Ictalurus punctatus (channel catfish): 108264731 Help Entry 108264731         CDS       T04658                                  Name (RefSeq) ryanodine receptor 1 isoform X6   KO K04961   ryanodine receptor 1 Organism ipu  Ictalurus punctatus (channel catfish) Pathway ipu04020   Calcium signaling pathway ipu04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:ipu00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     108264731    04020 Calcium signaling pathway     108264731  09180 Brite Hierarchies   09181 Protein families: metabolism    01009 Protein phosphatases and associated proteins [BR:ipu01009]     108264731   09183 Protein families: signaling and cellular processes    04147 Exosome [BR:ipu04147]     108264731    04040 Ion channels [BR:ipu04040]     108264731 Protein phosphatases and associated proteins [BR:ipu01009]  Protein serine/threonine phosphatases   Phosphoprotein phosphatases (PPPs)    Protein phosphatase-1     PP1-interacting proteins (PIPs)      108264731 Exosome [BR:ipu04147]  Exosomal proteins   Exosomal proteins of other body fluids (saliva and urine)    108264731 Ion channels [BR:ipu04040]  Voltage-gated cation channels   Ryanodine receptor    108264731 BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 Ins145_P3_rec MIR SPRY RIH_assoc Ion_trans EF-hand_7 Motif Other DBs NCBI-GeneID:  108264731 NCBI-ProteinID:  XP_017322035 Ensembl:  ENSIPUG00000008890 UniProt:  A0A2D0QX07 LinkDB All DBs Position 4:3834241..3930302 Genome browser AA seq 5081 aa AA seqDB search MAEGEGGDEEIQFLRTDDTVVLQCTATILKEQIKLCLSCEGFGNRLCFLETTSNAQNVPP DLAICAFILEQSLSVRALQEMLANTMEMEAVDLDQWSSQGGGHRTLLYGHAILLRHSHSG MYLSCLTTSRSLTDKLAFDVGLQEDSTGEACWWTIHPASKQRSEGEKVRVGDDLILVSVS SERYLHLSYASGDLMVDASFMQTLWNMNPVCSGCELAEGYLTGGHVLRLFHGHMDECLAI PPPDQGEDQRKIAQYESGAVCSQARSLWRLEPLRISWSGGHMKWGQPFRIRHITTGRYIC LNEEKGLMVLDPEKANTKQSAFCFRASKEKVEVVKKRDVEGMGIAEIKYGESMCFVQHVS TGLWLTYAALDAKAARLGTLKRKVTLHQEGHMDDALVMSRSQTEESQAARMIYSTTGLFK QFIKGLDSLSGKNRAAGPVSLPLDGVVLSLQDLIHYFQPPEEELEHEEKQTKLRSLRNRQ NLFQEEGMITIVLECVDRLNVYNTAAHFSEFAGEEAAESWKEIVNLLYELLASLIRGNRA NCALFCDNLDWLVSKLDRLEASSGILEVLYCILIESPEVLNIIQENHIKSIISLLDKHGR NHKVLDVLRSLCVCNGVAVRSNQNLITENLLPRRELLLQTNIVNYVSSVRPNIFLGTCEG STQYKKWYYEMIVDYVEPFVSAQATHLRVGWALTEGYSPYPGGGEGWGSNGVGDDLYSYG FDGLHLWSGHVARQVASPNQHILAADDVVSCCLDLSVPSISFRINGHPVQGMFENFNLDG LFFPVISFSAGVKARFLLGGRHGDFKFFPPPGYAPCYEALLPRERMRIEPIKEYKHDFSG VRNLLGPTQSLTHTSFTPCPVDTAQIVLPPHLERIREKLAENIHELWAVTRIEQGWTYGL FRDDNKKLHPCLVDFQSLPEPERNYNLQMSGETLKTLLALGCHVGMGDEKAEENLKKIKL PKTYVMSSGYKPAPLDLSHVKLTPNQNQLVEKLAENGHNVWARDRVRQGWTYSIVQDILN KRNPRLVPYVLLDERTKKTNRDSVNNAVRTLIGYGYNIEPPDQESSGHSLDSRRGDKVRI FRAEKQYAVTSGKWYFEFEAVTTGEMRVGWARPNVRAGTELGADELAYVFNGNRAQRWHI GNEPFGRQWLSGDVVGCMIDLVEMNIMFTLNGEMLISDSGSEMAFKDIEIGDGFIPVCAL GLSQMGRINLGQNVSSLRYFAICGLQEGFEPFAINMKRDITMWFSKSLPQFIPVPTNHNH