KEGG   VARIANT: 7039v1
Entry
7039v1                      Variant                                
Name
TGFA overexpression
Type
Gain of function
Gene
TGFA  protransforming growth factor alpha isoform 1 preproprotein [KO:K08774]
Organism
hsa_var Human gene variants (Homo sapiens)
Variation
overexpression
Network
nt06210  ERK signaling (cancer)
nt06214  PI3K signaling (cancer)
nt06220  Calcium signaling (cancer)
nt06260  Colorectal cancer
nt06263  Hepatocellular carcinoma
nt06526  MAPK signaling
nt06528  Calcium signaling
nt06530  PI3K signaling
Disease
H00020  Colorectal cancer
H00048  Hepatocellular carcinoma
Reference
PMID:16799620
  Authors
Breuhahn K, Longerich T, Schirmacher P
  Title
Dysregulation of growth factor signaling in human hepatocellular carcinoma.
  Journal
Oncogene 25:3787-800 (2006)
DOI:10.1038/sj.onc.1209556
Reference
PMID:9815784
  Authors
Kiss A, Wang NJ, Xie JP, Thorgeirsson SS
  Title
Analysis of transforming growth factor (TGF)-alpha/epidermal growth factor receptor, hepatocyte growth Factor/c-met,TGF-beta receptor type II, and p53 expression in human hepatocellular carcinomas.
  Journal
Clin Cancer Res 3:1059-66 (1997)
Reference
PMID:11252954
  Authors
Yarden Y, Sliwkowski MX.
  Title
Untangling the ErbB signalling network.
  Journal
Nat Rev Mol Cell Biol 2:127-37 (2001)
DOI:10.1038/35052073
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