KEGG ORTHOLOGY: K00461

ORTHOLOGY: K00461

Entry

K00461                      KO

Symbol

ALOX5

Name

arachidonate 5-lipoxygenase [EC:1.13.11.34]

Pathway

map00590

Arachidonic acid metabolism

map01100

Metabolic pathways

map04148

Efferocytosis

map04664

Fc epsilon RI signaling pathway

map04726

Serotonergic synapse

map04913

Ovarian steroidogenesis

map05145

Toxoplasmosis

Reaction

R01595

arachidonate:oxygen 5-oxidoreductase

R03058

arachidonate:oxygen 5-oxidoreductase

R08527

arachidonate 5-lipoxygenase

Disease

H00079

Asthma

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09103 Lipid metabolism
   00590 Arachidonic acid metabolism
    K00461  ALOX5; arachidonate 5-lipoxygenase
09140 Cellular Processes
  09141 Transport and catabolism
   04148 Efferocytosis
    K00461  ALOX5; arachidonate 5-lipoxygenase
09150 Organismal Systems
  09151 Immune system
   04664 Fc epsilon RI signaling pathway
    K00461  ALOX5; arachidonate 5-lipoxygenase
  09152 Endocrine system
   04913 Ovarian steroidogenesis
    K00461  ALOX5; arachidonate 5-lipoxygenase
  09156 Nervous system
   04726 Serotonergic synapse
    K00461  ALOX5; arachidonate 5-lipoxygenase
09160 Human Diseases
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    K00461  ALOX5; arachidonate 5-lipoxygenase
Enzymes [BR:ko01000]
1. Oxidoreductases
  1.13  Acting on single donors with incorporation of molecular oxygen (oxygenases)
   1.13.11  With incorporation of two atoms of oxygen
    1.13.11.34  arachidonate 5-lipoxygenase
     K00461  ALOX5; arachidonate 5-lipoxygenase

Other DBs

GO:

0004051

Genes

HSA:	240(ALOX5)

PTR:	450428(ALOX5)

PPS:	100979027(ALOX5)

GGO:	101135686(ALOX5)

PON:	100460538(ALOX5)

NLE:	100584513(ALOX5)

HMH:	116461149(ALOX5)

MCC:	707926(ALOX5)

MCF:	102132853(ALOX5)

MTHB:

126963209

MNI:	105486634(ALOX5)

CSAB:

103215810(ALOX5)

CATY:

105576135(ALOX5)

PANU:

101004229(ALOX5)

TGE:	112632137(ALOX5)

MLEU:

105532332(ALOX5)

RRO:	104678173(ALOX5)

RBB:	108522174(ALOX5)

TFN:	117082071(ALOX5)

PTEH:

111529801(ALOX5)

CANG:

105517726(ALOX5)

CJC:	100386217(ALOX5)

SBQ:	101031793(ALOX5)

CIMI:

108296336(ALOX5)

CSYR:

103256562(ALOX5)

MMUR:

105860128 105860129

LCAT:

123650024(ALOX5)

PCOQ:

105821653(ALOX5)

OGA:	100952067(ALOX5)

MMU:	11689(Alox5)

MCAL:

110297094(Alox5)

MPAH:

110315917(Alox5)

RNO:	25290(Alox5)

MCOC:

116099451(Alox5)

ANU:	117714890(Alox5)

MUN:	110563694(Alox5)

CGE:	100772492(Alox5)

MAUA:

101839970(Alox5)

PROB:

127236199(Alox5)

PLEU:

114689650(Alox5)

MORG:

121438814(Alox5)

MFOT:

126505462

AAMP:

119807525(Alox5)

NGI:	103737907(Alox5)

HGL:	101700210(Alox5)

CPOC:

100718093(Alox5)

CCAN:

109700324(Alox5)

DORD:

106001013(Alox5)

DSP:	122122367(Alox5)

PLOP:

125346580(Alox5)

NCAR:

124975507 124985161 124985243 124985624

OCU:

100341714

OPI:	101534185(ALOX5)

TUP:	102480526(ALOX5)

GVR:	103597659(ALOX5)

CFA:	477753(ALOX5)

CLUD:

112671999(ALOX5)

VVP:	112913415(ALOX5)

