KEGG   VARIANT: 4914v1
Entry
4914v1                      Variant                                
Name
TRK fusion
Gene
NTRK1  high affinity nerve growth factor receptor isoform 2 precursor [KO:K03176]
Organism
hsa_var Human gene variants (Homo sapiens)
Variation
TPM3-NTRK1 fusion caused by inversion inv(1)(q21-22q22-23)
COSF: 1330 1320 1319
Variation
TPR-NTRK1 fusion caused by inversion inv(1)(q21-22q25)
Network
nt06210  ERK signaling (cancer)
nt06274  Thyroid cancer
Disease
H00032  Thyroid cancer
Drug target
Entrectinib: D10926<JP/US>
Reference
PMID:16557281
  Authors
Kondo T, Ezzat S, Asa SL.
  Title
Pathogenetic mechanisms in thyroid follicular-cell neoplasia.
  Journal
Nat Rev Cancer 6:292-306 (2006)
DOI:10.1038/nrc1836
Reference
PMID:12652644
  Authors
Alberti L, Carniti C, Miranda C, Roccato E, Pierotti MA
  Title
RET and NTRK1 proto-oncogenes in human diseases.
  Journal
J Cell Physiol 195:168-86 (2003)
DOI:10.1002/jcp.10252
LinkDB

DBGET integrated database retrieval system