IELSRVDGTVDCAPCLKLTHKTFGSQNANTDMLFLRLSIPIEFHETFKVQAGTTPLTRTL TIPEDEVLEVDPDSDYEVLKKSACKKEQEEKEKEPSVPRDIPGVKENDKDTASEKGKKKG FLFKAKKAAMITPPPPPPVLPRLFEDVVPDERDDPEIILNTTTYYYSVRIFAGQEPGGVW VGWVTPDYHQYDLSFDLFKVRTVTVTVGDDKGNIHDSIKRSNCYMVWGGDLISGSQQRFS QEDLVVGCLVDLATGLMTFMANGKEINTFYQVEPNTKLFPAVFVQPFSQNMLQFELGKLK NIMPLSAAMFRSERMNPVPQCPPRLDVEMLTPVIWSRVPNHFLKPEVGKVSERHGWMVEC TEPLTLMALHIPEENRCIDILELSEHQDLLKFHHHTLMLYCAVCALGNNRVAHALCSHVD ESQLFYAIENTYLPGPLRIGYYDLLISIHLESAKRNRLGTNREFIVPMTKETLSITLYPD AEKAHDLPGVGLTTCLRPKLHFSAINFVGTDPDLYTLSPTFPLQELKTKSLCMLTEAVMD GSQAMRDPVGGSVEFHFVPILKLISTLLIMGIFNDDDVKHILKMIDPSVFSSAEEKASEE EGEGEAEKAVSKEQGEETKEKEEAAEGEAELLDEGVGEEEEDEELKALKKEEGEEGEELE KAEEEQQAGQKVGGEKAEEEKEAEEGEEGHEEEEEVPEEGLLQMKLPESVKLQMCTLLQY FCDCELRHRVEAIVAFSDTFVQQIQTNQRYRYNQLMRAFTMSAAETARRTREFRSPPQEQ VIMLTNFKHSPEDDECPVPEEVREPLQNFHSDILNHCGIHLEEEEEEEEVDMSLKGRLLK LVERVKKLRKQPEEEEKEPEPNEEPKPSTLQELISHTMIHWAQESFIQNPELVRMMFSLL HRQYDSLGELIRAVPKAYAINAVSVQDTMDLLECLGQIRSLLIVQMGPEEERLMIQSIGN IMNNKLFYQHPNLMRALGMHETVMEVMVNVLGGGGDSKEIRFPQMVTNCCRFLCYFCRIS RQNQRSMFDHLSYLLQNSGIGLGMRGSTPLDVAAASCIDNNELALALQEQDLEMVVTYLA GCGLQMCPMLLSKGYPDIGWNPGGGERYLDFLRFAVFVNGESVEENANVVVRLLIRRPEC FGPALRGEGGAGLLAAMEEAIKISEDPARDGPTPKKDRRFMFGAEEQQEENRLHLGNAIM SFYSALIDLLGRCAPEMHLIQAGKGEALRIRAILRSLVPIEDLVGVISLPVQIPTYGKDE QIVEPKMSASFVPDHKASMVLFLDRVYGIDNQDFLLHVLEVGFLPDMRAAASLDTVAFST TEMALALNRYLCSAVLPLLTKCAPLFAGTDHRAIMIDSMLHTIYRLSRGRALTKAQRDVI EDCLMSLVKYLHPSMLQHLLRRLVFDVPILNEYAKMPLKLLTNHYERCWKYYCLPNGWAN FGTTSEEELHLSRKLFWGIFESLAHKKFDAELFKIAMPCICAIAGAIPPDYVDASYSATE KKATVDAEGNFDPRPVETTNTIIPEKLDAFINKFAENTHDRWAFEKIQNNWTYGETLDEI GKTHPMLRPYKTFSEKDKEIYRWPIKESIKAMLAWEWTLEKARDEGEKVEKAATRKISQT AQATYDPSQGYSPQPVDLTTMALSRELQSMAEQLAENYHNTWGRKKKMELQAKGGGTHPL LVPYDTLTAKEKARDREKAQDLLKFLQFEGYAVTRGLKDMEQEISSIEKRFAYGFLQKLL KWMEIAQEFIAHLEAVVSSGRVEKSPHEQEIKFFAKILLPLVNQYFKNHCLYFLSTPAKV LGSGGHASNKEKEMIASIFCKLAALVRHRVSLFGTDASAVVNCLHILSHSLDARTVMKSG PEIVKAGLRSFFESAADDIEKMVENLKLGKVSTKNQVKGVSQNINYTTIALLPVLTSLFD HIAQHQFGDDVILDDLQISCYRLMCSIYSVGTVKTPHAEKLRPALGECLAHLAAAMPVAY LEPHLNEFNAYSVYTTKTPRERAILGLPSQVQELCLDIPELEVLMKEISDLAESGARYTE MPHVIEITLPMLCNYLPRWWERGPENFPEQEGQLCTEVTSEHLNQLLGSIMKIVVNNLGI DEASWMKRLAVFAQPIVSRAKPEMLKSHFIPTMEKLKKRSGKVVAEEDQLRMEGKTEVDS EEGTIRDEFAVLCRDLYALYPLLIRYVDNNRARWLTCPDPDAEDLFRMVGEVFIFWSKSH NFKREEQNFVVMNEINNMSFLTADSKSKMSKAGDGEGGGADAERTKKKRRGDRYSVQTSL IVAALKKLLPIGLNMCSPADQELINLAKIRYSLKDTDEEVREFLQNNLYLQGKVEDPSMR WQMALYKETSGKAEDAENPEKVVKRVQEVSAVLYHIEVTEHPYKSKKMVWHKLLSKQRRR AVVACFRMTPLYNIPRHRGSNMFLDGYRRNWLENEGYSFEDKMINDLSKTLEEEEEEEEE TEAKPDPLHQLILHFSRTALTEKTKLDVDHLYMAYADIMAKSCHMGEEDRGGEEEEEEEE GGEEPSFEVRQNEMEKEMEKQRLLYQQSRLHDRGAAEMVLQMISACKGEPGAMVSSTLKL GISILNGGNCDVQQRMLDYLKDKKDVGFFLSLQTLMQTCSVLDLNAFERQNKAEGLGMVS EEGTNMKLERDEKVMADDEFTCDLFRFLQLLCEGHNNDFQNYLRTQTGSTTTINIIICTV