Homo sapiens (human): 7407
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Entry
7407 CDS
T01001
Symbol
VARS1, G7A, NDMSCA, VARS, VARS2
Name
(RefSeq) valyl-tRNA synthetase 1
KO
K01873
valyl-tRNA synthetase [EC:
6.1.1.9
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa00970
Aminoacyl-tRNA biosynthesis
Disease
H02709
Neurodevelopmental disorder with aminoacyl-tRNA synthetase defect
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09120 Genetic Information Processing
09122 Translation
00970 Aminoacyl-tRNA biosynthesis
7407 (VARS1)
09180 Brite Hierarchies
09181 Protein families: metabolism
01007 Amino acid related enzymes [BR:
hsa01007
]
7407 (VARS1)
09182 Protein families: genetic information processing
03016 Transfer RNA biogenesis [BR:
hsa03016
]
7407 (VARS1)
Enzymes [BR:
hsa01000
]
6. Ligases
6.1 Forming carbon-oxygen bonds
6.1.1 Ligases forming aminoacyl-tRNA and related compounds
6.1.1.9 valine---tRNA ligase
7407 (VARS1)
Amino acid related enzymes [BR:
hsa01007
]
Aminoacyl-tRNA synthetase
Class I (U)
7407 (VARS1)
Transfer RNA biogenesis [BR:
hsa03016
]
Eukaryotic type
Aminoacyl-tRNA synthetases (AARSs)
Other AARSs
7407 (VARS1)
Prokaryotic type
7407 (VARS1)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
tRNA-synt_1
Anticodon_1
GST_C
tRNA-synt_1g
tRNA-synt_1_2
GST_C_2
tRNA-synt_1e
Jag_N
Arc1p_N_like
Motif
Other DBs
NCBI-GeneID:
7407
NCBI-ProteinID:
NP_006286
OMIM:
192150
HGNC:
12651
Ensembl:
ENSG00000204394
UniProt:
P26640
A0A024RCN6
LinkDB
All DBs
Position
6:complement(31777518..31795752)
Genome browser
AA seq
1264 aa
AA seq
DB search
MSTLYVSPHPDAFPSLRALIAARYGEAGEGPGWGGAHPRICLQPPPTSRTPFPPPRLPAL
EQGPGGLWVWGATAVAQLLWPAGLGGPGGSRAAVLVQQWVSYADTELIPAACGATLPALG
LRSSAQDPQAVLGALGRALSPLEEWLRLHTYLAGEAPTLADLAAVTALLLPFRYVLDPPA
RRIWNNVTRWFVTCVRQPEFRAVLGEVVLYSGARPLSHQPGPEAPALPKTAAQLKKEAKK
REKLEKFQQKQKIQQQQPPPGEKKPKPEKREKRDPGVITYDLPTPPGEKKDVSGPMPDSY
SPRYVEAAWYPWWEQQGFFKPEYGRPNVSAANPRGVFMMCIPPPNVTGSLHLGHALTNAI
QDSLTRWHRMRGETTLWNPGCDHAGIATQVVVEKKLWREQGLSRHQLGREAFLQEVWKWK
EEKGDRIYHQLKKLGSSLDWDRACFTMDPKLSAAVTEAFVRLHEEGIIYRSTRLVNWSCT
LNSAISDIEVDKKELTGRTLLSVPGYKEKVEFGVLVSFAYKVQGSDSDEEVVVATTRIET
MLGDVAVAVHPKDTRYQHLKGKNVIHPFLSRSLPIVFDEFVDMDFGTGAVKITPAHDQND
YEVGQRHGLEAISIMDSRGALINVPPPFLGLPRFEARKAVLVALKERGLFRGIEDNPMVV
PLCNRSKDVVEPLLRPQWYVRCGEMAQAASAAVTRGDLRILPEAHQRTWHAWMDNIREWC
ISRQLWWGHRIPAYFVTVSDPAVPPGEDPDGRYWVSGRNEAEAREKAAKEFGVSPDKISL
QQDEDVLDTWFSSGLFPLSILGWPNQSEDLSVFYPGTLLETGHDILFFWVARMVMLGLKL
TGRLPFREVYLHAIVRDAHGRKMSKSLGNVIDPLDVIYGISLQGLHNQLLNSNLDPSEVE
KAKEGQKADFPAGIPECGTDALRFGLCAYMSQGRDINLDVNRILGYRHFCNKLWNATKFA
LRGLGKGFVPSPTSQPGGHESLVDRWIRSRLTEAVRLSNQGFQAYDFPAVTTAQYSFWLY
ELCDVYLECLKPVLNGVDQVAAECARQTLYTCLDVGLRLLSPFMPFVTEELFQRLPRRMP
QAPPSLCVTPYPEPSECSWKDPEAEAALELALSITRAVRSLRADYNLTRIRPDCFLEVAD
EATGALASAVSGYVQALASAGVVAVLALGAPAPQGCAVALASDRCSIHLQLQGLVDPARE
LGKLQAKRVEAQRQAQRLRERRAASGYPVKVPLEVQEADEAKLQQTEAELRKVDEAIALF
QKML
NT seq
3795 nt
NT seq
+upstream
nt +downstream
nt
atgtccaccctctacgtctcccctcacccagatgccttccccagcctccgagccctcata
gccgctcgctatggggaggctggggagggtcccggatggggaggagcccacccccgcatc
tgtctccagccacccccgactagcaggactccctttcccccaccccgcctgccggccctg
gagcaggggcccggtgggctctgggtgtggggggccacggctgtggcccagctgctgtgg
ccagcaggcctggggggcccagggggcagccgggcggctgtccttgtccaacagtgggtc
agttacgccgacacggagttaataccagctgcctgtggagcaacgctgccggccctggga
ctccgaagctcggcccaggacccccaggctgtgctgggggccctgggcagggccctgagc
cccttggaggagtggcttcggctgcacacctacttggccggggaggcccccactctggct