VLG:	121483983(ALOX5)

NPO:	129522715(ALOX5)

AML:	100476416(ALOX5)

UMR:	103668062(ALOX5)

UAH:	113243124(ALOX5)

UAR:	123800343(ALOX5)

ELK:

111144974

LLV:

125085017

MPUF:

101684572(ALOX5)

MNP:	132016591(ALOX5)

NVS:	122900884(ALOX5)

ORO:	101381769(ALOX5)

EJU:	114205241(ALOX5)

ZCA:	113923418(ALOX5)

MLX:	118023026(ALOX5)

NSU:	110589221(ALOX5)

LWW:	102747716(ALOX5)

FCA:	101097422(ALOX5)

PYU:	121036944(ALOX5)

PCOO:

112854352(ALOX5)

PBG:	122492984(ALOX5)

LRUF:

124506966

PTG:	102973009(ALOX5)

PPAD:

109264579(ALOX5)

PUC:

125933342

AJU:

106989649

HHV:	120232804(ALOX5)

BTA:	404074(ALOX5)

BOM:	102270550(ALOX5)

BIU:	109553923(ALOX5)

BBUB:

102400249(ALOX5)

BBIS:

104999056(ALOX5)

CHX:	102168425(ALOX5)

OAS:	101117390(ALOX5)

BTAX:

128048043(ALOX5)

ODA:	120865494(ALOX5)

CCAD:

122446293(ALOX5)

MBEZ:

129555613(ALOX5)

SSC:	100156205(ALOX5)

CFR:	102507744(ALOX5)

CBAI:

105075631(ALOX5)

CDK:	105093424(ALOX5)

VPC:	102544906(ALOX5)

BACU:

103009115(ALOX5)

LVE:	103081267(ALOX5)

OOR:	101283796(ALOX5)

DLE:	111172567(ALOX5)

PCAD:

102987975(ALOX5) 114485528

PSIU:

116741371(ALOX5)

NASI:

112395753(ALOX5)

ECB:	100062042(ALOX5)

EPZ:	103553660(ALOX5)

EAI:	106846725(ALOX5)

MYB:	102249760(ALOX5)

MYD:	102754419(ALOX5)

MMYO:

118679341(ALOX5)

MLF:	102418693(ALOX5)

MNA:	107527950(ALOX5)

PKL:	118732103(ALOX5)

EFUS:

103292839(ALOX5)

HAI:	109389501(ALOX5)

DRO:	112305481(ALOX5)

SHON:

118994142(ALOX5)

AJM:	119035943(ALOX5)

PDIC:

114496046(ALOX5)

PHAS:

123821021(ALOX5)

MMF:	118632052(ALOX5)

RFQ:	117036416(ALOX5)

PPAM:

129073187(ALOX5)

PALE:

102898772(ALOX5)

PGIG:

120609662(ALOX5)

PVP:	105288958(ALOX5)

RAY:	107508911(ALOX5)

MJV:	108400689(ALOX5)

TOD:	119234526(ALOX5)

SARA:

101551293(ALOX5)

LAV:	100661336(ALOX5)

TMU:

101345496

ETF:	101653110(ALOX5)

DNM:	101433807(ALOX5)

MDO:	100013954(ALOX5)

GAS:	123236481(ALOX5)

SHR:	100932471(ALOX5)

PCW:	110213916(ALOX5)

OAA:	100077066(ALOX5)

GGA:	423769(ALOX5)

PCOC:

116238154(ALOX5)

MGP:	100542129(ALOX5)

CJO:	107315916(ALOX5)

TPAI:

128078157(ALOX5)

LMUT:

125692891(ALOX5)

NMEL:

110399270(ALOX5)

APLA:

101801930(ALOX5)

ACYG:

106049001(ALOX5)

CATA:

118254963(ALOX5)

AFUL:

116491605(ALOX5)

TGU:	100231888(ALOX5)

LSR:	110475663(ALOX5)

SCAN:

103813960(ALOX5)

PMOA:

120502228(ALOX5)

OTC:	121341694(ALOX5)

PRUF:

121350062(ALOX5)

GFR:	102035554(ALOX5)

FAB:	101813553(ALOX5)

OMA:	130254740(ALOX5)

