KEGG ORTHOLOGY: K04357

ORTHOLOGY: K04357

Entry

K04357                      KO

Symbol

EGF

Name

epidermal growth factor

Pathway

map01521

EGFR tyrosine kinase inhibitor resistance

map04010

MAPK signaling pathway

map04012

ErbB signaling pathway

map04014

Ras signaling pathway

map04015

Rap1 signaling pathway

map04020

Calcium signaling pathway

map04066

HIF-1 signaling pathway

map04068

FoxO signaling pathway

map04072

Phospholipase D signaling pathway

map04151

PI3K-Akt signaling pathway

map04510

Focal adhesion

map04540

Gap junction

map04630

JAK-STAT signaling pathway

map04810

Regulation of actin cytoskeleton

map05160

Hepatitis C

map05165

Human papillomavirus infection

map05200

Pathways in cancer

map05207

Chemical carcinogenesis - receptor activation

map05208

Chemical carcinogenesis - reactive oxygen species

map05210

Colorectal cancer

map05212

Pancreatic cancer

map05213

Endometrial cancer

map05214

Glioma

map05215

Prostate cancer

map05218

Melanoma

map05219

Bladder cancer

map05223

Non-small cell lung cancer

map05224

Breast cancer

map05226

Gastric cancer

map05231

Choline metabolism in cancer

map05235

PD-L1 expression and PD-1 checkpoint pathway in cancer

Disease

H00020

Colorectal cancer

H01210

Hypomagnesemia

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04357  EGF; epidermal growth factor
   04012 ErbB signaling pathway
    K04357  EGF; epidermal growth factor
   04014 Ras signaling pathway
    K04357  EGF; epidermal growth factor
   04015 Rap1 signaling pathway
    K04357  EGF; epidermal growth factor
   04630 JAK-STAT signaling pathway
    K04357  EGF; epidermal growth factor
   04066 HIF-1 signaling pathway
    K04357  EGF; epidermal growth factor
   04068 FoxO signaling pathway
    K04357  EGF; epidermal growth factor
   04020 Calcium signaling pathway
    K04357  EGF; epidermal growth factor
   04072 Phospholipase D signaling pathway
    K04357  EGF; epidermal growth factor
   04151 PI3K-Akt signaling pathway
    K04357  EGF; epidermal growth factor
09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K04357  EGF; epidermal growth factor
   04540 Gap junction
    K04357  EGF; epidermal growth factor
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K04357  EGF; epidermal growth factor
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K04357  EGF; epidermal growth factor
   05207 Chemical carcinogenesis - receptor activation
    K04357  EGF; epidermal growth factor
   05208 Chemical carcinogenesis - reactive oxygen species
    K04357  EGF; epidermal growth factor
   05231 Choline metabolism in cancer
    K04357  EGF; epidermal growth factor
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    K04357  EGF; epidermal growth factor
  09162 Cancer: specific types
   05210 Colorectal cancer
    K04357  EGF; epidermal growth factor
   05212 Pancreatic cancer
    K04357  EGF; epidermal growth factor
   05226 Gastric cancer
    K04357  EGF; epidermal growth factor
   05214 Glioma
    K04357  EGF; epidermal growth factor
   05218 Melanoma
    K04357  EGF; epidermal growth factor
   05219 Bladder cancer
    K04357  EGF; epidermal growth factor
   05215 Prostate cancer
    K04357  EGF; epidermal growth factor
   05213 Endometrial cancer
    K04357  EGF; epidermal growth factor
   05224 Breast cancer
    K04357  EGF; epidermal growth factor
   05223 Non-small cell lung cancer
    K04357  EGF; epidermal growth factor
  09172 Infectious disease: viral
   05160 Hepatitis C
    K04357  EGF; epidermal growth factor
   05165 Human papillomavirus infection
    K04357  EGF; epidermal growth factor
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    K04357  EGF; epidermal growth factor
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and neuropeptides
    K04357  EGF; epidermal growth factor
Cytokines and neuropeptides [BR:ko04052]
Cytokines
  Growth factors (RTK binding)
   K04357  EGF; epidermal growth factor

Other DBs

GO:

0005155

Genes

HSA:

1950(EGF)

PTR:	461435(EGF)

PPS:	100975632(EGF)

GGO:	101153700(EGF)

PON:	100455021(EGF)

PPYG:

129035589(EGF)

NLE:	100588963(EGF)

HMH:	116479721(EGF)

SSYN:

129480246(EGF)

MCC:	698619(EGF)

MCF:	102123415(EGF)

MTHB:

126954925

MNI:	105486254(EGF)

CSAB:

103236114(EGF)

CATY:

105571434(EGF)

PANU:

101026665(EGF)