DYLLRLQESISDFYWYYSGKDIIDAPGKRNFSKAMTVAKQVFNSLTEYIQGPCTGNQQSL AHSRLWDAVVGFLHVFAHMMMKLAQDSSQIGLLKELLDLQKDMVVMLLSLLEGNVVNGTI ARQMVDMLVESSSNVEMILKFFDMFLKLKDIVASDAFRDYVTDPRGLISKKDFSKAMDSQ KQYSPSEIQFLLSCSEADENEMINFEEFADRFQEPAKDIGFNIAVLLTNLSEHVPHDTRL QNFLEQAESILNYFRPFLGRIEIMGASRRIERIYFEISEANRNQWEMPQVRESKRQFIFD VVNEGGESEKMELFVNFCEDTIFEMNIASQISEQEEEGIGDKDDEEEEESGGGSNGEEGE EGNGDEAPAESSSAFADFIKSMVNFFNMFTFRNLRRRYRRLRKMTIKEMIVCLVTFFYTV IIGILHFIYSVCKGFFLLIWKTLFGGGLVEGAKKITLTEILTNMPDPTQDEVHGDQASEP GARNVQEAGGSGDGEEAGGGEVEDEDGQEAEGGGRPGIDAPGGLGDMGETEPEEPPTPEG TPLLMRKLRTEGAEGEVVAAEEPAKEEPTPEPEKADAENGEKTKKEPEPIPEEKVAEEEE EETKVKAKAKKEKHSAGDSFELWNELEVQRIKFMNYLSRNFYNLRFLALFIAFALNFILL FYKVSSSPPGEEFEGSGMFEGSGIPEGSGGEPEGSGMEENGEEDDEEGPLYYFLEESTGY MEPAMAFFGILHTVISFLCIIGYNCLKVPLVIFKREKELARKMEFDGLYVTEQPEDDDIK GQWDRLVLNTPTFPNNYWDKFVKRKVLEKYGDIYGRERIAELLGMDLASLDVSAMTHEKK PEPDNSMFTWLTSIDIKYQIWKFGVVFTDNTFLYLVWYMVMSLLGHYNNFFFACHLLDIA MGVKTLRTILSSVTHNGKQLVMTVGLLAVVVYLYTVVAFNFFRKFYNKSEDEDEPDMKCD DMMTCYLFHMYVGVRAGGGIGDEIEDPAGDEYELYRVVFDITFFFFVIVILLAIIQGLII DAFGELRDQQEQVREDMETKCFICGIGSDYFDTTPHGFETHTMEEHNLANYMFFLMYLIN KDETEHTGQESYVWKMYQERCWDFFPAGDCFRKQYEDQLAG NT seq 15246 nt NT seq  +upstreamnt  +downstreamnt atggcggaaggagagggaggggatgaggagatccagttcctgcgaacggatgacacggtg gtgctccagtgtacagcgaccatcctgaaggagcagatcaagctgtgcctgtcttgtgag ggcttcgggaaccgattgtgcttccttgaaacaacatccaatgcccagaatgtgccccct gacttggctatctgtgccttcatcctggagcagtcactctcggttcgggcactacaggag atgctggccaacaccatggagatggaggcagtcgatttggaccagtggtcctctcaggga ggaggccatcgaacacttctatatggccacgccatcttgctgagacacagccactctggc atgtacctcagttgcctgaccacatcacgctcgctcacggacaagctggccttcgatgtg ggcttgcaagaggactctacaggcgaagcgtgctggtggaccatccaccctgcatccaag cagaggtcagaaggtgagaaggtcagagtgggagatgacctgatcctggttagcgtgtca tctgagagatatctgcatctgtcctatgccagtggggacttgatggtagacgcctcgttc atgcaaactctgtggaacatgaatccagtgtgttcaggctgtgagctagcagagggttat ttgactggaggccatgttctacgcttgttccacggtcatatggacgagtgtctggccata ccgccacccgatcaaggagaagatcagcgcaagatcgcacagtatgagtcaggagccgtc tgtagtcaagcacgctctttgtggagacttgaacctttaagaatcagctggagtggtggt catatgaagtggggtcagccattccgcatacgccacatcactactggacgctacatttgt ttgaatgaagagaaaggtctgatggtgctcgaccctgagaaagccaacaccaagcagtca gctttctgtttccgtgcctccaaggagaaggtggaagtggtgaagaagcgtgatgttgag ggcatggggattgcagagatcaagtatggcgagtcgatgtgctttgtacagcacgtctcc acgggtctgtggctcacctacgctgccctcgatgccaaagcagctcgtctgggtactctg aaaagaaaggttactctgcatcaggaaggccacatggatgatgcgctggtgatgtcacgt tctcagacggaggagtctcaggcagcccgcatgatctacagcaccacaggcctttttaaa cagttcatcaaggggctggactctctgagtgggaagaacagggcggcaggtccggtctct ctgcctctggatggagtggttctctcccttcaggatctcatccactacttccagccgcct gaggaggagctggagcatgaggagaagcaaacaaaactgcgctcactgcgcaaccggcag aacctcttccaagaagagggaatgattaccatcgtgttggagtgtgtggacaggcttaat gtgtacaacactgctgctcacttctccgagtttgctggggaagaggcagctgagtcctgg aaggaaatagtcaacctgctctatgaactgctggcctcgcttatcagagggaaccgtgct