Kluyveromyces marxianus: KLMA_10065
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Entry
KLMA_10065 CDS
T05269
Symbol
HIS4
Name
(RefSeq) histidine biosynthesis trifunctional protein
KO
K14152
phosphoribosyl-ATP pyrophosphohydrolase / phosphoribosyl-AMP cyclohydrolase / histidinol dehydrogenase [EC:
3.6.1.31
3.5.4.19
1.1.1.23
]
Organism
kmx
Kluyveromyces marxianus
Pathway
kmx00340
Histidine metabolism
kmx01100
Metabolic pathways
kmx01110
Biosynthesis of secondary metabolites
kmx01230
Biosynthesis of amino acids
Module
kmx_M00026
Histidine biosynthesis, PRPP => histidine
Brite
KEGG Orthology (KO) [BR:
kmx00001
]
09100 Metabolism
09105 Amino acid metabolism
00340 Histidine metabolism
KLMA_10065 (HIS4)
Enzymes [BR:
kmx01000
]
1. Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.1.1 With NAD+ or NADP+ as acceptor
1.1.1.23 histidinol dehydrogenase
KLMA_10065 (HIS4)
3. Hydrolases
3.5 Acting on carbon-nitrogen bonds, other than peptide bonds
3.5.4 In cyclic amidines
3.5.4.19 phosphoribosyl-AMP cyclohydrolase
KLMA_10065 (HIS4)
3.6 Acting on acid anhydrides
3.6.1 In phosphorus-containing anhydrides
3.6.1.31 phosphoribosyl-ATP diphosphatase
KLMA_10065 (HIS4)
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Ortholog
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Gene cluster
GFIT
Motif
Pfam:
Histidinol_dh
PRA-CH
PRA-PH
NACHT_N
Motif
Other DBs
NCBI-GeneID:
34713749
NCBI-ProteinID:
XP_022673604
UniProt:
W0T294
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Position
1:complement(120238..122646)
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AA seq
802 aa
AA seq
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MLPLVPLLDATKALNEKPFIGLSKLLVLDGLTLTKEEIQDFTDKQEAFGQRVSVLVGKNK
FSDDDLISLLNNGISTLFVEDLEYANHLLEIGIPDIRLSLFKENAFRVKFGQVQEVSWSQ
LVKVSEITKQSFTNAILKGLKTDRSDGLYTTLVVDENERSLGLVYSSKESIAQAVESQTG
VYFSRSRNEIWRKGATSGNVQQLLSIDLDCDGDALKFVVRQGGSGSFCHLNTQSCFGDFK
NGLYGLQKLLQDRLVNAPEGSYTKRLFNDPDLLDAKIKEEAEEVTEAKEKKDIAWECADL
FYFTLVKLVASGVSLEDVENNLNMKHLKVTRRKGDAKPKFIKKEEPITETPYETSEEEKI
FLNVVSSSNKAAVEQAVTRPIQKTAEIMNLVKPIIDNVVKNGDKALIELTAKFDGVDLKS
PVLEAPFPPEYLEGLTDELREALDLSIENVRKFHAAQMQTETLEVETQPGVVCSRFPRPI
EKVGLYIPGGTAILPSTALMLGVPAQVAGCKEIVFASPPRKSDGRVSPEVVYVASKVGAS
KIVLAGGAQAVAAMAYGTETVPKVDKILGPGNQFVTAAKMHIQNDTQALCSIDMPAGPSE
VLVICDEEADVDYVASDLLSQAEHGIDSQVILVGVSLSETKIEALQNAVHEQAMKLPRVD
IVRKCIAHSSIILCESYEDAFKMSNQYAPEHLILQISNAQDYVKLVDHAGSVFVGAYTPE
SCGDYSSGTNHTLPTYGYARQYSGVNTSTFQKFITSQSVSPTGLENIGRAVMSIAAVEGL
DAHRNAVKIRMTKLGLLPPNFE
NT seq
2409 nt
NT seq
+upstream
nt +downstream
