Homo sapiens (human): 9459
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Entry
9459 CDS
T01001
Symbol
ARHGEF6, COOL2, Cool-2, MRX46, PIXA, alpha-PIX, alphaPIX
Name
(RefSeq) Rac/Cdc42 guanine nucleotide exchange factor 6
KO
K05729
Rho guanine nucleotide exchange factor 6
Organism
hsa
Homo sapiens (human)
Pathway
hsa04518
Integrin signaling
hsa04810
Regulation of actin cytoskeleton
hsa05212
Pancreatic cancer
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09130 Environmental Information Processing
09133 Signaling molecules and interaction
04518 Integrin signaling
9459 (ARHGEF6)
09140 Cellular Processes
09142 Cell motility
04810 Regulation of actin cytoskeleton
9459 (ARHGEF6)
09160 Human Diseases
09162 Cancer: specific types
05212 Pancreatic cancer
9459 (ARHGEF6)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:
hsa04131
]
9459 (ARHGEF6)
Membrane trafficking [BR:
hsa04131
]
Others
Rho GTPase associated proteins
Rho guanine nucleotide exchange factors (GEFs)
9459 (ARHGEF6)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
RhoGEF67_u2
betaPIX_CC
RhoGEF
CH
SH3_2
RhoGEF67_u1
SH3_9
SH3_1
PH
SOS1_NGEF_PH
CAMSAP_CH
ZapB
DH_Alsin
Motif
Other DBs
NCBI-GeneID:
9459
NCBI-ProteinID:
NP_004831
OMIM:
300267
HGNC:
685
Ensembl:
ENSG00000129675
UniProt:
Q15052
Q8N4Q3
Structure
PDB
PDBj
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All DBs
Position
X:complement(136665550..136780932)
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AA seq
776 aa
AA seq
DB search
MNPEEQIVTWLISLGVLESPKKTICDPEEFLKSSLKNGVVLCKLINRLMPGSVEKFCLDP
QTEADCINNINDFLKGCATLQVEIFDPDDLYSGVNFSKVLSTLLAVNKATEDQLSERPCG
RSSSLSAANTSQTNPQGAVSSTVSGLQRQSKTVEMTENGSHQLIVKARFNFKQTNEDELS
VCKGDIIYVTRVEEGGWWEGTLNGRTGWFPSNYVREIKSSERPLSPKAVKGFETAPLTKN
YYTVVLQNILDTEKEYAKELQSLLVTYLRPLQSNNNLSTVEVTSLLGNFEEVCTFQQTLC
QALEECSKFPENQHKVGGCLLSLMPHFKSMYLAYCANHPSAVNVLTQHSDELEQFMENQG
ASSPGILILTTNLSKPFMRLEKYVTLLQELERHMEDTHPDHQDILKAIVAFKTLMGQCQD
LRKRKQLELQILSEPIQAWEGEDIKNLGNVIFMSQVMVQYGACEEKEERYLMLFSNVLIM
LSASPRMSGFIYQGKIPIAGTVVTRLDEIEGNDCTFEITGNTVERIVVHCNNNQDFQEWL
EQLNRLIRGPASCSSLSKTSSSSCSAHSSFSSTGQPRGPLEPPQIIKPWSLSCLRPAPPL
RPSAALGYKERMSYILKESSKSPKTMKKFLHKRKTERKPSEEEYVIRKSTAALEEDAQIL
KVIEAYCTSANFQQGHGSSTRKDSIPQVLLPEEEKLIIEETRSNGQTIMEEKSLVDTVYA
LKDEVRELKQENKRMKQCLEEELKSRRDLEKLVRRLLKQTDECIRGESSSKTSILP
NT seq
2331 nt
NT seq
+upstream
nt +downstream
nt
atgaatccagaagaacaaatcgtgacatggcttatatctttgggagttttagagtcccct
aaaaagaccatctgtgatccggaggagtttttaaagtcctcgctgaaaaatggggtagtt
ctgtgcaaactgatcaacagactcatgcctggctctgtggaaaagttttgtctggatccc
caaactgaagctgactgcatcaacaacatcaatgacttcctgaaaggatgtgcaaccctc
caagtggaaatatttgatcctgatgacctttattcaggggtcaatttctccaaggtactg
agtactcttttagctgtcaacaaagcaacagaagatcagctatcagaaagaccatgtgga
cgttcctcttctcttagtgctgctaatacttctcagacaaacccacagggagcagtttct
agcacagtttcagggctgcaaaggcagtcaaagacagtggagatgacggaaaatggaagt
catcagttgatagtaaaagcaagattcaactttaagcagactaatgaggatgaactgtca
gtttgtaagggggacatcatttacgtcacacgagttgaagaaggaggctggtgggaaggc
acattaaatgggagaacaggctggttccccagtaattatgtccgtgaaattaaatccagt
gagagacctctctccccaaaagccgtcaaaggatttgaaactgctccacttaccaagaat
tattatactgtggtgttacagaacatcctggacactgaaaaagaatatgctaaagaactt
cagtctcttcttgttacttacttaagacccctgcagtccaataacaatctgagtactgtg
gaggttacatctttactgggaaacttcgaggaagtatgcacatttcaacagacactctgc
caagccttggaagaatgttcaaagtttccagaaaaccagcacaaagtaggaggttgtcta
ctgagtctcatgcctcattttaaatctatgtatctggcttactgtgcaaaccatccttca
gctgtaaatgtgctcactcagcacagtgatgagttggaacaattcatggaaaatcaaggt
gcatcgagcccaggtatcctcattttaacaacaaacctcagcaaaccattcatgcgactg
gagaaatatgttactctcttgcaagagttagaacggcatatggaggatactcatccagat
catcaggatattctgaaagcaatcgtagcattcaaaactctcatggggcaatgtcaagat
ctgaggaagagaaaacagctggagttacagatactgtccgaacctattcaggcatgggaa
ggagaagatattaaaaacttgggaaatgtgatttttatgtcacaagtaatggtgcagtat
ggagcatgtgaggaaaaagaggagcggtaccttatgttattttcaaatgtcctgataatg
ttatctgcaagtcctcggatgagtggctttatctatcagggaaaaataccaatagcagga
acggtggtgactagattagatgaaattgaagggaatgactgcacatttgaaatcactggt
aacacagtggagagaattgtggtccattgtaacaacaaccaggacttccaggaatggttg
gagcagctgaacagactgatcagaggacctgcctcttgcagttcattatccaaaacctca
tcgtcatcatgtagtgctcattcttcttttagctctaccggacagccccgaggacccttg
gagcctcctcaaattataaaaccgtggagtttaagttgtctacgacctgcacctccactt
agaccatcagcagcactaggttataaagagaggatgtcttatatcttaaaggagtctagt
aaaagccctaaaacgatgaagaaatttcttcataaaaggaagactgagagaaaaccatcg
gaggaggaatatgtgattaggaaaagtacagctgctctggaagaggatgctcaaatcctt
aaagtgatcgaagcctactgcaccagcgcaaattttcaacaaggccatggctcaagtact
cgaaaagattccattccacaagtcctactccctgaggaagagaaactcatcattgaagaa
accagaagcaacggccagaccatcatggaagaaaagagccttgttgatactgtttacgcc
ttgaaggacgaggtcagagaactgaagcaggaaaataaaagaatgaagcaatgcctggaa
gaagaactgaaatcaagaagggacctagaaaagctggtgcggaggcttttgaagcaaaca
gatgagtgtattcgaggcgagtccagtagcaagacctcaattcttccataa
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