KEGG   PATHWAY: hvg00945
Entry
hvg00945                    Pathway                                
Name
Stilbenoid, diarylheptanoid and gingerol biosynthesis - Hordeum vulgare subsp. vulgare (domesticated barley)
Description
Stilbenoids are a group of phenolic compounds, biosynthetically interrelated through their common origin from a C6-C2-C6 intermediate, such as resveratol found in grapes. Stilbenoids can also exist as glycosides (e.g., piceid). Combretastatins are potentially useful stilbenoid natural products with known antitumor activity. Diarylheptanoid is a compound group having phenyl rings at 1,7 positions of n-heptane (C6-C7-C6), such as curcumin found in the ginger family. [6]-Gingerol is a major active component of ginger and has diverse pharmacologic effects.
Class
Metabolism; Biosynthesis of other secondary metabolites
Pathway map
hvg00945  Stilbenoid, diarylheptanoid and gingerol biosynthesis
hvg00945

Organism
Hordeum vulgare subsp. vulgare (domesticated barley) [GN:hvg]
Gene
123397264  [KO:K13065] [EC:2.3.1.133]
123398028  [KO:K13065] [EC:2.3.1.133]
123398320  [KO:K13065] [EC:2.3.1.133]
123398632  [KO:K17212] [EC:2.3.1.211]
123399237  [KO:K00588] [EC:2.1.1.104]
123401571  [KO:K13065] [EC:2.3.1.133]
123402374  [KO:K17212] [EC:2.3.1.211]
123402663  [KO:K17212] [EC:2.3.1.211]
123403030  [KO:K17212] [EC:2.3.1.211]
123403696  [KO:K13065] [EC:2.3.1.133]
123403799  [KO:K13065] [EC:2.3.1.133]
123409106  [KO:K00487] [EC:1.14.14.91]
123409657  [KO:K17212] [EC:2.3.1.211]
123409667  [KO:K13065] [EC:2.3.1.133]
123410229  [KO:K00588] [EC:2.1.1.104]
123410442  [KO:K13065] [EC:2.3.1.133]
123412607  [KO:K13065] [EC:2.3.1.133]
123412676  [KO:K17212] [EC:2.3.1.211]
123413297  [KO:K17212] [EC:2.3.1.211]
123413350  [KO:K13065] [EC:2.3.1.133]
123429051  [KO:K17212] [EC:2.3.1.211]
123429079  [KO:K17212] [EC:2.3.1.211]
123429130  [KO:K17212] [EC:2.3.1.211]
123431004  [KO:K13065] [EC:2.3.1.133]
123443083  [KO:K00487] [EC:1.14.14.91]
123444018  [KO:K09754] [EC:1.14.14.96]
123444629  [KO:K09754] [EC:1.14.14.96]
123444718  [KO:K00487] [EC:1.14.14.91]
123445338  [KO:K13065] [EC:2.3.1.133]
123447500  [KO:K00487] [EC:1.14.14.91]
123450995  [KO:K17212] [EC:2.3.1.211]
Compound
C00223  p-Coumaroyl-CoA
C00323  Caffeoyl-CoA
C00406  Feruloyl-CoA
C00540  Cinnamoyl-CoA
C00852  Chlorogenate
C01745  Pinosylvin
C02947  4-Coumaroylshikimate
C03582  Resveratrol
C05901  Piceatannol
C10287  Pterostilbene
C10434  5-O-Caffeoylshikimic acid
C10443  Curcumin
C10462  [6]-Gingerol
C12208  p-Coumaroyl quinic acid
C17740  p-Coumaroyl-diketide-CoA
C17741  Feruloyl-diketide-CoA
C17742  Demethoxycurcumin
C17743  Bisdemethoxycurcumin
C17744  1-(4-Hydroxyphenyl)-1-decene-3,5-dione
C17745  1-(3,4-Dihydroxyphenyl)-1-decene-3,5-dione
C17746  1-Dehydro-[6]-gingerdione
C17747  5-Hydroxy-1-(4-hydroxyphenyl)-3-decanone
C17748  1-(3,4-Dihydroxyphenyl)-5-hydroxy-3-decanone
C17749  Curcumin monoglucoside
C17750  Curcumin diglucoside
C22988  4'-O-Methyl-trans-resveratrol
Reference
  Authors
Katsuyama Y, Kita T, Funa N, Horinouchi S
  Title
Curcuminoid biosynthesis by two type III polyketide synthases in the herb Curcuma longa.
  Journal
J Biol Chem 284:11160-70 (2009)
DOI:10.1074/jbc.M900070200
Reference
  Authors
Ramirez-Ahumada Mdel C, Timmermann BN, Gang DR
  Title
Biosynthesis of curcuminoids and gingerols in turmeric (Curcuma longa) and ginger (Zingiber officinale): identification of curcuminoid synthase and hydroxycinnamoyl-CoA thioesterases.
  Journal
Phytochemistry 67:2017-29 (2006)
DOI:10.1016/j.phytochem.2006.06.028
Reference
  Authors
Masada S, Terasaka K, Mizukami H
  Title
A single amino acid in the PSPG-box plays an important role in the catalytic function of CaUGT2 (Curcumin glucosyltransferase), a Group D Family 1 glucosyltransferase from Catharanthus roseus.
  Journal
FEBS Lett 581:2605-10 (2007)
DOI:10.1016/j.febslet.2007.05.002
Related
pathway
hvg00940  Phenylpropanoid biosynthesis
KO pathway
ko00945   

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