Homo sapiens (human): 487
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Entry
487 CDS
T01001
Symbol
ATP2A1, ATP2A, SERCA1
Name
(RefSeq) ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1
KO
K05853
P-type Ca2+ transporter type 2A [EC:
7.2.2.10
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa04020
Calcium signaling pathway
hsa04022
cGMP-PKG signaling pathway
hsa04024
cAMP signaling pathway
hsa04148
Efferocytosis
hsa04260
Cardiac muscle contraction
hsa04261
Adrenergic signaling in cardiomyocytes
hsa04380
Osteoclast differentiation
hsa04919
Thyroid hormone signaling pathway
hsa04972
Pancreatic secretion
hsa05010
Alzheimer disease
hsa05017
Spinocerebellar ataxia
hsa05022
Pathways of neurodegeneration - multiple diseases
hsa05410
Hypertrophic cardiomyopathy
hsa05412
Arrhythmogenic right ventricular cardiomyopathy
hsa05414
Dilated cardiomyopathy
hsa05415
Diabetic cardiomyopathy
Network
nt06528
Calcium signaling
Element
N01645
Cytosolic Ca2+ removal, SERCA
N01646
Regulation of SERCA
Disease
H01129
Brody myopathy
Drug target
Mipsagargin:
D10715
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09130 Environmental Information Processing
09132 Signal transduction
04020 Calcium signaling pathway
487 (ATP2A1)
04024 cAMP signaling pathway
487 (ATP2A1)
04022 cGMP-PKG signaling pathway
487 (ATP2A1)
09140 Cellular Processes
09141 Transport and catabolism
04148 Efferocytosis
487 (ATP2A1)
09150 Organismal Systems
09152 Endocrine system
04919 Thyroid hormone signaling pathway
487 (ATP2A1)
09153 Circulatory system
04260 Cardiac muscle contraction
487 (ATP2A1)
04261 Adrenergic signaling in cardiomyocytes
487 (ATP2A1)
09154 Digestive system
04972 Pancreatic secretion
487 (ATP2A1)
09158 Development and regeneration
04380 Osteoclast differentiation
487 (ATP2A1)
09160 Human Diseases
09164 Neurodegenerative disease
05010 Alzheimer disease
487 (ATP2A1)
05017 Spinocerebellar ataxia
487 (ATP2A1)
05022 Pathways of neurodegeneration - multiple diseases
487 (ATP2A1)
09166 Cardiovascular disease
05410 Hypertrophic cardiomyopathy
487 (ATP2A1)
05412 Arrhythmogenic right ventricular cardiomyopathy
487 (ATP2A1)
05414 Dilated cardiomyopathy
487 (ATP2A1)
05415 Diabetic cardiomyopathy
487 (ATP2A1)
Enzymes [BR:
hsa01000
]
7. Translocases
7.2 Catalysing the translocation of inorganic cations
7.2.2 Linked to the hydrolysis of a nucleoside triphosphate
7.2.2.10 P-type Ca2+ transporter
487 (ATP2A1)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
E1-E2_ATPase
Cation_ATPase_C
Cation_ATPase
Cation_ATPase_N
Hydrolase
Hydrolase_3
HAD
Motif
Other DBs
NCBI-GeneID:
487
NCBI-ProteinID:
NP_775293
OMIM:
108730
HGNC:
811
Ensembl:
ENSG00000196296
UniProt:
O14983
Q7Z675
LinkDB
All DBs
Position
16:28878488..28904466
Genome browser
AA seq
1001 aa
AA seq
DB search
MEAAHAKTTEECLAYFGVSETTGLTPDQVKRNLEKYGLNELPAEEGKTLWELVIEQFEDL
LVRILLLAACISFVLAWFEEGEETITAFVEPFVILLILIANAIVGVWQERNAENAIEALK
EYEPEMGKVYRADRKSVQRIKARDIVPGDIVEVAVGDKVPADIRILAIKSTTLRVDQSIL
TGESVSVIKHTEPVPDPRAVNQDKKNMLFSGTNIAAGKALGIVATTGVGTEIGKIRDQMA
ATEQDKTPLQQKLDEFGEQLSKVISLICVAVWLINIGHFNDPVHGGSWFRGAIYYFKIAV
ALAVAAIPEGLPAVITTCLALGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQ
MSVCKMFIIDKVDGDICLLNEFSITGSTYAPEGEVLKNDKPVRPGQYDGLVELATICALC
NDSSLDFNEAKGVYEKVGEATETALTTLVEKMNVFNTDVRSLSKVERANACNSVIRQLMK
KEFTLEFSRDRKSMSVYCSPAKSSRAAVGNKMFVKGAPEGVIDRCNYVRVGTTRVPLTGP
VKEKIMAVIKEWGTGRDTLRCLALATRDTPPKREEMVLDDSARFLEYETDLTFVGVVGML
DPPRKEVTGSIQLCRDAGIRVIMITGDNKGTAIAICRRIGIFGENEEVADRAYTGREFDD
