KEGG   Homo sapiens (human): 9820
Entry
9820              CDS       T01001                                 
Symbol
CUL7, 3M1, CUL-7, KIAA0076, dJ20C7.5
Name
(RefSeq) cullin 7
  KO
K10613  cullin 7
Organism
hsa  Homo sapiens (human)
Pathway
hsa04120  Ubiquitin mediated proteolysis
Disease
H00509  3M syndrome
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04120 Ubiquitin mediated proteolysis
    9820 (CUL7)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04121 Ubiquitin system [BR:hsa04121]
    9820 (CUL7)
   03036 Chromosome and associated proteins [BR:hsa03036]
    9820 (CUL7)
Ubiquitin system [BR:hsa04121]
 Ubiquitin ligases (E3)
  Multi subunit Ring-finger type E3
   Cul7 complex
    Cullin
     9820 (CUL7)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Centrosome formation proteins
   3M complex
    9820 (CUL7)
SSDB
Motif
Pfam: Cul7 Cullin ANAPC10 HEAT_2 Cullin_Nedd8 F5_F8_type_C
Other DBs
NCBI-GeneID: 9820
NCBI-ProteinID: NP_055595
OMIM: 609577
HGNC: 21024
Ensembl: ENSG00000044090
Pharos: Q14999(Tbio)
UniProt: Q14999
Structure
LinkDB
Position
6:complement(43037617..43053851)
AA seq 1698 aa
MVGELRYREFRVPLGPGLHAYPDELIRQRVGHDGHPEYQIRWLILRRGDEGDGGSGQVDC
KAEHILLWMSKDEIYANCHKMLGEDGQVIGPSQESAGEVGALDKSVLEEMETDVKSLIQR
ALRQLEECVGTIPPAPLLHTVHVLSAYASIEPLTGVFKDPRVLDLLMHMLSSPDYQIRWS
AGRMIQALSSHDAGTRTQILLSLSQQEAIEKHLDFDSRCALLALFAQATLSEHPMSFEGI
QLPQVPGRVLFSLVKRYLHVTSLLDQLNDSAAEPGAQNTSAPEELSGERGQLELEFSMAM
GTLISELVQAMRWDQASDRPRSSARSPGSIFQPQLADVSPGLPAAQAQPSFRRSRRFRPR
SEFASGNTYALYVRDTLQPGMRVRMLDDYEEISAGDEGEFRQSNNGVPPVQVFWESTGRT
YWVHWHMLEILGFEEDIEDMVEADEYQGAVASRVLGRALPAWRWRPMTELYAVPYVLPED
EDTEECEHLTLAEWWELLFFIKKLDGPDHQEVLQILQENLDGEILDDEILAELAVPIELA
QDLLLTLPQRLNDSALRDLINCHVYKKYGPEALAGNQAYPSLLEAQEDVLLLDAQAQAKD
SEDAAKVEAKEPPSQSPNTPLQRLVEGYGPAGKILLDLEQALSSEGTQENKVKPLLLQLQ
RQPQPFLALMQSLDTPETNRTLHLTVLRILKQLVDFPEALLLPWHEAVDACMACLRSPNT
DREVLQELIFFLHRLTSVSRDYAVVLNQLGARDAISKALEKHLGKLELAQELRDMVFKCE
KHAHLYRKLITNILGGCIQMVLGQIEDHRRTHQPINIPFFDVFLRYLCQGSSVEVKEDKC
WEKVEVSSNPHRASKLTDHNPKTYWESNGSAGSHYITLHMRRGILIRQLTLLVASEDSSY
MPARVVVCGGDSTSSLHTELNSVNVMPSASRVILLENLTRFWPIIQIRIKRCQQGGIDTR
IRGLEILGPKPTFWPVFREQLCRHTRLFYMVRAQAWSQDMAEDRRSLLHLSSRLNGALRQ
EQNFADRFLPDDEAAQALGKTCWEALVSPVVQNITSPDEDGISPLGWLLDQYLECQEAVF
NPQSRGPAFFSRVRRLTHLLVHVEPCEAPPPVVATPRPKGRNRSHDWSSLATRGLPSSIM
RNLTRCWRAVVEKQVNNFLTSSWRDDDFVPRYCEHFNILQNSSSELFGPRAAFLLALQNG
CAGALLKLPFLKAAHVSEQFARHIDQQIQGSRIGGAQEMERLAQLQQCLQAVLIFSGLEI
ATTFEHYYQHYMADRLLGVVSSWLEGAVLEQIGPCFPNRLPQQMLQSLSTSKELQRQFHV
YQLQQLDQELLKLEDTEKKIQVGLGASGKEHKSEKEEEAGAAAVVDVAEGEEEEEENEDL
YYEGAMPEVSVLVLSRHSWPVASICHTLNPRTCLPSYLRGTLNRYSNFYNKSQSHPALER
GSQRRLQWTWLGWAELQFGNQTLHVSTVQMWLLLYLNDLKAVSVESLLAFSGLSADMLNQ
AIGPLTSSRGPLDLHEQKDIPGGVLKIRDGSKEPRSRWDIVRLIPPQTYLQAEGEDGQNL
