| Entry |
|
|---|
| Symbol |
KMT2D, AAD10, ALR, BCAHH, CAGL114, KABUK1, KMS, MLL2, MLL4, TNRC21
|
|---|
| Name |
(RefSeq) lysine methyltransferase 2D
|
|---|
| KO |
|
|---|
| Organism |
|
|---|
| Pathway |
|
|---|
| Disease |
| H02434 | Diffuse large B-cell lymphoma, not otherwise specified |
| H02943 | Branchial arch abnormalities, choanal atresia, athelia, hearing loss, and hypothyroidism syndrome |
|
|---|
| Brite |
KEGG Orthology (KO) [BR:hsa00001]
09100 Metabolism
09105 Amino acid metabolism
00310 Lysine degradation
8085 (KMT2D)
09160 Human Diseases
09167 Endocrine and metabolic disease
04934 Cushing syndrome
8085 (KMT2D)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
03036 Chromosome and associated proteins [BR:hsa03036]
8085 (KMT2D)
Enzymes [BR:hsa01000]
2. Transferases
2.1 Transferring one-carbon groups
2.1.1 Methyltransferases
2.1.1.354 [histone H3]-lysine4 N-trimethyltransferase
8085 (KMT2D)
Chromosome and associated proteins [BR:hsa03036]
Eukaryotic type
Histone modification proteins
HMTs (histone methyltransferases)
HKMTs (histone lysine methyltransferases)
8085 (KMT2D)
HMT complexes
MLL-HCF complex
8085 (KMT2D)
|
|---|
| SSDB |
|
|---|
| Motif |
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|---|
| Other DBs |
|
|---|
| Structure |
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|---|
| LinkDB |
|
|---|
| Position |
12:complement(49018978..49060794)
|
|---|
| AA seq |
5537 aa
MDSQKLAGEDKDSEPAADGPAASEDPSATESDLPNPHVGEVSVLSSGSPRLQETPQDCSG
GPVRRCALCNCGEPSLHGQRELRRFELPFDWPRCPVVSPGGSPGPNEAVLPSEDLSQIGF
PEGLTPAHLGEPGGSCWAHHWCAAWSAGVWGQEGPELCGVDKAIFSGISQRCSHCTRLGA
SIPCRSPGCPRLYHFPCATASGSFLSMKTLQLLCPEHSEGAAYLEEARCAVCEGPGELCD
LFFCTSCGHHYHGACLDTALTARKRAGWQCPECKVCQACRKPGNDSKMLVCETCDKGYHT
FCLKPPMEELPAHSWKCKACRVCRACGAGSAELNPNSEWFENYSLCHRCHKAQGGQTIRS
VAEQHTPVCSRFSPPEPGDTPTDEPDALYVACQGQPKGGHVTSMQPKEPGPLQCEAKPLG
KAGVQLEPQLEAPLNEEMPLLPPPEESPLSPPPEESPTSPPPEASRLSPPPEELPASPLP
EALHLSRPLEESPLSPPPEESPLSPPPESSPFSPLEESPLSPPEESPPSPALETPLSPPP
EASPLSPPFEESPLSPPPEELPTSPPPEASRLSPPPEESPMSPPPEESPMSPPPEASRLF
PPFEESPLSPPPEESPLSPPPEASRLSPPPEDSPMSPPPEESPMSPPPEVSRLSPLPVVS
RLSPPPEESPLSPPPEESPTSPPPEASRLSPPPEDSPTSPPPEDSPASPPPEDSLMSLPL
EESPLLPLPEEPQLCPRSEGPHLSPRPEEPHLSPRPEEPHLSPQAEEPHLSPQPEEPCLC
AVPEEPHLSPQAEGPHLSPQPEELHLSPQTEEPHLSPVPEEPCLSPQPEESHLSPQSEEP
CLSPRPEESHLSPELEKPPLSPRPEKPPEEPGQCPAPEELPLFPPPGEPSLSPLLGEPAL
SEPGEPPLSPLPEELPLSPSGEPSLSPQLMPPDPLPPPLSPIITAAAPPALSPLGELEYP
FGAKGDSDPESPLAAPILETPISPPPEANCTDPEPVPPMILPPSPGSPVGPASPILMEPL
PPQCSPLLQHSLVPQNSPPSQCSPPALPLSVPSPLSPIGKVVGVSDEAELHEMETEKVSE
PECPALEPSATSPLPSPMGDLSCPAPSPAPALDDFSGLGEDTAPLDGIDAPGSQPEPGQT
PGSLASELKGSPVLLDPEELAPVTPMEVYPECKQTAGQGSPCEEQEEPRAPVAPTPPTLI
KSDIVNEISNLSQGDASASFPGSEPLLGSPDPEGGGSLSMELGVSTDVSPARDEGSLRLC
TDSLPETDDSLLCDAGTAISGGKAEGEKGRRRSSPARSRIKQGRSSSFPGRRRPRGGAHG
GRGRGRARLKSTASSIETLVVADIDSSPSKEEEEEDDDTMQNTVVLFSNTDKFVLMQDMC
VVCGSFGRGAEGHLLACSQCSQCYHPYCVNSKITKVMLLKGWRCVECIVCEVCGQASDPS
RLLLCDDCDISYHTYCLDPPLLTVPKGGWKCKWCVSCMQCGAASPGFHCEWQNSYTHCGP
CASLVTCPICHAPYVEEDLLIQCRHCERWMHAGCESLFTEDDVEQAADEGFDCVSCQPYV
