KEGG   Homo sapiens (human): 8836
Entry
8836              CDS       T01001                                 
Symbol
GGH, GATD10, GH
Name
(RefSeq) gamma-glutamyl hydrolase
  KO
K01307  gamma-glutamyl hydrolase [EC:3.4.19.9]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00790  Folate biosynthesis
hsa01240  Biosynthesis of cofactors
hsa01523  Antifolate resistance
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00790 Folate biosynthesis
    8836 (GGH)
 09160 Human Diseases
  09176 Drug resistance: antineoplastic
   01523 Antifolate resistance
    8836 (GGH)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:hsa01002]
    8836 (GGH)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.19  Omega peptidases
    3.4.19.9  folate gamma-glutamyl hydrolase
     8836 (GGH)
Peptidases and inhibitors [BR:hsa01002]
 Cysteine peptidases
  Family C26: gamma-glutamyl hydrolase family
   8836 (GGH)
SSDB
Motif
Pfam: Peptidase_C26 GATase
Other DBs
NCBI-GeneID: 8836
NCBI-ProteinID: NP_003869
OMIM: 601509
HGNC: 4248
Ensembl: ENSG00000137563
Vega: OTTHUMG00000164365
Pharos: Q92820(Tchem)
UniProt: Q92820
Structure
LinkDB
Position
8:complement(63015079..63038806)
AA seq 318 aa
MASPGCLLCVLGLLLCGAASLELSRPHGDTAKKPIIGILMQKCRNKVMKNYGRYYIAASY
VKYLESAGARVVPVRLDLTEKDYEILFKSINGILFPGGSVDLRRSDYAKVAKIFYNLSIQ
SFDDGDYFPVWGTCLGFEELSLLISGECLLTATDTVDVAMPLNFTGGQLHSRMFQNFPTE
LLLSLAVEPLTANFHKWSLSVKNFTMNEKLKKFFNVLTTNTDGKIEFISTMEGYKYPVYG
VQWHPEKAPYEWKNLDGISHAPNAVKTAFYLAEFFVNEARKNNHHFKSESEEEKALIYQF
SPIYTGNISSFQQCYIFD
NT seq 957 nt   +upstreamnt  +downstreamnt
atggccagtccgggctgcctgctgtgcgtgctgggcctgctactctgcggggcggcgagc
ctcgagctgtctagaccccacggcgacaccgccaagaagcccatcatcggaatattaatg
caaaaatgccgtaataaagtcatgaaaaactatggaagatactatattgctgcgtcctat
gtaaagtacttggagtctgcaggtgcgagagttgtaccagtaaggctggatcttacagag
aaagactatgaaatacttttcaaatctattaatggaatccttttccctggaggaagtgtt
gacctcagacgctcagattatgctaaagtggccaaaatattttataacttgtccatacag
agttttgatgatggagactattttcctgtgtggggcacatgccttggatttgaagagctt
tcactgctgattagtggagagtgcttattaactgccacagatactgttgacgtggcaatg
ccgctgaacttcactggaggtcaattgcacagcagaatgttccagaattttcctactgag
ttgttgctgtcattagcagtagaacctctgactgccaatttccataagtggagcctctcc
gtgaagaattttacaatgaatgaaaagttaaagaagtttttcaatgtcttaactacaaat
acagatggcaagattgagtttatttcaacaatggaaggatataagtatccagtatatggt
gtccagtggcatccagagaaagcaccttatgagtggaagaatttggatggcatttcccat
gcacctaatgctgtgaaaaccgcattttatttagcagagttttttgttaatgaagctcgg
aaaaacaaccatcattttaaatctgaatctgaagaggagaaagcattgatttatcagttc
agtccaatttatactggaaatatttcttcatttcagcaatgttacatatttgattga

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