EKRRNLLNCLIVRILKAHGDEGLHIDQLVCLVLEAWQKGPCPPRGLVSSLGKGSACSSTD
VLSCILHLLGKGTLRRHDDRPQVLSYAVPVTVMEPHTESLNPGSSGPNPPLTFHTLQIRS
RGVPYASCTATQSFSTFR
NT seq 5097 nt   +upstreamnt  +downstreamnt
atggtgggagaactccgctacagggaattcagggtgcccctggggcccggcttacatgcc
tatcctgatgagctgatccgccagcgcgtgggccatgatgggcatcctgagtaccagatc
cgttggctcatcctgcggcgtggcgatgagggggacgggggctctggccaagtggactgc
aaggctgagcacatcctgctgtggatgtccaaggatgagatctatgccaactgccacaag
atgctgggcgaggatggccaggtcatcgggccctcccaggagtctgcaggggaggttggg
gccctggacaaatctgtgctggaggagatggaaaccgacgtgaagtccctcattcagaga
gcccttcggcagctggaggagtgtgtgggcactatccctcctgctcctctacttcacact
gtccacgtgctcagcgcctatgccagcattgagcccctcactggagtattcaaggaccca
agggtcctggacttgctcatgcacatgttgagtagtcctgattatcagattcgctggagt
gcaggccggatgatacaagccctgtcctcccatgacgctgggacccggactcagatcctt
ctgtcactgagccaacaagaagccattgagaaacacctggattttgacagccgctgtgct
ctgctagcactgtttgcacaggccacgctctctgaacaccccatgtctttcgagggcatt
cagctaccacaggtcccaggaagggtgctcttctccctggtgaagcggtatttgcatgtc
acctcgctcctggatcagctgaacgacagtgctgcggagccaggagcccagaacacctct
gctcctgaggagttgagtggggagaggggtcaactggagctggagttcagtatggccatg
ggcaccctgatctcggagctggtgcaagccatgcgctgggaccaggcctcagacagacca
aggagctcagcacggtcccccggttccatcttccagcctcagctggcagatgtgagccca
gggctccccgctgcccaggctcagccctccttcaggaggtcaagacgttttcgccctcgt
tctgagttcgcaagtggcaatacctatgctttgtatgtgcgggacacactgcagccgggg
atgcgagtgcggatgctggatgattatgaggagatcagtgccggggatgagggcgagttt
cggcagagcaacaacggtgtgcctcctgtgcaggtattttgggagtcaacaggccgcacc
tattgggtgcactggcacatgctggagatcttgggctttgaggaagacattgaggacatg
gttgaggctgatgagtaccaaggggcagtggccagtagagtcctgggtagagccctgcct
gcctggcgctggaggcccatgacagaactctatgctgtgccttatgtgctgcctgaggat
gaggacactgaggagtgtgaacacctgaccctggctgagtggtgggaactcctcttcttc
atcaagaagctggatggacctgaccatcaggaggttctccagatcctccaggagaaccta
gatggggagattctggatgatgagatcctagctgaactggccgtgcccatagaattggcc
caggacttgctgctgactctgccacagcgactcaatgacagtgccctcagggacctgatc
aactgccatgtctacaagaagtatgggcctgaagccctagcagggaaccaagcctaccca
tcccttctagaagcccaagaagatgtcctcctgctagacgcgcaggcccaggctaaggac
tcagaagatgcagccaaagtggaagcaaaagaacccccatctcagagtcccaacactccc
ctgcagcgtctggtggagggttatggtccagctgggaaaatcctcctggatctagagcaa
gccctcagctcagaggggacccaggagaacaaggtcaagccactcctgctgcagctgcag
cggcagccgcagcccttcctggcactgatgcagagcctggacactccggagactaacagg
accctgcacctgactgtgctgagaatcctgaagcagctggtggacttccccgaggcactg
ctgctcccctggcacgaggccgtggatgcctgcatggcctgcctgcggtccccaaacact
gatcgagaggtgctccaggaactgattttcttcctgcaccgcctgacctcagtgagcagg
gactatgccgtggtgctgaatcagctgggagcaagagacgctatctccaaggccctggaa
aagcacctgggaaagctggagctggctcaggagctgcgggacatggtgttcaagtgtgag
aagcatgcccacctctaccgcaaactcatcaccaacatcctgggaggctgcatccagatg
gtgctgggccagatcgaagaccacagacgaacccaccaacccatcaacatccctttcttt
