KEGG   VARIANT: 2260v1
Entry
2260v1                      Variant                                
Name
FGFR1 amplification
Gene
FGFR1  fibroblast growth factor receptor 1 [KO:K04362]
Organism
hsa_var Human gene variants (Homo sapiens)
Variation
amplification
ClinVar: 59782
dbVar: nsv532311
Network
nt06210  ERK signaling (cancer)
nt06214  PI3K signaling (cancer)
nt06261  Gastric cancer
nt06270  Breast cancer
nt06526  MAPK signaling
nt06530  PI3K signaling
Disease
H00018  Gastric cancer
H00031  Breast cancer
Reference
PMID:24265351
  Authors
Dienstmann R, Rodon J, Prat A, Perez-Garcia J, Adamo B, Felip E, Cortes J, Iafrate AJ, Nuciforo P, Tabernero J
  Title
Genomic aberrations in the FGFR pathway: opportunities for targeted therapies in solid tumors.
  Journal
Ann Oncol 25:552-63 (2014)
DOI:10.1093/annonc/mdt419
Reference
PMID:20179196
  Authors
Turner N, Pearson A, Sharpe R, Lambros M, Geyer F, Lopez-Garcia MA, Natrajan R, Marchio C, Iorns E, Mackay A, Gillett C, Grigoriadis A, Tutt A, Reis-Filho JS, Ashworth A
  Title
FGFR1 amplification drives endocrine therapy resistance and is a therapeutic target in breast cancer.
  Journal
Cancer Res 70:2085-94 (2010)
DOI:10.1158/0008-5472.CAN-09-3746
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