KEGG   Homo sapiens (human): 8802
Entry
8802              CDS       T01001                                 
Symbol
SUCLG1, GALPHA, MTDPS9, SUCLA1
Name
(RefSeq) succinate-CoA ligase GDP/ADP-forming subunit alpha
  KO
K01899  succinyl-CoA synthetase alpha subunit [EC:6.2.1.4 6.2.1.5]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00020  Citrate cycle (TCA cycle)
hsa00640  Propanoate metabolism
hsa01100  Metabolic pathways
hsa01200  Carbon metabolism
Module
hsa_M00009  Citrate cycle (TCA cycle, Krebs cycle)
hsa_M00011  Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate
Network
nt06031  Citrate cycle and pyruvate metabolism
  Element
N01617  Citrate cycle, second carbon oxidation 2
Disease
H00469  Mitochondrial DNA depletion syndrome
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00020 Citrate cycle (TCA cycle)
    8802 (SUCLG1)
   00640 Propanoate metabolism
    8802 (SUCLG1)
Enzymes [BR:hsa01000]
 6. Ligases
  6.2  Forming carbon-sulfur bonds
   6.2.1  Acid-thiol ligases
    6.2.1.4  succinate---CoA ligase (GDP-forming)
     8802 (SUCLG1)
    6.2.1.5  succinate---CoA ligase (ADP-forming)
     8802 (SUCLG1)
SSDB
Motif
Pfam: CoA_binding Ligase_CoA Succ_CoA_lig CoA_binding_2
Other DBs
NCBI-GeneID: 8802
NCBI-ProteinID: NP_003840
OMIM: 611224
HGNC: 11449
Ensembl: ENSG00000163541
UniProt: P53597
Structure
LinkDB
Position
2:complement(84423528..84459280)
AA seq 346 aa
MTATLAAAADIATMVSGSSGLAAARLLSRSFLLPQNGIRHCSYTASRQHLYVDKNTKIIC
QGFTGKQGTFHSQQALEYGTKLVGGTTPGKGGQTHLGLPVFNTVKEAKEQTGATASVIYV
PPPFAAAAINEAIEAEIPLVVCITEGIPQQDMVRVKHKLLRQEKTRLIGPNCPGVINPGE
CKIGIMPGHIHKKGRIGIVSRSGTLTYEAVHQTTQVGLGQSLCVGIGGDPFNGTDFIDCL
EIFLNDSATEGIILIGEIGGNAEENAAEFLKQHNSGPNSKPVVSFIAGLTAPPGRRMGHA
GAIIAGGKGGAKEKISALQSAGVVVSMSPAQLGTTIYKEFEKRKML
NT seq 1041 nt   +upstreamnt  +downstreamnt
atgaccgcaacccttgccgctgccgctgacatcgctaccatggtctccggcagcagcggc
ctcgccgccgcccgtctcctgtcgcgcagcttcctcctgccgcagaatggaattcggcat
tgttcctacacagcttctcggcaacatctctatgttgataaaaatacaaagattatttgc
cagggtttcactggcaaacagggcacctttcacagccagcaggcattggaatatggcacc
aaactcgttggaggaaccactccagggaaaggaggccagacacatctgggcttacctgtc
tttaatactgtgaaggaggccaaagaacagacaggagcaacggcttctgtcatttatgtt
cctccgccttttgctgctgctgccattaatgaagctattgaggcagaaattcccttggtt
gtgtgtatcactgaaggaattccccagcaggacatggtacgagtcaagcacaaactgctg
cgccaggaaaagacaaggctaattgggcccaactgccctggagtcatcaatcctggagaa
tgtaaaattggcatcatgcctggccatattcacaaaaaaggaaggattggcattgtgtcc
agatctggcaccctgacttatgaagcagttcaccaaacaacgcaagttggattggggcag
tctttgtgcgttggcattggaggtgatccttttaatggaacagattttattgactgcctc
gaaatctttttgaacgattctgccacagaaggcatcatattgattggtgaaattggtggt
aatgcagaagagaatgctgcagaatttttgaagcaacataattcaggtccaaattccaag
cctgtagtgtccttcattgctggtttaactgctcctcctgggagaagaatgggtcatgcc
ggggcaattattgctggaggaaaaggtggagctaaagagaagatctctgcccttcagagt
gcaggagttgtggtcagtatgtctcctgcacagctgggaaccacgatctacaaggaattt
gaaaagaggaagatgctatga

KEGG   Homo sapiens (human): 8801
Entry
8801              CDS       T01001                                 
Symbol
SUCLG2, G-SCS, GBETA, GTPSCS
Name
(RefSeq) succinate-CoA ligase GDP-forming subunit beta
  KO
K01900  succinyl-CoA synthetase beta subunit [EC:6.2.1.4 6.2.1.5]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00020  Citrate cycle (TCA cycle)
hsa00640  Propanoate metabolism