TGE:	112624610(EGF)

MLEU:

105532399(EGF)

RRO:	104682421(EGF)

RBB:	108541026(EGF)

TFN:	117085785(EGF)

PTEH:

111547933(EGF)

CANG:

105514419(EGF)

CJC:	100388651(EGF)

SBQ:	101052478(EGF)

CIMI:

108290027(EGF)

ANAN:

105706249(EGF)

CSYR:

103267942(EGF)

MMUR:

105872305(EGF)

LCAT:

123627755(EGF)

PCOQ:

105818935(EGF)

OGA:	100959686(EGF)

MMU:	13645(Egf)

MCAL:

110291005(Egf)

MPAH:

110320006(Egf)

RNO:	25313(Egf)

MCOC:

116093773(Egf)

ANU:	117707556(Egf)

MUN:	110553196(Egf)

CGE:	100763146(Egf)

MAUA:

101830366(Egf)

PROB:

127223042(Egf)

PLEU:

114682692(Egf)

MORG:

121466544(Egf)

MFOT:

126509286

AAMP:

119800992(Egf)

NGI:	103742642(Egf)

HGL:	106007527(Egf)

CPOC:

100714471(Egf)

CCAN:

109700925(Egf)

DORD:

105991200(Egf)

DSP:	122127051(Egf)

PLOP:

125341585(Egf)

NCAR:

124994951

MMMA:

107141390(Egf)

OCU:

100008808

OPI:	101536206(EGF)

TUP:	102490423(EGF)

GVR:	103588497(EGF)

CFA:	403657(EGF)

CLUD:

112671646(EGF)

VVP:	112934223(EGF)

VLG:	121492863(EGF)

NPO:	129521218(EGF)

AML:

100467733

UMR:	103661742(EGF)

UAH:	113255562(EGF)

UAR:	123793362(EGF)

ELK:

111156359

LLV:

125093282

MPUF:

101682951(EGF)

MNP:	132002212(EGF)

MLK:	131829316(EGF)

NVS:	122889261(EGF)

ORO:	101377629(EGF)

EJU:	114222658(EGF)

ZCA:	113925832(EGF)

MLX:	118027092(EGF)

NSU:	110575510(EGF)

LWW:	102742915(EGF)

FCA:	493978(EGF)

PYU:	121031012(EGF)

PCOO:

112858016(EGF)

PBG:	122477450(EGF)

PVIV:

125164093(EGF)

LRUF:

124520329

PTG:	102959656(EGF)

PPAD:

109248153(EGF)

PUC:

125923024

AJU:

106983657

HHV:	120236138(EGF)

BTA:	530315(EGF)

BOM:	102285914(EGF)

BIU:	109559983(EGF)

BBUB:

102416325(EGF)

BBIS:

105002073(EGF)

CHX:	106502173(EGF)

BTAX:

128050008(EGF)

ODA:	120862277(EGF)

CCAD:

122422171(EGF)

MBEZ:

129561712(EGF)

SSC:	397083(EGF)

CFR:	102523769(EGF)

CBAI:

105067960(EGF)

CDK:	105089905(EGF)

VPC:	102537002(EGF)

BACU:

103004366(EGF)

BMUS:

118895543(EGF)

LVE:	103073883(EGF)

OOR:	101283152(EGF)

DLE:	111186135(EGF)

PCAD:

102977431(EGF)

PSIU:

116754608(EGF)

NASI:

112397683(EGF)

ECB:	106782874(EGF)

EPZ:

103543333

EAI:	106829795(EGF)

MYB:	102264252(EGF)

MYD:	102758044(EGF)

MMYO:

118672981(EGF)

MLF:	102424256(EGF)

MDT:	132214841(EGF)

PKL:	118702736(EGF)

EFUS:

114234667(EGF)

MNA:	107534373(EGF)

DRO:	112296254(EGF)

SHON:

118977074(EGF)

AJM:	119057431(EGF)

PDIC:

114492590(EGF)

PHAS:

123806865(EGF)

MMF:	118634494(EGF)

PPAM:

129085287(EGF)

HAI:	109379436(EGF)

RFQ:	117021897(EGF)

PALE:

102891552(EGF)

PGIG:

120591156(EGF)

PVP:	105293045(EGF)

RAY:	107508819(EGF)

MJV:	108408073(EGF)

TOD:	119243624(EGF)

SARA:

101541792(EGF)

SETR:

126027570(EGF)

LAV:	100670137(EGF)

TMU:

101355971

ETF:	101645300(EGF)

DNM:	101418748(EGF)

MDO:	100619143(EGF)

GAS:	123253141(EGF)

SHR:	100933169(EGF)

AFZ:

127540419

PCW:	110218605(EGF)

