Homo sapiens (human): 85440
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Entry
85440 CDS
T01001
Symbol
DOCK7, DEE23, EIEE23, ZIR2
Name
(RefSeq) dedicator of cytokinesis 7
KO
K21852
dedicator of cytokinesis protein 6/7/8
Organism
hsa
Homo sapiens (human)
Disease
H00606
Early infantile epileptic encephalopathy
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09180 Brite Hierarchies
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:
hsa04131
]
85440 (DOCK7)
Membrane trafficking [BR:
hsa04131
]
Others
Rho GTPase associated proteins
Rho guanine nucleotide exchange factors (GEFs)
85440 (DOCK7)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
DHR-2_Lobe_A
DOCK-C2
DOCK_C-D_N
DHR-2_Lobe_C
DHR-2_Lobe_B
DOCK_N
Motif
Other DBs
NCBI-GeneID:
85440
NCBI-ProteinID:
NP_001354490
OMIM:
615730
HGNC:
19190
Ensembl:
ENSG00000116641
UniProt:
Q96N67
Structure
PDB
PDBj
LinkDB
All DBs
Position
1:complement(62454726..62688386)
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AA seq
2140 aa
AA seq
DB search
MAERRAFAQKISRTVAAEVRKQISGQYSGSPQLLKNLNIVGNISHHTTVPLTEAVDPVDL
EDYLITHPLAVDSGPLRDLIEFPPDDIEVVYSPRDCRTLVSAVPEESEMDPHVRDCIRSY
TEDWAIVIRKYHKLGTGFNPNTLDKQKERQKGLPKQVFESDEAPDGNSYQDDQDDLKRRS
MSIDDTPRGSWACSIFDLKNSLPDALLPNLLDRTPNEEIDRQNDDQRKSNRHKELFALHP
SPDEEEPIERLSVPDIPKEHFGQRLLVKCLSLKFEIEIEPIFASLALYDVKEKKKISENF
YFDLNSEQMKGLLRPHVPPAAITTLARSAIFSITYPSQDVFLVIKLEKVLQQGDIGECAE
PYMIFKEADATKNKEKLEKLKSQADQFCQRLGKYRMPFAWTAIHLMNIVSSAGSLERDST
EVEISTGERKGSWSERRNSSIVGRRSLERTTSGDDACNLTSFRPATLTVTNFFKQEGDRL
SDEDLYKFLADMRRPSSVLRRLRPITAQLKIDISPAPENPHYCLTPELLQVKLYPDSRVR
PTREILEFPARDVYVPNTTYRNLLYIYPQSLNFANRQGSARNITVKVQFMYGEDPSNAMP
VIFGKSSCSEFSKEAYTAVVYHNRSPDFHEEIKVKLPATLTDHHHLLFTFYHVSCQQKQN
TPLETPVGYTWIPMLQNGRLKTGQFCLPVSLEKPPQAYSVLSPEVPLPGMKWVDNHKGVF
NVEVVAVSSIHTQDPYLDKFFALVNALDEHLFPVRIGDMRIMENNLENELKSSISALNSS
QLEPVVRFLHLLLDKLILLVIRPPVIAGQIVNLGQASFEAMASIINRLHKNLEGNHDQHG
RNSLLASYIHYVFRLPNTYPNSSSPGPGGLGGSVHYATMARSAVRPASLNLNRSRSLSNS
NPDISGTPTSPDDEVRSIIGSKGLDRSNSWVNTGGPKAAPWGSNPSPSAESTQAMDRSCN
RMSSHTETSSFLQTLTGRLPTKKLFHEELALQWVVCSGSVRESALQQAWFFFELMVKSMV
HHLYFNDKLEAPRKSRFPERFMDDIAALVSTIASDIVSRFQKDTEMVERLNTSLAFFLND
LLSVMDRGFVFSLIKSCYKQVSSKLYSLPNPSVLVSLRLDFLRIICSHEHYVTLNLPCSL
LTPPASPSPSVSSATSQSSGFSTNVQDQKIANMFELSVPFRQQHYLAGLVLTELAVILDP
DAEGLFGLHKKVINMVHNLLSSHDSDPRYSDPQIKARVAMLYLPLIGIIMETVPQLYDFT
ETHNQRGRPICIATDDYESESGSMISQTVAMAIAGTSVPQLTRPGSFLLTSTSGRQHTTF
SAESSRSLLICLLWVLKNADETVLQKWFTDLSVLQLNRLLDLLYLCVSCFEYKGKKVFER
MNSLTFKKSKDMRAKLEEAILGSIGARQEMVRRSRGQLGTYTIASPPERSPSGSAFGSQE
