Ictalurus furcatus (blue catfish): 128620136 Help Entry 128620136         CDS       T09387                                  Symbol ryr1a Name (RefSeq) ryanodine receptor 1   KO K04961   ryanodine receptor 1 Organism ifu  Ictalurus furcatus (blue catfish) Pathway ifu04020   Calcium signaling pathway ifu04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:ifu00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     128620136 (ryr1a)    04020 Calcium signaling pathway     128620136 (ryr1a)  09180 Brite Hierarchies   09181 Protein families: metabolism    01009 Protein phosphatases and associated proteins [BR:ifu01009]     128620136 (ryr1a)   09183 Protein families: signaling and cellular processes    04147 Exosome [BR:ifu04147]     128620136 (ryr1a)    04040 Ion channels [BR:ifu04040]     128620136 (ryr1a) Protein phosphatases and associated proteins [BR:ifu01009]  Protein serine/threonine phosphatases   Phosphoprotein phosphatases (PPPs)    Protein phosphatase-1     PP1-interacting proteins (PIPs)      128620136 (ryr1a) Exosome [BR:ifu04147]  Exosomal proteins   Exosomal proteins of other body fluids (saliva and urine)    128620136 (ryr1a) Ion channels [BR:ifu04040]  Voltage-gated cation channels   Ryanodine receptor    128620136 (ryr1a) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 Ins145_P3_rec SPRY MIR RIH_assoc Ion_trans EF-hand_7 Motif Other DBs NCBI-GeneID:  128620136 NCBI-ProteinID:  XP_053500806 LinkDB All DBs Position 16:5235490..5297810 Genome browser AA seq 5072 aa AA seqDB search MAEGGEGDEEIQFVRTEDQVVLQCTATILKEQIKLCLSCEGFGNRLCFLETTSNAQNVPP DLAICVFILEQSLSVRALQEMLSHTSEDVDLDKWSSQGGGHRTLLYGHAILLRHTHSGMY LSCLTTSRSLTDKLAFDVGLQEDSTGEACWWTIHPASKQRSEGEKVRVGDDLILVSVSSE RYLHLSYASGDLMVDASFMQTLWNMNPVSSGCELVEGYLTGGYVLRLFHGHMDECLAIPA AEQGEERKNAHYEGGPVCSHARSLWRLEPLRIGWSGGHIKWGQPFRVRHITTGRYLCLDD EKGLLVVDPEKANTKSSAFCFRASKEKTEVAQKRDVEGMGAPEIKYGESMCFVQHVATGL WLTYASVDAKSARLGPVKRKAILHQEGHMDDALTVARSQTEESQAARMIYSTAGLFTQFI KSLDTLSGKNKSAAPPPPSLPLESVVLLLQDLIFYFRPPDEDLEHEEKQSKLRSLKNRQN LFQEEGMITLVLDCIDRLNVYNTSAHFSEFAGEEAAESWKEIVNLLYELLASLIRGNRAN CALFCDNLDWLVSKLDRLEASSGILEVLYCILIESPEVLNIIQENHIKSIIALLDKHGRN HKVLDVLCSLCVCNGVAVRSNQNLITENLLPRRDLLLQTQIINYVTSMRPNIFLGTCEGS TQYKKWYYELIVDHVEPFLTAQAGHLRVGWALTEGYSPYPGGGEGWGGNGVGDDLYSYSF DGLHLWSGRVPRHVASPNQHILAAEDVVSCCLDLSVPSISFRINGHPVQGMFENFNLDGL FFPVVSFSAGIKVRFLLGGRHGDFKFVPPPGYAPCYEAVLPKDKLRIEPIKEYKNDLDND VRNLLGPTQSLSHTAFTPNPVDTVQIVLPPHLERIREKLAENSHELWAVTRIEQGWTYGP FRDDNKKLHPCLLDFQSLPEPERNYNLAMSGETLKTLLALGCHVGMGDEKAEENLKKIKL PKTYTQSNGYKPAPLDLNHVKLTPNQNTLVERLAENGHNVWARDRVRQGWTYSIVQDIVN KRNPRLVPYNLLDEKTKKTNRDTVCAAVRTLIGYGYNIEPPDQESSGHVGNGTGNKIRVF RAEKSYAVTQGKWYFEFEAVTVGEMRVGWARPNVHADKELGTDDLAYVFNGCKGQRWHVG SEPFGRQWQPGDVVGCMIDLAELNIMFTLNGEMLISDSGSEMAFKDIEIGEGFIPVCSLG LSQVGRINLGQNVSSLRYFTICGLQEGFEPFAINMKRDITMWFSKSLPQFIPVPTDHPHI