VKPVAPVAPPELVPMKVKEPEPQYFRFEGVWLTETGMALLRNLTMSPLHKRRQRRGRLGL
PGEAGLEGSEPSDALGPDDKKDGDLDTDELLKGEGGVEHMECEIKLEGPVSPDVEPGKEE
TEESKKRKRKPYRPGIGGFMVRQRKSHTRTKKGPAAQAEVLSGDGQPDEVIPADLPAEGA
VEQSLAEGDEKKKQQRRGRKKSKLEDMFPAYLQEAFFGKELLDLSRKALFAVGVGRPSFG
LGTPKAKGDGGSERKELPTSQKGDDGPDIADEESRGLEGKADTPGPEDGGVKASPVPSDP
EKPGTPGEGMLSSDLDRISTEELPKMESKDLQQLFKDVLGSEREQHLGCGTPGLEGSRTP
LQRPFLQGGLPLGNLPSSSPMDSYPGLCQSPFLDSRERGGFFSPEPGEPDSPWTGSGGTT
PSTPTTPTTEGEGDGLSYNQRSLQRWEKDEELGQLSTISPVLYANINFPNLKQDYPDWSS
RCKQIMKLWRKVPAADKAPYLQKAKDNRAAHRINKVQKQAESQINKQTKVGDIARKTDRP
ALHLRIPPQPGALGSPPPAAAPTIFIGSPTTPAGLSTSADGFLKPPAGSVPGPDSPGELF
LKLPPQVPAQVPSQDPFGLAPAYPLEPRFPTAPPTYPPYPSPTGAPAQPPMLGASSRPGA
GQPGEFHTTPPGTPRHQPSTPDPFLKPRCPSLDNLAVPESPGVGGGKASEPLLSPPPFGE
SRKALEVKKEELGASSPSYGPPNLGFVDSPSSGTHLGGLELKTPDVFKAPLTPRASQVEP
QSPGLGLRPQEPPPAQALAPSPPSHPDIFRPGSYTDPYAQPPLTPRPQPPPPESCCALPP
RSLPSDPFSRVPASPQSQSSSQSPLTPRPLSAEAFCPSPVTPRFQSPDPYSRPPSRPQSR
DPFAPLHKPPRPQPPEVAFKAGSLAHTSLGAGGFPAALPAGPAGELHAKVPSGQPPNFVR
SPGTGAFVGTPSPMRFTFPQAVGEPSLKPPVPQPGLPPPHGINSHFGPGPTLGKPQSTNY
TVATGNFHPSGSPLGPSSGSTGESYGLSPLRPPSVLPPPAPDGSLPYLSHGASQRSGITS
PVEKREDPGTGMGSSLATAELPGTQDPGMSGLSQTELEKQRQRQRLRELLIRQQIQRNTL
RQEKETAAAAAGAVGPPGSWGAEPSSPAFEQLSRGQTPFAGTQDKSSLVGLPPSKLSGPI
LGPGSFPSDDRLSRPPPPATPSSMDVNSRQLVGGSQAFYQRAPYPGSLPLQQQQQQLWQQ
QQATAATSMRFAMSARFPSTPGPELGRQALGSPLAGISTRLPGPGEPVPGPAGPAQFIEL
RHNVQKGLGPGGTPFPGQGPPQRPRFYPVSEDPHRLAPEGLRGLAVSGLPPQKPSAPPAP
ELNNSLHPTPHTKGPTLPTGLELVNRPPSSTELGRPNPLALEAGKLPCEDPELDDDFDAH
KALEDDEELAHLGLGVDVAKGDDELGTLENLETNDPHLDDLLNGDEFDLLAYTDPELDTG
DKKDIFNEHLRLVESANEKAEREALLRGVEPGPLGPEERPPPAADASEPRLASVLPEVKP
KVEEGGRHPSPCQFTIATPKVEPAPAANSLGLGLKPGQSMMGSRDTRMGTGPFSSSGHTA
EKASFGATGGPPAHLLTPSPLSGPGGSSLLEKFELESGALTLPGGPAASGDELDKMESSL
VASELPLLIEDLLEHEKKELQKKQQLSAQLQPAQQQQQQQQQHSLLSAPGPAQAMSLPHE
GSSPSLAGSQQQLSLGLAGARQPGLPQPLMPTQPPAHALQQRLAPSMAMVSNQGHMLSGQ
HGGQAGLVPQQSSQPVLSQKPMGTMPPSMCMKPQQLAMQQQLANSFFPDTDLDKFAAEDI
IDPIAKAKMVALKGIKKVMAQGSIGVAPGMNRQQVSLLAQRLSGGPSSDLQNHVAAGSGQ
ERSAGDPSQPRPNPPTFAQGVINEADQRQYEEWLFHTQQLLQMQLKVLEEQIGVHRKSRK
ALCAKQRTAKKAGREFPEADAEKLKLVTEQQSKIQKQLDQVRKQQKEHTNLMAEYRNKQQ
QQQQQQQQQQQQHSAVLALSPSQSPRLLTKLPGQLLPGHGLQPPQGPPGGQAGGLRLTPG
GMALPGQPGGPFLNTALAQQQQQQHSGGAGSLAGPSGGFFPGNLALRSLGPDSRLLQERQ
LQLQQQRMQLAQKLQQQQQQQQQQQHLLGQVAIQQQQQQGPGVQTNQALGPKPQGLMPPS
SHQGLLVQQLSPQPPQGPQGMLGPAQVAVLQQQHPGALGPQGPHRQVLMTQSRVLSSPQL
AQQGQGLMGHRLVTAQQQQQQQQHQQQGSMAGLSHLQQSLMSHSGQPKLSAQPMGSLQQL
QQQQQLQQQQQLQQQQQQQLQQQQQLQQQQLQQQQQQQQLQQQQQQQLQQQQQQLQQQQQ
QQQQQFQQQQQQQQMGLLNQSRTLLSPQQQQQQQVALGPGMPAKPLQHFSSPGALGPTLL
LTGKEQNTVDPAVSSEATEGPSTHQGGPLAIGTTPESMATEPGEVKPSLSGDSQLLLVQP
QPQPQPSSLQLQPPLRLPGQQQQQVSLLHTAGGGSHGQLGSGSSSEASSVPHLLAQPSVS
LGDQPGSMTQNLLGPQQPMLERPMQNNTGPQPPKPGPVLQSGQGLPGVGIMPTVGQLRAQ
LQGVLAKNPQLRHLSPQQQQQLQALLMQRQLQQSQAVRQTPPYQEPGTQTSPLQGLLGCQ
PQLGGFPGPQTGPLQELGAGPRPQGPPRLPAPPGALSTGPVLGPVHPTPPPSSPQEPKRP
SQLPSPSSQLPTEAQLPPTHPGTPKPQGPTLEPPPGRVSPAAAQLADTLFSKGLGPWDPP
DNLAETQKPEQSSLVPGHLDQVNGQVVPEASQLSIKQEPREEPCALGAQSVKREANGEPI
GAPGTSNHLLLAGPRSEAGHLLLQKLLRAKNVQLSTGRGSEGLRAEINGHIDSKLAGLEQ
