KEGG T01001: 79139

Homo sapiens (human): 79139

Entry

79139             CDS       T01001

Symbol

DERL1, DER-1, DER1, derlin-1

Name

(RefSeq) derlin 1

K11519

Derlin-1

Organism

hsa Homo sapiens (human)

Pathway

hsa04141

Protein processing in endoplasmic reticulum

hsa05014

Amyotrophic lateral sclerosis

hsa05022

Pathways of neurodegeneration - multiple diseases

Network

nt06464 Amyotrophic lateral sclerosis
nt06466 Pathways of neurodegeneration

Element

N01144

Mutation-caused aberrant SOD1 to 26S proteasome-mediated protein degradation

Brite

KEGG Orthology (KO) [BR:hsa00001]
09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04141 Protein processing in endoplasmic reticulum
    79139 (DERL1)
09160 Human Diseases
  09164 Neurodegenerative disease
   05014 Amyotrophic lateral sclerosis
    79139 (DERL1)
   05022 Pathways of neurodegeneration - multiple diseases
    79139 (DERL1)

SSDB

Motif

Pfam:

DER1 ActD

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

UniProt:

Structure

LinkDB

Position

8:complement(123013170..123042302)

AA seq 251 aa
MSDIGDWFRSIPAITRYWFAATVAVPLVGKLGLISPAYLFLWPEAFLYRFQIWRPITATF
YFPVGPGTGFLYLVNLYFLYQYSTRLETGAFDGRPADYLFMLLFNWICIVITGLAMDMQL
LMIPLIMSVLYVWAQLNRDMIVSFWFGTRFKACYLPWVILGFNYIIGGSVINELIGNLVG
HLYFFLMFRYPMDLGGRNFLSTPQFLYRWLPSRRGGVSGFGVPPASMRRAADQNGGGGRH
NWGQGFRLGDQ

NT seq 756 nt +upstreamnt +downstreamnt
atgtcggacatcggagactggttcaggagcatcccggcgatcacgcgctattggttcgcc
gccaccgtcgccgtgcccttggtcggcaaactcggcctcatcagcccggcctacctcttc
ctctggcccgaagccttcctttatcgctttcagatttggaggccaatcactgccaccttt
tatttccctgtgggtccaggaactggatttctttatttggtcaatttatatttcttatat
cagtattctacgcgacttgaaacaggagcttttgatgggaggccagcagactatttattc
atgctcctctttaactggatttgcatcgtgattactggcttagcaatggatatgcagttg
ctgatgattcctctgatcatgtcagtactttatgtctgggcccagctgaacagagacatg
attgtatcattttggtttggaacacgatttaaggcctgctatttaccctgggttatcctt
ggattcaactatatcatcggaggctcggtaatcaatgagcttattggaaatctggttgga
catctttattttttcctaatgttcagatacccaatggacttgggaggaagaaattttcta
tccacacctcagtttttgtaccgctggctgcccagtaggagaggaggagtatcaggattt
ggtgtgccccctgctagcatgaggcgagctgctgatcagaatggcggaggcgggagacac
aactggggccagggctttcgacttggagaccagtga

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