Homo sapiens (human): 7514
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Entry
7514 CDS
T01001
Symbol
XPO1, CRM-1, CRM1, emb, exp1
Name
(RefSeq) exportin 1
KO
K14290
exportin-1
Organism
hsa
Homo sapiens (human)
Pathway
hsa03008
Ribosome biogenesis in eukaryotes
hsa03013
Nucleocytoplasmic transport
hsa03250
Viral life cycle - HIV-1
hsa05164
Influenza A
hsa05166
Human T-cell leukemia virus 1 infection
Drug target
Eltanexor:
D11499
Selinexor:
D11222
<US>
Verdinexor:
D11223
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09120 Genetic Information Processing
09122 Translation
03013 Nucleocytoplasmic transport
7514 (XPO1)
03008 Ribosome biogenesis in eukaryotes
7514 (XPO1)
09125 Information processing in viruses
03250 Viral life cycle - HIV-1
7514 (XPO1)
09160 Human Diseases
09172 Infectious disease: viral
05166 Human T-cell leukemia virus 1 infection
7514 (XPO1)
05164 Influenza A
7514 (XPO1)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
03019 Messenger RNA biogenesis [BR:
hsa03019
]
7514 (XPO1)
03009 Ribosome biogenesis [BR:
hsa03009
]
7514 (XPO1)
03016 Transfer RNA biogenesis [BR:
hsa03016
]
7514 (XPO1)
03036 Chromosome and associated proteins [BR:
hsa03036
]
7514 (XPO1)
Messenger RNA biogenesis [BR:
hsa03019
]
Eukaryotic type
mRNA surveillance and transport factors
Transport factors
Ran-mediated transport factors
7514 (XPO1)
Ribosome biogenesis [BR:
hsa03009
]
Eukaryotic type
Pre-40S particles
Export and cytoplasmic maturation factors
7514 (XPO1)
Pre-60S particles
7514 (XPO1)
Transfer RNA biogenesis [BR:
hsa03016
]
Eukaryotic type
tRNA transport factors
tRNA export factors
7514 (XPO1)
Chromosome and associated proteins [BR:
hsa03036
]
Eukaryotic type
Centrosome formation proteins
Centrosome duplication proteins
Regulators of centriole replication
7514 (XPO1)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
CRM1_C
Xpo1
CRM1_repeat_2
CRM1_repeat_3
CRM1_repeat
IBN_N
mTOR_dom
Hydrolase_3
BspA_v
Motif
Other DBs
NCBI-GeneID:
7514
NCBI-ProteinID:
NP_003391
OMIM:
602559
HGNC:
12825
Ensembl:
ENSG00000082898
Pharos:
O14980
(Tbio)
UniProt:
O14980
B3KWD0
Structure
PDB
LinkDB
All DBs
Position
2:complement(61477849..61538612)
Genome browser
AA seq
1071 aa
AA seq
DB search
MPAIMTMLADHAARQLLDFSQKLDINLLDNVVNCLYHGEGAQQRMAQEVLTHLKEHPDAW
TRVDTILEFSQNMNTKYYGLQILENVIKTRWKILPRNQCEGIKKYVVGLIIKTSSDPTCV
EKEKVYIGKLNMILVQILKQEWPKHWPTFISDIVGASRTSESLCQNNMVILKLLSEEVFD
FSSGQITQVKSKHLKDSMCNEFSQIFQLCQFVMENSQNAPLVHATLETLLRFLNWIPLGY
IFETKLISTLIYKFLNVPMFRNVSLKCLTEIAGVSVSQYEEQFVTLFTLTMMQLKQMLPL
NTNIRLAYSNGKDDEQNFIQNLSLFLCTFLKEHDQLIEKRLNLRETLMEALHYMLLVSEV
EETEIFKICLEYWNHLAAELYRESPFSTSASPLLSGSQHFDVPPRRQLYLPMLFKVRLLM
VSRMAKPEEVLVVENDQGEVVREFMKDTDSINLYKNMRETLVYLTHLDYVDTERIMTEKL
HNQVNGTEWSWKNLNTLCWAIGSISGAMHEEDEKRFLVTVIKDLLGLCEQKRGKDNKAII
ASNIMYIVGQYPRFLRAHWKFLKTVVNKLFEFMHETHDGVQDMACDTFIKIAQKCRRHFV
QVQVGEVMPFIDEILNNINTIICDLQPQQVHTFYEAVGYMIGAQTDQTVQEHLIEKYMLL
PNQVWDSIIQQATKNVDILKDPETVKQLGSILKTNVRACKAVGHPFVIQLGRIYLDMLNV
YKCLSENISAAIQANGEMVTKQPLIRSMRTVKRETLKLISGWVSRSNDPQMVAENFVPPL
LDAVLIDYQRNVPAAREPEVLSTMAIIVNKLGGHITAEIPQIFDAVFECTLNMINKDFEE
YPEHRTNFFLLLQAVNSHCFPAFLAIPPTQFKLVLDSIIWAFKHTMRNVADTGLQILFTL
LQNVAQEEAAAQSFYQTYFCDILQHIFSVVTDTSHTAGLTMHASILAYMFNLVEEGKIST
SLNPGNPVNNQIFLQEYVANLLKSAFPHLQDAQVKLFVTGLFSLNQDIPAFKEHLRDFLV
QIKEFAGEDTSDLFLEEREIALRQADEEKHKRQMSVPGIFNPHEIPEEMCD
NT seq
3216 nt
NT seq
+upstream