aactgtgctctgttctgcgataatctggattggttggtcagtaaactggaccgtctggag gcctcctcaggcattctggaggtgttgtactgcattttgattgaaagccctgaagtcctg aacatcatccaggagaaccacatcaagtctattatctctcttctggacaagcacggacgc aatcacaaggtattggacgtgctgcgctctctgtgtgtatgcaacggcgtggccgtgagg tccaaccagaacctcatcacagaaaatctgctaccacgtcgtgagcttctgctccagacc aacatcgtaaattacgtcagtagtgtaagaccaaatatcttcctaggaacatgtgagggc tcaacacagtataagaagtggtactacgagatgattgtggactacgtggagccgtttgtg tcggctcaggctactcatttgcgtgttggctgggcacttacagaaggatatagtccctac cctggaggaggagaaggctggggaagcaatggagttggtgatgacctttactcttatgga tttgatggacttcacctgtggtcaggtcatgtggctcgtcaggtggcatcacccaatcag cacatcctggcagctgatgacgtcgtaagctgctgtctggatttgagcgtgcccagtatc tctttccgcatcaatgggcatcctgttcagggcatgtttgagaatttcaatttggacggc ctcttcttccctgttattagcttctcagctggggtcaaagctagatttctattgggtgga cgtcatggtgactttaagttcttccctccacctgggtatgctccatgttacgaggctctc ctgcccagagagaggatgcgaattgagcccatcaaagagtacaagcatgactttagtgga gtcagaaacctcctgggccccacacagtcgcttacacacacctcattcacaccttgtcct gtggacactgctcagattgtgttgcccccacacttggagcgcatccgagaaaaactggct gaaaacattcatgagctgtgggctgtcactcgcatcgaacagggttggacctatggtcta ttccgtgatgataataagaaactgcacccatgcctggtcgacttccagagcctgccagaa cctgagagaaactacaacttgcagatgtctggagaaactttaaagacacttctggctctg ggctgccatgtgggcatgggagatgagaaagcagaagaaaatctgaagaagatcaagctg cccaaaacgtatgtgatgagcagtgggtataagccagctcctctggacctcagccatgtg aaactgactcccaaccagaaccagctggtggagaaactggcggagaatggacacaatgtg tgggcacgagaccgtgtgaggcagggttggacttacagcatcgtacaggatattttgaat aaacgtaaccctcgtctggtaccgtacgtcttgctggatgagagaaccaagaaaaccaac agagacagtgtgaacaatgctgtacgcacccttattggctacggatacaatatcgagcca ccagaccaggagagtagtggccactcattggacagccgacgaggggataaggtgcgaatc ttcagggcggagaagcagtatgccgtgacctcagggaaatggtactttgagtttgaggcc gtgacgacgggagagatgagggtaggctgggctcgaccaaacgtgcgtgcaggcactgaa ctcggagctgatgaactggcttacgtcttcaatggaaacagggctcagcgctggcacatt ggaaatgagccattcgggcgccagtggctgtcaggagacgtggtgggctgcatgattgac ctggtagagatgaacatcatgttcactttgaatggagagatgctgatcagtgactctggc tctgagatggcctttaaagacattgagattggagatggtttcatccccgtgtgtgcactg ggcctgtctcagatgggccgtatcaacctgggccagaatgttagcagtctgcgctatttt gccatttgtggattgcaggagggatttgagcccttcgccatcaacatgaagagggacatc accatgtggttcagcaagagtttgccccagttcatcccagtgcctactaaccacaatcac attgagctgtctcgtgtggatggcacggtggactgcgccccctgtctgaaactcacccac aagacctttgggtctcagaatgccaacacagacatgctgttcctgaggctaagcatacct atcgagttccacgagactttcaaagtgcaggcaggcaccacacccctcactcgaacccta accatcccggaggatgaagtgttggaggtggatcctgactctgattacgaagtgctgaag aagtcagcctgcaagaaggagcaggaggagaaagagaaggagccgtctgtgcccagagac atacctggtgtcaaggagaatgacaaggacactgcctctgaaaaaggcaaaaagaaaggt ttcctgttcaaagctaagaaagcagccatgatcactcctccccctcctccccctgttcta cctcgcttgttcgaggacgtagtgccggatgaacgtgatgatcctgagatcattctcaat accactacttattattactcagtgcggatctttgctggtcaagagcccggtggtgtttgg