KLQGTPSNKEDAAARKPLTPKPKRVQKASDRLVSSRKKLRKEDGVRASEALLKQLKQELS
LLPLTEPAITANFSLFAPFGSGCPVNGQSQLRGAFGSGALPTGPDYYSQLLTKNNLSNPP
TPPSSLPPTPPPSVQQKMVNGVTPSEELGEHPKDAASARDSERALRDTSEVKSLDLLAAL
PTPPHNQTEDVRMESDEDSDSPDSIVPASSPESILGEEAPRFPHLGSGRWEQEDRALSPV
IPLIPRASIPVFPDTKPYGALGLEVPGKLPVTTWEKGKGSEVSVMLTVSAAAAKNLNGVM
VAVAELLSMKIPNSYEVLFPESPARAGTEPKKGEAEGPGGKEKGLEGKSPDTGPDWLKQF
DAVLPGYTLKSQLDILSLLKQESPAPEPPTQHSYTYNVSNLDVRQLSAPPPEEPSPPPSP
LAPSPASPPTEPLVELPTEPLAEPPVPSPLPLASSPESARPKPRARPPEEGEDSRPPRLK
KWKGVRWKRLRLLLTIQKGSGRQEDEREVAEFMEQLGTALRPDKVPRDMRRCCFCHEEGD
GATDGPARLLNLDLDLWVHLNCALWSTEVYETQGGALMNVEVALHRGLLTKCSLCQRTGA
TSSCNRMRCPNVYHFACAIRAKCMFFKDKTMLCPMHKIKGPCEQELSSFAVFRRVYIERD
EVKQIASIIQRGERLHMFRVGGLVFHAIGQLLPHQMADFHSATALYPVGYEATRIYWSLR
TNNRRCCYRCSIGENNGRPEFVIKVIEQGLEDLVFTDASPQAVWNRIIEPVAAMRKEADM
LRLFPEYLKGEELFGLTVHAVLRIAESLPGVESCQNYLFRYGRHPLMELPLMINPTGCAR
SEPKILTHYKRPHTLNSTSMSKAYQSTFTGETNTPYSKQFVHSKSSQYRRLRTEWKNNVY
LARSRIQGLGLYAAKDLEKHTMVIEYIGTIIRNEVANRREKIYEEQNRGIYMFRINNEHV
IDATLTGGPARYINHSCAPNCVAEVVTFDKEDKIIIISSRRIPKGEELTYDYQFDFEDDQ
HKIPCHCGAWNCRKWMN |
|---|
| NT seq |
16614 nt +upstreamnt +downstreamnt
atggacagccagaagctggctggtgaggataaagattcagaaccggcagctgatggacct
gcagcttctgaggacccaagtgccactgagtcagacctgcccaacccacatgtgggagag
gtctctgtccttagttctgggagtcccaggcttcaggagactcctcaggactgcagtggg
ggtccggtgcggcgttgtgctctctgtaactgcggggagcccagtctacacgggcagcgg
gagctacggcgctttgagttgccatttgattggccccggtgtccagtggtgtcccctggg
gggagcccagggcccaatgaggcagtgctgcccagtgaggacctatcacagattggtttc
cctgagggccttacacctgcccacctaggagaacctggagggtcctgctgggctcaccat
tggtgtgctgcatggtcggcaggcgtatgggggcaggagggcccagaactatgtggtgtg
gacaaggccatcttctcagggatctcacagcgctgctcccactgcaccaggctcggtgcc
tccatcccttgccgctcacctggatgtccacggctttaccacttcccctgcgcgactgcc
agcggttccttcctatccatgaaaacactgcagctgctatgcccagagcacagtgagggg
gctgcatatctggaggaggctcgctgtgcagtgtgtgaggggccaggggagttgtgtgac
ctgttcttctgtaccagctgtgggcatcactatcacggggcctgcctggacactgctctg
actgcccgcaaacgtgctggctggcagtgccctgaatgcaaagtgtgccaagcctgcagg
aaacctgggaatgactctaagatgttggtttgtgagacgtgtgacaaaggataccatact
ttctgcctaaaaccacccatggaggaactgcctgctcactcttggaagtgcaaggcgtgc
cgggtgtgccgggcctgtggggcgggctcagcagaactgaatcccaactcggagtggttt
gagaactactctctctgtcaccgctgtcacaaagcccagggaggtcagactatccgctcc
gttgctgagcagcataccccggtgtgtagcagattttcacccccagagcctggcgatacc
cccactgacgagcccgatgctctgtacgttgcatgccaagggcagccaaagggtgggcac
gtgacctctatgcaacccaaggaaccagggcccctgcaatgtgaagccaaaccactaggg
aaagcaggggtccaacttgagccccagttggaggcccccctaaacgaggagatgccactg
ctgcccccacctgaggagtcacccctgtccccaccacctgaggaatcacccacgtcccca
ccacctgaggcatcacgcctgtcaccaccacctgaggaattgcccgcatccccacttcct
gaggcattgcacctgtcccggccgctggaggaatcgcccctctctccgccgcctgaggag
tctcctctgtctcccccacctgaatcatcacctttttctccactggaggagtcgcccttg
tctccaccggaagagtcacccccatctcctgcacttgagacgcctctatccccaccacct
gaagcatcgcccctgtccccaccatttgaagaatctcctttgtccccgccacctgaggaa
ttgcccacttccccgccacctgaagcatctcgcctgtctccaccacctgaggagtcaccc
atgtcccctccacctgaagagtcacccatgtctccaccaccggaggcatctcgtctgttc
ccaccatttgaagagtctcctctgtcccctccacctgaggagtctcccctttccccacca
