KEGG   VARIANT: 2260v1
Entry
2260v1                      Variant                                
Name
FGFR1 amplification
Gene
FGFR1  fibroblast growth factor receptor 1 [KO:K04362]
Organism
hsa_var Human gene variants (Homo sapiens)
Variation
amplification
ClinVar: 59782
dbVar: nsv532311
Network
nt06210  ERK signaling
nt06214  PI3K signaling
nt06261  Gastric cancer
nt06270  Breast cancer
  Element
N00020  Amplified FGFR to RAS-ERK signaling pathway
N00038  Amplified FGFR to PI3K signaling pathway
Disease
H00018  Gastric cancer
H00031  Breast cancer
Reference
  Authors
Dienstmann R, Rodon J, Prat A, Perez-Garcia J, Adamo B, Felip E, Cortes J, Iafrate AJ, Nuciforo P, Tabernero J
  Title
Genomic aberrations in the FGFR pathway: opportunities for targeted therapies in solid tumors.
  Journal
Ann Oncol 25:552-63 (2014)
DOI:10.1093/annonc/mdt419
Reference
  Authors
Turner N, Pearson A, Sharpe R, Lambros M, Geyer F, Lopez-Garcia MA, Natrajan R, Marchio C, Iorns E, Mackay A, Gillett C, Grigoriadis A, Tutt A, Reis-Filho JS, Ashworth A
  Title
FGFR1 amplification drives endocrine therapy resistance and is a therapeutic target in breast cancer.
  Journal
Cancer Res 70:2085-94 (2010)
DOI:10.1158/0008-5472.CAN-09-3746
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