KEGG   PATHWAY: ko03070
Entry
ko03070                     Pathway                                
Name
Bacterial secretion system
Description
Gram-negative bacteria secrete a wide range of proteins whose functions include biogenesis of organelles, such as pilli and flagella, nutrient acquisition, virulence, and efflux of drugs and other toxins. Six distinct secretion systems have been shown to mediate protein export through the inner and outer membranes of Gram-negative bacteria. These pathways are highly conserved throughout the Gram-negative bacterial species. In Gram-positive bacteria, secreted proteins are commonly translocated across the single membrane by the Sec pathway or the two-arginine (Tat) pathway.
Class
Environmental Information Processing; Membrane transport
Pathway map
ko03070  Bacterial secretion system
ko03070

Other DBs
GO: 0030253 0015628 0030254 0030255 0046819 0033103 0044098 0043952 0043953
Orthology
K02452  gspC; general secretion pathway protein C
K02453  gspD; general secretion pathway protein D
K02454  gspE; general secretion pathway protein E [EC:7.4.2.8]
K02455  gspF; general secretion pathway protein F
K02456  gspG; general secretion pathway protein G
K02457  gspH; general secretion pathway protein H
K02458  gspI; general secretion pathway protein I
K02459  gspJ; general secretion pathway protein J
K02460  gspK; general secretion pathway protein K
K02461  gspL; general secretion pathway protein L
K02462  gspM; general secretion pathway protein M
K02464  gspO; general secretion pathway protein O [EC:3.4.23.43 2.1.1.-]
K02465  gspS; general secretion pathway protein S
K03070  secA; preprotein translocase subunit SecA [EC:7.4.2.8]
K03071  secB; preprotein translocase subunit SecB
K03072  secD; preprotein translocase subunit SecD
K03073  secE; preprotein translocase subunit SecE
K03074  secF; preprotein translocase subunit SecF
K03075  secG; preprotein translocase subunit SecG
K03076  secY; preprotein translocase subunit SecY
K03106  SRP54, ffh; signal recognition particle subunit SRP54 [EC:3.6.5.4]
K03110  ftsY; fused signal recognition particle receptor
K03116  tatA; sec-independent protein translocase protein TatA
K03117  tatB; sec-independent protein translocase protein TatB
K03118  tatC; sec-independent protein translocase protein TatC
K03194  virB1; type IV secretion system protein VirB1
K03195  virB10, lvhB10; type IV secretion system protein VirB10
K03196  virB11, lvhB11; type IV secretion system protein VirB11 [EC:7.4.2.8]
K03197  virB2, lvhB2; type IV secretion system protein VirB2
K03198  virB3, lvhB3; type IV secretion system protein VirB3
K03199  virB4, lvhB4; type IV secretion system protein VirB4 [EC:7.4.2.8]
K03200  virB5, lvhB5; type IV secretion system protein VirB5
K03201  virB6, lvhB6; type IV secretion system protein VirB6
K03202  virB7, lvhB7; type IV secretion system protein VirB7
K03203  virB8, lvhB8; type IV secretion system protein VirB8
K03204  virB9, lvhB9; type IV secretion system protein VirB9
K03205  virD4, lvhD4; type IV secretion system protein VirD4 [EC:7.4.2.8]
K03210  yajC; preprotein translocase subunit YajC
K03217  yidC, spoIIIJ, OXA1, ccfA; YidC/Oxa1 family membrane protein insertase
K03219  yscC, sctC, ssaC; type III secretion protein C
K03221  yscF, sctF, ssaG, prgI; type III secretion protein F
K03222  yscJ, sctJ, hrcJ, ssaJ; type III secretion protein J
K03223  yscL, sctL; type III secretion protein L
K03224  yscN, sctN, hrcN, ssaN; ATP synthase in type III secretion protein N [EC:7.4.2.8]
K03225  yscQ, sctQ, hrcQ, ssaQ, spaO; type III secretion protein Q
K03226  yscR, sctR, hrcR, ssaR; type III secretion protein R
K03227  yscS, sctS, hrcS, ssaS; type III secretion protein S
K03228  yscT, sctT, hrcT, ssaT; type III secretion protein T
K03229  yscU, sctU, hrcU, ssaU; type III secretion protein U
K03230  yscV, sctV, hrcV, ssaV, invA; type III secretion protein V
K03425  tatE; sec-independent protein translocase protein TatE
K04056  yscO, sctO; type III secretion protein O
K04057  yscP, sctP; type III secretion protein P
K04058  yscW, sctW; type III secretion protein W
K04059  yscX, sctX; type III secretion protein X
K11003  hlyD, cyaD; membrane fusion protein, hemolysin D
K11004  hlyB, cyaB; ATP-binding cassette, subfamily B, bacterial HlyB/CyaB
K11016  shlA, hhdA, hpmA; hemolysin
K11017  shlB, hhdB, hpmB; hemolysin activation/secretion protein
K11028  vacA; vacuolating cytotoxin
K11891  impL, vasK, icmF; type VI secretion system protein ImpL
K11892  impK, ompA, vasF, dotU; type VI secretion system protein ImpK
K11903  hcp; type VI secretion system secreted protein Hcp
K11904  vgrG; type VI secretion system secreted protein VgrG
K11906  vasD, lip; type VI secretion system protein VasD
K11907  vasG, clpV; type VI secretion system protein VasG
K11912  ppkA; serine/threonine-protein kinase PpkA [EC:2.7.11.1]
K11913  fha1; type VI secretion system protein
K11915  stp1, pppA; serine/threonine protein phosphatase Stp1 [EC:3.1.3.16]
K12257  secDF; SecD/SecF fusion protein
K12340  tolC, bepC, cyaE, raxC, sapF, rsaF, hasF; outer membrane protein
K12341  yadA; adhesin YadA
K12342  yadB_C; adhesin YadB/C
K13301  secM; secretion monitor
Compound
C00002  ATP
Reference
PMID:11173102
  Authors
Kim JF.