EVSRVDGTVDSAPCLKLTHRTFGSQNANTDLLFFRLSMPIEFHESFKVEAGATPLTRALT IPEDEALEVDPNSEYELLKKSATRREQEEKEKEPSVPKELPGTKEAENEKDTTTEKSKKR GFFSKAKKAAFIAPPPVVPTVPRLMEDVVPDDRDDVDIISNTTTHYYSVRVFAGQEPGGV WAGWVTPDYHYYDLHFDISKVRNVTVTVGDDKGNIHHSMKRSNCYMVWGGEFSGSQQTRI TQEDFVIGCLVDLDTGLMTFTANGKEVNTFYQVEPNTKLFPAVFCLPSSQNMLQVELGKL KNIMPISAAMFRSDRRNPVPQCPPRLDVQMLTPVIWSRMPNRFLSHQTGRVSERLGWMVQ CTDPLTMMALHIPEENRCIDILELSECTDLLKFHHHTLKLYGSVCALGNNRVAHALCSHV DESQLFYAIENSYLPGPIRSGYYDLLISMHLESAKRNRLMTNREFIVPMTDETRSITLRA HTLPAVGRSTCLRPTLQFSHTGFVGTNADLYTLSPFIPLQTLKDHALSMLTEAVQDGGQA MRDPVGGSVEFHFVPILKLISTLLIMGVFEDEDVKHILKLIEPTVFREEKGGQAEEDKSG EGAERQLASKEAGVEVKEKEERVDGWTEDEGMGEEEEEEEELEDDEEEEEDQTEQEDEEE HPAPEKADKEKAERREAEPQAEPEAGPIVGREEPKEEEEVGEGLLHMKLPESVKLQMCTL LQYFCDCELRHRVEAIVAFSDRFVTQVQSNQKQRYNQLMQAFTMTAAETARKTREFRSPP QEQVNMLMNFKNCPDEEDSPVPEEVRGELQMFHNDLLAHCGIHVEEEEEEEHVDTSLRGR FFRLLEKVKRLRRRKQETEKEPEEEKKPSTLQELISHTMIHWAQESFIQDPELVRLMFSL LHRQYDALGELIRALPKAYTINAVSMQDTMELLECLSQIRSLLIVQMGPEEERLMIQSIG NIMSNRVFYQHPNLMRALGMHETVMEVMVNVLGGGDSKEIRFPRMVTNCCRFLCYFCRIS RQNQRSMFDHLSYLLQNSGIGLGMRGSTPLDVAAASCIDNNELALALQEQDLEKVVKYLA GCGLQSCPMLLSKGYPDIGWNPCGGEKYLDFLRFAVFVNGESVEENANVVVRLLIRRPEC FGPALRGEGGNGLLAAIEEAIKISEDPARDGPTVKKDRRFPMFGGEEQHEESRVHLGNAI MSFYAALIDLLGRCAPEMHLIQAGKGEALRIRAILRSLVPIEDLVGVISLPQQIPAFGKD NSIIEPKMSASFVPDHKAPMVLFLDRVYGIDNQDFLLHVLEVGFLPDMRAAASLDTAAFS TTEMALALNRYLCSAVLPLITKCAPLFAGTDHRAIMIDSMLHTIYRLSRGRSLTKAQRDV IEECLMSLCKYLRPSMLQHLLRRLVFDVPILNEYAKMPLKLLTNHYERCWKYYCLPNGWA NFGVSSEEELHLTRKLFWGIFESLAHKKFDAELFKIAMPCICAIAGALPPDYVDASYCSK TEKKASVDAEGNFDPKPVDTTNTIIPEKLDGFINRYAEYTHDRWAFEKIQSNWTFGEVLD ENAKTHPMLRPYKTFSEKDKEIYRWPIKESIKAMIAWGWTLDKARDGDEDKGEKKAARKI SQTAQATYDPSHGYNPQPINISGMTLSRELQSMAEQLAENYHNTWGRKKKMELQAKGCGT HPLLVPYDTLTAKEKARDREKAHELLRFLQLNGYAVTRGLKDMESDISSIEKRFAYGFLQ KLLKWMDIAQEFIAHLEAVVSSGRVEKSPHEQEIKFFAKILLPLINQYFKNHCLYFLSTP AKILGSGGHASNKEKEMIASIFCKMSALVRHRVFLFGTDAPAIVNCLHILARSLDARTVM KSGPEIVKAGLRSFFESAADDIEKMVENLKLGKVSKGNQPVKGVSQNINYTTVALLPVLT SLFDHIAQHQFGDDVILDDLQMSCYRIMCSIYSLGTVKTPHAERHRPALGECLAHLAAAM PVAYLEPHLNEYNAFSVYTTKTPRERAILGLPNEVQELCLDIPELDVLIRDIGHLAESGA RYTEMPHVIEVTLPMLCNYLPRWWERGVENHPELEGKLCTHVTSEHLNQLLGSIMKIVVN NLGIDEAPWMKRLAVFSQPIVSRAKPEMLKSHFIPTMEKLKKRSAKVVAEEEHLRMEGKT EGDEEEGTIRDEFAVLCRDLYALYPLLIRYIDNNRARWLTCPDPDAEELFRMVGEVFIFW SKSHNFKREEQNFVVMNEINNMSFLTADSKSKMSKAGNAEAGGSDVERTKKKRRGDRYSV QTSLIVAALKKMLPIGLNMCSPADHELINLAKFRYSLKDTDEEVREFLQNNLHLQGKVEN PSMRWQMALYKMMAGKAEDADAPEKVVKRVQEVSAVLYHIEVTEHPFKSKKMVWHKLLSK QRRRAVVACFRMTPLYNLPSHRASNMFLDGYKRNWLHTEGLAFEDRMIDDLSKAMEEEEE EEEEKETKPDPLHQLILHFSRTALTEKSKLDIDYLYMAYADIMAKSCHIGEEDEGGDEDQ EGDEEEMSFEEKEMEKQRLLYQQSRLHNRGAAEMVLQMISACKGETGCMVSSTLKLGISI LNGGNSDVQQKMLDYLKDKKDVGFFLSLQTLMQTCCVLDLNAFERQNKAEGLGMVSEEGT NMKLERGEKVMADDEFTCDLFRFLQLLCEGHNNDFQNYLRTQTGSTTTINIIICTVDYLL