Homo sapiens (human): 87178
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Entry
87178 CDS
T01001
Symbol
PNPT1, COXPD13, DFNB70, OLD35, PNPASE, SCA25, old-35
Name
(RefSeq) polyribonucleotide nucleotidyltransferase 1, mitochondrial precursor
KO
K00962
polyribonucleotide nucleotidyltransferase [EC:
2.7.7.8
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa03018
RNA degradation
hsa03440
Homologous recombination
Disease
H00063
Spinocerebellar ataxia (SCA)
H00605
Deafness, autosomal recessive
H00891
Combined oxidative phosphorylation deficiency
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09120 Genetic Information Processing
09123 Folding, sorting and degradation
03018 RNA degradation
87178 (PNPT1)
09124 Replication and repair
03440 Homologous recombination
87178 (PNPT1)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
03019 Messenger RNA biogenesis [BR:
hsa03019
]
87178 (PNPT1)
03016 Transfer RNA biogenesis [BR:
hsa03016
]
87178 (PNPT1)
Enzymes [BR:
hsa01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.7 Nucleotidyltransferases
2.7.7.8 polyribonucleotide nucleotidyltransferase
87178 (PNPT1)
Messenger RNA biogenesis [BR:
hsa03019
]
Prokaryotic type
Bacterial mRNA degradation factors
RNA degradosome components
Other RNA degradosome components
87178 (PNPT1)
Transfer RNA biogenesis [BR:
hsa03016
]
Prokaryotic type
tRNA degradation factors
87178 (PNPT1)
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
RNase_PH
RNase_PH_C
KH_1
PNPase
S1
KH-I_KHDC4-BBP
Motif
Other DBs
NCBI-GeneID:
87178
NCBI-ProteinID:
NP_149100
OMIM:
610316
HGNC:
23166
Ensembl:
ENSP00000400646.2
UniProt:
Q8TCS8
Structure
PDB
PDBj
LinkDB
All DBs
Position
2:complement(55634061..55693844)
Genome browser
AA seq
783 aa
AA seq
DB search
MAACRYCCSCLRLRPLSDGPFLLPRRDRALTQLQVRALWSSAGSRAVAVDLGNRKLEISS
GKLARFADGSAVVQSGDTAVMVTAVSKTKPSPSQFMPLVVDYRQKAAAAGRIPTNYLRRE
IGTSDKEILTSRIIDRSIRPLFPAGYFYDTQVLCNLLAVDGVNEPDVLAINGASVALSLS
DIPWNGPVGAVRIGIIDGEYVVNPTRKEMSSSTLNLVVAGAPKSQIVMLEASAENILQQD
FCHAIKVGVKYTQQIIQGIQQLVKETGVTKRTPQKLFTPSPEIVKYTHKLAMERLYAVFT
DYEHDKVSRDEAVNKIRLDTEEQLKEKFPEADPYEIIESFNVVAKEVFRSIVLNEYKRCD
GRDLTSLRNVSCEVDMFKTLHGSALFQRGQTQVLCTVTFDSLESGIKSDQVITAINGIKD
KNFMLHYEFPPYATNEIGKVTGLNRRELGHGALAEKALYPVIPRDFPFTIRVTSEVLESN
GSSSMASACGGSLALMDSGVPISSAVAGVAIGLVTKTDPEKGEIEDYRLLTDILGIEDYN
GDMDFKIAGTNKGITALQADIKLPGIPIKIVMEAIQQASVAKKEILQIMNKTISKPRASR
KENGPVVETVQVPLSKRAKFVGPGGYNLKKLQAETGVTISQVDEETFSVFAPTPSAMHEA
RDFITEICKDDQEQQLEFGAVYTATITEIRDTGVMVKLYPNMTAVLLHNTQLDQRKIKHP
TALGLEVGQEIQVKYFGRDPADGRMRLSRKVLQSPATTVVRTLNDRSSIVMGEPISQSSS
