KEGG   Homo sapiens (human): 8394
Entry
8394              CDS       T01001                                 
Symbol
PIP5K1A
Name
(RefSeq) phosphatidylinositol-4-phosphate 5-kinase type 1 alpha
  KO
K00889  1-phosphatidylinositol-4-phosphate 5-kinase [EC:2.7.1.68]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00562  Inositol phosphate metabolism
hsa01100  Metabolic pathways
hsa04070  Phosphatidylinositol signaling system
hsa04072  Phospholipase D signaling pathway
hsa04144  Endocytosis
hsa04510  Focal adhesion
hsa04666  Fc gamma R-mediated phagocytosis
hsa04810  Regulation of actin cytoskeleton
hsa05135  Yersinia infection
hsa05231  Choline metabolism in cancer
Module
hsa_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    8394 (PIP5K1A)
 09130 Environmental Information Processing
  09132 Signal transduction
   04070 Phosphatidylinositol signaling system
    8394 (PIP5K1A)
   04072 Phospholipase D signaling pathway
    8394 (PIP5K1A)
 09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    8394 (PIP5K1A)
 09150 Organismal Systems
  09151 Immune system
   04666 Fc gamma R-mediated phagocytosis
    8394 (PIP5K1A)
 09160 Human Diseases
  09161 Cancer: overview
   05231 Choline metabolism in cancer
    8394 (PIP5K1A)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    8394 (PIP5K1A)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    8394 (PIP5K1A)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.68  1-phosphatidylinositol-4-phosphate 5-kinase
     8394 (PIP5K1A)
Membrane trafficking [BR:hsa04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Kinases and associated proteins
    8394 (PIP5K1A)
 Endocytosis
  Clathrin-mediated endocytosis
   LDLR adaptor proteins
    8394 (PIP5K1A)
 Endosome - Golgi transport
  Others
   Others
    8394 (PIP5K1A)
SSDB
Motif
Pfam: PIP5K
Other DBs
NCBI-GeneID: 8394
NCBI-ProteinID: NP_001129110
OMIM: 603275
HGNC: 8994
Ensembl: ENSG00000143398
UniProt: Q99755
LinkDB
Position
1:151195419..151249531
AA seq 562 aa
MASASSGPSSSVGFSSFDPAVPSCTLSSAASGIKRPMASEVLEARQDSYISLVPYASGMP
IKKIGHRSVDSSGETTYKKTTSSALKGAIQLGITHTVGSLSTKPERDVLMQDFYVVESIF
FPSEGSNLTPAHHYNDFRFKTYAPVAFRYFRELFGIRPDDYLYSLCSEPLIELCSSGASG
SLFYVSSDDEFIIKTVQHKEAEFLQKLLPGYYMNLNQNPRTLLPKFYGLYCVQAGGKNIR
IVVMNNLLPRSVKMHIKYDLKGSTYKRRASQKEREKPLPTFKDLDFLQDIPDGLFLDADM
YNALCKTLQRDCLVLQSFKIMDYSLLMSIHNIDHAQREPLSSETQYSVDTRRPAPQKALY
STAMESIQGEARRGGTMETDDHMGGIPARNSKGERLLLYIGIIDILQSYRFVKKLEHSWK
ALVHDGDTVSVHRPGFYAERFQRFMCNTVFKKIPLKPSPSKKFRSGSSFSRRAGSSGNSC
ITYQPSVSGEHKAQVTTKAEVEPGVHLGRPDVLPQTPPLEEISEGSPIPDPSFSPLVGET
LQMLTTSTTLEKLEVAESEFTH
NT seq 1689 nt   +upstreamnt  +downstreamnt
atggcgtcggcctcctccgggccgtcgtcttcggtcggtttttcatcctttgatcccgcg
gtcccttcctgtaccttgtcctcagcagcatctggaatcaagagacccatggcatctgag
gtcttggaagctagacaggattcttacatctcattggtgccttatgcctctggcatgccc
atcaagaaaataggccatagaagtgttgattcctcaggagagacaacatataaaaagaca
acctcatcagccttgaaaggtgccatccagttaggcattacccacactgtggggagcctg
agtaccaaaccagagcgtgatgtcctcatgcaagatttctacgtggttgagagtatcttc
tttcccagtgaagggagcaacctgacccctgctcatcactacaatgactttcgtttcaag
acctatgcacctgttgccttccgctacttccgggagctatttggtatccggcccgatgat
tacttgtattccctctgcagtgagccgctgattgaactctgtagctctggagctagtggt
tccctattctatgtgtccagcgacgatgagttcattattaagacagtccaacataaagag
gcggaatttctgcagaagctgcttccaggatactacatgaacctcaaccagaaccctcgg
actttgctgcctaaattctatggactgtactgtgtgcaggcaggtggcaagaacattcgg
attgtggtgatgaacaatcttttaccaagatcggtaaaaatgcatatcaaatatgacctc
aaaggctcaacctacaaacggcgggcttcccagaaagagcgagagaagcctcttcccaca
tttaaagacctagacttcttacaagacatccctgatggtctttttttggatgctgacatg
tacaacgctctctgtaagaccctgcagcgtgactgtttggtgctgcagagcttcaagata
atggattacagcctcttgatgtcaatccataatatagatcatgcacaacgagagccctta
agcagtgaaacacagtactcagttgatactcgaagaccggccccccaaaaggctctgtat
tccacagccatggaatccatccagggagaggctcgacggggtggtaccatggagactgat
gaccatatgggtggcatccctgcccggaatagtaaaggggaaaggcttctgctttatatt
ggcatcattgacattctacagtcttacaggtttgttaagaagttggagcactcttggaaa
gccctggtacatgacggagacactgtctcagtgcatcgcccaggcttctacgctgaacgg
ttccagcgcttcatgtgcaacacagtatttaagaagattcccttgaagccttctccttcc
aaaaagtttcggtctggctcatctttctctcggcgagcaggctccagtggcaactcctgc
attacttaccagccatcggtctctggggaacacaaggcacaagtgacaacaaaggcagaa
gtggagccaggcgttcaccttggtcgtcctgatgttttacctcagactccacctttggag
gaaatcagtgagggctcgcctattcctgaccccagtttctcacctctagttggagagact
ttgcaaatgctaactacaagtacaaccttggaaaagcttgaagttgcagagtcagagttc
acccattaa

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