hsa01100  Metabolic pathways
hsa01200  Carbon metabolism
Module
hsa_M00009  Citrate cycle (TCA cycle, Krebs cycle)
hsa_M00011  Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate
Network
nt06031  Citrate cycle and pyruvate metabolism
  Element
N01617  Citrate cycle, second carbon oxidation 2
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00020 Citrate cycle (TCA cycle)
    8801 (SUCLG2)
   00640 Propanoate metabolism
    8801 (SUCLG2)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:hsa04147]
    8801 (SUCLG2)
Enzymes [BR:hsa01000]
 6. Ligases
  6.2  Forming carbon-sulfur bonds
   6.2.1  Acid-thiol ligases
    6.2.1.4  succinate---CoA ligase (GDP-forming)
     8801 (SUCLG2)
    6.2.1.5  succinate---CoA ligase (ADP-forming)
     8801 (SUCLG2)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   8801 (SUCLG2)
SSDB
Motif
Pfam: ATP-grasp_2 Ligase_CoA Citrate_synth_N ATP-grasp_5 GARS_A ATP-grasp DUF3141
Other DBs
NCBI-GeneID: 8801
NCBI-ProteinID: NP_003839
OMIM: 603922
HGNC: 11450
Ensembl: ENSG00000172340
UniProt: Q96I99
Structure
LinkDB
Position
3:complement(67360460..67654612)
AA seq 432 aa
MASPVAAQAGKLLRALALRPRFLAAGSQAVQLTSRRWLNLQEYQSKKLMSDNGVRVQRFF
VADTANEALEAAKRLNAKEIVLKAQILAGGRGKGVFNSGLKGGVHLTKDPNVVGQLAKQM
IGYNLATKQTPKEGVKVNKVMVAEALDISRETYLAILMDRSCNGPVLVGSPQGGVDIEEV
AASNPELIFKEQIDIFEGIKDSQAQRMAENLGFVGPLKSQAADQITKLYNLFLKIDATQV
EVNPFGETPEGQVVCFDAKINFDDNAEFRQKDIFAMDDKSENEPIENEAAKYDLKYIGLD
GNIACFVNGAGLAMATCDIIFLNGGKPANFLDLGGGVKEAQVYQAFKLLTADPKVEAILV
NIFGGIVNCAIIANGITKACRELELKVPLVVRLEGTNVQEAQKILNNSGLPITSAIDLED
AAKKAVASVAKK
NT seq 1299 nt   +upstreamnt  +downstreamnt
atggcgtcccccgtagcagcgcaggccgggaagcttctgcgagccctagcgctgcggccc
cgcttcctggcggccgggtcccaggcagttcaattaacctccagaagatggctgaacctg
caggaataccagagcaagaaactgatgtctgacaacggagtgagagttcaaagattcttt
gtagcagacactgcaaatgaagctctcgaggctgctaagagactaaatgcaaaagaaatt
gttttaaaagcccagatcttagctggaggaagaggaaaaggtgtcttcaatagtggtttg
aaaggaggtgttcatttaacaaaagaccctaatgttgtgggacagctggctaaacagatg
attgggtacaatctagcgacaaaacaaactccaaaagaaggtgtgaaagttaacaaggtg
atggttgctgaagccttggatatttccagagaaacctacctggcaattctgatggaccgg
tcctgcaatggccccgtgctggtgggcagcccccaggggggcgtcgacattgaagaggtg
gctgcttcaaacccggagctcatttttaaggagcaaattgacatttttgaaggaataaag
gacagccaagctcagcggatggccgaaaatctaggcttcgttgggcctttgaaaagccag
gctgcagatcaaattacgaagctgtataatctcttcctgaaaattgatgctactcaggtg
gaagtgaatccctttggtgaaactccagaaggacaagttgtctgttttgatgccaagata
aactttgatgacaacgcagaattccgacaaaaagacatatttgctatggacgacaaatca
gagaatgagcccattgaaaatgaagctgccaaatatgatctaaaatacataggactagat
gggaacattgcctgctttgtgaatggtgctgggctcgccatggctacttgtgatatcatt
ttccttaatggtgggaagccagccaacttcttggatcttggaggtggtgtaaaggaagct
caagtatatcaagcattcaaattgctcacagctgatcctaaggttgaagccatccttgtc
aatatatttggtggtatcgtcaactgtgccatcattgccaatgggatcaccaaagcctgc
cgggagctagaactcaaggtgcccctggtggtccggcttgaaggaaccaacgtccaagag
gcccagaagatactcaacaacagcggactccccattacttcagccattgacctggaggat
gcagccaagaaggctgtggccagtgtggccaagaagtga

KEGG   Homo sapiens (human): 8803
Entry
8803              CDS       T01001                                 
Symbol
SUCLA2, A-BETA, A-SCS, LINC00444, MTDPS5, SCS-betaA
Name
(RefSeq) succinate-CoA ligase ADP-forming subunit beta
  KO
K01900  succinyl-CoA synthetase beta subunit [EC:6.2.1.4 6.2.1.5]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00020  Citrate cycle (TCA cycle)