gatgtgttcctcagatacctgtgccagggctccagtgtggaagtgaaggaggacaagtgc
tgggagaaggtggaggtgtcctccaacccgcaccgggccagcaagctgacggaccacaac
cccaagacctattgggagtccaacggcagcgccggctcccactacatcaccctgcacatg
cgccggggcatcctcatcaggcaactgactctgcttgtggctagtgaggactcgagttac
atgccggcccgagtggtggtgtgcgggggtgatagcactagctctcttcacacggaactc
aactcggtgaatgtgatgccctctgccagccgggtgatcctcctggagaacctgacccgc
ttctggcccatcatccagatccgcataaagcgctgccagcagggtggcattgatacgcgc
attcgggggttagagatcctaggccccaagcccacgttctggccagtgttccgggagcag
ctctgtcgtcacacacgcctcttctacatggttcgggcacaggcctggagccaggacatg
gcagaggaccgcaggagcctcctgcacctgagttctagactcaacggtgctctgcgccag
gagcagaattttgctgaccgcttcctccctgatgacgaggctgcccaagctctgggcaag
acctgctgggaggccctggtcagccccgtggtgcagaacatcacctcccctgatgaggat
ggcattagccccctgggttggctgctggaccagtacctggagtgtcaggaagctgtcttc
aacccccagagccgcggcccagctttcttctcgcgggtgcgccgtctcactcacctgctg
gtgcatgtcgagccctgtgaggcaccccctcctgtggtggccactcctcggcccaaaggc
agaaacagaagccacgactggagctccttggctacccggggccttccaagcagcatcatg
agaaacctgacgcgctgttggcgggccgtggtggagaagcaggtgaacaattttctgacc
tcatcctggcgggatgatgactttgtgccacgctactgtgagcactttaatattctgcag
aactcaagctctgaactgtttgggcctcgggcagccttcttgctggcgctgcaaaatggc
tgtgcgggagccttgctgaagctcccttttctcaaagctgcccacgtgagtgagcagttc
gcccggcacattgaccagcagatccagggcagccggatcggtggagcccaggaaatggag
aggctggcacagctgcagcaatgcctgcaagctgtcctgattttctccggcttggagata
gccaccacttttgagcattattaccagcactacatggcggaccgtctcctgggcgtggtc
tcgagctggctggagggggccgtgctggagcagatcggtccctgcttccccaaccgcctc
ccccagcagatgttgcagagcctgagcacctctaaggagctgcagcgccagttccacgtc
taccagctccagcagctggatcaggaactcctgaagctggaggatacagagaagaaaata
caggtgggccttggggccagtggcaaggagcacaagagcgagaaggaagaggaagctggg
gcagcagcagtggtggatgtggcggagggagaggaggaagaggaggagaatgaggacctc
tactatgaaggggcaatgccagaagtgtctgtgcttgtcctgtcccgacactcctggcct
gttgcctcaatctgccacacactgaaccccagaacctgcctgccctcctacctgaggggc
actttgaacagatactccaacttctacaacaagagtcagagccaccctgcccttgagcga
ggctcacagaggcgactgcagtggacgtggctgggctgggctgagctgcagtttgggaac
cagaccctgcatgtgtccaccgtgcagatgtggctactgctgtatctcaacgacctgaag
gcggtctctgtggagagtctgctggcgttctcagggctctccgcagacatgctcaatcag
gcgattgggcccctcacctcttcaagaggccccctggaccttcacgagcaaaaggatata
ccaggaggggtcctcaagattcgagatggcagcaaggaacccaggtcgagatgggacatt
gtgcggctcatcccacctcagacgtacctgcaagctgagggtgaagacggccagaacttg
gagaagagacggaatcttctgaactgcctcatcgtccgaatcctcaaggcccatggagat
gaggggctgcacattgaccagcttgtctgtctggtgctggaggcttggcagaagggcccg
tgtcctcccaggggtttggtcagcagccttggtaaggggtctgcatgcagcagcactgac
gtcctctcctgcatcctacacctcctgggcaagggcacgctgagacgccatgacgaccgg
ccccaggtgctgtcctatgcagtccctgtgactgtcatggagcctcacactgagtccctg
aacccaggctcctcaggccccaacccacccctcaccttccataccctacagattcgctcc
cggggtgtgccctatgcctcctgcactgccacccagagcttctctaccttccggtag

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