gacctggcggctgtcacagccttgctgctgcctttccgatacgtcctagacccacctgcc
cgccggatctggaataatgtgactcgctggtttgtcacgtgtgtccggcagccagaattc
cgagccgtgctaggagaagtggttctatactcaggagccaggcctctctctcatcagcca
ggccccgaggctcctgccctcccaaagacagctgctcagctcaagaaagaggcaaagaaa
cgggagaagctagagaaattccaacagaagcagaagatccaacagcagcagccacctcca
ggggagaagaaaccaaaaccagagaagagggagaaacgggatcctggggtcattacctat
gacctcccaaccccacccggggaaaagaaagatgtcagtggccccatgcccgactcctac
agccctcggtatgtggaggctgcctggtacccttggtgggagcagcagggcttcttcaag
ccagagtatgggcgtcctaatgtgtcagcagcaaatccccgaggtgtcttcatgatgtgc
atcccaccccccaatgtgacaggctccctgcacctgggccatgcactcaccaacgccatc
caggactccctgactcgatggcaccgcatgcgtggggagaccaccctgtggaaccctggc
tgtgaccatgcaggtattgccacccaggtggtggtggagaagaagctatggcgtgagcag
ggactgagccggcaccagctgggccgcgaggcctttctacaggaagtctggaagtggaag
gaggagaaaggtgaccggatttaccaccagttgaagaagcttggcagctccttggactgg
gatcgagcctgtttcaccatggaccctaaactctcagcagctgtgacagaggcctttgtc
cggcttcacgaggaaggcatcatctatcgcagtacccgccttgttaactggtcctgcacc
ctcaactccgccatctctgacattgaggtggataagaaggagctgacaggtcgcaccctg
ctctccgtgcctggctacaaggagaaggtggagttcggggtcctcgtgtcctttgcctat
aaggtccaaggctcagatagcgacgaggaggtggtggtggcaacaactcggatcgagaca
atgctgggagatgtggctgtagctgtgcaccccaaagataccagataccagcacctgaag
gggaagaacgtgatccacccattcctgtctcggagccttcccattgtcttcgatgaattt
gtggacatggactttggcacaggtgctgtgaagatcacccccgcacatgaccaaaatgac
tatgaagttgggcagcggcacgggctggaggccatcagcatcatggactcccggggggcc
ctcatcaatgtgcctccgcctttcctgggcctgcccaggtttgaggccaggaaagcggtg
ctggtggcgctgaaggagcggggactgttccgtggcattgaggacaaccccatggtggtg
ccactttgcaaccggtcgaaggacgtggtagagcctctgctgcggccgcagtggtacgtt
cgctgcggggagatggcccaggctgccagcgccgctgtgactcggggtgacctccgcatc
ctgcctgaggcccatcagcgcacatggcatgcctggatggacaacatccgggagtggtgc
atttccaggcagctgtggtggggccatcgcatcccagcctactttgtcactgtcagtgac
ccagcggtgccccctggggaggaccctgatgggcggtactgggtgagtggacgcaatgag
gcggaggcccgggagaaggcagccaaggagttcggagtgtcccctgacaagatcagtctc
cagcaagatgaggatgtattggatacctggttctcctctggcctcttccccttatccatt
ttgggctggcccaaccagtcagaagacctgagtgtgttctaccccgggacactgctggag
accggtcatgacatcctcttcttctgggtggcccggatggtcatgctgggcctgaagctc
acgggcaggctgccctttagagaggtctacctccatgccatcgtgcgagatgctcacggc
cggaagatgagcaagtctctaggcaatgtcatcgatcccctggacgtcatctatggaatc
tccctgcagggcctccacaaccagctgctgaacagcaacctggatcccagcgaggtggag
aaggccaaagaagggcagaaagctgacttcccagcggggattcctgaatgtggcaccgat
gctctccggtttggattatgtgcctacatgtcccagggtcgtgacatcaacctggatgtg
aaccggatactgggttaccgccacttctgcaacaagctctggaatgccaccaagtttgcc
cttcgtggccttgggaagggttttgtgccctcacccacctcccagcccggaggccatgag
agcctggtggaccgctggatccgcagccgcctgacagaggctgtgaggctcagcaatcaa
ggcttccaggcctacgacttcccggccgtcaccactgcccagtacagcttctggctctat
gagctctgtgatgtctacttggagtgcctgaaacctgtactgaatggggtggaccaggtg
gcagctgagtgtgcccgccagaccctgtacacttgcctggacgttggcctgcggctgctc
tcacccttcatgcccttcgtgacggaggagctgttccagaggctgccccggaggatgccg
caagctccccctagcctctgtgttaccccctacccggagccctcagagtgctcctggaag
gaccccgaggcagaagccgcccttgagctggcgctaagcatcacgcgagccgtgcgctcc
ctgcgggccgactacaacctcacccggatccggcctgactgtttcctggaagtggcggat
gaggccacgggcgccctggcatcggcggtgtcgggctacgtgcaggccctggccagcgca
ggtgtggtggctgttctggccctgggggctcccgccccccagggttgcgctgtggctctg
gcttctgatcgctgctccatccacctgcagcttcaggggctggtggaccctgcacgggag
ctgggcaagctgcaagccaagcgagttgaggcccagcggcaggcccagcgtctgcgggaa
cgccgtgctgcctcgggctatcctgtcaaggtgccgctcgaagtccaggaggcagatgaa
gccaagctccaacagacagaagcagagctcaggaaggtggatgaggccatcgccctattc
cagaagatgctgtga
DBGET
integrated database retrieval system