RLQESISDFYWYYSGKEIIDEPGKRNFSKAMTVAKQVFNTLTEYIQGPCTGNQQSLAHSR LWDAVVGFLHVFAHMMMKLAQDSSQIGLLKELLDLQKDMVVMLLSLLEGNIVNGTIARQM VDMLVESSSNVEMILKFFDMFLKLKDIVASGAFRDYVTDPRGLISKKDFQKAMDSQKQYT PSEIQFLLACSEADENEMINYEEFASRFQEPAKDIGFNIAVLLMNLSEHVPHDTRLQNFL EQAESVLNYFRPFLGRIEIMGASRKIERIYFEISEVNRKQWEMPQVRESKRQFIFDVVNE GGESEKMELFVNFCEDTIFEMNIASQISEKEEEKEEDDEEVDEGNEAGGDGADDEDGDKN NQSESSSAFADFLNSVVHFMGMFTFRNLRKQYRRLRKMTVKEISVGIATFLWTILLGVFH FIFSVCKGFFLIVWHTLFGGSLVEGAKNITVTELLASMPDPTQDEVHGDLPGEAGSGEEQ EAGGVTDSTEAAQGEEEYEDSTEQDVGKIPGIDTPGGLGDMGDTTPVEPPTPEGSPLTKR KMQPEEGGTEQTGAPEEPPPEPEKADTENREKMEKEAEQKTEGLQEKVKVQKPSKAKKEI KTIRDGGFELWNELDVQRNKFMNYLSRNFYNLRFLALFIAFALNFILLFYRVSDTPPGDE ELEGSGVFEGSGLFEGSGEQMDGSGAEDMGGDDDDDEDGPVYYFLEESTGYMQPTLSFLA IMHTVISFICIIGYNCLKIPLVIFKREKELARKLEFDGLYITDQPEDDDIKGQWDRLVLN TPSYPNNYWDKFVKRKVLDKYGDIYGRERIAELLGMDLASLDVSKQQTDKKPQESDNSML AWITSVDIKYQIWKFGVVFTDNTFLYLVWYTVMSLLGHYNNFFFACHLLDIAMGVKTLRT ILSSVTHNGKQLMMTVGLLAVVVYLYTVVAFNFFRKFYNKSEDEDEPDMKCDDMMTCYLF HMYVGVRAGGGIGDEIEDPAGDEYELYRVVFDITFFFFVIVILLAIIQGLIIDAFGELRD QQEQVKEDMETKCFICGIASDYFDTTPHGFETHTLEEHNLANYLFFLMYLINKEETEHTG QESYVWKMYQERCWDFFPAGDCFRKQYEDQLA NT seq 15219 nt NT seq  +upstreamnt  +downstreamnt atggctgaaggaggagaaggagacgaggagattcagtttgtacggacggaggatcaggtg gtgctacagtgtacagccactatactgaaggagcagattaaactctgcttgtcctgtgag ggatttggaaatcgactctgcttcctcgagacaacatctaacgctcagaatgtgccacct gatctggctatctgtgtcttcatcctggagcagtcattatctgtacgcgctctacaggag atgctctctcataccagcgaggatgtggatttggataaatggtcatcacaaggtggaggc catcggacgctgttgtacggacacgccatcctgctcagacacacacactcgggcatgtat cttagctgtttgacaacgtcacggtccctcacagacaagctggcgtttgacgttggctta caggaagactcgacaggtgaggcatgttggtggacgatccaccctgcttctaagcaaagg tcagaaggtgagaaggtcagagtgggtgatgacctcatcctggtcagtgtctcatctgaa aggtacctgcatctgtcctatgcgagtggagatctcatggtggacgcctccttcatgcag acgctgtggaacatgaacccagtgtccagtggatgtgagctggttgaagggtatttgacc gggggatacgtgcttcggctcttccacggtcacatggatgagtgtttagctattcctgct gctgaacagggggaagagcgcaaaaatgcccattacgagggaggcccagtttgcagtcat gccagatctctgtggagactcgagcccctccggattggatggagcggcggccatattaaa tggggtcagccattcagagtgcgtcacatcactacaggtcgatatttgtgtttagatgat gagaaaggcctgcttgttgtggatccagagaaagcaaacacaaagagctctgcgttctgc tttcgagcctcaaaggagaagaccgaagtggctcagaagcgtgatgtggaagggatgggt gctccggagataaagtacggcgagtccatgtgctttgtgcagcatgtagctacaggcctg tggctcacctacgcctctgtagatgctaaatctgctcgcctggggcctgtgaagcggaag gcgattcttcatcaggaaggtcacatggatgacgctctgaccgtcgctcgctctcagact gaagagtctcaggctgctagaatgatctacagcactgctggcctcttcacccagttcatc aagagtttggacactctgagtgggaagaataaaagcgctgctcctcctcctccatctctc ccactggagtctgttgtcctcttgctccaggatctgatcttctacttcagacctccagat gaggacctggagcacgaggagaaacagagcaaactgaggtctctcaaaaatagacagaac ctgtttcaggaagaggggatgatcactctggtgttggactgcattgatcgtctgaatgtc tacaacacttcggctcatttttccgagttcgctggagaggaggcagctgaatcctggaag