NLRWRKDMTHWRQNTEKLDKSRAEIEHEALIDGNLATEANLIILDTLEIVVQTVSVTESK
ESILGGVLKVLLHSMACNQSAVYLQHCFATQRALVSKFPELLFEEETEQCADLCLRLLRH
CSSSIGTIRSHASASLYLLMRQNFEIGNNFARVKMQVTMSLSSLVGTSQNFNEEFLRRSL
KTILTYAEEDLELRETTFPDQVQDLVFNLHMILSDTVKMKEHQEDPEMLIDLMYRIAKGY
QTSPDLRLTWLQNMAGKHSERSNHAEAAQCLVHSAALVAEYLSMLEDRKYLPVGCVTFQN
ISSNVLEESAVSDDVVSPDEEGICSGKYFTESGLVGLLEQAAASFSMAGMYEAVNEVYKV
LIPIHEANRDAKKLSTIHGKLQEAFSKIVHQSTGWERMFGTYFRVGFYGTKFGDLDEQEF
VYKEPAITKLAEISHRLEGFYGERFGEDVVEVIKDSNPVDKCKLDPNKAYIQITYVEPYF
DTYEMKDRITYFDKNYNLRRFMYCTPFTLDGRAHGELHEQFKRKTILTTSHAFPYIKTRV
NVTHKEEIILTPIEVAIEDMQKKTQELAFATHQDPADPKMLQMVLQGSVGTTVNQGPLEV
AQVFLSEIPSDPKLFRHHNKLRLCFKDFTKRCEDALRKNKSLIGPDQKEYQRELERNYHR
LKEALQPLINRKIPQLYKAVLPVTCHRDSFSRMSLRKMDL
NT seq
6423 nt
NT seq
+upstream
nt +downstream
nt
atggccgagcgccgcgccttcgcccagaagatcagcagaacggtggcagccgaagttagg
aagcagatctccggacaatatagtggttctccccaactgctcaaaaaccttaatattgtt
ggcaatatatcccatcacaccacagtgccccttaccgaagcagtagatccagtggatttg
gaagattacctcattactcatcctttggctgtggattctgggcctttacgggatttgatt
gaatttcctccagatgatattgaagttgtttatagtcctcgggactgcagaactcttgtt
tcagctgtacctgaagaaagtgaaatggatccacatgttagagactgtataagaagttat
acagaagactgggcaattgtcatcagaaaatatcataaattgggaacaggatttaatccc
aatacattagataaacagaaagaaaggcaaaaaggtttgccaaaacaagtttttgaatct
gatgaagctccagatggcaacagctaccaggatgatcaagatgaccttaaaagacgttca
atgtcaatagatgataccccaaggggtagctgggcctgtagtatctttgacttgaaaaat
tcacttcctgatgctttgcttcccaatttacttgatcgaactccaaatgaagaaatagac
cgtcagaatgatgaccaaaggaaatcaaaccgtcacaaagaactttttgctttgcatcca
tcaccagatgaggaagaaccaatagaacggcttagtgttcctgatatacccaaagaacat
tttggtcaaagacttcttgtaaaatgcttatcactcaagtttgaaattgaaattgaaccc
atttttgcaagtttggctttatatgatgtcaaggaaaagaaaaagatttcagaaaacttt
tattttgaccttaattctgagcagatgaaagggttgttacgtccacatgtaccacctgct
gccattactaccctggcaagatcagcaattttttctatcacttatccttcccaagatgtt
tttcttgtaataaagctagaaaaagtcctacagcaaggagacattggagagtgtgcagaa
ccatatatgattttcaaagaagcagatgccaccaagaataaagaaaaactggagaaactg
aagagtcaagcagatcagttttgccaaagacttgggaaatatcgcatgccttttgcttgg
actgcaatccatttaatgaatattgttagcagtgctgggagtttggaaagagattctaca
gaagtagaaatcagtactggagaacgaaaagggtcttggtcagagaggaggaattctagt
attgttggcagacgatcacttgaaaggacaacaagtggagatgatgcttgtaacttgacg
agctttcgaccagctactctcacagtgacaaatttttttaagcaggaaggagaccgctta
agtgatgaagatctctacaaattccttgctgatatgagaaggccatcttctgtcttacgg
cgactaagacctattacagctcagctcaagatagacatttctcccgcacctgaaaatccc
cattattgcctaactccggagctgcttcaagtgaagctttaccctgacagtagagttaga
