KEGG   VARIANT: 4824v1
Entry
4824v1                      Variant                                
Name
NKX3-1 loss
Gene
NKX3-1  NK3 homeobox 1 [KO:K09348]
Organism
hsa_var Human gene variants (Homo sapiens)
Variation
Allelic loss on 8p
Network
nt06214  PI3K signaling
nt06272  Prostate cancer
  Element
N00082  Loss of NKX3-1 to PI3K signaling pathway
Reference
  Authors
Gurel B, Ali TZ, Montgomery EA, Begum S, Hicks J, Goggins M, Eberhart CG, Clark DP, Bieberich CJ, Epstein JI, De Marzo AM
  Title
NKX3.1 as a marker of prostatic origin in metastatic tumors.
  Journal
Am J Surg Pathol 34:1097-105 (2010)
DOI:10.1097/PAS.0b013e3181e6cbf3
Reference
  Authors
Ouyang X, DeWeese TL, Nelson WG, Abate-Shen C
  Title
Loss-of-function of Nkx3.1 promotes increased oxidative damage in prostate carcinogenesis.
  Journal
Cancer Res 65:6773-9 (2005)
DOI:10.1158/0008-5472.CAN-05-1948
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