gagattgttaacctgctctacgagctgctggcgtctctgattagagggaacagagcgaac tgcgcactcttctgtgacaatctggactggctggtcagcaaactggaccgactggaggcc tcatccggcatcctggaggtgctgtactgcattctcatcgaaagccctgaggtgttaaac attatccaggagaaccacatcaagtccatcatagctctgctggacaaacatggacgcaat cacaaggtgttggacgtactctgctcgctgtgtgtgtgtaacggtgtggctgtgaggtcc aatcagaatctcatcacagagaatctacttccacgtcgtgaccttttgctccaaacgcaa atcattaattatgtcacaagcatgaggccaaacatcttcctggggacctgtgagggatcc acacagtataagaagtggtattacgagctgatcgtggatcacgtggagccgtttctgacg gcccaggcgggtcaccttcgggtgggctgggcactgactgagggttacagcccgtaccct ggtggaggagagggctggggcggtaatggtgtaggagatgacctctactcctacagcttt gatggcctccatctgtggtcggggcgtgtccctcgacacgtggcatcgcccaatcagcac attctggcagcagaagacgtagtgagctgctgtctggatctaagcgtgcccagtatctca ttccgcattaacgggcatcctgttcagggcatgttcgagaacttcaacctggacggcctc ttcttccctgtcgttagcttctccgctggaatcaaggtccggttcctcctgggtggacgc catggagactttaagtttgttccacctccgggatacgctccgtgctacgaggctgtgctg cccaaagacaaacttcgcatcgaacccattaaggagtataaaaacgacttggataatgat gtgaggaaccttctgggcccaacacagtctctgtcccacactgccttcactccaaatcct gtggacaccgtgcagattgttcttcctccacatctggagcggatcagagaaaaactggca gagaacagccacgagctctgggctgtaactcgcatcgaacagggctggacttacggacct ttccgtgatgataataaaaagctgcatccgtgtctgctggacttccagagccttccagag ccagagaggaactacaacctggcaatgtcaggggaaacgctcaaaactcttcttgccctg ggttgccatgttggaatgggagatgaaaaagcggaggaaaatttgaaaaagataaaactg cccaaaacctacacgcagagcaacggctataaacctgctcctctggacctgaaccacgtt aaactgaccccgaaccagaacacactggtggagcgactcgctgagaacggacacaacgtg tgggctcgagaccgcgtgcgccagggctggacttacagcatcgtacaggacattgtaaac aagcgtaacccccggctcgtgccatataatctcctggacgagaaaaccaagaagacgaac agagacaccgtgtgcgctgcggttcgaaccttgatcggttacggctacaacatcgagcct ccggaccaggagagcagcggccatgttggtaacggaactgggaataagatccgcgtgttc agggctgagaaatcgtacgctgtgactcagggaaaatggtactttgagtttgaggcggtg acagtgggggagatgagggtcggctgggccagaccaaacgtccacgctgataaagagctt ggcacagacgacctcgcctacgtctttaacggctgcaagggtcagcgttggcatgtgggc agcgagcccttcggtcgtcagtggcagccgggagacgtcgtgggctgcatgatcgacctc gccgagctgaacatcatgttcacgcttaacggagagatgctgatcagtgactccggctct gagatggctttcaaagacattgagattggagaaggctttatccctgtatgtagtctgggc ctctctcaggtgggtcggatcaacctgggccagaacgtcagcagcctgcggtattttact atctgcggtctgcaagaaggcttcgagcccttcgccataaacatgaagagagacatcacc atgtggttcagcaaaagcctgccgcagttcattcctgttcctactgaccaccctcacatc gaggtatcccgtgtggacggcacagtggacagcgccccctgtctcaaactgacccacagg acgttcggctcccagaacgccaacacggacctgctcttcttcagactgagcatgcccatc gagttccacgagtcgtttaaggtagaggcgggggcgacaccgctgacacgtgccctcacc atcccggaggacgaggccctggaggtcgaccccaactctgaatatgagctgctgaagaag agcgccacccgcagggagcaggaggagaaagaaaaggagccgtcggtacccaaagagctg ccgggcaccaaggaggcggagaacgagaaagacaccactacagagaagagcaaaaagaga ggatttttctccaaagcgaagaaggctgcttttatcgctcctccgcctgtcgttcccact gtccctcgcctgatggaggacgtcgtccctgatgatcgagacgacgtggacattatttcc aatacaactacacattactactcagtgcgtgtatttgcgggacaggagcccggtggagtg