KEGG   VARIANT: 1950v1
Entry
1950v1                      Variant                                
Name
EGF overexpression
Type
Gain of function
Gene
EGF  epidermal growth factor [KO:K04357]
Organism
hsa_var Human gene variants (Homo sapiens)
Variation
overexpression
Network
nt06210  ERK signaling (cancer)
nt06214  PI3K signaling (cancer)
nt06260  Colorectal cancer
nt06526  MAPK signaling
nt06530  PI3K signaling
Disease
H00020  Colorectal cancer
Reference
PMID:7912978
  Authors
Hayashi Y, Widjono YW, Ohta K, Hanioka K, Obayashi C, Itoh K, Imai Y, Itoh H
  Title
Expression of EGF, EGF-receptor, p53, v-erb B and ras p21 in colorectal neoplasms by immunostaining paraffin-embedded tissues.
  Journal
Pathol Int 44:124-30 (1994)
DOI:10.1111/j.1440-1827.1994.tb01696.x
Reference
  Authors
Spano JP, Fagard R, Soria JC, Rixe O, Khayat D, Milano G
  Title
Epidermal growth factor receptor signaling in colorectal cancer: preclinical data and therapeutic perspectives.
  Journal
Ann Oncol 16:189-94 (2005)
DOI:10.1093/annonc/mdi057
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