cctgaggcatcacgcctgtccccaccacctgaggactcgcctatgtccccaccacctgaa
gaatcacctatgtcccccccacctgaggtatcgcgcctatcccccctgcctgtggtgtca
cgcctgtctccaccgcctgaggaatctcccttgtccccaccgcctgaggagtctcccacg
tcccctccacctgaggcttcacgcctctccccaccacctgaggactcccccacatcccca
ccacctgaggactcacctgcttccccaccaccggaggactcgctcatgtccctgccgctg
gaggagtcacccctgttgccactacctgaggagccgcaactctgcccccggtccgagggg
ccgcacctgtcaccccggcctgaggagccgcacctgtccccccggcctgaggagccacac
ctatctccgcaggctgaggagccacacctgtccccccagcctgaggagccatgcctatgc
gctgtgcctgaggagccacacttgtccccccaggctgagggaccacatctgtcccctcag
cctgaggaattgcacctgtccccccagactgaggagccgcacctgtctcctgtgcctgag
gagccatgcttgtccccccaacctgaggaatcacacctgtccccccagtctgaggagcca
tgcctgtccccccggcctgaggaatcgcatctgtcccctgagcttgagaagccacccctg
tcccctcggcctgaaaagccccctgaggagccaggccaatgccctgcacctgaggagctg
cccttgttccctccccctggggaaccatccttatctcccttgcttggagagccagccctg
tctgagcctggggaaccacctctgtcccctctgcccgaggagctgccgttgtccccatct
ggggagccatccttgtcgcctcagctgatgccaccagatccccttcctcctccactctca
cccatcatcacagctgcggccccaccggccctgtctcctttgggggagttagagtacccc
tttggtgccaaaggggacagtgaccctgagtcaccgttggctgcccccatcctggagaca
cccatcagccctccaccagaagctaactgcactgaccctgagcctgtcccccctatgatc
cttcccccatctccaggctccccagtggggccggcttctcccatcctgatggagcccctt
cctcctcagtgttcgccactccttcagcattccctggttccccaaaactcccctccttcc
cagtgctctcctcctgccctaccactgtccgttccctccccgttgagtcccatagggaag
gtagtgggggtctcagatgaggctgagctgcacgagatggagactgagaaagtttcagaa
cctgaatgcccagccttggaacccagtgccaccagtcctctcccttccccaatgggggac
ctttcctgccccgcccccagccctgccccagccctggatgacttctctggcctaggggaa
gacacagcccctctggatgggattgatgctccgggttcacagccagagcctggacagacc
cctggcagtttggctagtgaacttaaaggctcccctgtgctcctggaccccgaggagctg
gcccctgtgacccctatggaggtctaccccgaatgcaagcagacagcagggcagggctca
ccatgtgaagaacaggaagagccacgtgcaccggtggcccccacaccacccactctcatc
aaatccgacatcgttaacgagatctctaatctgagccagggtgatgccagtgccagtttt
cctggctcagagcccctcctgggctctccagacccggaggggggtggctccctgtccatg
gagttgggggtctctacggatgttagtccagcccgagatgagggctccctacggctctgt
actgactcactgccagagactgatgactcactattgtgcgatgctgggacagctatcagc
ggaggcaaagctgagggggagaaggggcggcggcgcagctccccagcccgttcccgcatc
aaacagggtcgcagcagcagtttcccaggaagacgccggcctcgtggaggagcccatgga
ggacgtggtagaggacgggcccggctaaagtcaactgcttcttccattgagactctggta
gttgctgacattgatagctctcccagtaaggaggaggaggaagaagatgatgacaccatg
cagaataccgtggttctcttctccaacacagacaaatttgtcctaatgcaggacatgtgt
gtggtatgtggcagctttggccggggggcagagggccacctccttgcctgttcgcagtgc
tctcagtgctatcacccttactgtgtcaacagcaagatcaccaaggtgatgctgctcaag
ggctggcgttgtgtggagtgtattgtgtgtgaggtgtgtggccaggcctccgacccctca
cgcctgctgctctgtgatgactgtgatattagctaccacacatactgcctggacccccca
ctgctcaccgtccccaagggcggctggaagtgcaagtggtgtgtgtcctgtatgcagtgt
ggggctgcttcccctggcttccactgtgaatggcagaatagttacacacactgtgggccc
tgtgccagcctggtgacctgccctatctgtcatgctccttacgtagaagaggacctacta
atccagtgccgccactgtgaacggtggatgcatgcaggctgtgagagcctcttcacagag
gacgatgtggagcaggcagccgatgaaggctttgactgtgtctcctgccagccctacgtg
gtaaagcctgtggcgcctgttgcacctccagagctggtgcccatgaaggtgaaagagcca
gagccccagtactttcgcttcgaaggtgtgtggctgacagaaactggcatggccttgctg
cgtaacctgaccatgtcaccactgcacaagcggcgccaacggcgaggacggcttggcctc