NSQ
NT seq
2352 nt
NT seq
+upstream
nt +downstream
nt
atggcggcctgcaggtactgctgctcgtgcctccggctccggcccctgagcgatggtcct
ttccttctgccacggcgggatcgggcactcacccagttgcaagtgcgagcactatggagt
agcgcagggtctcgagctgtggccgtggacttaggcaacaggaaattagaaatatcttct
ggaaagctggccagatttgcagatggctctgctgtagtacagtcaggtgacactgcagta
atggtcacagcggtcagtaaaacaaaaccttccccttcccagtttatgcctttggtggtt
gactacagacaaaaagctgctgcagcaggtagaattcccacaaactatctgagaagagag
attggtacttctgataaagaaattctaacaagtcgaataatagatcgttcaattagaccg
ctctttccagctggctacttctatgatacacaggttctgtgtaatctgttagcagtagat
ggtgtaaatgagcctgatgtcctagcaattaatggcgcttccgtagccctctcattatca
gatattccttggaatggacctgttggggcagtacgaataggaataattgatggagaatat
gttgttaacccaacaagaaaagaaatgtcttctagtactttaaatttagtggttgctgga
gcacctaaaagtcagattgtcatgttggaagcctctgcagagaacattttacagcaggac
ttttgccatgctatcaaagtgggagtgaaatatacccaacaaataattcagggcattcag
cagttggtaaaagaaactggtgttaccaagaggacacctcagaagttatttaccccttcg
ccagagattgtgaaatatactcataaacttgctatggagagactctatgcagtttttaca
gattacgagcatgacaaagtttccagagatgaagctgttaacaaaataagattagatacg
gaggaacaactaaaagaaaaatttccagaagccgatccatatgaaataatagaatccttc
aatgttgttgcaaaggaagtttttagaagtattgttttgaatgaatacaaaaggtgcgat
ggtcgggatttgacttcacttaggaatgtaagttgtgaggtagatatgtttaaaaccctt
catggatcagcattatttcaaagaggacaaacacaggtgctttgtaccgttacatttgat
tcattagaatctggtattaagtcagatcaagttataacagctataaatgggataaaagat
aaaaatttcatgctgcactacgagtttcctccttatgcaactaatgaaattggcaaagtc
actggtttaaatagaagagaacttgggcatggtgctcttgctgagaaagctttgtatcct
gttattccccgagattttcctttcaccataagagttacatctgaagtcctagagtcaaat
gggtcatcttctatggcatctgcatgtggcggaagtttagcattaatggattcaggggtt
ccaatttcatctgctgttgcaggcgtagcaataggattggtcaccaaaaccgatcctgag
aagggtgaaatagaagattatcgtttgctgacagatattttgggaattgaagattacaat
ggtgacatggacttcaaaatagctggcactaataaaggaataactgcattacaggctgat
attaaattacctggaataccaataaaaattgtgatggaggctattcaacaagcttcagtg
gcaaaaaaggagatattacagatcatgaacaaaactatttcaaaacctcgagcatctaga
aaagaaaatggacctgttgtagaaactgttcaggttccattatcaaaacgagcaaaattt
gttggacctggtggctataacttaaaaaaacttcaggctgaaacaggtgtaactattagt
caggtggatgaagaaacgttttctgtatttgcaccaacacccagtgctatgcatgaggca
agagacttcattactgaaatctgcaaggatgatcaggagcagcaattagaatttggagca
gtatataccgccacaataactgaaatcagagatactggtgtaatggtaaaattatatcca
aatatgactgcggtactgcttcataacacacaacttgatcaacgaaagattaaacatcct
actgccctaggattagaagttggccaagaaattcaggtgaaatactttggacgtgaccca
gccgatggaagaatgaggctttctcgaaaagtgcttcagtcgccagctacaaccgtggtc
agaactttgaatgacagaagtagtattgtaatgggagaacctatttcacagtcatcatct
aattctcagtga
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