nt +downstream
nt
atgccagcaattatgacaatgttagcagaccatgcagctcgtcagctgcttgatttcagc
caaaaactggatatcaacttattagataatgtggtgaattgcttataccatggagaagga
gcccagcaaagaatggctcaagaagtactgacacatttaaaggagcatcctgatgcttgg
acaagagtcgacacaattttggaattttctcagaatatgaatacgaaatactatggacta
caaattttggaaaatgtgataaaaacaaggtggaagattcttccaaggaaccagtgcgaa
ggaataaaaaaatacgttgttggcctcattatcaagacgtcatctgacccaacttgtgta
gagaaagaaaaggtgtatatcggaaaattaaatatgatccttgttcagatactgaaacaa
gaatggcccaaacattggccaacttttatcagtgatattgttggagcaagtaggaccagc
gaaagtctctgtcaaaataatatggtgattcttaaactcttgagtgaagaagtatttgat
ttctctagtggacagataacccaagtcaaatctaagcatttaaaagacagcatgtgcaat
gaattctcacagatatttcaactgtgtcagtttgtaatggaaaattctcaaaatgctcca
cttgtacatgcaaccttggaaacattgctcagatttctgaactggattcccctgggatat
atttttgagaccaaattaatcagcacattgatttataagttcctgaatgttccaatgttt
cgaaatgtctctctgaagtgcctcactgagattgctggtgtgagtgtaagccaatatgaa
gaacaatttgtaacactatttactctgacaatgatgcaactaaagcagatgcttccttta
aataccaatattcgacttgcgtactcaaatggaaaagatgatgaacagaacttcattcaa
aatctcagtttgtttctctgcacctttcttaaggaacatgatcaacttatagaaaaaaga
ttaaatctcagggaaactcttatggaggcccttcattatatgttgttggtatctgaagta
gaagaaactgaaatctttaaaatttgtcttgaatactggaatcatttggctgctgaactc
tatagagagagtccattctctacatctgcctctccgttgctttctggaagtcaacatttt
gatgttcctcccaggagacagctatatttgcccatgttattcaaggtccgtttattaatg
gttagtcgaatggctaaaccagaggaagtattggttgtagagaatgatcaaggagaagtt
gtgagagaattcatgaaggatacagattccataaatttgtataagaatatgagggaaaca
ttggtttatcttactcatctggattatgtagatacagaaagaataatgacagagaagctt
cacaatcaagtgaatggtacagagtggtcatggaaaaatttgaatacattgtgttgggca
ataggctccattagtggagcaatgcatgaagaggacgaaaaacgatttcttgttactgtt
ataaaggatctattaggattatgtgaacagaaaagaggcaaagataataaagctattatt
gcatcaaatatcatgtacatagtaggtcaatacccacgttttttgagagctcactggaaa
tttctgaagactgtagttaacaagctgttcgaattcatgcatgagacccatgatggagtc
caggatatggcttgtgatactttcattaaaatagcccaaaaatgccgcaggcatttcgtt
caggttcaggttggagaagtgatgccatttattgatgaaattttgaacaacattaacact
attatttgtgatcttcagcctcaacaggttcatacgttttatgaagctgtggggtacatg
attggtgcacaaacagatcaaacagtacaagaacacttgatagaaaagtacatgttactc
cctaatcaagtgtgggatagtataatccagcaggcaaccaaaaatgtggatatactgaaa
gatcctgaaacagtcaagcagcttggtagcattttgaaaacaaatgtgagagcctgcaaa
gctgttggacacccctttgtaattcagcttggaagaatttatttagatatgcttaatgta
tacaagtgcctcagtgaaaatatttctgcagctatccaagctaatggtgaaatggttaca
aagcaaccattgattagaagtatgcgaactgtaaaaagggaaactttaaagttaatatct
ggttgggtgagccgatccaatgatccacagatggtcgctgaaaattttgttccccctctg
ttggatgcagttctcattgattatcagagaaatgtcccagctgctagagaaccagaagtg
cttagtactatggccataattgtcaacaagttagggggacatataacagctgaaatacct
caaatatttgatgctgtttttgaatgcacattgaatatgataaataaggactttgaagaa
tatcctgaacatagaacgaactttttcttactacttcaggctgtcaattctcattgtttc
ccagcattccttgctattccacctacacagtttaaacttgttttggattccatcatttgg
gctttcaaacatactatgaggaatgtcgcagatacgggcttacagatactttttacactc
ttacaaaatgttgcacaagaagaagctgcagctcagagtttttatcaaacttatttttgt
gatattctccagcatatcttttctgttgtgacagacacttcacatactgctggtttaaca
atgcatgcatcaattcttgcatatatgtttaatttggttgaagaaggaaaaataagtaca
tcattaaatcctggaaatccagttaacaaccaaatctttcttcaggaatatgtggctaat
ctccttaagtcggccttccctcacctacaagatgctcaagtaaagctctttgtgacaggg
cttttcagcttaaatcaagatattcctgctttcaaggaacatttaagagatttcctagtt
caaataaaggaatttgcaggtgaagacacttctgatttgtttttggaagagagagaaata
gccctacggcaggctgatgaagagaaacataaacgtcaaatgtctgtccctggcatcttt
aatccacatgagattccagaagaaatgtgtgattaa
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