KEGG   PATHWAY: ko01054
Entry
ko01054                     Pathway                                
Name
Nonribosomal peptide structures
Class
Metabolism; Metabolism of terpenoids and polyketides
Pathway map
ko01054  Nonribosomal peptide structures
ko01054

Orthology
K01779  racD; aspartate racemase [EC:5.1.1.13]
K15654  srfAA, licA, lchAA; surfactin/lichenysin synthetase A
K15655  srfAB, licB, lchAB; surfactin/lichenysin synthetase B
K15656  srfAC, licC, lchAC; surfactin/lichenysin synthetase C
K15661  ituA, mycA, bmyA; iturin family lipopeptide synthetase A
K15662  ituB, mycB, bmyB; iturin family lipopeptide synthetase B
K15663  ituC, mycC, bmyC; iturin family lipopeptide synthetase C
K15664  ppsA, fenC; plipastatin/fengycin lipopeptide synthetase A
K15665  ppsB, fenD; plipastatin/fengycin lipopeptide synthetase B
K15666  ppsC, fenE; plipastatin/fengycin lipopeptide synthetase C
K15667  ppsD, fenA; plipastatin/fengycin lipopeptide synthetase D
K15668  ppsE, fenB; plipastatin/fengycin lipopeptide synthetase E
K16093  bacA; bacitracin synthase 1
K16094  bacB; bacitracin synthase 2
K16095  bacC; bacitracin synthase 3
K16096  grsA; gramicidin S synthase 1
K16097  grsB; gramicidin S synthase 2
K16098  vioF; nonribosomal peptide synthetase protein VioF
K16099  vioA; nonribosomal peptide synthetase protein VioA
K16100  vioI; nonribosomal peptide synthetase protein VioI
K16101  vioG; nonribosomal peptide synthetase protein VioG
K16102  vioO; nonribosomal peptide synthetase protein VioO
K16103  vioM; nonribosomal peptide synthetase protein VioM
K16104  vioJ; 2,3-diaminopropionyl alpha,beta-desaturase
K16105  vioL; carbamoyltransferase
K16106  blmVI; nonribosomal peptide synthetase protein BlmVI
K16107  blmV; nonribosomal peptide synthetase protein BlmV
K16108  blmX; nonribosomal peptide synthetase protein BlmX
K16109  blmIX; nonribosomal peptide synthetase protein BlmIX
K16110  blmVIII; nonribosomal peptide synthetase protein BlmVIII
K16111  blmVII; nonribosomal peptide synthetase protein BlmVII
K16112  blmIV; nonribosomal peptide synthetase protein BlmIV
K16113  blmIII; nonribosomal peptide synthetase protein BlmIII
K16114  blmE; glycosyl transferase protein BlmE
K16115  blmF; glycosyl transferase / beta-hydroxylase protein BlmF
K16116  snbA; pristinamycin I synthetase 1
K16117  snbC; pristinamycin I synthase 2
K16118  snbDE; pristinamycin I synthase 3 and 4
K16122  tycA; tyrocidine synthetase I
K16123  tycB; tyrocidine synthetase II
K16124  tycC; tyrocidine synthetase III
K16125  syrE; syringomycin synthetase protein SyrE
K16126  syrB1; L-threonine---[L-threonyl-carrier protein] ligase [EC:6.2.1.70]
K16127  mcyG; microcystin synthetase protein McyG
K16128  mcyD; microcystin synthetase protein McyD
K16129  mcyE; microcystin synthetase protein McyE
K16130  mcyA; microcystin synthetase protein McyA
K16131  mcyB; microcystin synthetase protein McyB
K16132  mcyC; microcystin synthetase protein McyC
K16133  mcyI; microcystin synthetase protein McyI
K16134  mcyJ; microcystin synthetase protein McyJ
K26565  clbH; colibactin biosynthesis nonribosomal peptide synthase
K26566  clbE; colibactin biosynthesis acyl carrier protein
K26567  clbD; colibactin biosynthesis 3-hydroxyacyl-CoA dehydrogenase