TVP:	118854108(EGF)

OAA:	100074960(EGF)

GGA:	408035(EGF)

PCOC:

116231267(EGF)

MGP:	100543460(EGF)

CJO:	107313609(EGF)

TPAI:

128080350(EGF)

LMUT:

125692196(EGF)

NMEL:

110399042(EGF)

APLA:

101795002(EGF)

ACYG:

106038683(EGF)

CATA:

118254590(EGF)

AFUL:

116488496(EGF)

TGU:	100218747(EGF)

LSR:	110467994(EGF)

SCAN:

103826255(EGF)

PMOA:

120502809(EGF)

OTC:	121331417(EGF)

PRUF:

121360365(EGF)

GFR:	102034269(EGF)

FAB:	101819290(EGF)

OMA:	130252816(EGF)

PHI:	102112980(EGF)

PMAJ:

107203603(EGF)

CCAE:

111927782(EGF)

CCW:	104697130(EGF)

CBRC:

103617399(EGF)

ETL:	114062174(EGF)

ZAB:	102065155(EGF)

ZLE:	135446736(EGF)

ACHL:

103797310 103800957

SVG:	106854429(EGF)

MMEA:

130576234(EGF)

HRT:	120753452(EGF)

SATI:

136360503(EGF)

FPG:	101916879(EGF)

FCH:	102049265(EGF)

CCRI:

104161084

SHAB:

115610465(EGF)

ACUN:

113479739(EGF)

TALA:

104364351(EGF)

ACHC:

115344703(EGF)

HALD:

104321638(EGF)

HLE:	104843353(EGF)

AGEN:

126044935

GCL:

127015786

CSTI:

104558875(EGF)

LDI:	104343767(EGF)

MNB:	103772713(EGF)

DPUB:

104304147(EGF)

AVIT:

104274119(EGF)

BRHI:

104499298(EGF)

EGZ:	104135535(EGF)

NNI:	104021157(EGF)

PCRI:

104033554(EGF)

PCAO:

104043574(EGF)

PADL:

103926035(EGF)

AFOR:

103894243(EGF)

FGA:	104075495(EGF)

GSTE:

104254810(EGF)

CLV:	102083886(EGF)

MUI:	104538737(EGF)

PGUU:

104471930

EHS:	104516802(EGF)

CMAC:

104484067(EGF)

CUCA:

104062856(EGF)

TEO:	104375183(EGF)

BREG:

104633850(EGF)

OHA:	104327240(EGF)

ACAR:

104532081

CPEA:

104394485(EGF)

CVF:	104286838(EGF)

RTD:	128910553(EGF)

AAM:	106491937(EGF)

AROW:

112972475(EGF)

NPD:	112957256(EGF)

TGT:	104580798(EGF)

DNE:	112984130(EGF)

SCAM:

104138015(EGF)

ASN:	102388605(EGF)

AMJ:	102560233(EGF)

CPOO:

109309386(EGF)

GGN:	109301074(EGF)

PSS:	102453328(EGF)

CMY:	102933086(EGF)

CCAY:

125635272(EGF)

DCC:	119855290(EGF)

CPIC:

101934754(EGF)

TST:	117877887(EGF)

CABI:

116827248(EGF)

MRV:	120407021(EGF)

ACS:	100562822(egf)

ASAO:

132776917(EGF)

PVT:	110087292(EGF)

SUND:

121931923(EGF)

PBI:	103061516(EGF)

PMUR:

107290128(EGF)

CTIG:

120305920(EGF)

TSR:	106554022 106555130

PGUT:

117679942(EGF)

APRI:

131203443(EGF)

PTEX:

113434620(EGF)

NSS:	113412783(EGF)

VKO:	123022650(EGF)

PMUA:

114604055(EGF)

PRAF:

128421254(EGF)

ZVI:	118083713(EGF)

HCG:	128327743(EGF)

GJA:	107122699(EGF)

STOW:

125439707(EGF)

EMC:	129336966(EGF)

XLA:	108710179(egf.L)

XTR:	100127663(egf)

NPR:	108798307(EGF)

RTEM:

120917738(EGF)

BBUF:

120989919(EGF)

BGAR:

122946843(EGF)

MUO:	115461197(EGF)

GSH:	117365240(EGF)

DRE:	403045(egf)

SRX:	107723791 107740113

SANH:

107662948 107669104

SGH:	107569836 107602591

CCAR:

109057414 109088262

CAUA:

113114148

CGIB:

127971069

PTET:

122357370(egf)

LROH:

127175864(egf)

OMC:	131552902(egf)

PPRM:

120474329(egf)

RKG:	130095158(egf)

MAMB:

125259410(egf)

CIDE:

127494859

CERY:

137015259(egf)

MASI:

127412934 127418317

TROS:

130563551(egf)

TDW:	130438198(egf)

MANU:

129422811(egf)

IPU:

108268549

IFU:	128612081(egf)

PHYP:

113547167

SMEO:

124386114(egf)

TFD:	113648177(egf)

TVC:	132855618(egf)

TRN:	134319685(egf)

CMAO:

118806475(egf)

EEE:	113579942(egf)

CHAR:

105906165(egf)

TRU:	101061284(egf)

TFS:	130530828(egf)

TNG:	GSTEN00024402G001

LCO:	104917921(egf)

NCC:	104953729(egf)

TBEN:

117491568(egf)

CGOB:

115014303(egf)

PGEO:

117453993(egf)

GACU:

117553610(egf)

EMAC:

134859778(egf)

ELY:	117260540(egf)

EFO:	125894020(egf)

PLEP:

121947780(egf)

SLUC:

116052916(egf)

ECRA:

117951707(egf)

ESP:	116696510(egf)

PFLV:

114563345(egf)

GAT:	120818259(egf)

PPUG:

119211628(egf)

AFB:	129090086(egf)

CLUM:

117737231(egf)

PSWI:

130209810(egf)

MSAM:

119888559(egf)

SCHU:

122880618(egf)

CUD:	121516668(egf)

ALAT:

119008156(egf)

MZE:	101487082(egf)

ONL:	100706539(egf)

OAU:	116335758(egf)

OLA:	101167023(egf)

OML:	112141457(egf)

CSAI:

133447340(egf)

XMA:	102219388(egf)

XCO:	114138665(egf)

XHE:	116714467(egf)

PRET:

103471828(egf)

PFOR:

103137346(egf)

PLAI:

106960087(egf)

PMEI:

106929540(egf)

GAF:	122837113(egf)

PPRL:

129360254 129360259

CVG:	107095811(egf)

CTUL:

119772614(egf)

GMU:	124860567(egf)

NFU:	107374766(egf)

KMR:	108236662(egf)

ALIM:

106513245

NWH:	119408618(egf)

AOCE:

111588376(egf)

MCEP:

125008212(egf)

CSEM:

103390644(egf)

POV:	109625474(egf)

SSEN:

122778301(egf)

HHIP:

117769534(egf)

HSP:	118111983(egf)

PPLT:

128446238(egf)

SMAU:

118319905(egf)

LCF:

108885177

SDU:	111232468(egf)

SLAL:

111648180(egf)

XGL:	120785682(egf)

HCQ:	109524192(egf)

SSCV:

125986952

SBIA:

133508301(egf)

PEE:	133407368(egf)

PTAO:

133485125(egf)

BPEC:

110153711(egf)

MALB:

109964289

BSPL:

114864025(egf)

SJO:	128362833(egf)

SASA:

106611584(egf)

STRU:

115205115(egf)

OTW:	112256330(egf)

OMY:	110505117(egf)

OGO:	124011368(egf)

ONE:	115129161(egf)

OKI:

109904732

OKE:	118363115(egf)

SALP:

111968192(egf)

SNH:

120061877

CCLU:

121537076(egf)

ELS:	105027559(egf)

SFM:	108938717(egf)

PKI:	111849374(egf)

LOC:	102689722(egf)

PSPA:

121295627 121322456

ARUT:

117408408 117421414

PSEX:

120533101(egf)

LCM:	102348800 102356822(EGF)

CMK:	103180890(egf)

RTP:	109929559(egf)

CPLA:

122553658(egf)

HOC:	132816749(egf)

LERI:

129703176(egf)

SKO:

102807105

HRO:	HELRODRAFT_189631

HRF:

124145077

ADF:

107331023

» show all

Reference

PMID:3491360

Authors

Bell GI, Fong NM, Stempien MM, Wormsted MA, Caput D, Ku LL, Urdea MS, Rall LB, Sanchez-Pescador R

Title

Human epidermal growth factor precursor: cDNA sequence, expression in vitro and gene organization.

Journal

Nucleic Acids Res 14:8427-46 (1986)
DOI:10.1093/nar/14.21.8427

Sequence

[hsa:1950]

Reference

PMID:10964941

Authors

Hermann PM, van Kesteren RE, Wildering WC, Painter SD, Reno JM, Smith JS, Kumar SB, Geraerts WP, Ericsson LH, Smit AB, Bulloch AG, Nagle GT

Title

Neurotrophic actions of a novel molluscan epidermal growth factor.

Journal

J Neurosci 20:6355-64 (2000)
DOI:10.1523/JNEUROSCI.20-17-06355.2000

Sequence

[mmu:13645]

LinkDB

DBGET integrated database retrieval system