Homo sapiens (human): 8216
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Entry
8216 CDS
T01001
Symbol
LZTR1, BTBD29, LZTR-1, NS10, NS2, SWNTS2
Name
(RefSeq) leucine zipper like post translational regulator 1
KO
K23330
leucine-zipper-like transcriptional regulator 1
Organism
hsa
Homo sapiens (human)
Network
nt06526
MAPK signaling
Element
N01596
Regulation of GF-RTK-RAS-ERK signaling, RAS ubiquitination by CUL3 complex
Disease
H00523
Noonan syndrome and related disorders
H01738
Noonan syndrome
H02945
Schwannomatosis
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09180 Brite Hierarchies
09182 Protein families: genetic information processing
04121 Ubiquitin system [BR:
hsa04121
]
8216 (LZTR1)
Ubiquitin system [BR:
hsa04121
]
Ubiquitin ligases (E3)
Multi subunit type E3
Cul3 complex
Adoptor and target recognizing subunit (BTB)
8216 (LZTR1)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Kelch_KLHDC2_KLHL20_DRC7
Beta-prop_FBX42
Beta-prop_ATRN-LZTR1
Kelch_1
Kelch_HCF
BTB
Kelch_2
Kelch_FKB95
NANM
Beta-prop_TYW4
Beta-prop_Calicin
BACK
BACK_BTBD8
RAG2
BACK_BPM_SPOP
Motif
Other DBs
NCBI-GeneID:
8216
NCBI-ProteinID:
NP_006758
OMIM:
600574
HGNC:
6742
Ensembl:
ENSG00000099949
UniProt:
Q8N653
A0A384NL67
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Position
22:20982297..20999032
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AA seq
840 aa
AA seq
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MAGPGSTGGQIGAAALAGGARSKVAPSVDFDHSCSDSVEYLTLNFGPFETVHRWRRLPPC
DEFVGARRSKHTVVAYKDAIYVFGGDNGKTMLNDLLRFDVKDCSWCRAFTTGTPPAPRYH
HSAVVYGSSMFVFGGYTGDIYSNSNLKNKNDLFEYKFATGQWTEWKIEGRLPVARSAHGA
TVYSDKLWIFAGYDGNARLNDMWTIGLQDRELTCWEEVAQSGEIPPSCCNFPVAVCRDKM
FVFSGQSGAKITNNLFQFEFKDKTWTRIPTEHLLRGSPPPPQRRYGHTMVAFDRHLYVFG
GAADNTLPNELHCYDVDFQTWEVVQPSSDSEVGGAEVPERACASEEVPTLTYEERVGFKK
SRDVFGLDFGTTSAKQPTQPASELPSGRLFHAAAVISDAMYIFGGTVDNNIRSGEMYRFQ
FSCYPKCTLHEDYGRLWESRQFCDVEFVLGEKEECVQGHVAIVTARSRWLRRKITQARER
LAQKLEQEAAPVPREAPGVAAGGARPPLLHVAIREAEARPFEVLMQFLYTDKIKYPRKGH
VEDVLLIMDVYKLALSFQLCRLEQLCRQYIEASVDLQNVLVVCESAARLQLSQLKEHCLN
FVVKESHFNQVIMMKEFERLSSPLIVEIVRRKQQPPPRTPLDQPVDIGTSLIQDMKAYLE
GAGAEFCDITLLLDGHPRPAHKAILAARSSYFEAMFRSFMPEDGQVNISIGEMVPSRQAF
ESMLRYIYYGEVNMPPEDSLYLFAAPYYYGFYNNRLQAYCKQNLEMNVTVQNVLQILEAA
DKTQALDMKRHCLHIIVHQFTKVSKLPTLRSLSQQLLLDIIDSLASHISDKQCAELGADI
NT seq
2523 nt
NT seq
+upstream
nt +downstream
nt
atggctggaccgggcagcacgggggggcagatcggggctgcggccctggcaggcggcgcg
cggtccaaggtagccccgagcgtggacttcgaccatagctgctcggacagtgtcgagtac