tgggcaggctgggttactcctgattaccactattatgaccttcatttcgatatcagtaaa gtgagaaacgtcacagtcactgtgggtgatgataaaggcaacatacaccacagcatgaag cgcagtaactgttacatggtgtggggcggagagttcagcggctcgcaacaaacacgcatc actcaggaggactttgtcattggctgcctggtggatctggacacgggtctcatgaccttc acggccaatgggaaagaggtgaacacgttctaccaggtggagcccaataccaaactcttc cctgctgttttctgtttgccctccagccagaacatgctgcaggtggagctcggcaagctc aagaatatcatgcccatctcggcagccatgtttcgcagcgatcggaggaatccggtcccg cagtgccctccccgcctcgatgtccagatgctgaccccggtgatctggagccgcatgcca aaccgcttcctgtcccatcagactggccgcgttagtgagagacttggctggatggtacag tgcacagacccgctcaccatgatggcactacacattccagaggagaacaggtgtattgat atcctggaactttcggagtgtactgacttgctgaagtttcaccaccacacgctgaagctc tatggctcggtgtgcgctctaggaaacaaccgcgtggcccacgccctctgcagccacgtg gacgagtctcagctcttctacgctatagagaactcgtacctgcccggcccgatccgcagc ggctactacgacctgctcatctccatgcacctggagtcggccaagaggaaccgcctcatg actaaccgggagtttatcgtgcccatgactgatgagacacgctccatcacgctgagggct cacacactccccgccgtgggacgctccacctgcctccgacctacactgcagttctcacac accggcttcgtgggtaccaacgctgacctgtacacactcagtcctttcataccactgcag acgctgaaagaccacgccctgagcatgttaacggaggctgtgcaggacggaggccaggcc atgcgtgatcctgtagggggcagcgtggagttccactttgttcctatcctgaagctgatc agtacgctgctcatcatgggtgtgtttgaggacgaggacgtgaaacacatcctcaaactc atcgagcccaccgtgttccgagaggagaaaggcggtcaagcggaggaggacaagagcgga gaaggagcagagcggcagctcgcttctaaagaggcaggagtggaggtgaaggaaaaggag gaacgggtggatgggtggactgaggacgaaggaatgggagaggaggaagaagaggaagaa gaactggaagatgacgaagaggaggaggaagaccagacagagcaggaagatgaggaagag caccctgcacctgagaaagctgacaaagagaaagcagagcgtagagaggcggagccacag gctgagccagaggccgggcctatagtggggagggaggagcctaaagaggaggaggaagtc ggggaggggctactgcatatgaaactacccgagtctgtaaagttgcagatgtgtactctg ctgcagtatttctgcgactgtgagctgcgtcaccgcgttgaggccattgtcgctttctct gataggttcgtcactcaggttcagtccaatcagaagcagcgttataaccaactcatgcag gccttcaccatgacagcagcagagacggctcgcaaaaccagagagttccgttcaccacca caagaacaggtgaacatgctgatgaattttaagaattgtccagacgaagaggacagtcct gttcctgaggaagtccgtggcgaacttcagatgtttcacaatgacctgctggctcactgc ggtatacatgttgaggaagaggaggaggaagagcacgtggacacgtcgctgcgtggacga ttcttcaggttactcgaaaaagtgaaaagactacggaggagaaagcaggagacggagaag gagccagaggaagagaagaaacccagcactttgcaggagctgatctcccacacaatgata cactgggctcaggagtcgttcatccaggacccagagctggtgaggctcatgttcagcctg ctgcaccggcagtacgatgctctgggagagctgatccgcgctctacccaaagcctacacc atcaacgccgtgtccatgcaggacaccatggagctgctcgagtgtcttagccagatccgc tcgcttctcatcgtccagatgggccctgaggaggagaggctcatgatccagagcatcgga aatataatgagtaacagggtgttctaccagcatcccaatctgatgagagcgctgggcatg cacgagaccgtcatggaggtcatggtcaacgtactcgggggcggagactcgaaggagatc cgtttcccacgcatggtgactaactgctgtcgtttcctgtgttatttctgccgaatcagc cgtcagaatcagcgctccatgttcgaccacttgagttacctgctgcagaacagtggcatc ggcctggggatgcgaggctctacacctcttgatgtcgctgcagcgtcctgtatcgataac aacgagctggcgctggctcttcaggagcaggacctggagaaggtggtaaagtatttggcc ggttgcgggctgcagagttgccccatgctcttgtcgaaaggttaccctgatatcggctgg