Homo sapiens (human): 79717
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Entry
79717 CDS
T01001
Symbol
PPCS, CMD2C
Name
(RefSeq) phosphopantothenoylcysteine synthetase
KO
K01922
phosphopantothenate---cysteine ligase (ATP) [EC:
6.3.2.51
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa00770
Pantothenate and CoA biosynthesis
hsa01100
Metabolic pathways
hsa01240
Biosynthesis of cofactors
Module
hsa_M00120
Coenzyme A biosynthesis, pantothenate => CoA
Disease
H00294
Dilated cardiomyopathy
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09100 Metabolism
09108 Metabolism of cofactors and vitamins
00770 Pantothenate and CoA biosynthesis
79717 (PPCS)
Enzymes [BR:
hsa01000
]
6. Ligases
6.3 Forming carbon-nitrogen bonds
6.3.2 Acid-D-amino-acid ligases (peptide synthases)
6.3.2.51 phosphopantothenate---cysteine ligase (ATP)
79717 (PPCS)
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Motif
Pfam:
DFP
Collectrin
Motif
Other DBs
NCBI-GeneID:
79717
NCBI-ProteinID:
NP_078940
OMIM:
609853
HGNC:
25686
Ensembl:
ENSG00000127125
UniProt:
Q9HAB8
Structure
PDB
PDBj
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All DBs
Position
1:42456341..42473417
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AA seq
311 aa
AA seq
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MAEMDPVAEFPQPPGAARWAEVMARFAARLGAQGRRVVLVTSGGTKVPLEARPVRFLDNF
SSGRRGATSAEAFLAAGYGVLFLYRARSAFPYAHRFPPQTWLSALRPSGPALSGLLSLEA
EENALPGFAEALRSYQEAAAAGTFLAVEFTTLADYLHLLQAAAQALNPLGPSAMFYLAAA
VSDFYVPVSEMPEHKIQSSGGPLQITMKMVPKLLSPLVKDWAPKAFIISFKLETDPAIVI
NRARKALEIYQHQVVVANILESRQSFVFIVTKDSETKLLLSEEEIEKGVEIEEKIVDNLQ
SRHTAFIGDRN
NT seq
936 nt
NT seq
+upstream
nt +downstream
nt
atggcggaaatggatccggtagccgagttcccccagcctcccggtgctgcgcgctgggct
gaggttatggctcgcttcgcggccaggctgggcgcgcagggccggcgggtggtgttggtt
acgtcaggcggcaccaaggtcccactggaagcgcggccggtgcgcttcctggacaacttc
agcagcgggcggcgcggtgcaacctcggccgaggccttcctagccgccggctacggggtc
ctgttcttgtatcgcgctcgctctgccttcccctatgcccaccgcttcccaccccagact
tggctgtccgctctgcggccttcgggcccagccctttcgggcttgctgagcctggaggcc
gaggagaatgcacttccgggttttgctgaggctctgaggagctaccaggaggctgcggct
gcaggcaccttcctggcagtagagttcaccactttggcggactatttgcatctgttgcag
gctgcggcccaggcactcaatccgctaggcccttctgcgatgttttacctggctgcggct
gtgtcagatttctatgttcctgtctctgaaatgcctgaacacaagatccagtcatctggg
ggcccactgcagataacaatgaagatggtgccaaaactgctttctcctttggttaaagat
tgggctcccaaagcatttataatttcctttaagttggagactgaccccgccattgtaatt
aatcgagctcggaaggctttggaaatttatcagcatcaagtggtggtggctaatatcctt
gagtcacgacagtcctttgtgtttattgtaaccaaagactcggaaaccaagttattgcta
tcagaggaagaaatagaaaaaggcgtagagatagaagagaagatagtggataatcttcag
tctcgacacacagcttttataggtgacagaaactga
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