PHI:	102112541(ALOX5)

PMAJ:

107207120(ALOX5)

CCAE:

111931122(ALOX5)

CCW:	104697933(ALOX5)

CBRC:

103624590(ALOX5)

ETL:	114054707(ALOX5)

ZAB:	102062876(ALOX5)

ACHL:

103800605(ALOX5)

SVG:	106852593(ALOX5)

MMEA:

130578798(ALOX5)

HRT:	120756195(ALOX5)

FPG:	101914238(ALOX5)

FCH:	102053142(ALOX5)

CLV:	102085004(ALOX5)

EGZ:	104129027(ALOX5)

NNI:	104014074(ALOX5)

PCRI:

104029677(ALOX5)

PLET:

104626025(ALOX5)

EHS:	104506301(ALOX5)

PCAO:

104042894(ALOX5)

ACUN:

113481652(ALOX5)

TALA:

104365651(ALOX5)

PADL:

103914082(ALOX5)

AFOR:

103897820(ALOX5)

ACHC:

115348416(ALOX5)

HALD:

104320512(ALOX5)

HLE:	104829333(ALOX5)

AGEN:

126043077

GCL:

127017658

CCRI:

104162138(ALOX5)

CSTI:

104560045(ALOX5)

CMAC:

104486519(ALOX5)

MUI:	104535976(ALOX5)

BREG:

104631879(ALOX5)

FGA:	104076430(ALOX5)

GSTE:

104256524(ALOX5)

MNB:	103781231(ALOX5)

OHA:	104330385(ALOX5)

NNT:	104403581(ALOX5)

SHAB:

115608655(ALOX5)

DPUB:

104297702(ALOX5)

ACAR:

104521858(ALOX5)

CPEA:

104391514(ALOX5)

AVIT:

104276083(ALOX5)

CVF:	104289812(ALOX5)

RTD:	128911621(ALOX5)

CUCA:

104067974(ALOX5)

BRHI:

104501850(ALOX5)

AAM:	106497785(ALOX5)

AROW:

112963900(ALOX5)

NPD:	112957209(ALOX5)

TGT:	104577674(ALOX5)

DNE:	112990662(ALOX5)

SCAM:

104146056(ALOX5)

ASN:	102371605(ALOX5)

AMJ:	102568608(ALOX5)

CPOO:

109324293(ALOX5)

GGN:	109287144(ALOX5)

PSS:	102462244(ALOX5)

CMY:	102944803(ALOX5)

CCAY:

125640309(ALOX5)

DCC:	119859437(ALOX5)

CPIC:

101932214(ALOX5)

TST:	117880642(ALOX5)

CABI:

116823588(ALOX5)

MRV:	120369164(ALOX5)

ACS:	100556313(alox5)

PVT:

110090785

SUND:

121927518(ALOX5)

PMUR:

107292379(ALOX5)

CTIG:

120300245(ALOX5)

TSR:	106553343(ALOX5)

PGUT:

117661247(ALOX5)

APRI:

131194940(ALOX5) 131195008

PTEX:

113448132(ALOX5)

NSS:	113426131(ALOX5)

VKO:	123029661(ALOX5)

PMUA:

114601080(ALOX5)

PRAF:

128417991(ALOX5)

ZVI:	118079372(ALOX5)

HCG:	128324892(ALOX5)

GJA:	107113129(ALOX5)

STOW:

125443871(ALOX5)

EMC:	129333365(ALOX5)

XLA:	108696220(alox5.L) 108697207(alox5.S)

XTR:	100036609(alox5)

NPR:	108800085(ALOX5)

RTEM:

120947174(ALOX5)

BBUF:

121004372(ALOX5)

BGAR:

122940049(ALOX5)

MUO:	115470372 115470373

GSH:	117358965 117358966

DRE:	567204(alox5a) 573013(alox5b.1) 724056(alox5b.2)

SRX:	107708393 107713771 107747471

SANH:

107671382 107677802 107678516 107684374 107690200

SGH:	107571808 107572920 107575181 107575442 107582511 107589586

CCAR:

109049814 109052610 109065335 109081069 109101776 109108493

CAUA:

113048375 113048377 113057166 113066049 113066078 113112941

CGIB:

127955930 127967689 127970034 128026407

PTET:

122342996 122342997 122342998 122343010 122357073(alox5a)

LROH:

127160167 127175177(alox5a)

OMC:	131538449 131538622 131538839 131539153 131539371 131552688(alox5a)

PPRM:

120460470 120463765 120463775 120478382 120479775(alox5a) 120492594

MAMB:

125257158 125265844 125276632(alox5a) 125279367 125279782

CIDE:

127508776 127516455 127517370

MASI:

127412305 127413837 127420989 127420992

TROS:

130559644(alox5a) 130565158

MANU:

129415496(alox5a) 129439374 129439376 129439390 129439603 129439605 129439607 129439610 129439611

IPU:	108263823(alox5a)

IFU:	128605533(alox5a)

PHYP:

113546154(alox5)

SMEO:

124378204(alox5a)

TFD:	113639934(alox5a)

AMEX:

103035394(alox5)

CMAO:

118810335(alox5a)

EEE:	113587960(alox5)

CHAR:

105909748(alox5a)

TRU:	101066485 101077167(alox5) 101077844 115249685

TFS:	130533608 130533609 130533610 130533611 130533612

TNG:	GSTEN00016500G001

LCO:	104930113(alox5)

NCC:	104946287(alox5)

CGOB:

115020076(alox5)

ELY:

117248563

EFO:	125903456(alox5a)

PLEP:

121954568 121954569

SLUC:

116054107(alox5a)

ECRA:

117960578(alox5a)

ESP:	116704939(alox5)

PFLV:

114572645(alox5)

GAT:	120820912(alox5a)

PPUG:

119213967(alox5a)

AFB:	129092018(alox5a)

CLUM:

117743732 117743733

MSAM:

119916966(alox5a)

SCHU:

122884911

CUD:	121510776 121511083 121511143 121511190

ALAT:

119034095(alox5a)

MZE:	101482427(alox5)

ONL:	100693453(alox5)

OAU:	116316616(alox5a)

OLA:	101160835(alox5) 101165738

OML:	112162158(alox5a)

XMA:	102230376(alox5)

XCO:	114137934(alox5)

XHE:	116712547(alox5)

PRET:

103476884(alox5)

PFOR:

103147712(alox5)

PLAI:

106955189(alox5)

PMEI:

106907603(alox5)

GAF:	122843057(alox5a)

CVG:	107091526(alox5)

CTUL:

119788547(alox5a)

GMU:	124858722(alox5a)

NFU:	107375698(alox5)

KMR:

108243211

ALIM:

106529456(alox5)

NWH:	119418429(alox5a)

AOCE:

111564375(alox5)

MCEP:

125018433(alox5a)

CSEM:

103387317(alox5)

POV:	109631496(alox5)

SSEN:

122781462(alox5a)

HHIP:

117775306(alox5a)

HSP:	118118901(alox5a)

LCF:	108884347(alox5a)

SDU:	111235185(alox5)

SLAL:

111654678(alox5)

XGL:	120796514(alox5a)

HCQ:	109509924 109509925(alox5)

SSCV:

125978684 125978685

BPEC:

110164412(alox5)

MALB:

109961016(alox5)

BSPL:

114870428(alox5a)

SASA:

100194803(lox5) 106613187

STRU:

115153372 115193564

OTW:	112253187 112256283

OMY:	110502637 110532793

OGO:	124037261 124041114

ONE:	115113091 115134961

OKI:	109890066 109899823

OKE:	118366116(alox5a) 118369426

SALP:

111978799

SNH:	120017762 120045686

CCLU:

121553196 121583968

ELS:	105010608(alox5)

SFM:	108921027(alox5) 108937538

PKI:	111837191 111846223 111846232 111849566(alox5)

AANG:

118218047 118218049 118218050 118218460

LOC:	102697549(alox5)

PSPA:

121325182(alox5a)

ARUT:

117416027 117417615(alox5a)

PSEX:

120516309(alox5a)

LCM:	102353934(ALOX5)

CMK:	103185827(alox5a)

RTP:	109921931(alox5)

CPLA:

122541744

LERI:

129694146 129713061 129713062

BFO:	118407044 118407190 118410745 118416628 118419219 118419222 118423903 118424144

BBEL:

109463619 109467523 109473009 109474494 109474550 109474633 109476869 109478405 109478532 109479429 109480412 109481529 109483336 109486824 109487021 109487229 109487274 109487288

CIN:	100176198 100176411 100176744 100178151 100178342 100178563 100179479

SCLV:

120327656 120328067 120330915 120339739 120339931 120339932 120342283 120342991

SPU:	115918885 574670 575389 579368 583823 584481 584789 585142 591845 754628 763828 764400

LPIC:

129260605 129274105 129274606 129275104 129276415 129276420 129276477 129276781

APLC:

110975305 110975972 110976201 110977737 110977751

SKO:	100369676 100369827 102805620

TPAL:

IEL:

PVM:

PCLA:

PTRU:

ESN:

PPOI:

DSV:

RSAN:

RMP:

CSCU:

PTEP:

UDV:

SDM:

LPOL:

PMEO:

HRO:	HELRODRAFT_66521

LGI:	LOTGIDRAFT_137999 LOTGIDRAFT_171808 LOTGIDRAFT_209217 LOTGIDRAFT_224684

PCAN:

112558951

BGT:	106067963 106069395

GAE:	121374655 121392860

HRF:	124111845 124113998 124114830 124115001 124115002 124123794 124143720

HRJ:	124254639 124259952 124261755 124261766 124285520

CRG:	105319481 105324873 105327235 105327236 105327296 105327652 105333405 105333406 105336201 117683956

CVN:	111100560 111104171 111125061 111131676

CANU:

128163050 128163051 128175011 128175263 128177600 128177852 128177871 128178663 128184671 128184672 128184673 128192060

OED:	125650846 125652902 125652924 125652925 125681975

MYI:	110457288 110457778 110458666 110458669 110458670 110458673 110458677 110458678

PMAX:

117322747 117324142 117324143 117329167 117329376 117329377 117329378 117329966

MMER:

123539768 123540524 123541567 123553096 123557731

RPHI:

132725606 132736951 132754139 132757137 132759084

DPOL:

127832686 127836363 127838598 127841037

OBI:	106867440 106867441 106867443 106873090 106873091 106873092

OSN:	115215746 115215749 115215753 115221275 115221688 115226898 115227054

LAK:	106150754 106166490 106170509 106178940

OVI:	T265_15039

NVE:	5499732 5504404 5514194 5514339

EPA:	110239121 110242596 110248339 110250751 110253407

ATEN:

116286796 116290323 116294452 116296880 116301055 116304961 116304967 116307613

ADF:	107327113 107341953 107341972 107345340 107350206 107352928

AMIL:

114958630 114959396 114968909 114970008 114971001

PDAM:

113664617 113665281 113666770 113675130 113675559 113675883 113682318 113683498 113685341

SPIS:

111321744 111326629 111326882 111326890 111328829 111341264

DGT:	114516532 114516794 114521367 114521368 114527546 114529580 114531948 114541102

XEN:	124433523 124439795 124443860 124444372 124444381 124444382 124450812 124454266

HMG:	100200947 100209770 100213618 100215649

HSY:	130622682 130630034 130630315 130630536 130647477

TAD:	TRIADDRAFT_50085 TRIADDRAFT_63720

AQU:

100635761

CCP:	CHC_T00008739001

MXA:

MXAN_1744

MSD:	MYSTI_02579

MFB:	MFUL124B02_14090

CCX:	COCOR_02733(loxA)

MBD:	MEBOL_004947

» show all

Reference

PMID:2829172

Authors

Matsumoto T, Funk CD, Radmark O, Hoog JO, Jornvall H, Samuelsson B

Title

Molecular cloning and amino acid sequence of human 5-lipoxygenase.

Journal

Proc Natl Acad Sci U S A 85:26-30 (1988)
DOI:10.1073/pnas.85.1.26

Sequence

[hsa:240]

Reference

PMID:12432920

Authors

Radmark O

Title

Arachidonate 5-lipoxygenase.

Journal

Prostaglandins Other Lipid Mediat 68-69:211-34 (2002)
DOI:10.1016/S0090-6980(02)00032-1

LinkDB

DBGET integrated database retrieval system