aacccatgcggtggagaaaaatacctcgacttcctccgattcgccgtctttgttaatgga gagagcgtggaggagaatgccaacgtggtggtgcgtctcctgatcagacggcccgagtgt ttcggccctgcgctcagaggagagggtggtaatggccttttggccgccattgaagaagcc attaagatctctgaggacccggccagagacggccccactgtcaaaaaggacagacgcttc cctatgtttggaggagaagagcaacacgaggagagcagagttcatctgggaaatgccatc atgtccttctacgccgctctcatcgacctgctgggacgctgcgctcctgaaatgcatctg atccaggcagggaaaggagaagctctgaggatcagggctattctcagatctctggttccc attgaggatctcgtaggtgttattagtcttccacagcagatccctgcgtttggaaaagac aacagtattatcgagccaaagatgtctgccagttttgtcccggatcacaaggcccccatg gtgctgttcctagacagagtgtacggcatagataaccaggatttcctcctacatgtgctg gaagttggatttcttcccgacatgcgagcagcagcttccttggatacggctgcgttcagt actacagagatggctctggctctgaaccgctatctctgctcggctgtcctccctctcatc actaaatgcgctcctctgttcgccggcaccgatcaccgcgccatcatgatcgactccatg ctgcacaccatctacaggctctcccgaggacgctcgctcactaaagctcagagagacgtc atcgaggagtgcctcatgtctctgtgcaagtatctgcggccatcgatgcttcaacacctt ctaagaagactcgtgtttgatgtgcccattctcaatgagtatgccaaaatgcccctgaag ttgctgactaatcattacgaacgctgctggaagtattactgcctgcccaatggctgggcc aacttcggtgtgtcatcagaggaagagcttcacctgacccgcaaactcttctgggggatt tttgaatctctggcgcacaagaaatttgatgcagaattgtttaaaatcgcaatgccctgc atctgtgccatagccggtgccctacctcctgattatgtggatgccagttactgttccaaa acagaaaagaaagcgtctgtcgatgccgagggaaactttgatcccaaaccggtggacacg accaacactataatccctgagaaactggacggatttatcaacagatacgcagagtacacc catgatagatgggcttttgagaagatccaaagcaactggacatttggtgaagtgctggat gaaaacgccaagactcatcctatgctcagaccgtacaaaacattttctgagaaggataaa gaaatttaccgctggcctattaaagaatccataaaggccatgatagcctggggatggacg ctcgacaaagccagagacggagacgaagacaaaggagagaagaaagcggcacggaaaatc tctcagaccgcacaggcgacgtatgacccgagccacggctacaaccctcagcctataaac atatccggcatgactctgtccagagagctgcagtccatggcggagcagctggccgagaat taccacaatacctggggacgcaagaagaagatggagctccaggcgaagggttgtgggact caccctctgctcgttccctacgacacgctaacggccaaagagaaagctcgagaccgcgag aaggcgcatgagctgctcagattcctccagctgaacggatacgcagtgacgagagggctg aaggacatggagagcgacatctcctccattgagaagcgctttgcctacggcttcttacag aagctgctcaagtggatggacatcgctcaggagttcatcgctcatctcgaggcggtggtc agcagcggtcgtgtggagaaatcacctcatgagcaggagatcaagttcttcgccaagatc ctcttgccgttgataaatcagtattttaaaaaccactgcctctatttcctgtccactcct gctaaaatcctgggcagcggcggccacgcctcgaataaggagaaagaaatgatcgccagt atattctgtaagatgtctgctctggtgagacacagagtttttctcttcggaacggacgcc cctgctatcgtgaactgtctccacatactcgcacgctcgctcgacgcaagaacggtgatg aaatcaggacccgagattgtgaaggccgggttgagatcattcttcgagagtgcggctgat gacatcgaaaagatggtggagaacctcaaactgggcaaagtgtcgaaaggcaaccagccg gtgaaaggcgtatctcaaaatattaactatactaccgtggccctgctgccggtcctcacc tcgctgttcgatcacatcgcacagcaccagtttggagacgacgtcatactggatgacctg cagatgtcctgctacagaatcatgtgcagcatttactctctcggcaccgtcaagactcct catgccgaaagacacaggccagctttgggagagtgtttggctcatttagctgcagcgatg cctgtggcgtacctcgagcctcatctgaacgagtacaatgctttctctgtttataccacc