gttggttgggtcacccctgactaccaccagtacgatcttagctttgacctcttcaaagtt cgtactgtcacagtgactgtaggtgatgacaagggcaacattcatgacagcataaaaagg agcaactgctacatggtgtggggaggcgacttaatcagtggttcccagcagcgcttcagc caggaggatctggtagttggctgcttggtagacttggccactggtcttatgactttcatg gccaatgggaaggaaatcaacaccttttaccaggtggagcccaacaccaagcttttccct gctgtgtttgttcagcccttcagccagaacatgctacagtttgagctgggaaagctaaag aatattatgcctctctcagcggccatgtttcgcagtgaaaggatgaacccagtgcctcag tgtcctcctcgtctggatgtggagatgctcacaccggttatatggagtcgagtcccaaac cacttcttgaaacccgaagtgggtaaagtgagtgagaggcacggctggatggtagaatgc actgagccactcaccttgatggcactgcacatccctgaggagaacagatgtattgacatc ttggaattgtccgaacaccaagacctgttgaagttccaccaccacactctgatgctgtat tgtgctgtgtgtgctctgggcaacaatcgtgtggcccacgctctgtgcagccacgtggat gagtcgcagcttttctacgccatcgagaacacatacctgcctgggccgctgcgtatcggc tactacgacctgctcatcagcatccatctagagtcggccaagcgcaaccgtctgggcact aaccgtgagtttatagtgcccatgacgaaggagacgctcagtatcactctttacccagat gctgaaaaagcccatgatctgcctggtgtgggtctgaccacctgcctcaggcccaaactc cacttctcagctattaactttgtgggcaccgatccagacctgtatactctgagccctacc ttccctctgcaggagctaaagaccaagtctctgtgcatgctcactgaggctgtaatggat ggcagtcaggctatgcgtgatccagtagggggaagtgtcgagttccactttgtgcccatc cttaaactcatcagcactctcctcatcatgggcatcttcaacgacgacgacgtcaagcac atccttaagatgattgaccccagtgttttcagctcagcagaagagaaagcttcagaggag gaaggagagggggaagcggagaaagctgtgtctaaagagcaaggagaggaaaccaaagag aaagaggaggccgctgagggagaggcggagctgctggacgaaggagtaggagaagaggaa gaggacgaggagctcaaagccctcaagaaggaggaaggggaggagggagaggagctagag aaggcagaggaggagcagcaggcaggacaaaaagtgggtggagaaaaagcagaggaggag aaagaggcagaggaaggagaagagggacatgaggaagaggaggaggtgcctgaggaagga ctgctgcaaatgaaacttcccgagtcagtcaaactgcagatgtgcaccctgctgcagtat ttctgtgactgtgagctgaggcaccgtgtagaagccattgttgctttctccgatacattt gtgcagcaaatccagaccaaccaacgttatcgctacaatcagctcatgagagcgttcacc atgagcgctgctgagacagcccgaaggacccgagagttccggtctcctccgcaagagcag gttatcatgctgactaacttcaagcacagtcctgaagatgatgagtgtccagtacctgag gaagtacgagaacctctccagaatttccacagtgacatcctgaatcattgtggtatacac ctggaagaagaggaggaagaggaagaggtggacatgtcgcttaaaggaagattgctcaag ttggtggaaagagttaaaaaattgcgtaagcagccggaagaagaagaaaaagagcctgaa cccaatgaagagcctaaacccagcaccttgcaggagctgatctctcacacaatgatccat tgggctcaggagtcattcatccaaaacccagagctagtgcgaatgatgttcagcttgctg caccggcagtatgactctctgggcgagttgattcgagctgtgcccaaagcctacgccatc aacgctgtgtccgtgcaggacaccatggaccttctagagtgtctaggccagatccgctca cttctcattgttcagatgggtcctgaagaggagagactcatgattcagagcatcggtaac atcatgaacaataagttgttctaccagcaccccaacttaatgagggctcttgggatgcac gagaccgttatggaggtcatggtcaacgtgctcggaggtggaggagactcaaaggaaatt agattcccccaaatggtgacgaactgttgccgcttcctgtgttatttctgccgtatcagt cgtcagaaccaacgctccatgttcgaccacctttcatacctgcttcagaacagtggcatt ggcttgggaatgcgtggatctacacccctggatgtagctgcagcttcctgtattgacaac aatgagctggctttagcattgcaggagcaagacctggagatggtggtgacatatctggct ggatgtggcctgcagatgtgcccaatgctgttgtctaaaggttacccggacatcggctgg