01395   Autosomal recessive progressive external ophthalmoplegia H02492   Microcephaly, growth restriction, and increased sister chromatid exchange Brite KEGG Orthology (KO) [BR:hsa00001]  09120 Genetic Information Processing   09124 Replication and repair    03440 Homologous recombination     7156 (TOP3A)    03460 Fanconi anemia pathway     7156 (TOP3A)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    03032 DNA replication proteins [BR:hsa03032]     7156 (TOP3A)    03400 DNA repair and recombination proteins [BR:hsa03400]     7156 (TOP3A) Enzymes [BR:hsa01000]  5. Isomerases   5.6  Isomerases altering macromolecular conformation    5.6.2  Enzymes altering nucleic acid conformation     5.6.2.1  DNA topoisomerase      7156 (TOP3A) DNA replication proteins [BR:hsa03032]  Eukaryotic type   DNA Topoisomerases    7156 (TOP3A) DNA repair and recombination proteins [BR:hsa03400]  Eukaryotic type   DSBR (double strand breaks repair)    HR (homologous recombination)     Bloom's syndrome complex (BTR)      7156 (TOP3A)    FA (Fanconi anemia) pathway      7156 (TOP3A) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  Topoisom_bac Zn_ribbon_GRF Toprim Zn_ribbon_Top1 zf-C2H2_10 Zn_ribbon_GRF_2 Zn_ribbon_recom Motif Other DBs NCBI-GeneID:  7156 NCBI-ProteinID:  NP_004609 OMIM:  601243 HGNC:  11992 Ensembl:  ENSG00000177302 UniProt:  Q13472 Structure PDBPDBj LinkDB All DBs Position 17:complement(18271428..18314994) Genome browser AA seq 1001 aa AA seqDB search MIFPVARYALRWLRRPEDRAFSRAAMEMALRGVRKVLCVAEKNDAAKGIADLLSNGRMRR REGLSKFNKIYEFDYHLYGQNVTMVMTSVSGHLLAHDFQMQFRKWQSCNPLVLFEAEIEK YCPENFVDIKKTLERETRQCQALVIWTDCDREGENIGFEIIHVCKAVKPNLQVLRARFSE ITPHAVRTACENLTEPDQRVSDAVDVRQELDLRIGAAFTRFQTLRLQRIFPEVLAEQLIS YGSCQFPTLGFVVERFKAIQAFVPEIFHRIKVTHDHKDGIVEFNWKRHRLFNHTACLVLY QLCVEDPMATVVEVRSKPKSKWRPQALDTVELEKLASRKLRINAKETMRIAEKLYTQGYI SYPRTETNIFPRDLNLTVLVEQQTPDPRWGAFAQSILERGGPTPRNGNKSDQAHPPIHPT KYTNNLQGDEQRLYEFIVRHFLACCSQDAQGQETTVEIDIAQERFVAHGLMILARNYLDV YPYDHWSDKILPVYEQGSHFQPSTVEMVDGETSPPKLLTEADLIALMEKHGIGTDATHAE HIETIKARMYVGLTPDKRFLPGHLGMGLVEGYDSMGYEMSKPDLRAELEADLKLICDGKK DKFVVLRQQVQKYKQVFIEAVAKAKKLDEALAQYFGNGTELAQQEDIYPAMPEPIRKCPQ CNKDMVLKTKKNGGFYLSCMGFPECRSAVWLPDSVLEASRDSSVCPVCQPHPVYRLKLKF KRGSLPPTMPLEFVCCIGGCDDTLREILDLRFSGGPPRASQPSGRLQANQSLNRMDNSQH PQPADSRQTGSSKALAQTLPPPTAAGESNSVTCNCGQEAVLLTVRKEGPNRGRQFFKCNG GSCNFFLWADSPNPGAGGPPALAYRPLGASLGCPPGPGIHLGGFGNPGDGSGSGTSCLCS QPSVTRTVQKDGPNKGRQFHTCAKPREQQCGFFQWVDENTAPGTSGAPSWTGDRGRTLES EARSKRPRASSSDMGSTAKKPRKCSLCHQPGHTRPFCPQNR NT seq 3006 nt NT seq  +upstreamnt  +downstreamnt atgatctttcctgtcgcccgctacgcgctccggtggctgcgacggcccgaagaccgtgcc ttttcccgcgccgccatggagatggccctccgaggcgtgcggaaagtcctctgtgtggcc gaaaaaaacgacgcggccaaggggatcgccgacctgctgtcaaacggtcgcatgaggcgg agagaaggactttcaaaattcaacaagatctatgaatttgattatcatctgtatggccag aatgttaccatggtaatgacttcagtttctggacatttactggctcatgatttccagatg