aaaacccccagagagagagccatcctgggtctgcctaatgaggtgcaggagttgtgtttg gacatcccggagctggacgtgttgataagggatatcggtcacctggccgaatcaggcgca cgctacacggagatgccccacgtgattgaggtcaccctgcccatgctgtgtaactatctg ccccgctggtgggagaggggcgtggaaaaccaccccgagctggagggcaaactctgcacc cacgtcacctccgagcacctcaaccagctcctgggcagcatcatgaagatcgtcgtcaac aacctgggcattgacgaggctccctggatgaaaagactggcagtgttctctcagccgatc gtgagcagagcgaagccagagatgctcaagtctcacttcatcccgacgatggagaagctg aagaagcgctcggcgaaggtggtggctgaggaggagcacttgcgcatggagggcaaaacg gagggtgacgaggaggagggaactatacgggacgagttcgccgtcctctgcagagattta tacgctctttaccctctactcatccgctacatagacaacaacagggcgaggtggttaacc tgccctgaccccgatgctgaggaactgttccgtatggtaggagaggtcttcatcttctgg tccaaatctcataactttaagcgtgaggagcagaactttgtggtgatgaacgagataaac aacatgtccttcctcaccgccgacagcaagagcaagatgagtaaggccggaaacgctgag gctggcggctctgatgtagaacgtactaagaagaagaggcgaggggaccgttactctgtg cagacctctctgatcgtggccgctctgaagaagatgctccctatcggtctcaacatgtgc tctccggccgatcatgagctcattaacctcgccaagttccgctactctctgaaagacacg gatgaagaggtgagagagttcctacagaacaacctgcatcttcagggaaaggtggagaat ccctccatgcgttggcagatggctctgtataagatgatggcaggaaaggcggaggatgcc gacgctccagagaaagtggtgaaaagagtacaggaggtttcagcagtgctttaccacatc gaggtgaccgagcatccgttcaaatccaaaaagatggtttggcacaaactgctgtccaag cagagacggcgtgcggtggtggcctgcttcaggatgactccgctgtacaacctgcccagc catcgagcctctaacatgttcctcgatggatataaaagaaactggctccacaccgaaggc ctcgcttttgaagaccggatgatcgatgacttatcaaaggcgatggaggaagaggaggag gaagaagaggagaaagagacgaagcctgatcctcttcatcagctcatccttcacttcagc cgcaccgctctcacagagaaaagcaaactcgatatagattatttgtacatggcgtatgct gacatcatggcaaagagctgccacataggtgaggaggatgaaggtggggatgaagatcag gagggagatgaagaggaaatgtcgtttgaggagaaagagatggagaaacagaggctcctg tatcagcagtctcggcttcataatcgtggagctgcggagatggtgctgcagatgatcagc gcgtgtaaaggtgagaccggctgcatggtgtcgtccactttaaagctgggaatttccatc ctgaacgggggaaacagtgatgtgcaacagaaaatgctggactatctgaaggacaaaaag gacgttggctttttcctcagtttgcagactctgatgcagacctgctgcgtgttggacctg aacgcctttgagagacagaataaagctgaaggtttgggcatggtgtcagaggagggaaca aacatgaagctagaacggggtgagaaagtgatggctgatgacgagttcacctgcgacctc ttccgcttcctgcagctgctctgtgaaggacacaataatgatttccagaattacctcaga acgcagacaggaagcacaacgaccatcaacatcatcatctgcactgtggattacttgctc cgcctgcaggagtccatcagcgatttctactggtattactcaggtaaagagatcatagac gagccgggaaagagaaacttctctaaagccatgactgtggccaagcaggtgttcaacaca ctcactgagtacatacagggtccgtgtacaggtaaccagcagtctttggcccacagcagg ctttgggatgctgttgttggtttccttcatgtttttgctcacatgatgatgaagctggct caggactcgagtcagatcggcctgctgaaagagctgctggacctgcagaaggacatggta gtcatgctgctctctctactcgagggtaatatcgtaaacggcacgattgctcgtcagatg gtggacatgctggtcgagtcttccagtaatgttgagatgatcctcaaattcttcgacatg ttcctcaaactgaaagacatcgtcgcttctggcgcgttccgtgattacgtaactgatccc agaggactgatctccaaaaaggacttccagaaagctatggacagtcagaagcagtacacg ccctcagagatccagttcctcctggcctgctcggaagccgacgagaacgagatgatcaac tacgaggaatttgctagccgattccaggagccggcgaaggacatcgggttcaacatcgcc