Homo sapiens (human): 9459
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Entry
9459 CDS
T01001
Symbol
ARHGEF6, COOL2, Cool-2, MRX46, PIXA, alpha-PIX, alphaPIX
Name
(RefSeq) Rac/Cdc42 guanine nucleotide exchange factor 6
KO
K05729
Rho guanine nucleotide exchange factor 6
Organism
hsa
Homo sapiens (human)
Pathway
hsa04810
Regulation of actin cytoskeleton
hsa05212
Pancreatic cancer
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09140 Cellular Processes
09142 Cell motility
04810 Regulation of actin cytoskeleton
9459 (ARHGEF6)
09160 Human Diseases
09162 Cancer: specific types
05212 Pancreatic cancer
9459 (ARHGEF6)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:
hsa04131
]
9459 (ARHGEF6)
Membrane trafficking [BR:
hsa04131
]
Others
Rho GTPase associated proteins
Rho guanine nucleotide exchange factors (GEFs)
9459 (ARHGEF6)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
RhoGEF67_u2
betaPIX_CC
RhoGEF
CH
SH3_2
RhoGEF67_u1
SH3_9
SH3_1
PH
SOS1_NGEF_PH
CAMSAP_CH
ZapB
Motif
Other DBs
NCBI-GeneID:
9459
NCBI-ProteinID:
NP_004831
OMIM:
300267
HGNC:
685
Ensembl:
ENSG00000129675
UniProt:
Q15052
Q8N4Q3
Structure
PDB
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All DBs
Position
X:complement(136665550..136780932)
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AA seq
776 aa
AA seq
DB search
MNPEEQIVTWLISLGVLESPKKTICDPEEFLKSSLKNGVVLCKLINRLMPGSVEKFCLDP
QTEADCINNINDFLKGCATLQVEIFDPDDLYSGVNFSKVLSTLLAVNKATEDQLSERPCG
RSSSLSAANTSQTNPQGAVSSTVSGLQRQSKTVEMTENGSHQLIVKARFNFKQTNEDELS
VCKGDIIYVTRVEEGGWWEGTLNGRTGWFPSNYVREIKSSERPLSPKAVKGFETAPLTKN
YYTVVLQNILDTEKEYAKELQSLLVTYLRPLQSNNNLSTVEVTSLLGNFEEVCTFQQTLC
QALEECSKFPENQHKVGGCLLSLMPHFKSMYLAYCANHPSAVNVLTQHSDELEQFMENQG
ASSPGILILTTNLSKPFMRLEKYVTLLQELERHMEDTHPDHQDILKAIVAFKTLMGQCQD
LRKRKQLELQILSEPIQAWEGEDIKNLGNVIFMSQVMVQYGACEEKEERYLMLFSNVLIM
LSASPRMSGFIYQGKIPIAGTVVTRLDEIEGNDCTFEITGNTVERIVVHCNNNQDFQEWL
EQLNRLIRGPASCSSLSKTSSSSCSAHSSFSSTGQPRGPLEPPQIIKPWSLSCLRPAPPL
RPSAALGYKERMSYILKESSKSPKTMKKFLHKRKTERKPSEEEYVIRKSTAALEEDAQIL
KVIEAYCTSANFQQGHGSSTRKDSIPQVLLPEEEKLIIEETRSNGQTIMEEKSLVDTVYA
LKDEVRELKQENKRMKQCLEEELKSRRDLEKLVRRLLKQTDECIRGESSSKTSILP
NT seq
2331 nt
NT seq
+upstream
nt +downstream
nt
atgaatccagaagaacaaatcgtgacatggcttatatctttgggagttttagagtcccct
aaaaagaccatctgtgatccggaggagtttttaaagtcctcgctgaaaaatggggtagtt
ctgtgcaaactgatcaacagactcatgcctggctctgtggaaaagttttgtctggatccc
caaactgaagctgactgcatcaacaacatcaatgacttcctgaaaggatgtgcaaccctc
caagtggaaatatttgatcctgatgacctttattcaggggtcaatttctccaaggtactg
agtactcttttagctgtcaacaaagcaacagaagatcagctatcagaaagaccatgtgga
cgttcctcttctcttagtgctgctaatacttctcagacaaacccacagggagcagtttct
agcacagtttcagggctgcaaaggcagtcaaagacagtggagatgacggaaaatggaagt
catcagttgatagtaaaagcaagattcaactttaagcagactaatgaggatgaactgtca
gtttgtaagggggacatcatttacgtcacacgagttgaagaaggaggctggtgggaaggc
acattaaatgggagaacaggctggttccccagtaattatgtccgtgaaattaaatccagt
gagagacctctctccccaaaagccgtcaaaggatttgaaactgctccacttaccaagaat
tattatactgtggtgttacagaacatcctggacactgaaaaagaatatgctaaagaactt
cagtctcttcttgttacttacttaagacccctgcagtccaataacaatctgagtactgtg
gaggttacatctttactgggaaacttcgaggaagtatgcacatttcaacagacactctgc
caagccttggaagaatgttcaaagtttccagaaaaccagcacaaagtaggaggttgtcta
ctgagtctcatgcctcattttaaatctatgtatctggcttactgtgcaaaccatccttca
gctgtaaatgtgctcactcagcacagtgatgagttggaacaattcatggaaaatcaaggt
gcatcgagcccaggtatcctcattttaacaacaaacctcagcaaaccattcatgcgactg
gagaaatatgttactctcttgcaagagttagaacggcatatggaggatactcatccagat
catcaggatattctgaaagcaatcgtagcattcaaaactctcatggggcaatgtcaagat
ctgaggaagagaaaacagctggagttacagatactgtccgaacctattcaggcatgggaa
ggagaagatattaaaaacttgggaaatgtgatttttatgtcacaagtaatggtgcagtat
ggagcatgtgaggaaaaagaggagcggtaccttatgttattttcaaatgtcctgataatg
ttatctgcaagtcctcggatgagtggctttatctatcagggaaaaataccaatagcagga
acggtggtgactagattagatgaaattgaagggaatgactgcacatttgaaatcactggt
aacacagtggagagaattgtggtccattgtaacaacaaccaggacttccaggaatggttg
gagcagctgaacagactgatcagaggacctgcctcttgcagttcattatccaaaacctca
tcgtcatcatgtagtgctcattcttcttttagctctaccggacagccccgaggacccttg
gagcctcctcaaattataaaaccgtggagtttaagttgtctacgacctgcacctccactt
agaccatcagcagcactaggttataaagagaggatgtcttatatcttaaaggagtctagt
aaaagccctaaaacgatgaagaaatttcttcataaaaggaagactgagagaaaaccatcg
gaggaggaatatgtgattaggaaaagtacagctgctctggaagaggatgctcaaatcctt
aaagtgatcgaagcctactgcaccagcgcaaattttcaacaaggccatggctcaagtact
cgaaaagattccattccacaagtcctactccctgaggaagagaaactcatcattgaagaa
accagaagcaacggccagaccatcatggaagaaaagagccttgttgatactgtttacgcc
ttgaaggacgaggtcagagaactgaagcaggaaaataaaagaatgaagcaatgcctggaa
gaagaactgaaatcaagaagggacctagaaaagctggtgcggaggcttttgaagcaaaca
gatgagtgtattcgaggcgagtccagtagcaagacctcaattcttccataa
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