Homo sapiens (human): 9380
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Entry
9380 CDS
T01001
Symbol
GRHPR, GLXR, GLYD, PH2
Name
(RefSeq) glyoxylate and hydroxypyruvate reductase
KO
K00049
glyoxylate/hydroxypyruvate reductase [EC:
1.1.1.79
1.1.1.81
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa00260
Glycine, serine and threonine metabolism
hsa00620
Pyruvate metabolism
hsa00630
Glyoxylate and dicarboxylate metabolism
hsa01100
Metabolic pathways
Disease
H00117
Primary hyperoxaluria
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09100 Metabolism
09101 Carbohydrate metabolism
00620 Pyruvate metabolism
9380 (GRHPR)
00630 Glyoxylate and dicarboxylate metabolism
9380 (GRHPR)
09105 Amino acid metabolism
00260 Glycine, serine and threonine metabolism
9380 (GRHPR)
Enzymes [BR:
hsa01000
]
1. Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.1.1 With NAD+ or NADP+ as acceptor
1.1.1.79 glyoxylate reductase (NADP+)
9380 (GRHPR)
1.1.1.81 hydroxypyruvate reductase
9380 (GRHPR)
BRITE hierarchy
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Ortholog
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Gene cluster
GFIT
Motif
Pfam:
2-Hacid_dh_C
2-Hacid_dh
NAD_binding_2
F420_oxidored
KR
KARI_N
Shikimate_DH
ThiF
TrkA_N
Motif
Other DBs
NCBI-GeneID:
9380
NCBI-ProteinID:
NP_036335
OMIM:
604296
HGNC:
4570
Ensembl:
ENSG00000137106
UniProt:
Q9UBQ7
A0A384N605
Structure
PDB
PDBj
LinkDB
All DBs
Position
9:37422435..37439494
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AA seq
328 aa
AA seq
DB search
MRPVRLMKVFVTRRIPAEGRVALARAADCEVEQWDSDEPIPAKELERGVAGAHGLLCLLS
DHVDKRILDAAGANLKVISTMSVGIDHLALDEIKKRGIRVGYTPDVLTDTTAELAVSLLL
TTCRRLPEAIEEVKNGGWTSWKPLWLCGYGLTQSTVGIIGLGRIGQAIARRLKPFGVQRF
LYTGRQPRPEEAAEFQAEFVSTPELAAQSDFIVVACSLTPATEGLCNKDFFQKMKETAVF
INISRGDVVNQDDLYQALASGKIAAAGLDVTSPEPLPTNHPLLTLKNCVILPHIGSATHR
TRNTMSLLAANNLLAGLRGEPMPSELKL
NT seq
987 nt
NT seq
+upstream
nt +downstream
nt
atgagaccggtgcgactcatgaaggtgttcgtcacccgcaggatacccgccgagggtagg
gtcgcgctcgcccgggcggcagactgtgaggtggagcagtgggactcggatgagcccatc
cctgccaaggagctagagcgaggtgtggcgggggcccacggcctgctctgcctcctctcc
gaccacgtggacaagaggatcctggatgctgcaggggccaatctcaaagtcatcagcacc
atgtctgtgggcatcgaccacttggctttggatgaaatcaagaagcgtgggatccgagtt
ggctacaccccagatgtcctgacagataccaccgccgaactcgcagtctccctgctactt
accacctgccgccggttgccggaggccatcgaggaagtgaagaatggtggctggacctcg
tggaagcccctctggctgtgtggctatggactcacgcagagcactgtcggcatcatcggg
ctggggcgcataggccaggccattgctcggcgtctgaaaccattcggtgtccagagattt
ctgtacacagggcgccagcccaggcctgaggaagcagcagaattccaggcagagtttgtg
tctacccctgagctggctgcccaatctgatttcatcgtcgtggcctgctccttaacacct
gcaaccgagggactctgcaacaaggacttcttccagaagatgaaggaaacagctgtgttc
atcaacatcagcaggggcgacgtcgtaaaccaggacgacctgtaccaggccttggccagt
ggtaagattgcagctgctggactggatgtgacgagcccagaaccactgcctacaaaccac
cctctcctgaccctgaagaactgtgtgattctgccccacattggcagtgccacccacaga
acccgcaacaccatgtccttgttggcagctaacaacttgctggctggcctgagaggggag
ccgatgcctagtgaactcaagctgtag
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