Homo sapiens (human): 7453
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Entry
7453 CDS
T01001
Symbol
WARS1, GAMMA-2, HMN9, HMND9, IFI53, IFP53, NEDMSBA, WARS
Name
(RefSeq) tryptophanyl-tRNA synthetase 1
KO
K01867
tryptophanyl-tRNA synthetase [EC:
6.1.1.2
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa00970
Aminoacyl-tRNA biosynthesis
Disease
H00856
Distal hereditary motor neuropathies
H02709
Neurodevelopmental disorder with aminoacyl-tRNA synthetase defect
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09120 Genetic Information Processing
09122 Translation
00970 Aminoacyl-tRNA biosynthesis
7453 (WARS1)
09180 Brite Hierarchies
09181 Protein families: metabolism
01007 Amino acid related enzymes [BR:
hsa01007
]
7453 (WARS1)
09182 Protein families: genetic information processing
03016 Transfer RNA biogenesis [BR:
hsa03016
]
7453 (WARS1)
Enzymes [BR:
hsa01000
]
6. Ligases
6.1 Forming carbon-oxygen bonds
6.1.1 Ligases forming aminoacyl-tRNA and related compounds
6.1.1.2 tryptophan---tRNA ligase
7453 (WARS1)
Amino acid related enzymes [BR:
hsa01007
]
Aminoacyl-tRNA synthetase
Class I (G)
7453 (WARS1)
Transfer RNA biogenesis [BR:
hsa03016
]
Eukaryotic type
Aminoacyl-tRNA synthetases (AARSs)
Other AARSs
7453 (WARS1)
Prokaryotic type
7453 (WARS1)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
tRNA-synt_1b
WHEP-TRS
Motif
Other DBs
NCBI-GeneID:
7453
NCBI-ProteinID:
NP_004175
OMIM:
191050
HGNC:
12729
Ensembl:
ENSG00000140105
UniProt:
P23381
A0A024R6K8
Structure
PDB
PDBj
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All DBs
Position
14:complement(100333790..100376327)
Genome browser
AA seq
471 aa
AA seq
DB search
MPNSEPASLLELFNSIATQGELVRSLKAGNASKDEIDSAVKMLVSLKMSYKAAAGEDYKA
DCPPGNPAPTSNHGPDATEAEEDFVDPWTVQTSSAKGIDYDKLIVRFGSSKIDKELINRI
ERATGQRPHHFLRRGIFFSHRDMNQVLDAYENKKPFYLYTGRGPSSEAMHVGHLIPFIFT
KWLQDVFNVPLVIQMTDDEKYLWKDLTLDQAYSYAVENAKDIIACGFDINKTFIFSDLDY
MGMSSGFYKNVVKIQKHVTFNQVKGIFGFTDSDCIGKISFPAIQAAPSFSNSFPQIFRDR
TDIQCLIPCAIDQDPYFRMTRDVAPRIGYPKPALLHSTFFPALQGAQTKMSASDPNSSIF
LTDTAKQIKTKVNKHAFSGGRDTIEEHRQFGGNCDVDVSFMYLTFFLEDDDKLEQIRKDY
TSGAMLTGELKKALIEVLQPLIAEHQARRKEVTDEIVKEFMTPRKLSFDFQ
NT seq
1416 nt
NT seq
+upstream
nt +downstream
nt
atgcccaacagtgagcccgcatctctgctggagctgttcaacagcatcgccacacaaggg
gagctcgtaaggtccctcaaagcgggaaatgcgtcaaaggatgaaattgattctgcagta
aagatgttggtgtcattaaaaatgagctacaaagctgccgcgggggaggattacaaggct
gactgtcctccagggaacccagcacctaccagtaatcatggcccagatgccacagaagct
gaagaggattttgtggacccatggacagtacagacaagcagtgcaaaaggcatagactac
gataagctcattgttcggtttggaagtagtaaaattgacaaagagctaataaaccgaata
gagagagccaccggccaaagaccacaccacttcctgcgcagaggcatcttcttctcacac
agagatatgaatcaggttcttgatgcctatgaaaataagaagccattttatctgtacacg
ggccggggcccctcttctgaagcaatgcatgtaggtcacctcattccatttattttcaca
aagtggctccaggatgtatttaacgtgcccttggtcatccagatgacggatgacgagaag
tatctgtggaaggacctgaccctggaccaggcctatagctatgctgtggagaatgccaag
gacatcatcgcctgtggctttgacatcaacaagactttcatattctctgacctggactac
atggggatgagctcaggtttctacaaaaatgtggtgaagattcaaaagcatgttaccttc
aaccaagtgaaaggcattttcggcttcactgacagcgactgcattgggaagatcagtttt
cctgccatccaggctgctccctccttcagcaactcattcccacagatcttccgagacagg
acggatatccagtgccttatcccatgtgccattgaccaggatccttactttagaatgaca
agggacgtcgcccccaggatcggctatcctaaaccagccctgctgcactccaccttcttc
ccagccctgcagggcgcccagaccaaaatgagtgccagcgaccccaactcctccatcttc
ctcaccgacacggccaagcagatcaaaaccaaggtcaataagcatgcgttttctggaggg
agagacaccatcgaggagcacaggcagtttgggggcaactgtgatgtggacgtgtctttc
atgtacctgaccttcttcctcgaggacgacgacaagctcgagcagatcaggaaggattac
accagcggagccatgctcaccggtgagctcaagaaggcactcatagaggttctgcagccc
ttgatcgcagagcaccaggcccggcgcaaggaggtcacggatgagatagtgaaagagttc
atgactccccggaagctgtccttcgactttcagtag
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