LPLAEQREACRRACCFARVEPSHKSKIVEYLQSYDEITAMTGDGVNDAPALKKAEIGIAM
GSGTAVAKTASEMVLADDNFSTIVAAVEEGRAIYNNMKQFIRYLISSNVGEVVCIFLTAA
LGLPEALIPVQLLWVNLVTDGLPATALGFNPPDLDIMDRPPRSPKEPLISGWLFFRYMAI
GGYVGAATVGAAAWWFLYAEDGPHVNYSQLTHFMQCTEDNTHFEGIDCEVFEAPEPMTMA
LSVLVTIEMCNALNSLSENQSLLRMPPWVNIWLLGSICLSMSLHFLILYVDPLPMIFKLR
ALDLTQWLMVLKISLPVIGLDEILKFVARNYLEDPEDERRK
NT seq
3006 nt
NT seq
+upstream
nt +downstream
nt
atggaggccgctcatgctaaaaccacggaggaatgtttggcctattttggggtgagtgag
accacgggcctcaccccggaccaagttaagcggaatctggagaaatacggcctcaatgag
ctccctgctgaggaagggaagaccctgtgggagctggtgatagagcagtttgaagacctc
ctggtgcggattctcctcctggccgcatgcatttccttcgtgctggcctggtttgaggaa
ggtgaagagaccatcactgcctttgttgaaccctttgtcatcctcttgatcctcattgcc
aatgccatcgtgggggtttggcaggagcggaacgcagagaacgccatcgaggccctgaag
gagtatgagccagagatggggaaggtctaccgggctgaccgcaagtcagtgcaaaggatc
aaggctcgggacatcgtccctggggacatcgtggaggtggctgtgggggacaaagtccct
gcagacatccgaatcctcgccatcaaatccaccacgctgcgggttgaccagtccatcctg
acaggcgagtctgtatctgtcatcaaacacacggagcccgttcctgacccccgagctgtc
aaccaggacaagaagaacatgcttttctcgggcaccaacattgcagccggcaaggccttg
ggcatcgtggccaccactggtgtgggcaccgagattgggaagatccgagaccaaatggct
gccacagaacaggacaagacccccttgcagcagaagctggatgagtttggggagcagctc
tccaaggtcatctccctcatctgtgtggctgtctggcttatcaacattggccacttcaac
gaccccgtccatgggggctcctggttccgcggggccatctactactttaagattgccgtg
gccttggctgtggctgccatccccgaaggtcttcctgcagtcatcaccacctgcctggcc
ctgggtacccgtcggatggcaaagaagaatgccattgtaagaagcttgccctccgtagag
accctgggctgcacctctgtcatctgttccgacaagacaggcaccctcaccaccaaccag
atgtctgtctgcaagatgtttatcattgacaaggtggatggggacatctgcctcctgaat
gagttctccatcaccggctccacttacgctccagagggagaggtcttgaagaatgataag
ccagtccggccagggcagtatgacgggctggtggagctggccaccatctgtgccctctgc
aatgactcctccttggacttcaacgaggccaaaggtgtctatgagaaggtcggcgaggcc
accgagacagcactcaccaccctggtggagaagatgaatgtgttcaacacggatgtgaga
agcctctcgaaggtggagagagccaacgcctgcaactcggtgatccgccagctaatgaag
aaggaattcaccctggagttctcccgagacagaaagtccatgtctgtctattgctcccca
gccaaatcttcccgggctgctgtgggcaacaagatgtttgtcaagggtgcccctgagggc
gtcatcgaccgctgtaactatgtgcgagttggcaccacccgggtgccactgacggggccg
gtgaaggaaaagatcatggcggtgatcaaggagtggggcactggccgggacaccctgcgc
tgcttggccctggccacccgggacacccccccgaagcgagaggaaatggtcctggatgac
tctgccaggttcctggagtatgagacggacctgacattcgtgggtgtagtgggcatgctg
gaccctccgcgcaaggaggtcacgggctccatccagctgtgccgtgacgccgggatccgg
gtgatcatgatcactggggacaacaagggcacagccattgccatctgccggcgaattggc
atctttggggagaacgaggaggtggccgatcgcgcctacacgggccgagagttcgacgac
ctgcccctggctgaacagcgggaagcctgccgacgtgcctgctgcttcgcccgtgtggag
ccctcgcacaagtccaagattgtggagtacctgcagtcctacgatgagatcacagccatg
acaggtgatggcgtcaatgacgcccctgccctgaagaaggctgagattggcattgccatg
ggatctggcactgccgtggccaagactgcctctgagatggtgctggctgacgacaacttc
tccaccatcgtagctgctgtggaggagggccgcgccatctacaacaacatgaagcagttc
atccgctacctcatttcctccaacgtgggcgaggtggtctgtatcttcctgaccgctgcc
ctggggctgcctgaggccctgatcccggtgcagctgctatgggtgaacttggtgaccgac
gggctcccagccacagccctgggcttcaacccaccagacctggacatcatggaccgcccc
ccccggagccccaaggagcccctcatcagtggctggctcttcttccgctacatggcaatc
gggggctatgtgggtgcagccaccgtgggagcagctgcctggtggttcctgtacgctgag
gatgggcctcatgtcaactacagccagctgactcacttcatgcagtgcaccgaggacaac
acccactttgagggcatagactgtgaggtcttcgaggcccccgagcccatgaccatggcc
ctgtccgtgctggtgaccatcgagatgtgcaatgcactgaacagcctgtccgagaaccag
tccctgctgcggatgccaccctgggtgaacatctggctgctgggctccatctgcctctcc
atgtccctgcacttcctcatcctctatgttgaccccctgccgatgatcttcaagctccgg
gccctggacctcacccagtggctcatggtcctcaagatctcactgccagtcattgggctc
gacgaaatcctcaagttcgttgctcggaactacctagaggatccagaagatgaaagaagg
aagtga
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