KEGG   VARIANT: 240v1
Entry
240v1                      Variant                                 
Name
ALOX5 mutation
Type
Loss of function
Gene
ALOX5  arachidonate 5-lipoxygenase [KO:K00461]
Organism
hsa_var Human gene variants (Homo sapiens)
Variation
mutations
OmimVar: 152390
Network
nt06535  Efferocytosis
Disease
H00079  Asthma
Reference
  Authors
Drazen JM, Yandava CN, Dube L, Szczerback N, Hippensteel R, Pillari A, Israel E, Schork N, Silverman ES, Katz DA, Drajesk J
  Title
Pharmacogenetic association between ALOX5 promoter genotype and the response to anti-asthma treatment.
  Journal
Nat Genet 22:168-70 (1999)
DOI:10.1038/9680
Reference
  Authors
Dwyer JH, Allayee H, Dwyer KM, Fan J, Wu H, Mar R, Lusis AJ, Mehrabian M
  Title
Arachidonate 5-lipoxygenase promoter genotype, dietary arachidonic acid, and atherosclerosis.
  Journal
N Engl J Med 350:29-37 (2004)
DOI:10.1056/NEJMoa025079
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