K26568  clbF; colibactin biosynthesis acyl-CoA dehydrogenase
K26569  clbG; colibactin biosynthesis malonyl-CoA transacylase
K26570  clbQ; colibactin biosynthesis thioesterase
K26571  clbL; colibactin biosynthesis amidase
K26572  clbN; colibactin biosynthesis nonribosomal peptide synthase
K26573  clbB; colibactin biosynthesis hybrid nonribosomal peptide/polyketide synthase
K26574  clbC; colibactin biosynthesis polyketide synthase
K26575  clbI; colibactin biosynthesis polyketide synthase
K26576  clbO; colibactin biosynthesis polyketide synthase
K26577  clbK; colibactin biosynthesis hybrid nonribosomal peptide/polyketide synthase
K26578  clbJ; colibactin biosynthesis nonribosomal peptide synthase
K26579  clbP; colibactin biosynthesis peptidase
Compound
C00065  L-Serine
C01540  Viomycin
C01895  Bleomycin B2
C05371  Microcystin LR
C11218  Gramicidin S
C11615  Pristinamycin IA
C12030  Mycosubtilin
C12041  Tyrocidine
C12042  Fengycin
C12043  Surfactin
C12265  Lichenysin D
C12266  Iturin A
C12267  Bacillomycin D
C12268  Syringomycin
C15482  Bacitracin A
C18618  Aminomalonyl-[acp]
C22668  Colibactin
Reference
PMID:9864322
  Authors
Konz D, Doekel S, Marahiel MA.
  Title
Molecular and biochemical characterization of the protein template controlling biosynthesis of the lipopeptide lichenysin.
  Journal
J Bacteriol 181:133-40 (1999)
DOI:10.1128/JB.181.1.133-140.1999
Reference
  Authors
Moyne AL, Cleveland TE, Tuzun S.
  Title
Molecular characterization and analysis of the operon encoding the antifungal lipopeptide bacillomycin D.
  Journal
FEMS Microbiol Lett 234:43-9 (2004)
DOI:10.1016/j.femsle.2004.03.011
Reference
PMID:9830033
  Authors
Guenzi E, Galli G, Grgurina I, Gross DC, Grandi G.
  Title
Characterization of the syringomycin synthetase gene cluster. A link between prokaryotic and eukaryotic peptide synthetases.
  Journal
J Biol Chem 273:32857-63 (1998)
DOI:10.1074/jbc.273.49.32857
Reference
PMID:9303382
  Authors
de Crecy-Lagard V, Saurin W, Thibaut D, Gil P, Naudin L, Crouzet J, Blanc V
  Title
Streptogramin B biosynthesis in Streptomyces pristinaespiralis and Streptomyces virginiae: molecular characterization of the last structural peptide synthetase gene.
  Journal
Antimicrob Agents Chemother 41:1904-9 (1997)
DOI:10.1128/AAC.41.9.1904
Reference
  Authors
Du L, Sanchez C, Chen M, Edwards DJ, Shen B.
  Title
The biosynthetic gene cluster for the antitumor drug bleomycin from Streptomyces verticillus ATCC15003 supporting functional interactions between nonribosomal peptide synthetases and a polyketide synthase.
  Journal
Chem Biol 7:623-42 (2000)
DOI:10.1016/S1074-5521(00)00011-9
Reference
  Authors
Rouhiainen L, Vakkilainen T, Siemer BL, Buikema W, Haselkorn R, Sivonen K
  Title
Genes coding for hepatotoxic heptapeptides (microcystins) in the cyanobacterium Anabaena strain 90.
  Journal
Appl Environ Microbiol 70:686-92 (2004)
DOI:10.1128/AEM.70.2.686-692.2004
Reference
  Authors
Trauger JW, Kohli RM, Mootz HD, Marahiel MA, Walsh CT.
  Title
Peptide cyclization catalysed by the thioesterase domain of tyrocidine synthetase.
  Journal
Nature 407:215-8 (2000)
DOI:10.1038/35025116

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