ERK signaling |
| | | | D1,D2 | | | | | | | | | | | D3 | | | | | |
N00001 |
![](/tmp/network_171931660370696/1_N00001_ds.png) |
EGF | → | EGFR | → | GRB2 | → | SOS | → | RAS | → | RAF | → | MEK | → | ERK | → | CCND1 |
| | | | D1,D2 | | | | | | | | | | | D3 | | | |
N00276 |
![](/tmp/network_171931660370696/2_N00276_ds.png) |
EGF* | → | EGFR | → | GRB2 | → | SOS | → | RAS | → | RAF | → | MEK | → | ERK |
| | | | D1,D2 | | | | | | | | | | | D3 | | | |
N00229 |
![](/tmp/network_171931660370696/3_N00229_ds.png) |
TGFA | → | EGFR | → | GRB2 | → | SOS | → | RAS | → | RAF | → | MEK | → | ERK |
| | | | D1,D2 | | | | | | | | | | | D3 | | | |
N00230 |
![](/tmp/network_171931660370696/4_N00230_ds.png) |
TGFA* | → | EGFR | → | GRB2 | → | SOS | → | RAS | → | RAF | → | MEK | → | ERK |
| | | | D1,D2 | | | | | | | | | | | D3 | | | |
N00277 |
![](/tmp/network_171931660370696/5_N00277_ds.png) |
EREG | → | EGFR | → | GRB2 | → | SOS | → | RAS | → | RAF | → | MEK | → | ERK |
| | | | D1,D2 | | | | | | | | | | | D3 | | | |
N00278 |
![](/tmp/network_171931660370696/6_N00278_ds.png) |
EREG* | → | EGFR | → | GRB2 | → | SOS | → | RAS | → | RAF | → | MEK | → | ERK |
| | | | D1,D2 | | | | | | | | | | | D3 | | | |
N00279 |
![](/tmp/network_171931660370696/7_N00279_ds.png) |
AREG | → | EGFR | → | GRB2 | → | SOS | → | RAS | → | RAF | → | MEK | → | ERK |
| | | | D1,D2 | | | | | | | | | | | D3 | | | |
N00280 |
![](/tmp/network_171931660370696/8_N00280_ds.png) |
AREG* | → | EGFR | → | GRB2 | → | SOS | → | RAS | → | RAF | → | MEK | → | ERK |
| | | | | | | | | | | | | | D3 | | | |
N00041 |
![](/tmp/network_171931660370696/9_N00041_ds.png) |
| | EGFR* | → | GRB2 | → | SOS | → | RAS | → | RAF | → | MEK | → | ERK |
| | | | | | | | | | | | | | D3 | | | | | |
N00012 |
![](/tmp/network_171931660370696/10_N00012_ds.png) |
| | | | | | | | (KRAS*,NRAS*) | → | RAF | → | MEK | → | ERK | → | CCND1 |
PI3K signaling |
| | | | D1,D2 | | | | | | | | | |
N00033 |
![](/tmp/network_171931660370696/12_N00033_ds.png) |
EGF | → | EGFR | → | PI3K | → | PIP3 | → | AKT | ⊣ | BAD |
| | | | D1,D2 | | | | | | | |
N00281 |
![](/tmp/network_171931660370696/13_N00281_ds.png) |
EGF* | → | EGFR | → | PI3K | → | PIP3 | → | AKT |
| | | | D1,D2 | | | | | | | | | |
N00231 |
![](/tmp/network_171931660370696/14_N00231_ds.png) |
TGFA | → | EGFR | → | PI3K | → | PIP3 | → | AKT | → | MTOR |
| | | | D1,D2 | | | | | | | |
N00232 |
![](/tmp/network_171931660370696/15_N00232_ds.png) |
TGFA* | → | EGFR | → | PI3K | → | PIP3 | → | AKT |
| | | | D1,D2 | | | | | | | | | | | |
N00282 |
![](/tmp/network_171931660370696/16_N00282_ds.png) |
EREG | → | EGFR | → | PI3K | → | PIP3 | → | AKT | → | MTOR | → | S6K |