ccaggcgaggcaggattggagggttctgagccctcagatgcccttggccctgatgacaag
aaggatggggacctggacaccgatgagctgctcaagggtgaaggtggtgtggagcacatg
gagtgcgaaattaaactggagggccccgtcagccctgatgtggagcctggcaaagaggag
accgaggaaagcaaaaaacgcaagcgtaaaccatatcggcctggcattggtggtttcatg
gtgcgacagcggaaatcccacacacgcacgaaaaaggggcctgctgcacaggcggaggtg
ttgagtggggatgggcagcccgacgaggtgatacctgctgacctgcctgcagagggcgcc
gtggagcagagcttagctgaaggggatgagaagaagaagcaacagcggcgagggcgcaag
aagagcaaactggaggacatgttccctgcttacttgcaggaagccttctttgggaaggag
ctgctggacctgagccgtaaggccctttttgcagttggggtgggccggccaagctttgga
ctagggaccccaaaagccaagggagatggaggctcagaaaggaaggaactccccacatcg
cagaaaggagatgatggtccagatattgcagatgaagaatcccgtggcctcgagggcaaa
gccgatacaccaggacctgaggatgggggcgtgaaggcatccccagtgcccagtgaccct
gagaagccaggcaccccaggtgaagggatgcttagctctgacttagacaggatttccaca
gaagaactgcccaagatggaatccaaggacctgcagcagctcttcaaggatgttctgggc
tctgaacgagaacagcatctgggttgtggaacccctggcctagaaggcagccgtacgcca
ctgcagaggccctttcttcaaggtggactccctttgggcaatctgccctccagcagccca
atggactcctacccaggcctctgccagtccccgttcctggattctagggagcgcgggggc
ttctttagcccggaacccggtgagcccgacagcccctggacgggctcaggtggcaccacg
ccctccacccccacaacccccaccacggagggtgagggcgacggactctcctataaccag
cggagtcttcagcgctgggagaaggatgaggagttgggccagctgtccaccatctcacct
gtgctctatgccaacattaattttcctaatctcaagcaagactacccagactggtcaagc
cgttgcaaacaaatcatgaagctctggagaaaggttccagcagctgacaaagccccctac
ctgcaaaaggccaaagataaccgggcagctcaccgcatcaacaaggtgcagaagcaggct
gagagccagatcaacaagcagaccaaggtgggcgacatagcccgtaagactgaccgaccg
gccctacatctccgcattcccccgcagccaggggcactgggcagcccgccccccgctgct
gcccccaccattttcattggcagccccactacccccgccggcttgtctacctctgcggac
gggttcctgaagccgccggcgggctcggtgcctggccctgactcgcctggtgagctcttc
ctcaagctcccaccccaggtgcccgcccaagtgccttcgcaggacccctttggactggcc
cctgcctatcccctggagccccgcttccccacggcaccgcccacctatcccccctatcct
agtcctacgggggcccctgcgcagcccccgatgctgggcgcctcatctcgtcctggggct
ggccagccaggggaattccacactaccccacctggcacccccagacaccagccctccaca
cctgacccattcctcaaaccccgctgcccctcgctggataacttggctgtgcctgagagc
cctggggtagggggaggcaaagcttccgagcccctgctctcgcccccaccttttggggag
tcccggaaggccctagaggtgaagaaggaagagcttggggcatcctctcctagctatggg
cccccaaacctgggctttgttgactcaccctcctcaggcacccacctgggtggcctggag
ttaaagacacctgatgtcttcaaagcccccctgacccctcgggcatctcaggtagagccc
cagagcccgggcttgggcctaaggccccaggagccaccccctgcccaggctttggcacct
tctcctccaagtcacccagacatctttcgccctggctcctacactgacccatatgctcag
cccccattgactcctcggccccaacctccgccccctgagagctgctgtgctctgccccct
cgctcactgccctccgaccctttctcccgagtgcctgccagtcctcagtcccagtccagc
tcccagtctccactgacaccccggcctctgtctgctgaagctttttgcccatcacccgtt
acccctcgcttccagtcccctgacccttattctcgcccaccctcacgccctcagtcccgt
gacccatttgccccattgcataagccaccccgaccccagccccctgaagttgcctttaag
gctgggtctctagcccacacttcgctgggggctggggggttcccagcagccctgcccgcg
gggccagcaggtgagctccatgccaaggtcccaagtgggcagccccccaattttgtccgg
tcccctgggacgggtgcatttgtgggcaccccctctcccatgcgtttcactttccctcag
gcagtaggggagccttccctaaagccccctgtccctcagcctggtctcccgccaccccat
gggatcaacagccattttgggcccggccccaccttgggcaagcctcaaagcacaaactac
acagtagccacagggaacttccacccatcgggcagccccctggggcccagcagcgggtcc