nt
atgttacctcttgtgcccttactggatgctaccaaagcattgaatgaaaagccttttatt
ggcttatcgaaattgttagtcttagatggactaactctaactaaagaagaaattcaggat
ttcaccgataagcaagaagcttttggtcaaagggtgtccgttcttgtaggaaagaacaaa
ttcagcgatgatgacttaatttcattgttgaataatggtatttctaccctattcgtcgaa
gatttagaatacgctaaccatttgttagaaattggcattccagatatcagattgtctttg
ttcaaagaaaacgccttccgagtaaaattcggccaagtacaagaagtttcttggagccaa
ctagttaaggtttctgaaattacaaaacaaagctttactaatgccattttgaaaggtttg
aaaactgatcgttctgatggattgtacacaactttagttgttgatgaaaatgagcgatct
ctaggattggtttattctagcaaagaatccattgcacaggctgttgaaagccaaacaggt
gtatacttttctcgctcacgtaatgaaatttggcgcaaaggtgccacttccggtaatgtt
caacagttactctctattgacttggattgtgatggcgacgctttgaaatttgtcgtaaga
caaggtgggtctggttctttctgtcacttaaacactcaatcatgctttggtgatttcaag
aatgggctgtacggtcttcaaaagcttttacaggatagacttgtaaatgccccagaaggt
tcatacactaaaagacttttcaacgatcctgatttattagatgcgaagattaaagaagag
gcagaagaagtcactgaagctaaagaaaaaaaagatattgcatgggaatgtgctgatcta
ttctacttcaccctagttaagctagttgcgagtggtgtttcgttggaggatgtggaaaat
aatttgaacatgaagcatttgaaagttaccagaagaaaaggtgatgcaaagccaaagttc
atcaaaaaggaagagcctatcactgaaactccatatgaaacttctgaggaggaaaaaata
ttcctaaatgttgtttcatcttccaataaagctgctgttgagcaagcagttaccagacca
attcaaaagactgcagagatcatgaacttagttaaaccaatcattgataatgttgttaaa
aatggggataaggctttgattgaactaacggcaaaattcgacggtgttgacttaaagtca
ccagtcttagaagctcctttcccaccagaatatctagagggcttaacagacgaattgagg
gaggcattggatttgtcaattgaaaacgtcagaaagttccatgccgcacaaatgcaaact
gaaacactagaagttgaaacccaacctggcgttgtgtgctctagatttccaagaccaatt
gaaaaagtgggtctgtatattcctggtggtacagctatcttacctagtactgctttaatg
ttaggtgtgcccgcccaagttgctggttgtaaagagattgtgtttgcgtctcctcctaga
aagtctgatggaagagtttctcctgaagtggtctatgttgctagtaaagttggtgcttca
aagattgtcttagctggtggtgcacaagctgtggcagctatggcctatggaactgaaacc
gttcctaaagttgataaaattcttggccccggtaaccagttcgttactgcagccaaaatg
cacattcagaatgacacccaagcattgtgctccattgatatgcctgctggtccaagtgaa
gttttggttatttgtgatgaagaagctgatgttgattatgtggcttctgacctgttatct
caagctgaacatggtattgattctcaagttattttggtcggtgtttctttatccgaaact
aagatagaagctctacagaatgcggttcatgagcaggcaatgaagcttccaagagtcgac
atcgtccgtaagtgcattgctcacagctccattatcctatgtgaatcatacgaagatgct
ttcaagatgtctaatcaatacgcacccgaacatttgattctacaaatttctaatgctcaa
gattatgtaaaacttgttgatcatgcaggttcagtctttgttggagcgtacactccagaa
tcttgtggtgattactccagtggtacaaaccacacattgccaacatatggttatgcaaga
caatacagtggtgttaatacttcgacattccagaagtttatcacctctcaatcagtttct
cctactggtctagaaaatattggtcgtgcagtaatgagtattgccgctgttgaaggattg
gatgcccacagaaacgcggttaagatcagaatgacaaaattaggacttttaccacctaat
tttgaataa
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