KEGG   VARIANT: 3481v1
Entry
3481v1                      Variant                                
Name
IGF2 overexpression
Type
Gain of function
Gene
IGF2  insulin like growth factor 2 [KO:K13769]
Organism
hsa_var Human gene variants (Homo sapiens)
Variation
overexpression
Network
nt06210  ERK signaling (cancer)
nt06214  PI3K signaling (cancer)
nt06263  Hepatocellular carcinoma
nt06526  MAPK signaling
nt06530  PI3K signaling
Disease
H00048  Hepatocellular carcinoma
Reference
  Authors
Whittaker S, Marais R, Zhu AX
  Title
The role of signaling pathways in the development and treatment of hepatocellular carcinoma.
  Journal
Oncogene 29:4989-5005 (2010)
DOI:10.1038/onc.2010.236
Reference
  Authors
Alexia C, Fallot G, Lasfer M, Schweizer-Groyer G, Groyer A
  Title
An evaluation of the role of insulin-like growth factors (IGF) and of type-I IGF receptor signalling in hepatocarcinogenesis and in the resistance of hepatocarcinoma cells against drug-induced apoptosis.
  Journal
Biochem Pharmacol 68:1003-15 (2004)
DOI:10.1016/j.bcp.2004.05.029
Reference
  Authors
Minguez B, Tovar V, Chiang D, Villanueva A, Llovet JM
  Title
Pathogenesis of hepatocellular carcinoma and molecular therapies.
  Journal
Curr Opin Gastroenterol 25:186-94 (2009)
DOI:10.1097/MOG.0b013e32832962a1
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