acaggggagagctatgggctgtccccactacgccctccgtcggttctgccaccacctgca
cccgacggatccctcccctacctgtcccatggagcctcacagcgatcaggcatcacctct
cctgtcgaaaagcgagaagacccagggactggaatgggtagctctttggcgacagctgaa
ctcccaggtacccaggacccaggcatgtccggccttagccaaacagagctggagaagcaa
cggcagcgccagcgactacgagagctgctgattcggcagcagatccagcgcaacaccctg
cggcaggagaaggaaacagctgcagcagctgcaggagcagtggggcctccaggcagctgg
ggtgctgagcccagcagccctgcctttgagcagctgagtcgaggccagaccccctttgct
gggacacaggacaagagcagccttgtggggttgcccccaagcaagctgagtggccccatc
ctggggccagggtccttccctagcgatgaccgactctcccggccacctccaccagccacg
ccttcctctatggatgtgaacagccggcaactggtaggaggctcccaagctttctatcag
cgagcaccctatcctgggtccctgcccttacagcagcaacagcaacaactgtggcagcaa
caacaggcaacagcagcaacctccatgcgatttgccatgtcagctcgctttccatcaact
cctggacctgaacttggccgccaagccctaggttccccgttggcgggaatttccacccgt
ctgccaggccctggtgagccagtgcctggtccagctggtcctgcccagttcattgagctg
cggcacaatgtacagaaaggactgggacctgggggcactccgtttcctggtcagggccca
cctcagagaccccgtttttaccctgtaagtgaggacccccaccgactggctcctgaaggg
cttcggggcctggcggtatcaggtcttcccccacagaaaccctcagccccaccggcccct
gaattgaacaacagtcttcatccaacaccccacaccaagggtcctaccctgccaactggt
ttggagctggtcaaccggcccccgtcgagcactgagcttggccgccccaatcctctggcc
ctggaagctgggaagttgccctgtgaggatcccgagctggatgacgattttgatgcccac
aaggccctagaggatgatgaagagcttgctcacctgggtctgggtgtggatgtggccaag
ggtgatgatgaacttggcaccttagaaaacctggagaccaatgacccccacttggatgac
ctgctcaatggagacgagtttgacctgctggcatatactgatcctgagctggacactggg
gacaagaaggatatcttcaatgagcacctgaggctggtagaatcggctaatgagaaggct
gaacgggaggccctgctgcggggggtggagccaggacccttgggccctgaggagcgccct
ccccctgctgctgatgcctctgaaccccgcctggcatctgtgctccctgaggtgaagccc
aaggtggaggagggtggacgccacccttctccttgccaattcaccattgctacccccaag
gtagagcccgcacctgctgccaattcccttggcctggggctaaagccaggacagagcatg
atgggcagccgggatacccggatgggcacagggccattttctagcagtgggcacacagct
gagaaggcctcctttggggccacgggaggaccaccagctcacctgctgacccccagccca
ctgagtggcccaggaggatcctccctgctggaaaagtttgagctcgagagtggggctttg
accttgcctggtggacctgcagcatctggggatgagctagacaagatggagagctcactg
gtagccagcgagttacccctgctcattgaggacctgttggagcatgagaagaaggagctg
cagaagaagcagcagctttcagcacagttgcagcctgcccagcagcagcagcaacagcag
cagcagcattccctactgtctgcaccaggccctgcccaggccatgtctttgccacatgag
ggctcttctcccagtttggctgggtcccaacagcagctttccctgggtcttgcaggtgcc
cgacagccaggtttgccccagccactgatgcccacccagccaccagctcatgccctccag
caacgcctggctccatccatggctatggtgtccaatcaagggcatatgctaagtgggcag
catggagggcaggcaggcttggtaccccagcagagctcacagccagtgctatcacagaag
cccatgggcaccatgccaccttccatgtgcatgaagccgcagcaattggcaatgcagcag
cagctggcaaacagcttcttcccagatacagacctggacaaatttgctgcagaagatatc
attgatcccattgcaaaggccaagatggtggctttgaaaggcatcaagaaagtgatggct
cagggcagcattggggtggcacctggtatgaacagacagcaagtgtctctgctagcccag
aggctctcggggggacctagcagtgatctgcagaaccatgtggcagctgggagtggccag
gagcggagtgctggtgatccctcccagcctcgtcccaacccgcccacttttgctcaggga
gtgatcaatgaagctgaccagcggcagtatgaggagtggctgttccatacccagcagctc
ctacagatgcagctgaaggtgctagaggagcagattggtgtacaccgcaagtcccggaag
gctctgtgtgccaagcagcgcactgccaaaaaagctggccgtgagttcccagaagctgat
gctgagaagctcaagctggttacagagcagcagagcaagatccagaaacaactggatcag