| | | | D1,D2 | | | | | | | | | |
N00283 |
![](/tmp/network_171931660370696/17_N00283_ds.png) |
EREG* | → | EGFR | → | PI3K | → | PIP3 | → | AKT | → | S6K |
| | | | D1,D2 | | | | | | | | | | | |
N00284 |
![](/tmp/network_171931660370696/18_N00284_ds.png) |
AREG | → | EGFR | → | PI3K | → | PIP3 | → | AKT | → | MTOR | → | S6K |
| | | | D1,D2 | | | | | | | | | |
N00285 |
![](/tmp/network_171931660370696/19_N00285_ds.png) |
AREG* | → | EGFR | → | PI3K | → | PIP3 | → | AKT | → | S6K |
N00042 |
![](/tmp/network_171931660370696/20_N00042_ds.png) |
| | EGFR* | → | PI3K | → | PIP3 | → | AKT | → | MTOR | → | S6K |
| | | | D1,D2 | | | | | | | | | | | | | | | |
N00030 |
![](/tmp/network_171931660370696/21_N00030_ds.png) |
EGF | → | EGFR | → | GRB2 | → | SOS | → | RAS | → | PI3K | → | PIP3 | → | AKT | ⊣ | BAD |
N00032 |
![](/tmp/network_171931660370696/22_N00032_ds.png) |
| | | | | | | | (KRAS*,NRAS*) | → | PI3K | → | PIP3 | → | AKT | ⊣ | BAD |
Other RAS signaling |
| | | | D1,D2 | | | | | | | | | | | |
N00103 |
![](/tmp/network_171931660370696/24_N00103_ds.png) |
EGF | → | EGFR | → | GRB2 | → | SOS | → | RAS | → | RALGDS | → | RAL |
N00104 |
![](/tmp/network_171931660370696/25_N00104_ds.png) |
| | | | | | | | KRAS* | → | RALGDS | → | RAL |
WNT signaling |
N00056 |
![](/tmp/network_171931660370696/27_N00056_ds.png) |
WNT | → | (FZD+LRP5/6) | → | (DVL+FRAT) | ⊣ | (GSK3B+AXIN+APC) | ⊣ | CTNNB1 | → | TCF/LEF | ⇒ | (MYC,CCND1) |
N00057 |
![](/tmp/network_171931660370696/28_N00057_ds.png) |
| | | | | | (GSK3B+AXIN) | ⌿ | APC* | ⌿ | CTNNB1 | → | TCF/LEF | ⇒ | (BIRC5,MYC,CCND1) |
N00058 |
![](/tmp/network_171931660370696/29_N00058_ds.png) |
| | | | | | (GSK3B+AXIN+APC) | ⌿ | CTNNB1* | → | TCF/LEF | ⇒ | (BIRC5,MYC,CCND1) |
TGFB signaling |
N00063 |
![](/tmp/network_171931660370696/31_N00063_ds.png) |
TGFB | → | (TGFBR2+TGFBR1) | → | (SMAD2,SMAD3) | = | SMAD4 |
N00064 |
![](/tmp/network_171931660370696/32_N00064_ds.png) |
| | (TGFBR2*+TGFBR1) | ⌿ | (SMAD2,SMAD3) |
N00065 |
![](/tmp/network_171931660370696/33_N00065_ds.png) |
| | (TGFBR2+TGFBR1) | ⌿ | (SMAD2*,SMAD3) |
Apoptosis |
N00098 |
![](/tmp/network_171931660370696/35_N00098_ds.png) |
(PMAIP1,BBC3,BAD,B.. | ⊣ | (BCL2,BCL2L1) | ⊣ | (BAX,BAK1) | → | CYCS | = | APAF1 | → | CASP9 | → | (CASP3,CASP7) |
N00099 |
![](/tmp/network_171931660370696/36_N00099_ds.png) |
| | | | BAX* | ⌿ | CYCS |
N00101 |
![](/tmp/network_171931660370696/37_N00101_ds.png) |
CASP3 | → | DCC | → | (CASP9+APPL1) | → | CASP3 |
N00102 |
![](/tmp/network_171931660370696/38_N00102_ds.png) |
CASP3 | ⌿ | DCC* | ⌿ | (CASP9+APPL1) |
Transcription |
N00115 |
![](/tmp/network_171931660370696/40_N00115_ds.png) |
TP53* | ⌿ | (CDKN1A,GADD45,BAX.. |
|