Homo sapiens (human): 488
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Entry
488 CDS
T01001
Symbol
ATP2A2, ATP2B, DAR, DD, RHABDO2, SERCA2
Name
(RefSeq) ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2
KO
K05853
P-type Ca2+ transporter type 2A [EC:
7.2.2.10
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa04020
Calcium signaling pathway
hsa04022
cGMP-PKG signaling pathway
hsa04024
cAMP signaling pathway
hsa04148
Efferocytosis
hsa04260
Cardiac muscle contraction
hsa04261
Adrenergic signaling in cardiomyocytes
hsa04380
Osteoclast differentiation
hsa04919
Thyroid hormone signaling pathway
hsa04972
Pancreatic secretion
hsa05010
Alzheimer disease
hsa05017
Spinocerebellar ataxia
hsa05022
Pathways of neurodegeneration - multiple diseases
hsa05410
Hypertrophic cardiomyopathy
hsa05412
Arrhythmogenic right ventricular cardiomyopathy
hsa05414
Dilated cardiomyopathy
hsa05415
Diabetic cardiomyopathy
Network
nt06322
TRH-TSH-TH signaling
nt06528
Calcium signaling
nt06535
Efferocytosis
Element
N00798
Thyroid hormone signaling pathway
N01645
Cytosolic Ca2+ removal, SERCA
N01646
Regulation of SERCA
N01775
Inactivation of CaMKII by inducing SERCA2
Disease
H00715
Darier disease
H00755
Acrokeratosis verruciformis
Drug target
Mipsagargin:
D10715
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09130 Environmental Information Processing
09132 Signal transduction
04020 Calcium signaling pathway
488 (ATP2A2)
04024 cAMP signaling pathway
488 (ATP2A2)
04022 cGMP-PKG signaling pathway
488 (ATP2A2)
09140 Cellular Processes
09141 Transport and catabolism
04148 Efferocytosis
488 (ATP2A2)
09150 Organismal Systems
09152 Endocrine system
04919 Thyroid hormone signaling pathway
488 (ATP2A2)
09153 Circulatory system
04260 Cardiac muscle contraction
488 (ATP2A2)
04261 Adrenergic signaling in cardiomyocytes
488 (ATP2A2)
09154 Digestive system
04972 Pancreatic secretion
488 (ATP2A2)
09158 Development and regeneration
04380 Osteoclast differentiation
488 (ATP2A2)
09160 Human Diseases
09164 Neurodegenerative disease
05010 Alzheimer disease
488 (ATP2A2)
05017 Spinocerebellar ataxia
488 (ATP2A2)
05022 Pathways of neurodegeneration - multiple diseases
488 (ATP2A2)
09166 Cardiovascular disease
05410 Hypertrophic cardiomyopathy
488 (ATP2A2)
05412 Arrhythmogenic right ventricular cardiomyopathy
488 (ATP2A2)
05414 Dilated cardiomyopathy
488 (ATP2A2)
05415 Diabetic cardiomyopathy
488 (ATP2A2)
Enzymes [BR:
hsa01000
]
7. Translocases
7.2 Catalysing the translocation of inorganic cations
7.2.2 Linked to the hydrolysis of a nucleoside triphosphate
7.2.2.10 P-type Ca2+ transporter
488 (ATP2A2)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
Cation_ATPase
Cation_ATPase_C
E1-E2_ATPase
Cation_ATPase_N
Hydrolase
Hydrolase_3
HAD
Motif
Other DBs
NCBI-GeneID:
488
NCBI-ProteinID:
NP_733765
OMIM:
108740
HGNC:
812
Ensembl:
ENSG00000174437
UniProt:
P16615
A0A0S2Z3L2
Structure
PDB
PDBj
LinkDB
All DBs
Position
12:110280616..110351093
Genome browser
AA seq
1042 aa
AA seq
DB search
MENAHTKTVEEVLGHFGVNESTGLSLEQVKKLKERWGSNELPAEEGKTLLELVIEQFEDL
LVRILLLAACISFVLAWFEEGEETITAFVEPFVILLILVANAIVGVWQERNAENAIEALK
EYEPEMGKVYRQDRKSVQRIKAKDIVPGDIVEIAVGDKVPADIRLTSIKSTTLRVDQSIL
TGESVSVIKHTDPVPDPRAVNQDKKNMLFSGTNIAAGKAMGVVVATGVNTEIGKIRDEMV
ATEQERTPLQQKLDEFGEQLSKVISLICIAVWIINIGHFNDPVHGGSWIRGAIYYFKIAV
ALAVAAIPEGLPAVITTCLALGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQ
MSVCRMFILDRVEGDTCSLNEFTITGSTYAPIGEVHKDDKPVNCHQYDGLVELATICALC
NDSALDYNEAKGVYEKVGEATETALTCLVEKMNVFDTELKGLSKIERANACNSVIKQLMK
KEFTLEFSRDRKSMSVYCTPNKPSRTSMSKMFVKGAPEGVIDRCTHIRVGSTKVPMTSGV
KQKIMSVIREWGSGSDTLRCLALATHDNPLRREEMHLEDSANFIKYETNLTFVGCVGMLD
PPRIEVASSVKLCRQAGIRVIMITGDNKGTAVAICRRIGIFGQDEDVTSKAFTGREFDEL
