KEGG   ORTHOLOGY: K00461
Entry
K00461                      KO                                     
Symbol
ALOX5
Name
arachidonate 5-lipoxygenase [EC:1.13.11.34]
Pathway
map00590  Arachidonic acid metabolism
map01100  Metabolic pathways
map04664  Fc epsilon RI signaling pathway
map04726  Serotonergic synapse
map04913  Ovarian steroidogenesis
map05145  Toxoplasmosis
Disease
H00079  Asthma
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00590 Arachidonic acid metabolism
    K00461  ALOX5; arachidonate 5-lipoxygenase
 09150 Organismal Systems
  09151 Immune system
   04664 Fc epsilon RI signaling pathway
    K00461  ALOX5; arachidonate 5-lipoxygenase
  09152 Endocrine system
   04913 Ovarian steroidogenesis
    K00461  ALOX5; arachidonate 5-lipoxygenase
  09156 Nervous system
   04726 Serotonergic synapse
    K00461  ALOX5; arachidonate 5-lipoxygenase
 09160 Human Diseases
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    K00461  ALOX5; arachidonate 5-lipoxygenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.13  Acting on single donors with incorporation of molecular oxygen (oxygenases)
   1.13.11  With incorporation of two atoms of oxygen
    1.13.11.34  arachidonate 5-lipoxygenase
     K00461  ALOX5; arachidonate 5-lipoxygenase
Other DBs
RN: R01595 R03058 R08527
GO: 0004051
Genes
HSA: 240(ALOX5)
PTR: 450428(ALOX5)
PPS: 100979027(ALOX5)
GGO: 101135686(ALOX5)
PON: 100460538(ALOX5)
NLE: 100584513(ALOX5)
MCC: 707926(ALOX5)
MCF: 102132853(ALOX5)
CSAB: 103215810(ALOX5)
CATY: 105576135(ALOX5)
PANU: 101004229(ALOX5)
TGE: 112632137(ALOX5)
RRO: 104678173(ALOX5)
RBB: 108522174(ALOX5)
TFN: 117082071(ALOX5)
PTEH: 111529801(ALOX5)
CJC: 100386217(ALOX5)
SBQ: 101031793(ALOX5)
CSYR: 103256562(ALOX5)
OGA: 100952067(ALOX5)
MMU: 11689(Alox5)
MCAL: 110297094(Alox5)
MPAH: 110315917(Alox5)
RNO: 25290(Alox5)
MCOC: 116099451(Alox5)
CGE: 100772492(Alox5)
PLEU: 114689650(Alox5)
NGI: 103737907(Alox5)
HGL: 101700210(Alox5)
CPOC: 100718093(Alox5)
CCAN: 109700324(Alox5)
DORD: 106001013(Alox5)
DSP: 122122367(Alox5)
OCU: 100341714(ALOX5)
OPI: 101534185(ALOX5)
TUP: 102480526(ALOX5)
CFA: 477753(ALOX5)
VVP: 112913415(ALOX5)
VLG: 121483983(ALOX5)
AML: 100476416(ALOX5)
UMR: 103668062(ALOX5)
UAH: 113243124(ALOX5)
UAR: 123800343(ALOX5)
ELK: 111144974
LLV: 125085017
MPUF: 101684572(ALOX5)
ORO: 101381769(ALOX5)
EJU: 114205241(ALOX5)
ZCA: 113923418(ALOX5)
MLX: 118023026(ALOX5)
FCA: 101097422(ALOX5)
PYU: 121036944(ALOX5)
PBG: 122492984(ALOX5)
PTG: 102973009(ALOX5)
PPAD: 109264579(ALOX5)
AJU: 106989649(ALOX5)
HHV: 120232804(ALOX5)
BTA: 404074(ALOX5)
BOM: 102270550(ALOX5)
BIU: 109553923(ALOX5)
BBUB: 102400249(ALOX5)
CHX: 102168425(ALOX5)
OAS: 101117390(ALOX5)
ODA: 120865494(ALOX5)
CCAD: 122446293(ALOX5)
SSC: 100156205(ALOX5)
CFR: 102507744(ALOX5)
CBAI: 105075631(ALOX5)
CDK: 105093424(ALOX5)
VPC: 102544906(ALOX5)
BACU: 103009115(ALOX5)
LVE: 103081267(ALOX5)
OOR: 101283796(ALOX5)
DLE: 111172567(ALOX5)
PCAD: 102987975(ALOX5) 114485528
PSIU: 116741371(ALOX5)
ECB: 100062042(ALOX5)
EPZ: 103553660(ALOX5)
EAI: 106846725(ALOX5)
MYB: 102249760(ALOX5)
MYD: 102754419(ALOX5)
MMYO: 118679341(ALOX5)
MLF: 102418693(ALOX5)
MNA: 107527950(ALOX5)
PKL: 118732103(ALOX5)
HAI: 109389501(ALOX5)
DRO: 112305481(ALOX5)
SHON: 118994142(ALOX5)
AJM: 119035943(ALOX5)
PDIC: 114496046(ALOX5)
PHAS: 123821021(ALOX5)
MMF: 118632052(ALOX5)
RFQ: 117036416(ALOX5)
PALE: 102898772(ALOX5)
PGIG: 120609662(ALOX5)
PVP: 105288958(ALOX5)
RAY: 107508911(ALOX5)
MJV: 108400689(ALOX5)
TOD: 119234526(ALOX5)
SARA: 101551293(ALOX5)
LAV: 100661336(ALOX5)
TMU: 101345496
DNM: 101433807(ALOX5)
MDO: 100013954(ALOX5)