aaccccggcggcggagagcgctatctggacttcctccgctttgctgtgtttgttaatggt gagagtgtggaggagaacgctaatgtggttgtgcgcctgctcatccgtcgtcctgagtgc tttggccctgccctgagaggagagggaggagctgggctgctggctgctatggaggaagcc attaagatctcggaggatccagccagggacggaccaaccccgaagaaagacagacgcttc atgtttggtgcagaggagcaacaggaggagaacaggttgcatcttgggaatgccattatg tcattctactcggcgctaattgacttgctgggtcgctgtgcccctgagatgcatttgatc caggctggcaagggtgaggctctgagaatcagagctatcttgaggtctttggttcctata gaagacctggtgggagtcatcagtcttccggtgcagatcccaacctatggaaaagatgaa cagattgttgaacccaagatgtctgccagttttgtaccagaccacaaggcctccatggtg ttgttcctagacagagtgtatggcattgataatcaagactttctgctgcatgtgctggaa gtcggcttcctcccggacatgagagccgcagcttctctggacacagtggcattcagtacc accgagatggcgttggcactcaaccgttatctgtgttcagctgtgctaccacttctgacc aagtgtgctccactgtttgcgggtactgaccaccgtgccatcatgattgactccatgctg cacaccatctaccgactgtcccgcggccgcgcactcaccaaagcccagcgtgatgtcatc gaggactgcctcatgtctttggtcaagtacctgcacccatcaatgctgcagcatctgttg cggagacttgtattcgatgtgccaatcctcaacgaatatgccaagatgcctctgaaactg ctgactaatcactatgagcgctgctggaagtactactgcctaccaaatggctgggccaat tttggtaccacatcagaggaggagttgcatctctcacgtaaacttttctggggaatcttt gagtctctagcacacaagaaatttgatgcggagttgttcaagattgccatgccatgcatt tgtgccattgctggtgccatccctcctgactatgtagatgccagctattctgccacggag aaaaaagccacagttgatgctgagggcaacttcgatcccagaccggtggagactaccaat accatcatcccagaaaaactagatgccttcatcaacaaatttgcagagaatactcacgat aggtgggcgtttgaaaagatccagaataactggacctatggagagacactggatgagatt gggaagacccatcctatgctccggccttataaaacattttctgaaaaggataaggagatc taccgctggcccatcaaagaatccattaaagccatgctggcctgggagtggactttagag aaagctcgagatgagggtgagaaggttgaaaaggccgccactaggaagatctctcaaact gctcaggcaacttatgatcctagtcagggatactcgccccagcctgtggatttaaccacc atggctttgtccagagagctgcagtctatggcagagcaactggctgaaaattaccacaat acctggggcaggaagaagaagatggagcttcaagccaaaggtggtggtacccatcctctg cttgttccttatgacactctgacggccaaggagaaagcccgtgacagggaaaaagctcaa gacctccttaaattcctccagtttgaaggttatgctgtcactaggggcttgaaggacatg gagcaggagatctcctccattgagaaacgtttcgcttatggcttcctccagaagcttctg aagtggatggagattgctcaagagttcattgcacacctggaggctgttgtgagtagtgga agagtcgagaaatcccctcatgagcaggagatcaaattctttgccaagatcctgctgcca ctggttaaccagtactttaaaaaccactgcctctacttcctttctactcctgctaaagta ctgggcagcggtggtcatgcctccaacaaggaaaaagagatgattgccagtatcttctgt aagttggctgctctagtgaggcacagagtttccctctttggaactgatgcttcagcagtg gtaaactgcttacacatcctgtctcattcactggatgccagaactgtgatgaaatctgga cctgagatcgtaaaagcaggcctccgttcattctttgagagcgctgctgatgacattgag aagatggttgagaatcttaaactgggcaaggtgtccaccaaaaaccaggttaaaggtgtg tcccaaaatattaactacactaccattgccctactgccagtgcttacttcactcttcgac cacatcgcccagcaccagtttggtgatgatgtcatcttggatgacttgcagatatcttgc tatcgtctcatgtgcagcatctactcagtgggtacagttaagacccctcatgctgaaaaa ctaaggcctgctcttggtgagtgtctggctcatttggctgctgccatgcctgtggcctat cttgagccccacctcaatgagttcaatgcatactcggtctacacaacaaaaacaccaaga gagagagccatcctgggactcccgagtcaggtgcaagagttgtgcttggacatcccagag