NPSAQRDACLNARCFARVEPSHKSKIVEFLQSFDEITAMTGDGVNDAPALKKAEIGIAMG
SGTAVAKTASEMVLADDNFSTIVAAVEEGRAIYNNMKQFIRYLISSNVGEVVCIFLTAAL
GFPEALIPVQLLWVNLVTDGLPATALGFNPPDLDIMNKPPRNPKEPLISGWLFFRYLAIG
CYVGAATVGAAAWWFIAADGGPRVSFYQLSHFLQCKEDNPDFEGVDCAIFESPYPMTMAL
SVLVTIEMCNALNSLSENQSLLRMPPWENIWLVGSICLSMSLHFLILYVEPLPLIFQITP
LNVTQWLMVLKISLPVILMDETLKFVARNYLEPGKECVQPATKSCSFSACTDGISWPFVL
LIMPLVIWVYSTDTNFSDMFWS
NT seq
3129 nt
NT seq
+upstream
nt +downstream
nt
atggagaacgcgcacaccaagacggtggaggaggtgctgggccacttcggcgtcaacgag
agtacggggctgagcctggaacaggtcaagaagcttaaggagagatggggctccaacgag
ttaccggctgaagaaggaaaaaccttgctggaacttgtgattgagcagtttgaagacttg
ctagttaggattttattactggcagcatgtatatcttttgttttggcttggtttgaagaa
ggtgaagaaacaattacagcctttgtagaaccttttgtaattttactcatattagtagcc
aatgcaattgtgggtgtatggcaggaaagaaatgctgaaaatgccatcgaagcccttaag
gaatatgagcctgaaatgggcaaagtgtatcgacaggacagaaagagtgtgcagcggatt
aaagctaaagacatagttcctggtgatattgtagaaattgctgttggtgacaaagttcct
gctgatataaggttaacttccatcaaatctaccacactaagagttgaccagtcaattctc
acaggtgaatctgtctctgtcatcaagcacactgatcccgtccctgacccacgagctgtc
aaccaagataaaaagaacatgctgttttctggtacaaacattgctgctgggaaagctatg
ggagtggtggtagcaactggagttaacaccgaaattggcaagatccgggatgaaatggtg
gcaacagaacaggagagaacaccccttcagcaaaaactagatgaatttggggaacagctt
tccaaagtcatctcccttatttgcattgcagtctggatcataaatattgggcacttcaat
gacccggttcatggagggtcctggatcagaggtgctatttactactttaaaattgcagtg
gccctggctgtagcagccattcctgaaggtctgcctgcagtcatcaccacctgcctggct
cttggaactcgcagaatggcaaagaaaaatgccattgttcgaagcctcccgtctgtggaa
acccttggttgtacttctgttatctgctcagacaagactggtacacttacaacaaaccag
atgtcagtctgcaggatgttcattctggacagagtggaaggtgatacttgttcccttaat
gagtttaccataactggatcaacttatgcacctattggagaagtgcataaagatgataaa
ccagtgaattgtcaccagtatgatggtctggtagaattagcaacaatttgtgctctttgt
aatgactctgctttggattacaatgaggcaaagggtgtgtatgaaaaagttggagaagct
acagagactgctctcacttgcctagtagagaagatgaatgtatttgataccgaattgaag
ggtctttctaaaatagaacgtgcaaatgcctgcaactcagtcattaaacagctgatgaaa
aaggaattcactctagagttttcacgtgacagaaagtcaatgtcggtttactgtacacca
aataaaccaagcaggacatcaatgagcaagatgtttgtgaagggtgctcctgaaggtgtc
attgacaggtgcacccacattcgagttggaagtactaaggttcctatgacctctggagtc
aaacagaagatcatgtctgtcattcgagagtggggtagtggcagcgacacactgcgatgc
ctggccctggccactcatgacaacccactgagaagagaagaaatgcaccttgaggactct
gccaactttattaaatatgagaccaatctgaccttcgttggctgcgtgggcatgctggat
cctccgagaatcgaggtggcctcctccgtgaagctgtgccggcaagcaggcatccgggtc
atcatgatcactggggacaacaagggcactgctgtggccatctgtcgccgcatcggcatc
ttcgggcaggatgaggacgtgacgtcaaaagctttcacaggccgggagtttgatgaactc
aacccctccgcccagcgagacgcctgcctgaacgcccgctgttttgctcgagttgaaccc
tcccacaagtctaaaatcgtagaatttcttcagtcttttgatgagattacagctatgact
ggcgatggcgtgaacgatgctcctgctctgaagaaagccgagattggcattgctatgggc
tctggcactgcggtggctaaaaccgcctctgagatggtcctggcggatgacaacttctcc
accattgtggctgccgttgaggaggggcgggcaatctacaacaacatgaaacagttcatc
cgctacctcatctcgtccaacgtcggggaagttgtctgtattttcctgacagcagccctt
ggatttcccgaggctttgattcctgttcagctgctctgggtcaatctggtgacagatggc
ctgcctgccactgcactggggttcaaccctcctgatctggacatcatgaataaacctccc
cggaacccaaaggaaccattgatcagcgggtggctctttttccgttacttggctattggc
tgttacgtcggcgctgctaccgtgggtgctgctgcatggtggttcattgctgctgacggt
ggtccaagagtgtccttctaccagctgagtcatttcctacagtgtaaagaggacaacccg
gactttgaaggcgtggattgtgcaatctttgaatccccatacccgatgacaatggcgctc
tctgttctagtaactatagaaatgtgtaacgccctcaacagcttgtccgaaaaccagtcc
ttgctgaggatgcccccctgggagaacatctggctcgtgggctccatctgcctgtccatg
tcactccacttcctgatcctctatgtcgaacccttgccactcatcttccagatcacaccg
ctgaacgtgacccagtggctgatggtgctgaaaatctccttgcccgtgattctcatggat
gagacgctcaagtttgtggcccgcaactacctggaacctggtaaagagtgtgtgcagcct
gccaccaaatcctgctcgttctcggcatgcaccgatgggatttcctggccgtttgtgctg
ctcataatgcccctggtgatctgggtctatagcacagacactaactttagcgatatgttc
tggtcttga
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integrated database retrieval system
