KEGG   VARIANT: 3356v1
Entry
3356v1                      Variant                                
Name
HTR2A mutation
Type
Loss of function
Gene
HTR2A  5-hydroxytryptamine receptor 2A [KO:K04157]
Organism
hsa_var Human gene variants (Homo sapiens)
Variation
mutations
OmimVar: 182135
Network
nt06544  Neuroactive ligand signaling
Disease
H01450  Obsessive-compulsive disorder
H01646  Major depressive disorder
H01649  Schizophrenia
Reference
PMID:9130948
  Authors
Williams J, McGuffin P, Nothen M, Owen MJ
  Title
Meta-analysis of association between the 5-HT2a receptor T102C polymorphism and schizophrenia. EMASS Collaborative Group. European Multicentre Association Study  of Schizophrenia.
  Journal
Lancet 349:1221 (1997)
DOI:10.1016/s0140-6736(05)62413-0
Reference
  Authors
Walitza S, Bove DS, Romanos M, Renner T, Held L, Simons M, Wewetzer C, Fleischhaker C, Remschmidt H, Warnke A, Grunblatt E
  Title
Pilot study on HTR2A promoter polymorphism, -1438G/A (rs6311) and a nearby copy number variation showed association with onset and severity in early onset  obsessive-compulsive disorder.
  Journal
J Neural Transm (Vienna) 119:507-15 (2012)
DOI:10.1007/s00702-011-0699-1
Reference
  Authors
McMahon FJ, Buervenich S, Charney D, Lipsky R, Rush AJ, Wilson AF, Sorant AJM, Papanicolaou GJ, Laje G, Fava M, Trivedi MH, Wisniewski SR, Manji H
  Title
Variation in the gene encoding the serotonin 2A receptor is associated with outcome of antidepressant treatment.
  Journal
Am J Hum Genet 78:804-814 (2006)
DOI:10.1086/503820
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