ctggaagtgctaatgaaagagattagtgacctggcagagtctggagctcgttacactgag atgccgcacgtgatcgagatcacgctgcccatgctgtgtaactacctcccgcgctggtgg gaaagagggcctgagaacttccctgagcaggagggacaactctgcactgaggtcacttct gaacatctcaaccagctgctgggcagcatcatgaagatcgtggtcaacaacctgggcatc gatgaggcctcctggatgaagagattggctgtttttgcccagcctattgttagcagggcc aagccagagatgctcaagtctcacttcatccccacgatggagaagctgaagaaacgctca gggaaggtagtagctgaggaggatcagttacgtatggagggcaagacagaggtggacagt gaagaaggcacaatccgagatgagtttgctgtgctctgcagggacctgtatgccctctat ccactgctcatccgctatgtggacaacaacagggcaagatggctaacctgccctgatcct gatgctgaagacctgttcaggatggtgggagaagttttcatcttctggtcaaaatctcat aacttcaagcgcgaggagcagaactttgtggtgatgaatgagattaataacatgtctttc ctcaccgctgacagcaagagtaagatgagcaaggctggggatggagagggcgggggagct gatgcggaacgtacgaagaagaagcggcgtggtgatcgctactcggtccagacctcgctg attgtagctgctctgaagaaactcctgcccattggtctgaatatgtgttctcctgcagat caagagctcatcaacttggcgaagatccgttattcactgaaagacacagatgaggaagtg agggagttcctgcagaataacctttatctgcaaggcaaggtggaggacccctccatgcgc tggcagatggctctgtataaggaaacctcaggcaaagcggaggatgctgaaaatccagag aaggttgtgaagagagtacaggaagtttctgctgtgctttaccatattgaagtgactgaa cacccttataaatccaagaagatggtttggcacaagctgttgtcgaagcagcgtcgccgg gctgttgtggcatgtttcagaatgactccattgtataatatcccaaggcaccgggggtcg aacatgttcctagatggttacagacgcaactggttggagaacgagggctactcattcgag gataagatgatcaatgatctgtctaaaacattggaggaagaagaggaggaagaagaggag accgaggccaagccggatcctctgcatcagctcattcttcactttagccgcacagctctc actgaaaaaacaaaacttgatgtagatcatctgtacatggcatatgctgatattatggca aagagctgccacatgggtgaggaggacagagggggagaggaggaggaggaggaggaggag gggggcgaggagccatcgtttgaggtgcggcagaatgagatggagaaggagatggagaag cagaggctcctgtaccagcagtcgcgactccatgaccgtggagcagctgagatggtactg cagatgataagcgcctgcaaaggtgagcctggagccatggtgtcttccacactcaagctg ggcatctccatccttaacggaggcaactgtgatgttcagcagagaatgctggattacctt aaggataagaaagacgttggtttcttcctgagtttgcagactctgatgcagacctgcagt gttctggacttgaatgcatttgagaggcagaataaagcagaagggcttggaatggtttca gaggagggcacaaatatgaagctagaacgggatgagaaagtgatggcggatgatgaattc acgtgcgacctcttccgtttcctgcagctgctttgtgagggccacaataacgatttccag aactacctgcgcacccagactggcagcaccaccaccatcaacattatcatctgtactgtg gactacctgctgagactgcaggaatctatcagcgacttctactggtattattctggaaaa gacatcatcgatgcaccaggcaagaggaacttctccaaagcaatgacagtggccaagcag gtctttaacagtctcacggaatacatacagggcccatgcactgggaaccagcagtctctg gctcacagtagattgtgggatgccgtggtgggattcctccatgtatttgcacacatgatg atgaaattggcacaggattccagtcagattggtctcctaaaagagcttctagaccttcag aaagatatggtggttatgctgctttcacttctggagggtaacgttgtgaatggcaccatt gctcgccagatggtggacatgttggtggagtcatctagcaatgtagagatgatcctcaag ttctttgacatgttccttaagctgaaagacattgtggcttcggatgcattccgggactat gtgactgacccacgtggcctgatctctaaaaaggacttttccaaagccatggatagccaa aagcagtactctccatctgagatccaattccttctgtcatgctctgaggctgatgaaaac gaaatgatcaactttgaagagtttgctgatcgttttcaggagccagccaaggacattggg