gtccggaaacagcagaaggagcacactaatctcatggcagaatatcggaacaagcagcag
caacaacagcagcagcagcagcaacaacagcaacagcactcagctgtgctggctctcagc
ccttcccagagtccccggctgctcaccaagctccctggtcagctgctccctggccatggg
ctgcagccaccacaggggcctccgggtgggcaagccggaggtcttcgcctgacccctggg
ggtatggcactacctggacagcctggtggccccttccttaatacagctctggcccaacag
cagcaacagcaacattctggtggggctggatccctggctggcccttcagggggcttcttc
cctggcaaccttgctcttcgaagcctcggacctgattcaaggcttttacaggaaaggcag
ctgcagctgcagcagcaacgtatgcagctggcccagaaactgcagcagcagcagcagcag
caacagcagcagcagcaccttctaggacaggtggcaatccagcagcaacagcagcagggt
cctggagtacagacaaaccaagctctgggtcccaagccccagggccttatgcctcccagc
agccaccaaggcctcctggtccagcagctgtcccctcaaccaccccaggggccccagggc
atgctgggccctgcccaggtggctgtgttgcagcagcagcaccctggagctttgggcccc
cagggccctcacagacaggtgcttatgacccagtcccgggtgctcagttccccccagctg
gcacagcagggtcagggccttatgggacacaggctggtcacagcccagcagcagcagcag
caacaacagcaccaacagcaagggtccatggcagggctgtcccatcttcagcagagtctg
atgtcacacagtgggcagcccaaactgagcgctcagcccatgggctctttacagcagctt
cagcagcagcagcagctgcaacagcaacagcaacttcagcagcagcagcagcagcagcta
caacagcaacagcaacttcagcagcaacagcttcaacagcagcaacagcagcagcagctt
caacaacagcagcagcaacagcttcaacagcagcaacagcagctacaacagcaacagcaa
caacaacagcagcagtttcaacagcagcagcaacagcagcagatgggccttttaaaccag
agtcgaactttactgtctcctcagcaacaacagcagcagcaagtggcacttggccctggc
atgccagcaaagcctcttcaacacttttctagccctggagccctgggtccaaccctcctc
ctgacgggcaaggaacaaaacaccgtagacccagccgtttcttcagaggccactgagggg
ccctctacacatcagggagggccgttagcaataggaactacccctgagtcaatggccact
gaaccaggagaggtaaagccctcactctctggggactcacaactcctgcttgtccaaccc
cagccccagcctcagcccagctctctgcagctgcagccacctctgaggcttccaggacaa
cagcagcagcaagttagcctgctccacacagcaggtggaggaagccatgggcagctaggc
agtggatcatcttctgaggcctcatctgtgccccacctgctggctcagccctctgtttcc
ttaggggatcagcctgggtccatgacccagaaccttctgggcccccaacagcccatgcta
gagcggcccatgcaaaataatacagggccacaacctcccaaaccaggacctgtcctccag
tctgggcagggtctgcctggggttggaatcatgcctacggtgggtcagcttcgagcacag
ctccaaggagtcctggccaaaaacccacagctgcggcacttaagtcctcagcagcagcag
cagctacaggcactcctcatgcagcggcagctgcagcagagtcaggcagtacgccagacc
ccaccctaccaggagcctgggacccagacctctcccctccagggcctcctgggctgccaa
cctcaacttgggggcttccctggaccacagacaggccccctccaggagctaggggcaggg
cctcgacctcagggcccaccccggctccctgccccaccaggagccttatctacaggacca
gtccttggccctgtccatcccacacctccaccatccagccctcaagagccaaagagacct
tcacaattaccttcccccagctcccagcttcccactgaggcccagctccctcccacccat
ccagggacccccaaacctcaggggccaaccttggagccgcctcctgggagggtctcacct
gctgctgcccagcttgcagataccttgtttagcaagggtctgggaccttgggatccccca
gacaacctagcagaaacccagaagccagagcagagcagcctggtacctgggcatctggac
caggtgaatggacaggtggtgcctgaggcatcccaactcagcatcaagcaggaacctcgg
gaagagccatgtgccctgggagcccagtcagtgaagagggaggccaatggggagccaata
ggggcaccaggaaccagcaaccacctcctgctggcaggccctcgctcagaagctgggcat
ctgctcttgcagaagctactccgggcaaagaatgtgcaactcagcactgggcgggggtcc
gaggggctgcgagctgagatcaacgggcacattgacagcaagctggctgggctggagcag
aaactacagggtacccccagcaacaaggaggatgcagcagcaaggaagcctttgacaccg
aagcccaagcgggtacagaaggcaagcgacaggttggtgagctcccgaaagaagctgcgg
aaggaggacggggtcagggccagcgaggccttgctgaaacagctgaaacaggagctgtcc
