Homo sapiens (human): 8940
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Entry
8940 CDS
T01001
Symbol
TOP3B, TOP3B1
Name
(RefSeq) DNA topoisomerase III beta
KO
K03165
DNA topoisomerase III [EC:
5.6.2.1
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa03440
Homologous recombination
hsa03460
Fanconi anemia pathway
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09120 Genetic Information Processing
09124 Replication and repair
03440 Homologous recombination
8940 (TOP3B)
03460 Fanconi anemia pathway
8940 (TOP3B)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
03032 DNA replication proteins [BR:
hsa03032
]
8940 (TOP3B)
03400 DNA repair and recombination proteins [BR:
hsa03400
]
8940 (TOP3B)
Enzymes [BR:
hsa01000
]
5. Isomerases
5.6 Isomerases altering macromolecular conformation
5.6.2 Enzymes altering nucleic acid conformation
5.6.2.1 DNA topoisomerase
8940 (TOP3B)
DNA replication proteins [BR:
hsa03032
]
Eukaryotic type
DNA Topoisomerases
8940 (TOP3B)
DNA repair and recombination proteins [BR:
hsa03400
]
Eukaryotic type
DSBR (double strand breaks repair)
HR (homologous recombination)
Bloom's syndrome complex (BTR)
8940 (TOP3B)
FA (Fanconi anemia) pathway
8940 (TOP3B)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Topoisom_bac
Zn_ribbon_TOP3B
Toprim
Motif
Other DBs
NCBI-GeneID:
8940
NCBI-ProteinID:
NP_001269041
OMIM:
603582
HGNC:
11993
Ensembl:
ENSG00000100038
UniProt:
O95985
Structure
PDB
PDBj
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All DBs
Position
22:complement(21957025..21982787)
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AA seq
862 aa
AA seq
DB search
MKTVLMVAEKPSLAQSIAKILSRGSLSSHKGLNGACSVHEYTGTFAGQPVRFKMTSVCGH
VMTLDFLGKYNKWDKVDPAELFSQAPTEKKEANPKLNMVKFLQVEGRGCDYIVLWLDCDK
EGENICFEVLDAVLPVMNKAHGGEKTVFRARFSSITDTDICNAMACLGEPDHNEALSVDA
RQELDLRIGCAFTRFQTKYFQGKYGDLDSSLISFGPCQTPTLGFCVERHDKIQSFKPETY
WVLQAKVNTDKDRSLLLDWDRVRVFDREIAQMFLNMTKLEKEAQVEATSRKEKAKQRPLA
LNTVEMLRVASSSLGMGPQHAMQTAERLYTQGYISYPRTETTHYPENFDLKGSLRQQANH
PYWADTVKRLLAEGINRPRKGHDAGDHPPITPMKSATEAELGGDAWRLYEYITRHFIATV
SHDCKYLQSTISFRIGPELFTCSGKTVLSPGFTEVMPWQSVPLEESLPTCQRGDAFPVGE
VKMLEKQTNPPDYLTEAELITLMEKHGIGTDASIPVHINNICQRNYVTVESGRRLKPTNL
GIVLVHGYYKIDAELVLPTIRSAVEKQLNLIAQGKADYRQVLGHTLDVFKRKFHYFVDSI
AGMDELMEVSFSPLAATGKPLSRCGKCHRFMKYIQAKPSRLHCSHCDETYTLPQNGTIKL
YKELRCPLDDFELVLWSSGSRGKSYPLCPYCYNHPPFRDMKKGMGCNECTHPSCQHSLSM
LGIGQCVECESGVLVLDPTSGPKWKVACNKCNVVAHCFENAHRVRVSADTCSVCEAALLD
VDFNKAKSPLPGDETQHMGCVFCDPVFQELVELKHAASCHPMHRGGPGRRQGRGRGRARR
PPGKPNPRRPKDKMSALAAYFV
NT seq
2589 nt
NT seq
+upstream
nt +downstream
nt
atgaagactgtgctcatggttgctgaaaagccgtccttggcacagtcaattgccaaaatc