tttaacattgctgttctactcaccaacctttcagagcatgtgccccatgacacgcgcctg cagaacttcttggagcaagctgaaagcatcttgaactatttccgtcccttcctgggccgc atcgaaatcatgggcgccagtcggaggattgagcgtatctactttgagatcagtgaggcc aacaggaaccagtgggaaatgcctcaggtcagagaatctaagaggcagtttatattcgat gtggtcaatgaaggtggtgagtctgagaagatggagctatttgtcaacttctgcgaggac accatctttgagatgaacattgcctcccagatctctgagcaagaggaagaaggaattgga gataaggatgatgaagaagaagaggaaagtggtggaggatcaaatggagaagaaggagag gaagggaatggagacgaggccccagccgagtccagttcagcattcgcagacttcatcaag agcatggtgaacttcttcaatatgtttaccttccgcaaccttagacgacgctatcgcaga cttcggaagatgactataaaggaaatgattgtatgcctggtcaccttcttctataccgtc atcattggaatccttcattttatctacagcgtatgcaaaggctttttcctgctgatatgg aaaacgctgtttggtggtggccttgtggagggagctaaaaagataacgttaacagaaatt cttactaacatgcctgatccaactcaggacgaggtgcacggtgaccaagcatctgagcct ggagctagaaacgtccaggaagcaggtggatcaggagatggagaggaagcaggtggtgga gaggtagaagatgaggatgggcaagaggcagaaggaggaggcagacctggaattgatgcc cctggaggtctaggagatatgggagagacagagcctgaggaacccccaacacctgagggt accccactactgatgaggaaactgcggactgaaggagcagagggagaagtagtggcagca gaagagccagcaaaggaagagccaaccccagaaccagagaaggcagatgctgaaaatgga gagaaaactaagaaagaacctgagcccataccagaggagaaagtggctgaggaggaggag gaggagacaaaagtaaaagccaaagccaagaaagaaaaacattctgctggagatagcttt gagctctggaatgaattggaggtgcagaggatcaagttcatgaactacctgtctcgcaac ttctacaacctgcgcttcctggctctgttcattgcctttgctctgaacttcatcctgctc ttttacaaggtgtccagcagccccccaggtgaggagttcgaaggttcgggcatgtttgag ggttctggaattcctgagggctctggcggtgaacctgagggttctggaatggaggagaat ggagaggaagatgacgaagaagggcctctctattacttcctggaagagagcaccggttac atggaacctgcaatggccttcttcggcattttacacaccgtcatatcttttctttgcatt attggctacaactgtctcaaggttcccttggttatttttaagagggagaaggagctggcc cgtaagatggaatttgacggcctctatgtgactgaacagccagaagatgatgacatcaag ggccagtgggatagactggtgttaaatacaccaaccttcccaaataactattgggacaag tttgtaaagagaaaggtgttggagaagtacggagatatctatggcagagagaggattgcc gagctgttaggaatggacttggcatcgctggatgtcagtgcaatgacgcatgagaaaaag cctgaacctgacaactccatgttcacctggctgacctccatcgacatcaagtaccagatc tggaagtttggagttgtgttcacagataatactttcctctacctggtgtggtacatggtc atgtccttgctcggtcactacaacaacttcttcttcgcctgtcacctgctggacatcgcc atgggcgtcaaaaccttgcgcaccatcctgtcctccgtgacacacaatggcaagcagctg gtgatgacagtgggtttgctagctgtagtcgtgtacctgtacactgtcgtggccttcaac ttcttccgcaagttctacaacaagagcgaggacgaggatgagccagacatgaagtgcgat gacatgatgacttgctacttgttccacatgtatgtgggtgtgagagccggtggtggtata ggtgatgagattgaggatccggctggagatgaatatgagctgtaccgtgtcgtctttgac atcactttcttctttttcgtcattgtcattcttttggccatcattcagggtctgatcatt gatgccttcggtgagctgagagatcagcaggaacaggtcagagaggacatggagactaaa tgcttcatctgcggaattggaagtgactactttgacacgactccgcatggtttcgagaca catacgatggaagagcacaacttagccaactacatgttcttcctgatgtatctaattaat aaagatgaaacggagcacactggacaggaatcctatgtgtggaaaatgtaccaggagcga tgctgggacttcttcccagctggcgactgtttcagaaagcaatacgaggatcagctcgct ggctaa

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