Homo sapiens (human): 8694
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Entry
8694 CDS
T01001
Symbol
DGAT1, ARAT, ARGP1, DGAT, DIAR7
Name
(RefSeq) diacylglycerol O-acyltransferase 1
KO
K11155
diacylglycerol O-acyltransferase 1 [EC:
2.3.1.20
2.3.1.75
2.3.1.76
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa00561
Glycerolipid metabolism
hsa00830
Retinol metabolism
hsa01100
Metabolic pathways
hsa04975
Fat digestion and absorption
Module
hsa_M00089
Triacylglycerol biosynthesis
Disease
H01174
Congenital diarrhea
Drug target
Pradigastat (
DG01846
):
D10657
D10664
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09100 Metabolism
09103 Lipid metabolism
00561 Glycerolipid metabolism
8694 (DGAT1)
09108 Metabolism of cofactors and vitamins
00830 Retinol metabolism
8694 (DGAT1)
09150 Organismal Systems
09154 Digestive system
04975 Fat digestion and absorption
8694 (DGAT1)
Enzymes [BR:
hsa01000
]
2. Transferases
2.3 Acyltransferases
2.3.1 Transferring groups other than aminoacyl groups
2.3.1.20 diacylglycerol O-acyltransferase
8694 (DGAT1)
2.3.1.75 long-chain-alcohol O-fatty-acyltransferase
8694 (DGAT1)
2.3.1.76 retinol O-fatty-acyltransferase
8694 (DGAT1)
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Gene cluster
GFIT
Motif
Pfam:
MBOAT
Motif
Other DBs
NCBI-GeneID:
8694
NCBI-ProteinID:
NP_036211
OMIM:
604900
HGNC:
2843
Ensembl:
ENSG00000185000
UniProt:
O75907
Structure
PDB
PDBj
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All DBs
Position
8:complement(144314584..144326852)
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AA seq
488 aa
AA seq
DB search
MGDRGSSRRRRTGSRPSSHGGGGPAAAEEEVRDAAAGPDVGAAGDAPAPAPNKDGDAGVG
SGHWELRCHRLQDSLFSSDSGFSNYRGILNWCVVMLILSNARLFLENLIKYGILVDPIQV
VSLFLKDPYSWPAPCLVIAANVFAVAAFQVEKRLAVGALTEQAGLLLHVANLATILCFPA
AVVLLVESITPVGSLLALMAHTILFLKLFSYRDVNSWCRRARAKAASAGKKASSAAAPHT
VSYPDNLTYRDLYYFLFAPTLCYELNFPRSPRIRKRFLLRRILEMLFFTQLQVGLIQQWM
VPTIQNSMKPFKDMDYSRIIERLLKLAVPNHLIWLIFFYWLFHSCLNAVAELMQFGDREF
YRDWWNSESVTYFWQNWNIPVHKWCIRHFYKPMLRRGSSKWMARTGVFLASAFFHEYLVS
VPLRMFRLWAFTGMMAQIPLAWFVGRFFQGNYGNAAVWLSLIIGQPIAVLMYVHDYYVLN
YEAPAAEA
NT seq
1467 nt
NT seq
+upstream
nt +downstream
nt
atgggcgaccgcggcagctcccggcgccggaggacagggtcgcggccctcgagccacggc
ggcggcgggcctgcggcggcggaagaggaggtgcgggacgccgctgcgggccccgacgtg
ggagccgcgggggacgcgccagccccggcccccaacaaggacggagacgccggcgtgggc
agcggccactgggagctgaggtgccatcgcctgcaggattctttattcagctctgacagt
ggcttcagcaactaccgtggcatcctgaactggtgtgtggtgatgctgatcttgagcaat
gcccggttatttctggagaacctcatcaagtatggcatcctggtggaccccatccaggtg
gtttctctgttcctgaaggatccctatagctggcccgccccatgcctggttattgcggcc
aatgtctttgctgtggctgcattccaggttgagaagcgcctggcggtgggtgccctgacg
gagcaggcgggactgctgctgcacgtggccaacctggccaccattctgtgtttcccagcg
gctgtggtcttactggttgagtctatcactccagtgggctccctgctggcgctgatggcg
cacaccatcctcttcctcaagctcttctcctaccgcgacgtcaactcatggtgccgcagg
gccagggccaaggctgcctctgcagggaagaaggccagcagtgctgctgccccgcacacc
gtgagctacccggacaatctgacctaccgcgatctctactacttcctcttcgcccccacc
ttgtgctacgagctcaactttccccgctctccccgcatccggaagcgctttctgctgcga
cggatccttgagatgctgttcttcacccagctccaggtggggctgatccagcagtggatg
gtccccaccatccagaactccatgaagcccttcaaggacatggactactcacgcatcatc
gagcgcctcctgaagctggcggtccccaatcacctcatctggctcatcttcttctactgg
ctcttccactcctgcctgaatgccgtggctgagctcatgcagtttggagaccgggagttc
taccgggactggtggaactccgagtctgtcacctacttctggcagaactggaacatccct
gtgcacaagtggtgcatcagacacttctacaagcccatgcttcgacggggcagcagcaag
tggatggccaggacaggggtgttcctggcctcggccttcttccacgagtacctggtgagc
gtccctctgcgaatgttccgcctctgggcgttcacgggcatgatggctcagatcccactg
gcctggttcgtgggccgctttttccagggcaactatggcaacgcagctgtgtggctgtcg
ctcatcatcggacagccaatagccgtcctcatgtacgtccacgactactacgtgctcaac
tatgaggccccagcggcagaggcctga
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