KEGG   Homo sapiens (human): 9420
Entry
9420              CDS       T01001                                 

Gene name
CYP7B1, CBAS3, CP7B, SPG5A
Definition
(RefSeq) cytochrome P450 family 7 subfamily B member 1
  KO
K07430  25/26-hydroxycholesterol 7alpha-hydroxylase [EC:1.14.14.29]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00120  Primary bile acid biosynthesis
hsa00140  Steroid hormone biosynthesis
Network
nt06022  Bile acid biosynthesis
  Element
N00805  Bile acid biosynthesis
N00806  ACOX2 deficiency in bile acid biosynthesis
N00807  AMACR deficiency in bile acid biosynthesis
N00808  CYP27A1 deficiency in bile acid biosynthesis
N00809  AKR1D1 deficiency in bile acid biosynthesis
N00810  HSD3B7 deficiency in bile acid biosynthesis
N00811  CYP7B1 deficiency in bile acid biosynthesis
Disease
H00266  Hereditary spastic paraplegia
H00628  Congenital bile acid synthesis defect
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09103 Lipid metabolism
   00120 Primary bile acid biosynthesis
    9420 (CYP7B1)
   00140 Steroid hormone biosynthesis
    9420 (CYP7B1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450 [BR:hsa00199]
    9420 (CYP7B1)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.29  25/26-hydroxycholesterol 7alpha-hydroxylase
     9420 (CYP7B1)
Cytochrome P450 [BR:hsa00199]
 Cytochrome P450, animal type
  CYP7 family
   9420 (CYP7B1)
SSDB
Motif
Pfam: p450
Other DBs
NCBI-GeneID: 9420
NCBI-ProteinID: NP_004811
OMIM: 603711
HGNC: 2652
Ensembl: ENSG00000172817
Vega: OTTHUMG00000164387
Pharos: O75881(Tbio)
UniProt: O75881 Q05C57
LinkDB
Position
8q12.3
AA seq 506 aa
MAGEVSAATGRFSLERLGLPGLALAAALLLLALCLLVRRTRRPGEPPLIKGWLPYLGVVL
NLRKDPLRFMKTLQKQHGDTFTVLLGGKYITFILDPFQYQLVIKNHKQLSFRVFSNKLLE
KAFSISQLQKNHDMNDELHLCYQFLQGKSLDILLESMMQNLKQVFEPQLLKTTSWDTAEL
YPFCSSIIFEITFTTIYGKVIVCDNNKFISELRDDFLKFDDKFAYLVSNIPIELLGNVKS
IREKIIKCFSSEKLAKMQGWSEVFQSRQDVLEKYYVHEDLEIGAHHLGFLWASVANTIPT
MFWAMYYLLRHPEAMAAVRDEIDRLLQSTGQKKGSGFPIHLTREQLDSLICLESSIFEAL
RLSSYSTTIRFVEEDLTLSSETGDYCVRKGDLVAIFPPVLHGDPEIFEAPEEFRYDRFIE
DGKKKTTFFKRGKKLKCYLMPFGTGTSKCPGRFFALMEIKQLLVILLTYFDLEIIDDKPI
GLNYSRLLFGIQYPDSDVLFRYKVKS
NT seq 1521 nt   +upstreamnt  +downstreamnt
atggcaggagaagtgtccgcggccacgggccgcttttcgctggagcggttgggcctcccg
ggcctggccctcgccgcggccctgctgctcctggccctctgcttgcttgtccggcgcacc
aggagacccggtgagcctccattgataaaaggttggcttccttatcttggagtggtcctg
aacttacgaaaagaccccttaaggttcatgaaaacacttcaaaagcaacatggtgacact
ttcacagttcttcttggtggaaagtacataacatttatcctggaccccttccagtaccag
ctagtgataaaaaatcataaacaattaagctttcgagtattttctaataaattattagag
aaagcatttagcatcagtcagttgcaaaaaaatcatgacatgaatgatgagcttcacctc
tgctatcaatttttgcaaggcaaatctttggacatactcttggaaagcatgatgcagaat
ctaaaacaagtttttgaaccccagctgttaaaaaccacaagttgggacacggcagaactg
tatccattctgcagctcaataatatttgagatcacatttacaactatatatggaaaagtt
attgtttgtgacaacaacaaatttattagtgagctaagagatgattttttaaaatttgat
gacaagtttgcatatttagtatccaacatacccattgagcttctaggaaatgtcaagtct
attagagagaaaattataaaatgcttctcatcagaaaagttagccaagatgcaaggatgg
tcagaagtttttcaaagcaggcaagatgtcctggagaaatattatgtgcacgaggacctt
gaaataggagcacatcatttaggctttctctgggcctctgtggcaaacactattccaact
atgttctgggcaatgtattatcttctgcggcacccagaagctatggcagcagtgcgtgac
gaaattgaccgtttgctgcagtcaacaggtcaaaagaaagggtctggatttcccatccac
ctcaccagagaacaattggacagcctaatctgcctagaaagcagcatttttgaagcttta
cgactgtcctcatattcaaccaccattcgttttgttgaggaggatttgactctcagttca
gagaccggggactactgtgtgcgaaagggagacttggtagccatctttcctccagtccta
catggtgaccctgaaatctttgaagctccagaggagtttagatatgatcgttttatagaa
gatggtaagaagaaaaccacctttttcaaaagagggaaaaagctgaagtgttacctaatg
ccgtttggaactggaaccagcaaatgtccaggccgattttttgcacttatggaaataaaa
caattgttggttatacttttaacttattttgatttagaaataattgatgataagcccata
ggactaaactacagccgcttgttgtttggtattcagtatccagattctgatgttttattt
agatacaaagtgaaatcttag

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