GAS: 123236481(ALOX5)
SHR: 100932471(ALOX5)
PCW: 110213916(ALOX5)
OAA: 100077066(ALOX5)
GGA: 423769(ALOX5)
PCOC: 116238154(ALOX5)
MGP: 100542129(ALOX5)
CJO: 107315916(ALOX5)
NMEL: 110399270(ALOX5)
APLA: 101801930(ALOX5)
ACYG: 106049001(ALOX5)
AFUL: 116491605(ALOX5)
TGU: 100231888(ALOX5)
LSR: 110475663(ALOX5)
SCAN: 103813960(ALOX5)
PMOA: 120502228(ALOX5)
OTC: 121341694(ALOX5)
PRUF: 121350062(ALOX5)
GFR: 102035554(ALOX5)
FAB: 101813553(ALOX5)
PHI: 102112541(ALOX5)
PMAJ: 107207120(ALOX5)
CCAE: 111931122(ALOX5)
CCW: 104697933(ALOX5)
ETL: 114054707(ALOX5)
ZAB: 102062876(ALOX5)
FPG: 101914238(ALOX5)
FCH: 102053142(ALOX5)
CLV: 102085004(ALOX5)
EGZ: 104129027(ALOX5)
NNI: 104014074(ALOX5)
ACUN: 113481652(ALOX5)
TALA: 104365651(ALOX5)
PADL: 103914082(ALOX5)
ACHC: 115348416(ALOX5)
AAM: 106497785(ALOX5)
AROW: 112963900(ALOX5)
NPD: 112957209(ALOX5)
DNE: 112990662(ALOX5)
ASN: 102371605(ALOX5)
AMJ: 102568608(ALOX5)
CPOO: 109324293(ALOX5)
GGN: 109287144(ALOX5)
PSS: 102462244(ALOX5)
CMY: 102944803(ALOX5)
CPIC: 101932214(ALOX5)
TST: 117880642(ALOX5)
CABI: 116823588(ALOX5)
MRV: 120369164(ALOX5)
ACS: 100556313(alox5)
PVT: 110090785
SUND: 121927518(ALOX5)
PMUR: 107292379(ALOX5)
TSR: 106553343(ALOX5)
PGUT: 117661247(ALOX5)
VKO: 123029661(ALOX5)
PMUA: 114601080(ALOX5)
ZVI: 118079372(ALOX5)
GJA: 107113129(ALOX5)
STOW: 125443871(ALOX5)
XLA: 108696220(alox5.L) 108697207(alox5.S)
XTR: 100036609(alox5)
NPR: 108800085(ALOX5)
RTEM: 120947174(ALOX5)
BBUF: 121004372(ALOX5)
BGAR: 122940049(ALOX5)
DRE: 567204(alox5a) 573013(alox5b.1) 724056(alox5b.2)
IPU: 108263823(alox5a)
PHYP: 113546154(alox5)
SMEO: 124378204(alox5a)
TFD: 113639934(alox5a)
AMEX: 103035394(alox5)
EEE: 113587960(alox5)
LCO: 104930113(alox5)
NCC: 104946287(alox5)
CGOB: 115020076(alox5)
ELY: 117248563
SLUC: 116054107(alox5a)
ECRA: 117960578(alox5a)
PFLV: 114572645(alox5)
GAT: 120820912(alox5a)
PPUG: 119213967(alox5a)
MSAM: 119916966(alox5a)
MZE: 101482427(alox5)
ONL: 100693453(alox5)
OAU: 116316616(alox5a)
OLA: 101160835(alox5) 101165738
OML: 112162158(alox5a)
XMA: 102230376(alox5)
XCO: 114137934(alox5)
XHE: 116712547(alox5)
PRET: 103476884(alox5)
PFOR: 103147712(alox5)
PLAI: 106955189(alox5)
PMEI: 106907603(alox5)
GAF: 122843057(alox5a)
CVG: 107091526(alox5)
CTUL: 119788547(alox5a)
GMU: 124858722(alox5a)
NFU: 107375698(alox5)
KMR: 108243211
ALIM: 106529456(alox5)
NWH: 119418429(alox5a)
AOCE: 111564375(alox5)
CSEM: 103387317(alox5)
POV: 109631496(alox5)
SSEN: 122781462(alox5a)
HHIP: 117775306(alox5a)
LCF: 108884347(alox5)
SDU: 111235185(alox5)
SLAL: 111654678(alox5)
XGL: 120796514(alox5a)
HCQ: 109509924 109509925(alox5)
BPEC: 110164412(alox5)
MALB: 109961016(alox5)
SASA: 100194803(lox5) 106613187
SALP: 111978799
ELS: 105010608(alox5)
SFM: 108921027(alox5) 108937538
LOC: 102697549(alox5)
PSPA: 121325182(alox5a)
ARUT: 117416027 117417615(alox5a)
LCM: 102353934(ALOX5)
CMK: 103185827(alox5a)
RTP: 109921931(alox5)
PVM: 113804806
PCLA: 123760292
PTRU: 123516860
DSV: 119449406
RSAN: 119382445
RMP: 119178021
PTEP: 107442379
SDM: 118200660
PCAN: 112558951
AQU: 100635761
MXA: MXAN_1744
CCX: COCOR_02733(loxA)
 » show all
Reference
PMID:2829172
  Authors
Matsumoto T, Funk CD, Radmark O, Hoog JO, Jornvall H, Samuelsson B
  Title
Molecular cloning and amino acid sequence of human 5-lipoxygenase.
  Journal
Proc Natl Acad Sci U S A 85:26-30 (1988)
DOI:10.1073/pnas.85.1.26
  Sequence
[hsa:240]
Reference
  Authors
Radmark O
  Title
Arachidonate 5-lipoxygenase.
  Journal
Prostaglandins Other Lipid Mediat 68-69:211-34 (2002)
DOI:10.1016/S0090-6980(02)00032-1
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