KEGG   VARIANT: 2263v1
Entry
2263v1                      Variant                                
Name
FGFR2 amplification
Type
Gain of function
Gene
FGFR2  fibroblast growth factor receptor 2 [KO:K05093]
Organism
hsa_var Human gene variants (Homo sapiens)
Variation
amplification
ClinVar: 396706 153718 148679
dbVar: nsv2774502 nsv995712 nsv868923
Network
nt06210  ERK signaling (cancer)
nt06214  PI3K signaling (cancer)
nt06261  Gastric cancer
nt06270  Breast cancer
nt06526  MAPK signaling
nt06530  PI3K signaling
Disease
H00018  Gastric cancer
H00031  Breast cancer
Drug target
Infigratinib (DG03062): D11611
Reference
PMID:2377625
  Authors
Hattori Y, Odagiri H, Nakatani H, Miyagawa K, Naito K, Sakamoto H, Katoh O, Yoshida T, Sugimura T, Terada M
  Title
K-sam, an amplified gene in stomach cancer, is a member of the heparin-binding growth factor receptor genes.
  Journal
Proc Natl Acad Sci U S A 87:5983-7 (1990)
DOI:10.1073/pnas.87.15.5983
Reference
PMID:26267324
  Authors
Riquelme I, Saavedra K, Espinoza JA, Weber H, Garcia P, Nervi B, Garrido M, Corvalan AH, Roa JC, Bizama C
  Title
Molecular classification of gastric cancer: Towards a pathway-driven targeted therapy.
  Journal
Oncotarget 6:24750-79 (2015)
DOI:10.18632/oncotarget.4990
Reference
PMID:16997151
  Authors
Vauhkonen M, Vauhkonen H, Sipponen P
  Title
Pathology and molecular biology of gastric cancer.
  Journal
Best Pract Res Clin Gastroenterol 20:651-74 (2006)
DOI:10.1016/j.bpg.2006.03.016
Reference
PMID:23696246
  Authors
Katoh M, Nakagama H
  Title
FGF receptors: cancer biology and therapeutics.
  Journal
Med Res Rev 34:280-300 (2014)
DOI:10.1002/med.21288
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