cctaccagagaaatcttagagtttcccgcaagggatgtttatgttccaaacactacttac
agaaatcttctctacatataccctcagagtcttaattttgccaatcgtcaaggttctgct
agaaatataacagtgaaagtccagtttatgtatggagaggatccaagcaatgccatgccg
gtaatctttggtaaatctagctgttcagaattttcaaaggaagcctatacagccgtagta
tatcataacaggtctcctgattttcatgaagaaatcaaggttaagcttcctgctacttta
actgaccatcatcacttgctttttactttttatcatgttagttgtcaacaaaaacaaaat
actcctcttgaaacaccagttggatatacatggataccaatgcttcagaatggacggttg
aagactggccagttttgcttgccagtctcattggaaaaaccaccacaggcttattctgta
ctgtctcctgaggttcctctacctggcatgaaatgggtagataatcacaaaggtgttttt
aatgttgaagttgttgctgtttcgtctatccatacacaagatccttatcttgacaaattt
tttgctctggtcaatgctctggatgaacacctgttcccagtccgaattggggacatgcga
atcatggaaaataacttagaaaatgaattgaagagcagtatttcagcactgaattcatcc
cagctggaaccagtggtccgatttcttcatcttctgctagataaactgatacttttagtt
attagacctcctgtcattgctggccaaatagttaacctaggtcaagcatcttttgaagcc
atggcatcaattataaatcgacttcacaaaaacttggaaggaaatcatgaccagcatggc
agaaacagccttcttgcatcatatattcattatgttttccgcctaccaaatacttaccct
aattcatcatcaccaggtcctgggggtttgggaggatcagtgcattatgccacaatggct
agatctgcggtgagacctgcaagccttaatttaaatcgttctcgaagccttagtaatagc
aatccagatatatctgggactcccacgtcaccagatgatgaagttcgatcaatcatcggg
agtaagggtttagatcgctccaattcctgggttaacactggtggtccaaaagctgcccca
tggggatccaaccccagtccaagtgcagaatcaacacaggctatggatcgaagttgtaat
cgtatgtcttcgcacacagagacgtcaagtttcttacaaacattaacgggacgcttacca
actaaaaagctttttcacgaggagctggctttgcagtgggttgtttgcagtggcagcgtt
cgggaatcagctttgcaacaagcctggttcttttttgaattaatggtaaagagcatggtg
caccatttatactttaatgataaacttgaggctccaaggaaaagtcgttttccagaacgt
ttcatggatgacattgcagctcttgtcagcacgattgctagtgatatagtttcacgattt
cagaaggacacagaaatggttgagagactcaatacaagccttgcattctttctcaatgat
ctgttgtctgttatggacagaggatttgtttttagccttataaagtcctgctataaacag
gtgtcttcaaagctttactcattaccgaatcccagtgttctggtgtccttgaggctggat
tttctacgaatcatctgcagtcatgagcactatgttacattaaacttaccctgcagctta
cttactccacctgcatctccatcaccttctgtttcttctgcaacatctcagagttctgga
ttttctacgaatgtacaagaccaaaagattgcaaatatgtttgaattatccgtgcctttc
cgccaacagcattatttggcaggacttgtgttaacagagctggctgtcattttagaccct
gatgctgaaggactgtttggattgcataagaaagtcatcaatatggtacacaatttactc
tccagtcacgactcagacccgcggtactctgaccctcagataaaggctcgagtggccatg
ttgtatctacctctgattggtattatcatggaaactgtacctcagctgtatgattttaca
gaaactcacaatcaacgaggaagaccaatttgtatagccactgatgattatgaaagtgag
agcggaagtatgataagccagaccgttgccatggcaatcgcagggacatcggtccctcaa
ctaacaaggcctggcagtttcctcctcacgtcaacgagtggcaggcaacacactaccttt
tcagcagaatcaagtcgaagccttttgatctgtctactttgggttctcaaaaatgcagat
gaaacagttctacagaagtggtttacagatctctcagtcttgcagctaaaccggctatta