gtgctcctgatgaacctttccgagcacgtcccacacgacaccaggctccagaatttcctg gaacaggccgagagcgtcctgaactacttcaggccgtttttgggacggatcgagatcatg ggcgcgagcagaaagatcgagaggatctatttcgagatcagcgaggtcaaccggaagcag tgggagatgcctcaggtccgagagtccaagcggcagttcattttcgacgttgtcaacgag ggtggagaatcagagaagatggagctttttgtcaatttctgcgaggacaccatttttgag atgaacatcgcatcccagatctcagagaaggaagaagagaaagaagaagatgatgaggaa gtagacgagggaaacgaggcagggggagacggagctgatgatgaagatggcgataaaaac aaccaatcggagtcgagctctgcgtttgctgacttcctgaacagcgtggttcacttcatg ggcatgttcaccttccgtaacctgcgcaaacagtacaggcggctcagaaagatgaccgtc aaggagatcagcgtcggcatcgccaccttcctctggaccatcttactgggcgtgttccac ttcattttcagtgtgtgtaaaggattcttcctgatcgtttggcacactcttttcggaggc agtttggtggaaggagccaaaaacatcacagtgacggagctcctggccagcatgcctgac cccacgcaagacgaagtgcacggagaccttcctggagaagcaggaagcggtgaagaacag gaagcgggaggagtaacggattccactgaggcggcacaaggagaagaagaatatgaagac agcacagagcaagatgtggggaagatcccaggtatcgacacacctggaggtctgggagat atgggagatacgacacctgttgaaccaccaactccagagggttctcctttaaccaagagg aagatgcagcccgaggagggaggaaccgagcagacaggagctcctgaagagcctcctcca gagccggagaaagccgacactgaaaatagagagaagatggaaaaggaagccgagcagaag accgaggggctgcaggaaaaagtaaaggtccagaagcccagcaaggccaagaaagagata aaaacgatcagagacggaggatttgagctgtggaacgagctggatgtccagcgaaataaa ttcatgaattatctgtctcgcaacttctacaacctccgcttccttgctttgtttatcgcc ttcgccttgaacttcatcctgctcttctacagggtgtcggacacgcctccgggtgatgag gagcttgaaggttccggtgtgtttgagggttctgggctttttgaaggttcgggtgaacag atggacggctctggagcggaggatatgggaggtgacgatgatgatgatgaggatggccct gtgtattactttctggaggagagcacaggatacatgcagcccacgctgtccttcctcgcc atcatgcacaccgtcatctccttcatctgcatcatcggatacaactgtctcaagatccca ctggtgatctttaagcgagagaaggagctggcgaggaagctggagtttgatggtctttac attaccgaccagcctgaagatgatgatattaaaggacagtgggacagactcgtgctcaac actccctcgtatcctaataactactgggacaagtttgtcaaacgcaaggtgctagataaa tacggcgatatttatggacgagagcggatcgcagagctgttggggatggacctcgcgtcg ctggacgtcagcaaacaacaaaccgataaaaaaccgcaagaatcggataactccatgtta gcctggatcacttcagtcgatatcaagtatcagatctggaagtttggagtcgtgtttaca gacaacacgttcctctacctggtgtggtacacggtgatgtcactgctcggacactacaac aactttttcttcgcgtgtcacctgctggacatcgccatgggcgtgaagacactgcgcacc atcctgtcctccgtcacgcacaacggcaaacagctgatgatgacggtgggtttgttagca gtggtcgtgtacctctacaccgtggttgcgtttaatttcttccgcaaattctacaacaag agtgaggacgaagacgagcctgacatgaagtgcgatgacatgatgacatgttatctgttc cacatgtatgttggcgtgagagcaggtggaggtatcggtgacgagattgaggatcctgca ggtgatgagtacgaactttaccgcgttgttttcgacatcaccttcttcttcttcgtcatc gtcattctgctggccatcattcagggtttgatcatcgatgccttcggtgagctgagagac cagcaggagcaggtgaaagaagatatggagaccaaatgtttcatctgtggcattgcgagc gattactttgacaccactccgcacggctttgagacgcacaccttagaggaacacaacctg gccaactacctattcttcctgatgtacctcataaacaaggaggagactgagcacaccggg caggagtcatatgtgtggaagatgtatcaggagcgctgttgggatttcttccctgctggt gactgttttagaaaacagtatgaggatcagctggcatag

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