ctctctagagggagcctgtcctcacacaaagggctgaacggggcctgctcagtccacgag
tacactgggacctttgctggccagccagtgcgcttcaagatgacgtctgtctgtggtcac
gtgatgaccctggatttcctgggaaaatacaacaaatgggacaaagtggaccccgcagaa
ctgttcagccaagctcccacggagaagaaagaagctaaccccaagctgaacatggtgaag
ttcctgcaggtggagggcagaggctgcgactacatcgtgctgtggctggactgcgacaag
gagggggagaacatctgctttgaggttcttgatgctgttctgcccgtcatgaacaaggcc
catggtggcgagaagaccgtgttccgggccaggtttagctccatcacggacacagacatc
tgtaatgccatggcctgcctaggcgagcctgaccacaacgaggcgctctcagtggatgct
cgccaggagctggacctgcgaatcggctgtgcattcaccaggtttcagactaaatatttc
caggggaaatacggtgatttagacagctctctcatctcctttgggccgtgtcagactcca
accctgggattctgtgtggagagacatgataaaatccagtccttcaaaccagagacctac
tgggtgctgcaggccaaggttaacactgacaaagacagatctctccttttggactgggac
cgagtaagagtgtttgaccgggagatcgcacagatgtttttaaacatgacaaagctggag
aaggaagcccaggtggaggccacaagcaggaaagaaaaggccaagcagaggcccctggcc
ctgaacactgtggagatgctgcgtgtggccagctcttctctgggcatggggccgcagcac
gccatgcagacggctgagcggctctacacgcaaggctacatcagctacccacggacagag
accacccactaccctgagaactttgacctgaagggctctctgcggcagcaggccaaccac
ccctactgggccgacacggtgaagcggttgttagcagaaggtatcaaccgcccgcggaaa
ggccatgacgccggcgaccatccccccatcacccccatgaagtctgccacagaggccgaa
ttagggggtgacgcgtggcggctctatgagtacatcaccagacacttcatcgccacggtc
agccatgactgcaagtacctgcagagcaccatctccttcagaattgggcccgagctcttc
acctgctccgggaagaccgtcctctcaccaggcttcacggaggtcatgccctggcagagc
gtgcccctggaggagagcctgcccacttgccagcggggtgatgccttccctgtgggcgag
gtgaagatgctggagaagcagacgaacccacccgactacctgacggaggccgagctcatc
acgctcatggagaagcatggcatcggcacggatgccagcatccctgtgcatatcaacaac
atctgccagcgcaactatgtcacggtggagagcgggcgccggctcaagcccaccaacctc
ggcatcgtcctggtgcacggctactataagattgatgcagagctggtgctccccaccatc
cgcagtgcagtggagaagcagctgaacctgatcgcccagggcaaggccgactaccgccag
gtcctgggccacaccctggacgtgttcaagaggaagttccactactttgtcgactccatt
gctggcatggatgagttgatggaggtgtctttctcgcccctggcggccacaggcaagccc
ctctcacgctgtgggaagtgccaccgcttcatgaagtacatccaggccaagccaagccgc
ctgcactgctcccactgcgatgagacctacacgctcccccagaacggcaccatcaagctc
tacaaggagctccgctgccctctggatgacttcgagctggtcctgtggtcatcaggctct
cggggcaagagctacccgctgtgcccctactgctacaaccacccacccttccgagacatg
aagaaaggcatgggctgcaacgagtgtacgcacccctcctgccagcactcgctgagcatg
ctgggcatcggccagtgcgtggaatgtgagagcggggtgctggtgctggaccccacctcg
ggccccaagtggaaggtggcctgcaacaagtgcaacgtggtagcgcactgcttcgagaac
gcccaccgcgtgcgggtgtccgccgacacctgcagtgtctgtgaggccgccttgcttgat
gtggacttcaacaaggccaagtccccactcccgggcgatgagacgcagcacatgggctgc
gtcttttgtgaccccgtcttccaggagctggtggagctgaagcatgcggcctcctgccac
cccatgcaccgcggtggaccagggagaaggcagggtcgagggcggggccgggccaggagg
ccccctgggaagcccaaccccagacggcccaaggacaagatgtcagccctggccgcctac
tttgtatga
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