cagtttcgaaaatggcagagctgcaaccctcttgtcctctttgaagcagaaattgaaaag tactgcccagagaattttgtagacatcaagaaaactttggaacgagagactcgccagtgc caggctctggtgatctggactgactgtgatagagaaggcgaaaacatcgggtttgagatt atccacgtgtgtaaggctgtaaagcccaatctgcaggtgttgcgagcccgattctctgag atcacaccccatgccgtcaggacagcttgtgaaaacctgaccgagcctgatcagagggtg agcgatgctgtggatgtgaggcaggagctggacctgaggattggagctgcctttactagg ttccagaccctgcggcttcagaggatttttcctgaggtgctggcagagcagctcatcagt tacggcagctgccagttccccacactgggctttgtggtggagcggttcaaagccattcag gcttttgtaccagaaatcttccacagaattaaagtaactcatgaccacaaagatggtatc gtagaattcaactggaaaaggcatcgactctttaaccacacggcttgcctagttctctat cagttgtgtgtggaggatcccatggcaactgtggtagaggtcagatctaagcccaagagc aagtggcggcctcaagccttggacactgtggagcttgagaagctggcttctcgaaagttg agaataaatgctaaagaaaccatgaggattgctgagaagctctacactcaagggtacatc agctatccccgaacagaaacaaacatttttcccagagacttaaacctgacggtgttggtg gaacagcagacccccgatccacgctggggggcctttgcccagagcattctagagcggggt ggtcccaccccacgcaatgggaacaagtctgaccaagctcaccctcccattcaccccacc aaatacaccaacaacttacagggagatgaacagcgactgtacgagtttattgttcgccat ttcctggcttgctgctcccaggatgctcaggggcaggagaccacagtggagatcgacatc gctcaggaacgctttgtggcccatggcctcatgattctggcccgaaactatctggatgtg tatccatatgatcactggagtgacaagatcctccctgtctatgagcaaggatcccacttt cagcccagcaccgtggagatggtggacggggagaccagcccacccaagctgctcaccgag gccgacctcattgccctcatggagaagcatggcattggtacggatgccactcatgcggag cacatcgagaccatcaaagcccggatgtacgtgggcctcaccccagacaagcggttcctc cctgggcacctgggcatgggacttgtggaaggttatgattccatgggctatgaaatgtct aagcctgacctccgggctgaactggaagctgatctgaagctgatctgtgatggcaaaaag gacaaatttgtggttctaaggcagcaagtgcagaaatacaagcaggttttcattgaagcg gtggctaaagcaaagaaattggacgaggccttggcccagtactttgggaatgggacagag ttggcccagcaagaagatatctacccagccatgccagagcccatcaggaagtgcccacag tgcaacaaggacatggtccttaagaccaagaagaatggcgggttctacctcagctgcatg ggtttcccagagtgtcgctcagctgtgtggcttcctgactcggtgctggaggccagcagg gacagcagtgtgtgtccagtttgtcagccacaccctgtgtacaggttaaagttaaagttt aagcgcggtagccttcccccgaccatgcctctggagtttgtttgctgcatcggcggatgc gacgacaccctgagggagatcctggacctgagattttcagggggcccccccagggctagc cagccctctggccgcctgcaggctaaccagtccctgaacaggatggacaacagccagcac ccccagcctgctgacagcagacagactgggtcctcaaaggctctggcccagaccctccca ccacccacggctgctggtgaaagcaattctgtgacctgcaactgtggccaggaggctgtg ctgctcactgtccgtaaggagggccccaaccggggccggcagttctttaagtgcaacgga ggtagctgcaacttcttcctgtgggcagacagccccaatccgggagcaggagggcctcct gccttggcatatagacccctgggcgcctccctgggatgcccaccaggcccagggatccac ctaggtgggtttggcaaccctggtgatggcagtggtagtggcacatcctgcctttgcagc cagccctccgtcacacggactgtgcagaaggatggacccaacaaggggcgccagttccac acatgtgccaagccgagagagcagcagtgtggctttttccagtgggtcgatgagaacacc gctccagggacttctggagccccgtcctggacaggagacagaggaagaaccctggagtcg gaagccagaagcaaaaggccccgggccagttcctcagacatggggtccacagcaaagaaa ccccggaaatgcagcctttgccaccagcctggacacacccgtcccttttgtcctcagaac agatga

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