ctgacgctcaacttcgggcccttcgaaacagtgcatcgctggcggcgcctcccgccctgc
gacgagttcgtgggtgcccggcgcagcaagcacacagtggtggcctataaagatgccatt
tatgtatttggtggagacaatgggaagaccatgctcaatgacctcctgcggttcgatgtg
aaagactgctcctggtgcagggcctttaccactgggaccccaccggccccccgttaccac
cactcggccgtcgtctatgggagcagcatgtttgtctttgggggttacactggggacatt
tattccaattctaacttgaagaataaaaacgacctctttgaatacaagtttgcaactggc
cagtggacggagtggaaaattgaaggacggttgccagtcgctaggtcagcccatggggcc
acggtgtacagtgacaagctgtggatctttgctggctatgacggcaacgccaggttgaat
gacatgtggacaattggcctccaggaccgagagctcacctgctgggaggaggtggcccag
agtggcgagatccccccatcttgctgcaacttccccgtggctgtgtgccgggacaagatg
tttgtattctctgggcaaagcggagccaaaataaccaacaacctcttccagtttgaattc
aaggacaagacgtggacacgcatcccaactgaacacctgctccggggctccccaccaccc
ccgcagcggcgctacgggcataccatggtggcctttgaccgccacctctatgtgtttggg
ggtgcggccgacaacacgctgcccaacgagctgcactgctatgacgtggacttccagacc
tgggaggtcgtccagcccagctccgacagcgaggttggtggggctgaagtgcccgagcga
gcctgtgcttccgaggaggtgcccaccctgacctatgaggagcgggttggcttcaagaag
tcccgagatgtgtttggcctggactttggcaccacctcagccaagcagcccacccagcct
gcctcggagctgcccagtgggaggctcttccacgcggctgctgtcatctcggacgccatg
tacatcttcgggggcacggtggacaacaacatccgcagcggggagatgtacaggttccag
ttctcctgttaccctaaatgcacgctgcacgaggactacgggcggctgtgggagagccgc
cagttctgcgacgtggagttcgtgctgggtgagaaggaggagtgcgtgcagggccacgta
gccattgtcacagcgcggagccgctggcttcgcaggaagatcacgcaggcgcgggagagg
ctggcccagaagctggagcaggaggccgccccagttcccagggaggcccccggcgtggct
gctggtggggcccggccgcccctgctgcacgtggccatccgggaggccgaggcccggccc
ttcgaggtgctcatgcagttcctctacaccgacaagatcaaatacccacggaaaggccat
gtggaggatgtgctgctcatcatggatgtgtacaaactggcactgagcttccagttgtgc
cgcctggagcagctgtgccgccagtacatcgaggcctccgtggacctgcagaacgtgctg
gttgtgtgcgagagtgccgcccggctgcagctgagccaactcaaggagcactgcctgaac
ttcgtggtaaaggagtcccacttcaaccaggtgatcatgatgaaggagttcgagcgcctc
tcctctccactgatagtggagattgtgcggcggaagcagcagccgccccctcgcactccc
ttggaccagccagtggacattggcacatctctgatccaggacatgaaggcatacctggag
ggagcgggcgcggaattctgtgacatcactctgttgcttgacgggcacccacggccagcc
cacaaggctatcctggccgcccgctccagctactttgaagccatgttccggtccttcatg
cccgaagatgggcaggtgaacatctccatcggggagatggtgcccagcaggcaggccttc
gagtccatgctgcgctacatctactacggcgaggtcaacatgccgcccgaggactcgctc
tacttgtttgcggccccctactactacggcttctacaacaaccggctgcaggcgtactgc
aagcagaacctggagatgaacgtgacggtgcagaacgtgctgcagatcctggaggcagct
gacaaaacgcaggcactggacatgaagcggcactgcctgcacatcattgtgcaccagttc
accaaggtctccaagttgcccaccctgcggtcgctgagccagcagctgctgctggacatc
atagactccctggcctcccacatctcagacaagcagtgcgcagagctgggcgccgacatc
tga
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