  Title
Revisiting the chlamydial type III protein secretion system: clues to the origin of type III protein secretion.
  Journal
Trends Genet 17:65-9 (2001)
DOI:10.1016/S0168-9525(00)02175-2
Reference
PMID:11309112
  Authors
Plano GV, Day JB, Ferracci F.
  Title
Type III export: new uses for an old pathway.
  Journal
Mol Microbiol 40:284-93 (2001)
DOI:10.1046/j.1365-2958.2001.02354.x
Reference
PMID:11413015
  Authors
Gauthier A, Finlay BB.
  Title
Bacterial pathogenesis: the answer to virulence is in the pore.
  Journal
Curr Biol 11:R264-7 (2001)
DOI:10.1016/S0960-9822(01)00134-8
Reference
PMID:10047550
  Authors
Burns DL.
  Title
Biochemistry of type IV secretion.
  Journal
Curr Opin Microbiol 2:25-9 (1999)
DOI:10.1016/S1369-5274(99)80004-6
Reference
PMID:10920394
  Authors
Christie PJ, Vogel JP.
  Title
Bacterial type IV secretion: conjugation systems adapted to deliver effector molecules to host cells.
  Journal
Trends Microbiol 8:354-60 (2000)
DOI:10.1016/S0966-842X(00)01792-3
Reference
PMID:11309113
  Authors
Christie PJ.
  Title
Type IV secretion: intercellular transfer of macromolecules by systems ancestrally related to conjugation machines.
  Journal
Mol Microbiol 40:294-305 (2001)
DOI:10.1046/j.1365-2958.2001.02302.x
Reference
PMID:10481178
  Authors
Nunn D.
  Title
Bacterial type II protein export and pilus biogenesis: more than just homologies?
  Journal
Trends Cell Biol 9:402-8 (1999)
DOI:10.1016/S0962-8924(99)01634-7
Reference
PMID:11309111
  Authors
Sandkvist M.
  Title
Biology of type II secretion.
  Journal
Mol Microbiol 40:271-83 (2001)
DOI:10.1046/j.1365-2958.2001.02403.x
Reference
PMID:11349009
  Authors
Sandkvist M.
  Title
Type II secretion and pathogenesis.
  Journal
Infect Immun 69:3523-35 (2001)
DOI:10.1128/IAI.69.6.3523-3535.2001
Reference
PMID:15546664
  Authors
Delepelaire P
  Title
Type I secretion in gram-negative bacteria.
  Journal
Biochim Biophys Acta 1694:149-61 (2004)
DOI:10.1016/j.bbamcr.2004.05.001
Reference
PMID:18406342
  Authors
Hazes B, Frost L
  Title
Towards a systems biology approach to study type II/IV secretion systems.
  Journal
Biochim Biophys Acta 1778:1839-50 (2008)
DOI:10.1016/j.bbamem.2008.03.011
Reference
PMID:16448494
  Authors
Johnson TL, Abendroth J, Hol WG, Sandkvist M
  Title
Type II secretion: from structure to function.
  Journal
FEMS Microbiol Lett 255:175-86 (2006)
DOI:10.1111/j.1574-6968.2006.00102.x
Reference
PMID:15546665
  Authors
Filloux A
  Title
The underlying mechanisms of type II protein secretion.
  Journal
Biochim Biophys Acta 1694:163-79 (2004)
DOI:10.1016/j.bbamcr.2004.05.003
Reference
PMID:19396170
  Authors
Spreter T, Yip CK, Sanowar S, Andre I, Kimbrough TG, Vuckovic M, Pfuetzner RA, Deng W, Yu AC, Finlay BB, Baker D, Miller SI, Strynadka NC
  Title
A conserved structural motif mediates formation of the periplasmic rings in the type III secretion system.
