KEGG   Homo sapiens (human): 8874
Entry
8874              CDS       T01001                                 
Symbol
ARHGEF7, BETA-PIX, COOL-1, COOL1, Nbla10314, P50, P50BP, P85, P85COOL1, P85SPR, PAK3, PIXB
Name
(RefSeq) Rho guanine nucleotide exchange factor 7
  KO
K13710  Rho guanine nucleotide exchange factor 7
Organism
hsa  Homo sapiens (human)
Pathway
hsa04810  Regulation of actin cytoskeleton
hsa05135  Yersinia infection
Network
nt06180  Pathogenic Escherichia coli
nt06182  Shigella
  Element
N01070  ITGA/B-FAK-CDC42 signaling pathway
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    8874 (ARHGEF7)
 09160 Human Diseases
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    8874 (ARHGEF7)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    8874 (ARHGEF7)
Membrane trafficking [BR:hsa04131]
 Others
  Rho GTPase associated proteins
   Rho guanine nucleotide exchange factors (GEFs)
    8874 (ARHGEF7)
SSDB
Motif
Pfam: RhoGEF67_u2 RhoGEF SH3_2 SH3_1 SH3_9 RhoGEF67_u1 PH CH SOS1_NGEF_PH
Other DBs
NCBI-GeneID: 8874
NCBI-ProteinID: NP_001106983
OMIM: 605477
HGNC: 15607
Ensembl: ENSG00000102606
UniProt: Q14155 Q5W9H1
Structure
LinkDB
Position
13:111114619..111305734
AA seq 803 aa
MNSAEQTVTWLITLGVLESPKKTISDPEGFLQASLKDGVVLCRLLERLLPGTIEKVYPEP
RSESECLSNIREFLRGCGASLRLELLFPPSQPPQHLVTTILLSASTFDANDLYQGQNFNK
VLSSLVTLNKVTADIGLGSDSVCARPSSHRIKSFDSLGSQSLHTRTSKLFQGQYRSLDMT
DNSNNQLVVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVRE
VKASEKPVSPKSGTLKSPPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYLRP
LQTSEKLSSANISYLMGNLEEICSFQQMLVQSLEECTKLPEAQQRVGGCFLNLMPQMKTL
YLTYCANHPSAVNVLTEHSEELGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLKEL
ERHMEDYHTDRQDIQKSMAAFKNLSAQCQEVRKRKELELQILTEAIRNWEGDDIKTLGNV
TYMSQVLIQCAGSEEKNERYLLLFPNVLLMLSASPRMSGFIYQGKLPTTGMTITKLEDSE
NHRNAFEISGSMIERILVSCNNQQDLQEWVEHLQKQTKVTSVGNPTIKPHSVPSHTLPSH
PVTPSSKHADSKPAPLTPAYHTLPHPSHHGTPHTTINWGPLEPPKTPKPWSLSCLRPAPP
LRPSAALCYKEDLSKSPKTMKKLLPKRKPERKPSDEEFASRKSTAALEEDAQILKVIEAY
CTSAKTRQTLNSTWQGTDLMHNHVLADDDQPSLDSLGRRSSLSRLEPSDLSEDSDYDSIW
TAHSYRMGSTSRKSCCSYISHQN
NT seq 2412 nt   +upstreamnt  +downstreamnt
atgaattccgccgagcaaaccgttacgtggctcatcactctgggggtgctggagtcgccc
aaaaaaaccatctcggacccggagggctttctgcaggcgtcgctgaaggatggggtggtc
ctctgcaggctgctggagcgcctgctccccgggaccatcgagaaagtctaccccgagccc
cggagcgagagcgagtgcctgagcaacatccgcgagttcctgcgcggctgcggggcttcc
ctgcggctggagctcctgtttcctccttcccagcctcctcagcatctggtaaccaccatt
ctcttgtctgcttctacgtttgatgcaaatgatttgtatcaggggcagaattttaacaag
gtcctcagttccttagtgactctaaataaagtaacagcagacatcgggctggggagtgac
tccgtgtgtgcccggccctcgtctcaccgcataaagtcttttgactcccttggatcacag
tctttgcacactcggacttcaaaactgttccagggccagtatcggagtttggacatgacc
gataatagcaacaatcaactggtagtaagagcaaagtttaacttccagcagaccaatgag
gacgagctttccttctcaaaaggagacgtcatccatgtcacccgtgtggaagagggaggc
tggtgggagggcacactcaacggccggaccggctggttccccagcaactacgtgcgcgag
gtcaaggccagcgagaagcctgtgtctcccaaatcaggaacactgaagagccctcccaaa
ggatttgatacgactgccataaacaaaagctattacaatgtggtgctacagaatatttta
gaaacagaaaatgaatattctaaagaacttcagactgtgctttcaacgtacctacggcca
ttgcagaccagtgagaagttaagttcagcaaacatttcatatttaatgggaaatctagaa
gaaatatgttctttccagcaaatgctcgtacagtctttagaagaatgcaccaagttgccc
gaagctcagcagagagtcggaggctgctttttaaacctgatgccacagatgaaaaccctg
tacctcacgtattgtgccaatcacccttctgcagtgaatgtcctcacggaacacagtgag
gagttgggggagttcatggagaccaaaggtgccagcagccctgggattctcgtgctgacc
acgggcctgagcaaacccttcatgcgcctggataaataccctacgctgctcaaagagctc
gagagacacatggaggattatcatacagatagacaagatattcaaaaatccatggctgcc
ttcaaaaacctttcagcccaatgtcaagaagtccggaagaggaaagagcttgagctgcag
atcctgacggaagccatccggaactgggagggcgatgacattaaaactctgggcaacgtc
acttacatgtcccaggtcctgattcagtgtgccggaagtgaggaaaagaatgaaagatat
cttctactcttcccaaatgttttgctaatgttgtctgccagtcctaggatgagtggcttt
atctatcagggaaagcttccaacgacaggaatgacaatcacaaagcttgaggacagtgaa
aatcatagaaatgcatttgaaatatcagggagcatgattgagcggatattagtgtcgtgc
aacaaccagcaggatctgcaggaatgggtggagcacctacagaagcaaacgaaggtcacg
tctgtgggaaaccccaccataaagcctcattcagtgccatctcataccctcccctcccac
ccggtcactccgtccagcaagcacgcagacagcaagcccgcgccgctgacgcccgcctac
cacacgctgccccacccctcccaccacggcaccccgcacaccaccatcaactggggaccc
ctggagcctccgaaaacacccaagccctggagcctgagctgcctgcggcccgcgcctccc
ctccggccctcagctgctctctgctacaaggaggatcttagtaagagccctaagaccatg
aaaaagctgctgcccaagcgcaaacctgaacggaagccttcagatgaggagttcgcgtcc
cggaaaagcacagctgctttggaagaagatgctcagattctgaaagtcattgaagcttac
tgcaccagcgccaaaacaaggcaaacactcaattcaacatggcaaggcactgacctgatg
cataatcacgtcttggctgatgatgaccaaccaagcctagactccctggggcgtcgcagt
agcctttctcgtttggagccttcagacctctcggaagactctgactatgacagtatatgg
acagcccatagttacagaatgggttctacatctcgtaagagctgttgctcatatatctct
caccagaactaa

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