KEGG   MODULE: hsa_M00882
Entry
hsa_M00882        Pathway   Module                                 
Name
Lipoic acid biosynthesis, eukaryotes, octanoyl-ACP => dihydrolipoyl-H
Definition
K23735 K03644
Diagram
hsa_M00882  Lipoic acid biosynthesis, eukaryotes, octanoyl-ACP => dihydrolipoyl-H
hsa_M00882

Class
Pathway modules; Metabolism of cofactors and vitamins; Cofactor and vitamin metabolism
Pathway
hsa00785  Lipoic acid metabolism
hsa01240  Biosynthesis of cofactors
hsa01100  Metabolic pathways
Organism
Homo sapiens (human) [GN:hsa]
Gene
11019  LIAS; lipoic acid synthetase [KO:K03644]
387787  LIPT2; lipoyl(octanoyl) transferase 2 [KO:K23735]
Reaction
Compound
C05752  Octanoyl-[acp]
C22159  [Glycine cleavage system H]-N6-octanoyl-L-lysine
C02972  [Glycine cleavage system H]-N6-[(R)-dihydrolipoyl]-L-lysine
Reference
  Authors
Cronan JE
  Title
Assembly of Lipoic Acid on Its Cognate Enzymes: an Extraordinary and Essential Biosynthetic Pathway.
  Journal
Microbiol Mol Biol Rev 80:429-50 (2016)
DOI:10.1128/MMBR.00073-15
Reference
  Authors
Solmonson A, DeBerardinis RJ
  Title
Lipoic acid metabolism and mitochondrial redox regulation.
  Journal
J Biol Chem 293:7522-7530 (2018)
DOI:10.1074/jbc.TM117.000259
KO module
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