hsa00640  Propanoate metabolism
hsa01100  Metabolic pathways
hsa01200  Carbon metabolism
Module
hsa_M00009  Citrate cycle (TCA cycle, Krebs cycle)
hsa_M00011  Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate
Network
nt06031  Citrate cycle and pyruvate metabolism
  Element
N01617  Citrate cycle, second carbon oxidation 2
Disease
H00469  Mitochondrial DNA depletion syndrome
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00020 Citrate cycle (TCA cycle)
    8803 (SUCLA2)
   00640 Propanoate metabolism
    8803 (SUCLA2)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:hsa04147]
    8803 (SUCLA2)
Enzymes [BR:hsa01000]
 6. Ligases
  6.2  Forming carbon-sulfur bonds
   6.2.1  Acid-thiol ligases
    6.2.1.4  succinate---CoA ligase (GDP-forming)
     8803 (SUCLA2)
    6.2.1.5  succinate---CoA ligase (ADP-forming)
     8803 (SUCLA2)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   8803 (SUCLA2)
SSDB
Motif
Pfam: ATP-grasp_2 Ligase_CoA Citrate_synth_N ATP-grasp_5 CPSase_L_D2 GARS_A
Other DBs
NCBI-GeneID: 8803
NCBI-ProteinID: NP_003841
OMIM: 603921
HGNC: 11448
Ensembl: ENSG00000136143
UniProt: Q9P2R7 E5KS60 Q9Y4T0
Structure
LinkDB
Position
13:complement(47942656..48001273)
AA seq 463 aa
MAASMFYGRLVAVATLRNHRPRTAQRAAAQVLGSSGLFNNHGLQVQQQQQRNLSLHEYMS
MELLQEAGVSVPKGYVAKSPDEAYAIAKKLGSKDVVIKAQVLAGGRGKGTFESGLKGGVK
IVFSPEEAKAVSSQMIGKKLFTKQTGEKGRICNQVLVCERKYPRREYYFAITMERSFQGP
VLIGSSHGGVNIEDVAAESPEAIIKEPIDIEEGIKKEQALQLAQKMGFPPNIVESAAENM
VKLYSLFLKYDATMIEINPMVEDSDGAVLCMDAKINFDSNSAYRQKKIFDLQDWTQEDER
DKDAAKANLNYIGLDGNIGCLVNGAGLAMATMDIIKLHGGTPANFLDVGGGATVHQVTEA
FKLITSDKKVLAILVNIFGGIMRCDVIAQGIVMAVKDLEIKIPVVVRLQGTRVDDAKALI
ADSGLKILACDDLDEAARMVVKLSEIVTLAKQAHVDVKFQLPI
NT seq 1392 nt   +upstreamnt  +downstreamnt
atggcggcctccatgttctacggcaggctagtggccgtggccacccttcggaaccaccgg
cctcggacggcccagcgggctgctgctcaggttctgggaagttctggattgtttaataac
catggactccaagtacagcagcaacagcaaaggaatctctcactacatgaatacatgagt
atggaattattgcaagaagctggtgtctccgttcccaaaggatatgtggcaaagtcacca
gatgaagcttatgcaattgccaaaaaattaggttcaaaagatgtcgtgataaaggcacag
gttttagctggtggtagaggaaaaggaacatttgaaagtggcctcaaaggaggagtgaag
atagttttctctccagaagaagcaaaagctgtttcttcacaaatgattgggaaaaaattg
tttaccaagcaaacgggagaaaagggcagaatatgcaatcaagtattggtctgtgagcga
aaatatcccaggagagaatactactttgcaataacaatggaaaggtcatttcaaggtcct
gtattaataggaagttcacatggtggtgtcaacattgaagatgttgctgctgagtctcct
gaagcaataattaaagaacctattgatattgaagaaggcatcaaaaaggaacaagctctc
cagcttgcacagaagatgggatttccacctaatattgtggaatcagcagcagaaaacatg
gtcaagctttacagcctttttctgaaatacgatgcaaccatgatagaaataaatccaatg
gtggaagattcagatggagctgtattgtgtatggatgcaaagatcaattttgactctaat
tcagcctatcgccaaaagaaaatctttgatctacaggactggacccaggaagatgaaagg
gacaaagatgctgctaaggcaaatctcaactacattggcctcgatggaaatataggctgc
ctagtaaatggtgctggtttggctatggccacaatggatataataaaacttcatggaggg
actccagccaacttccttgatgttggtggtggtgctacagtccatcaagtaacagaagca
tttaagcttatcacttcagataaaaaggtactggctattctggtcaacatttttggagga
atcatgcgctgtgatgttattgcacagggtatagtcatggcagtaaaagacttggaaatt
aaaatacctgttgtggtacggttacaaggtacacgagtcgatgatgctaaggcactgata
gcggacagtggacttaaaatacttgcttgtgatgacttggatgaagctgctagaatggtt
gtaaagctctctgaaatagtgaccttagcgaagcaagcacatgtggatgtgaaatttcag
ttgccaatatga

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