  Journal
Nat Struct Mol Biol 16:468-76 (2009)
DOI:10.1038/nsmb.1603
Reference
PMID:15590783
  Authors
Ghosh P
  Title
Process of protein transport by the type III secretion system.
  Journal
Microbiol Mol Biol Rev 68:771-95 (2004)
DOI:10.1128/MMBR.68.4.771-795.2004
Reference
PMID:12360191
  Authors
Cornelis GR
  Title
The Yersinia Ysc-Yop 'type III' weaponry.
  Journal
Nat Rev Mol Cell Biol 3:742-52 (2002)
DOI:10.1038/nrm932
Reference
PMID:17215876
  Authors
Baron C
  Title
VirB8: a conserved type IV secretion system assembly factor and drug target.
  Journal
Biochem Cell Biol 84:890-9 (2006)
DOI:10.1139/o06-148
Reference
PMID:17943123
  Authors
Kwok T, Zabler D, Urman S, Rohde M, Hartig R, Wessler S, Misselwitz R, Berger J, Sewald N, Konig W, Backert S
  Title
Helicobacter exploits integrin for type IV secretion and kinase activation.
  Journal
Nature 449:862-6 (2007)
DOI:10.1038/nature06187
Reference
PMID:16092524
  Authors
Christie PJ, Cascales E
  Title
Structural and dynamic properties of bacterial type IV secretion systems (review).
  Journal
Mol Membr Biol 22:51-61 (2005)
DOI:10.1080/09687860500063316
Reference
PMID:15546668
  Authors
Christie PJ
  Title
Type IV secretion: the Agrobacterium VirB/D4 and related conjugation systems.
  Journal
Biochim Biophys Acta 1694:219-34 (2004)
DOI:10.1016/j.bbamcr.2004.02.013
Reference
PMID:15590781
  Authors
Henderson IR, Navarro-Garcia F, Desvaux M, Fernandez RC, Ala'Aldeen D
  Title
Type V protein secretion pathway: the autotransporter story.
  Journal
Microbiol Mol Biol Rev 68:692-744 (2004)
DOI:10.1128/MMBR.68.4.692-744.2004
Reference
PMID:9778731
  Authors
Henderson IR, Navarro-Garcia F, Nataro JP
  Title
The great escape: structure and function of the autotransporter proteins.
  Journal
Trends Microbiol 6:370-8 (1998)
DOI:10.1016/S0966-842X(98)01318-3
Reference
PMID:18524912
  Authors
Filloux A, Hachani A, Bleves S
  Title
The bacterial type VI secretion machine: yet another player for protein transport across membranes.
  Journal
Microbiology 154:1570-83 (2008)
DOI:10.1099/mic.0.2008/016840-0
Reference
PMID:19251641
  Authors
Leiman PG, Basler M, Ramagopal UA, Bonanno JB, Sauder JM, Pukatzki S, Burley SK, Almo SC, Mekalanos JJ
  Title
Type VI secretion apparatus and phage tail-associated protein complexes share a common evolutionary origin.
  Journal
Proc Natl Acad Sci U S A 106:4154-9 (2009)
DOI:10.1073/pnas.0813360106
Reference
PMID:17603507
  Authors
Kulasekara HD, Miller SI
  Title
Threonine phosphorylation times bacterial secretion.
  Journal
Nat Cell Biol 9:734-6 (2007)
DOI:10.1038/ncb0707-734
Reference
PMID:18078384
  Authors
Driessen AJ, Nouwen N
  Title
Protein translocation across the bacterial cytoplasmic membrane.
  Journal
Annu Rev Biochem 77:643-67 (2008)
DOI:10.1146/annurev.biochem.77.061606.160747
Reference
PMID:14641032
  Authors
Pool MR
  Title
Getting to the membrane: how is co-translational protein targeting to the endoplasmic reticulum regulated?
  Journal
Biochem Soc Trans 31:1232-7 (2003)
DOI:10.1042/bst0311232
Reference
PMID:19299134
  Authors
Desvaux M, Hebraud M, Talon R, Henderson IR
  Title
Secretion and subcellular localizations of bacterial proteins: a semantic awareness issue.
  Journal
Trends Microbiol 17:139-45 (2009)
DOI:10.1016/j.tim.2009.01.004
Reference
PMID:15063851
  Authors
Nakatogawa H, Murakami A, Ito K
  Title
Control of SecA and SecM translation by protein secretion.
  Journal
Curr Opin Microbiol 7:145-50 (2004)
DOI:10.1016/j.mib.2004.01.001

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