ctgctgcccctaacggagcctgctatcaccgccaattttagcctctttgccccctttggc
agtggctgcccagtcaatgggcagagccagctgaggggggcctttggaagtggggcgctg
cccactggccctgactactattcccagctgcttaccaagaataacctgagtaacccgccg
acaccaccctcgtcgctgccccccaccccacccccatcggtgcagcagaagatggtgaat
ggcgtcaccccatctgaagagctgggggagcaccccaaggatgctgcctctgcccgggat
agtgaaagggcactgagggatacttcagaggtgaagagtctagacctgctggctgccttg
cctacaccccctcacaatcagactgaggatgtcaggatggagagtgatgaggatagcgat
tctcctgacagcattgtgccagcttcatcccctgagagcatcttgggggaggaggcccct
cgtttccctcatctgggctcaggccggtgggagcaagaggaccgggccctctcccctgtc
atccccctcattcctcgggccagcatcccagtcttcccagataccaaaccttatggggcc
cttggcctggaggtccctggaaagctgcctgtcacaacttgggaaaagggcaaaggaagt
gaggtgtcagtcatgctcacagtctctgctgctgcagccaagaacctgaatggcgtgatg
gtggcagtggcggagctgctgagcatgaagatccccaactcctatgaggtgctgttccca
gagagccccgcccgggcaggcactgagccaaagaagggggaagctgagggtcctggtggg
aaggaaaagggtctggaaggcaagagcccagacactggccctgattggctgaagcagttt
gatgcagtgttgcctggctataccctgaagagccaactagacatcttgagcctcctgaaa
caggagagccccgccccagagccacccactcagcacagctatacctacaatgtctccaat
ctggatgtgcgacagctctcggccccacctcctgaagaaccctccccgcccccttccccc
ttggcaccttctcctgccagtccccctactgagcccttggttgaacttcccaccgaaccc
ttggctgagccacccgtcccctcacctctgccactggcctcatcccctgaatcagcccga
cccaagccccgtgcccggccccctgaagaaggtgaagattcccgtcctcctcgcctcaag
aaatggaaaggagtgcgctggaagcggcttcggctgctgctgaccatccagaagggcagt
gggcggcaggaggatgagcgggaagtggcagagtttatggagcagcttggcacagccttg
cgacctgacaaggtaccgcgagacatgcgtcgctgctgtttctgtcatgaggagggtgac
ggggccactgatgggcctgcccgtctgctgaacctggacctggacctgtgggtgcacctc
aactgtgccctttggtccacggaggtgtatgagacccagggcggggcactgatgaatgtg
gaggttgccctgcaccgaggactgctaaccaagtgctccctgtgccagcgaactggtgcc
accagcagctgcaatcgcatgcgttgccccaatgtctaccattttgcttgtgccatccgt
gccaagtgcatgttcttcaaggacaagaccatgctgtgtccaatgcataagatcaagggg
ccctgtgagcaagagctgagctcttttgctgtcttccggcgggtctacattgagcgggac
gaggtgaagcaaatcgctagcatcattcagcggggagaacggctgcacatgttccgtgtg
gggggccttgtgttccacgccatcggacagctgctgcctcaccagatggctgactttcat
agtgccactgccctctatcccgtgggctacgaggccacgcgcatctattggagcctccgc
accaacaatcgtcgctgctgctatcgctgttctattggtgagaacaacgggcggccggag
tttgtaatcaaagtcatcgagcagggcctggaggacctggtcttcactgacgcctctccc
caggccgtgtggaatcgcatcattgagcctgtggctgccatgagaaaagaggctgacatg
ctgcgactcttccctgagtatctgaagggcgaggagctctttgggctgacggtgcatgcc
gtgcttcgcatagctgaatcactgcccggggtggagagctgtcaaaactatttattccgc
tatgggcgccacccccttatggagctgccactcatgatcaaccccactggctgtgcccga
tcagagcctaaaatcctcacacactacaaacggccccataccctgaacagcaccagcatg
tctaaggcatatcagagcaccttcacaggcgagaccaacaccccctacagcaagcagttt
gtgcactccaagtcatctcagtaccggcggctgcgcaccgaatggaagaacaacgtgtac
ctggctcgctcccgtatccagggcctggggctctatgcagccaaggacctagaaaagcac
acaatggttatcgagtacattggcaccatcattcggaacgaggtggccaaccggcgggag
aaaatctacgaagagcagaatcgaggcatctacatgttccgaataaacaatgaacatgtg
attgatgctacgttgaccggcggccctgccaggtacattaaccattcctgtgcccctaac
tgtgtggccgaagtcgtgacatttgacaaagaggacaaaatcatcatcatctccagccgg
cgaatccccaaaggagaggagctaacctatgactatcagtttgattttgaggacgatcag
cacaagatcccctgccactgtggagcctggaattgtcggaaatggatgaactaa |
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