KEGG   VARIANT: 1950v1
Entry
1950v1                      Variant                                
Name
EGF overexpression
Gene
EGF  epidermal growth factor [KO:K04357]
Organism
hsa_var Human gene variants (Homo sapiens)
Variation
overexpression
Network
nt06210  ERK signaling
nt06214  PI3K signaling
nt06260  Colorectal cancer
  Element
N00276  EGF-overexpression to RAS-ERK signaling pathway
N00281  EGF-overexpression to PI3K signaling pathway
Reference
PMID:7912978
  Authors
Hayashi Y, Widjono YW, Ohta K, Hanioka K, Obayashi C, Itoh K, Imai Y, Itoh H
  Title
Expression of EGF, EGF-receptor, p53, v-erb B and ras p21 in colorectal neoplasms by immunostaining paraffin-embedded tissues.
  Journal
Pathol Int 44:124-30 (1994)
DOI:10.1111/j.1440-1827.1994.tb01696.x
Reference
  Authors
Spano JP, Fagard R, Soria JC, Rixe O, Khayat D, Milano G
  Title
Epidermal growth factor receptor signaling in colorectal cancer: preclinical data and therapeutic perspectives.
  Journal
Ann Oncol 16:189-94 (2005)
DOI:10.1093/annonc/mdi057
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