gatctgctttatctctgtgtgtcttgctttgagtataaagggaaaaaagtgtttgaacga
atgaatagcttgacctttaagaaatcaaaagacatgagagcaaagcttgaagaagctatt
cttgggagcataggtgccaggcaagaaatggtacggcgaagccgaggacagctcggtacg
tacacaatagcttctcctcctgagagaagcccatctggaagtgcctttggaagtcaagaa
aatttgaggtggaggaaagatatgactcactggcgtcaaaacacagagaagcttgacaaa
tcaagagcagagattgaacacgaagcactgattgatggaaacctggctacagaagcaaac
ctaatcattttagatacattagagattgttgttcagaccgtttctgtaacggaatccaaa
gagagcattcttggtggagtgctaaaagtgctactacacagcatggcctgtaaccaaagt
gcagtttatctacaacactgttttgctacacagagagccttggtttcaaagtttcctgaa
ctcttatttgaagaagagacagagcagtgtgctgatttatgcctcaggcttctccgacac
tgtagcagtagcatcggtacaatacggtcacacgccagtgcctccctttacctactaatg
aggcaaaactttgagattgggaataactttgccagggttaaaatgcaggtaacaatgtca
ctatcctccttggtgggcacatctcagaattttaatgaagaattcttaagacgttctcta
aagactatattgacatatgctgaagaagatctggaattgagggaaacaacatttcctgat
caggtccaggatctggttttcaatctccatatgattctttctgatactgtgaaaatgaag
gaacaccaggaggatcctgaaatgttgattgatctaatgtacagaattgccaagggttac
cagacctctccagatctgcgattgacctggttgcagaacatggcaggcaagcactcagaa
cgaagcaatcatgctgaagctgcacagtgtctagtccactcagcagcacttgttgctgaa
tatttgagcatgctggaggaccggaaatatcttcctgtgggatgtgtaacatttcagaat
atttcatctaatgttttagaagaatctgcggtctcagatgatgtggtatctccagatgaa
gaaggtatctgctctggaaaatactttactgagtcaggacttgtgggattactggaacaa
gcagctgcttccttctctatggctggcatgtatgaagcagttaatgaagtttacaaagta
cttattcctattcatgaagctaatcgggatgcaaagaaactatccacaattcatggtaaa
cttcaagaagcattcagcaaaattgttcatcagagtactggctgggagcggatgtttggc
acctattttcgtgttggtttttatggaaccaagttcggggatttggatgaacaagaattt
gtttacaaggagcctgcaataaccaaacttgcagagatatctcacagattggagggattt
tacggagaaagatttggagaggatgtggttgaagtaatcaaagactctaatcctgtagac
aagtgtaaattagatcctaacaaggcatatattcagattacctatgtggagccatacttt
gacacatatgagatgaaggacagaatcacctatttcgacaaaaattacaatcttcgtcga
ttcatgtactgtacaccctttactttagatggccgtgcccatggggaacttcatgaacaa
ttcaaaaggaagaccattctgactacgtctcatgcctttccttatattaaaacaagggtc
aatgtcactcataaagaagagatcatcttaacaccaattgaagttgctattgaggacatg
cagaaaaagacacaggagttggcatttgcaacacatcaggatcccgcagaccccaaaatg
cttcagatggtactccagggatctgtaggcaccacagtgaatcaggggcctttggaagtt
gcccaggtttttctgtctgaaatacctagtgacccaaagctcttcagacatcataataaa
ctgcgactctgctttaaagattttactaaaaggtgtgaagatgccttaagaaaaaataag
agcttaattgggccggatcaaaaggagtatcaaagggaactggagagaaactatcatcgc
cttaaagaggccctacagccactgatcaacagaaagatccctcagttatacaaggcagta
ttgcctgtcacctgccacagagattccttcagtcgaatgagccttcgcaaaatggatctc
taa
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