Homo sapiens (human): 8139 Help Entry 8139              CDS       T01001                                  Symbol GAN, GAN1, GIG, KLHL16 Name (RefSeq) gigaxonin isoform 1   KO K10453   kelch-like protein 16 (gigaxonin) Organism hsa  Homo sapiens (human) Network nt06541  Cytoskeleton in neurons   Element N01855   Neurofilament regulation, ubiqutination by Gigaxonin Disease H01259   Giant axonal neuropathy Brite KEGG Orthology (KO) [BR:hsa00001]  09180 Brite Hierarchies   09182 Protein families: genetic information processing    04121 Ubiquitin system [BR:hsa04121]     8139 (GAN) Ubiquitin system [BR:hsa04121]  Ubiquitin ligases (E3)   Multi subunit type E3    Cul3 complex     Adoptor and target recognizing subunit (BTB)      8139 (GAN) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  Kelch_1 BACK Kelch_KLHDC2_KLHL20_DRC7 Beta-prop_Calicin BTB Kelch_FKB95 Beta-prop_ATRN-LZTR1 Beta-prop_FBX42 Kelch_2 NANM DUF6242_C BTB_KLHL33 BTB_3 Motif Other DBs NCBI-GeneID:  8139 NCBI-ProteinID:  NP_071324 OMIM:  605379 HGNC:  4137 Ensembl:  ENSP00000497351.1 UniProt:  Q9H2C0 A0A0S2Z4W2 B3KTC3 Structure PDBPDBj LinkDB All DBs Position 16:81314962..81390809 Genome browser AA seq 597 aa AA seqDB search MAEGSAVSDPQHAARLLRALSSFREESRFCDAHLVLDGEEIPVQKNILAAASPYIRTKLN YNPPKDDGSTYKIELEGISVMVMREILDYIFSGQIRLNEDTIQDVVQAADLLLLTDLKTL CCEFLEGCIAAENCIGIRDFALHYCLHHVHYLATEYLETHFRDVSSTEEFLELSPQKLKE VISLEKLNVGNERYVFEAVIRWIAHDTEIRKVHMKDVMSALWVSGLDSSYLREQMLNEPL VREIVKECSNIPLSQPQQGEAMLANFKPRGYSECIVTVGGEERVSRKPTAAMRCMCPLYD PNRQLWIELAPLSMPRINHGVLSAEGFLFVFGGQDENKQTLSSGEKYDPDANTWTALPPM NEARHNFGIVEIDGMLYILGGEDGEKELISMECYDIYSKTWTKQPDLTMVRKIGCYAAMK KKIYAMGGGSYGKLFESVECYDPRTQQWTAICPLKERRFGAVACGVAMELYVFGGVRSRE DAQGSEMVTCKSEFYHDEFKRWIYLNDQNLCIPASSSFVYGAVPIGASIYVIGDLDTGTN YDYVREFKRSTGTWHHTKPLLPSDLRRTGCAALRIANCKLFRLQLQQGLFRIRVHSP NT seq 1794 nt NT seq  +upstreamnt  +downstreamnt atggctgagggcagtgccgtgtctgaccctcagcacgccgcgcgtctgctgcgagcgctc agctctttccgcgaggagtctcgcttctgcgacgcgcacctggtcctcgacggggaggag atcccggtgcagaagaacatcctggcggcggccagcccgtacatcaggacaaagttaaac tataatcctccaaaagatgatggatcaacttataagattgaacttgaagggatatcggta atggttatgagagagatcctggattacatcttcagtgggcagatcaggctaaatgaagat acaatccaagatgttgttcaggcagctgacctgctgctactgacggaccttaaaaccctg tgctgtgagtttttggaaggctgcattgctgctgagaactgtattggtatccgtgacttt gcactacattactgcctccatcacgttcattaccttgccacagaatacctggagactcat ttccgagacgtcagcagcacggaagaattcttagagctgagtcctcaaaagcttaaagaa gtgatttctcttgagaagttaaacgttggcaatgaaagatatgtctttgaagcagtaatt cgatggatagcacatgatacagaaataagaaaggtccacatgaaggatgttatgtcagct ctgtgggtttcagggttggactccagttatttacgggaacagatgctgaatgaaccatta gtacgagaaattgtcaaagagtgtagcaatataccgctcagccagccgcagcaaggggag gcgatgctggccaacttcaaaccccggggctactctgagtgcatcgtgactgttggtgga gaagagagagtttcacggaaacccacagcagcgatgcgatgcatgtgccctctctatgac cctaacaggcagctttggatcgaactggcccctttaagcatgccgagaattaaccatgga gttctctcagcagaaggatttttgtttgtattcgggggccaagatgaaaataagcagact cttagctcaggagaaaagtatgatccagatgcaaatacatggacagcattgccacctatg aacgaggcaagacataacttcggaattgtggagatagatgggatgctgtacattttggga ggagaggatggtgaaaaggagctgatttccatggagtgttacgatatttattctaaaacc tggacaaagcaacctgatttgaccatggtcagaaagatcggctgctatgcagctatgaaa aagaaaatctacgccatgggtggaggctcctacggaaagctttttgagtctgtagagtgt tatgatcccaggacccagcagtggactgccatatgtccactaaaagagaggaggtttgga gcggtggcctgtggagttgctatggagctgtatgtgtttgggggagtccgaagtcgtgag gacgcccagggtagcgagatggtaacttgcaagtccgagttctaccatgatgagtttaaa aggtggatctatcttaacgaccagaatttatgcatccccgccagttcctcttttgtttat ggagctgtacctataggagccagtatttatgttattggagatcttgatacaggtaccaat tacgactacgtgcgtgagtttaaaagaagcacaggaacctggcaccacactaaaccactc cttccatccgaccttcgccgtacaggatgtgcagccttacgcattgcgaattgcaagctt ttccgcctgcagcttcagcaaggcttattccgtattcgtgttcattccccttga

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