Entry Name Cell cycle - Caulobacter
Description Cell cycle progression of Caulobacter crescentus is implemented by an elaborate transcriptional regulatory network. During the life cycle, Caulobacter divides asymmetrically producing two distinct cell types with specialized development programs. The sessile stalked cell immediately initiates a new round of division cycle, whereas the motile swarmer cell remains in the G1 phase for a defined interval before differentiating into the stalked cell and entering into the S phase. The division process is centered around three master regulator proteins, DnaA, GcrA, and CtrA. DnaA and GcrA together drive the synthesis of proteins needed to complete DNA replication. CtrA controls the transcription of a diverse group of genes, which are required for essential morphological, metabolic, and cell cycle events.
Class Cellular Processes; Cell growth and deathBRITE hierarchy
Pathway map Other DBs Orthology K02313 dnaA; chromosomal replication initiator protein
K02488 pleD; two-component system, cell cycle response regulator [EC:2.7.7.65 ]
K02563 murG; UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase [EC:2.4.1.227 ]
K02651 flp, pilA; pilus assembly protein Flp/PilA
K03531 ftsZ; cell division protein FtsZ
K03544 clpX; ATP-dependent Clp protease ATP-binding subunit ClpX
K03588 ftsW, spoVE; cell division protein FtsW
K03589 ftsQ; cell division protein FtsQ
K03590 ftsA; cell division protein FtsA
K07716 pleC; two-component system, cell cycle sensor histidine kinase PleC [EC:2.7.13.3 ]
K11357 divJ; two-component system, cell cycle sensor histidine kinase DivJ [EC:2.7.13.3 ]
K11443 divK; two-component system, cell cycle response regulator DivK
K11749 rseP; regulator of sigma E protease [EC:3.4.24.-]
K13582 podJ; localization factor PodJL
K13583 gcrA; GcrA cell cycle regulator
K13584 ctrA; two-component system, cell cycle response regulator CtrA
K13585 hfaA; holdfast attachment protein HfaA
K13586 hfaB; holdfast attachment protein HfaB
K13587 cckA; two-component system, cell cycle sensor histidine kinase and response regulator CckA [EC:2.7.13.3 ]
K13588 chpT; histidine phosphotransferase ChpT
K13589 cpdR; two-component system, cell cycle response regulator CpdR
K13591 popA; two-component system, cell cycle response regulator PopA
K13592 rcdA; regulator of CtrA degradation
K13593 tipF; cyclic-di-GMP phosphodiesterase, flagellum assembly factor TipF
Compound Reference Authors Shen X, Collier J, Dill D, Shapiro L, Horowitz M, McAdams HH
Title Architecture and inherent robustness of a bacterial cell-cycle control system.
Journal Reference Authors Curtis PD, Brun YV
Title Getting in the loop: regulation of development in Caulobacter crescentus.
Journal Reference Authors Skerker JM, Laub MT
Title Cell-cycle progression and the generation of asymmetry in Caulobacter crescentus.
Journal Reference Authors Jenal U, Galperin MY
Title Single domain response regulators: molecular switches with emerging roles in cell organization and dynamics.
Journal Reference Authors Thanbichler M
Title Spatial regulation in Caulobacter crescentus.
Journal Reference Authors Jenal U
Title The role of proteolysis in the Caulobacter crescentus cell cycle and development.
Journal Reference Authors Hengge R
Title Principles of c-di-GMP signalling in bacteria.
Journal Reference Authors Goley ED, Toro E, McAdams HH, Shapiro L
Title Dynamic chromosome organization and protein localization coordinate the regulatory circuitry that drives the bacterial cell cycle.
Journal Reference Authors Li S, Brazhnik P, Sobral B, Tyson JJ
Title Temporal controls of the asymmetric cell division cycle in Caulobacter crescentus.
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