Entry |
|
Name |
|
Type |
Loss of function
|
Gene |
APC APC regulator of WNT signaling pathway [KO: K02085]
|
Organism |
hsa_var Human gene variants (Homo sapiens)
|
Variation |
|
Variation |
|
Variation |
|
Network |
|
Disease |
H01025 | Familial adenomatous polyposis |
|
Reference |
|
Authors |
Miyaki M, Konishi M, Kikuchi-Yanoshita R, Enomoto M, Igari T, Tanaka K, Muraoka M, Takahashi H, Amada Y, Fukayama M, et al. |
Title |
Characteristics of somatic mutation of the adenomatous polyposis coli gene in colorectal tumors. |
Journal |
Cancer Res 54:3011-20 (1994) |
Reference |
|
Authors |
Kaufmann A, Vogt S, Uhlhaas S, Stienen D, Kurth I, Hameister H, Mangold E, Kotting J, Kaminsky E, Propping P, Friedl W, Aretz S |
Title |
Analysis of rare APC variants at the mRNA level: six pathogenic mutations and literature review. |
Journal |
|
Reference |
|
Authors |
Takayama T, Miyanishi K, Hayashi T, Sato Y, Niitsu Y. |
Title |
Colorectal cancer: genetics of development and metastasis. |
Journal |
|
Reference |
|
Authors |
Nishisho I, Nakamura Y, Miyoshi Y, Miki Y, Ando H, Horii A, Koyama K, Utsunomiya J, Baba S, Hedge P |
Title |
Mutations of chromosome 5q21 genes in FAP and colorectal cancer patients. |
Journal |
|
Reference |
|
Authors |
Nakatsuru S, Yanagisawa A, Ichii S, Tahara E, Kato Y, Nakamura Y, Horii A |
Title |
Somatic mutation of the APC gene in gastric cancer: frequent mutations in very well differentiated adenocarcinoma and signet-ring cell carcinoma. |
Journal |
|
Reference |
|
Authors |
Tamura G, Maesawa C, Suzuki Y, Tamada H, Satoh M, Ogasawara S, Kashiwaba M, Satodate R |
Title |
Mutations of the APC gene occur during early stages of gastric adenoma development. |
Journal |
Cancer Res 54:1149-51 (1994) |
LinkDB |
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