PATHWAY: ko02020 Help
Entry Name Two-component system
Description Two-component signal transduction systems enable bacteria to sense, respond, and adapt to changes in their environment or in their intracellular state. Each two-component system consists of a sensor protein-histidine kinase (HK) and a response regulator (RR). In the prototypical two-component pathway, the sensor HK phosphorylates its own conserved His residue in response to a signal(s) in the environment. Subsequently, the phosphoryl group of HK is transferred onto a specific Asp residue on the RR. The activated RR can then effect changes in cellular physiology, often by regulating gene expression. Two-component pathways thus often enable cells to sense and respond to stimuli by inducing changes in transcription.
Class Environmental Information Processing; Signal transductionBRITE hierarchy
Pathway map Module Other DBs Orthology K00027 ME2, sfcA, maeA; malate dehydrogenase (oxaloacetate-decarboxylating) [EC:1.1.1.38 ]
K00244 frdA; succinate dehydrogenase flavoprotein subunit [EC:1.3.5.1 ]
K00245 frdB; succinate dehydrogenase iron-sulfur subunit [EC:1.3.5.1 ]
K00246 frdC; succinate dehydrogenase subunit C
K00247 frdD; succinate dehydrogenase subunit D
K00370 narG, narZ, nxrA; nitrate reductase / nitrite oxidoreductase, alpha subunit [EC:1.7.5.1 1.7.99.-]
K00371 narH, narY, nxrB; nitrate reductase / nitrite oxidoreductase, beta subunit [EC:1.7.5.1 1.7.99.-]
K00373 narJ, narW; nitrate reductase molybdenum cofactor assembly chaperone NarJ/NarW
K00374 narI, narV; nitrate reductase gamma subunit [EC:1.7.5.1 1.7.99.-]
K00404 ccoN; cytochrome c oxidase cbb3-type subunit I [EC:7.1.1.9 ]
K00405 ccoO; cytochrome c oxidase cbb3-type subunit II
K00406 ccoP; cytochrome c oxidase cbb3-type subunit III
K00407 ccoQ; cytochrome c oxidase cbb3-type subunit IV
K00410 fbcH; ubiquinol-cytochrome c reductase cytochrome b/c1 subunit
K00411 UQCRFS1, RIP1, petA; ubiquinol-cytochrome c reductase iron-sulfur subunit [EC:7.1.1.8 ]
K00412 CYTB, petB; ubiquinol-cytochrome c reductase cytochrome b subunit
K00413 CYC1, CYT1, petC; ubiquinol-cytochrome c reductase cytochrome c1 subunit
K00424 cydX; cytochrome bd-I ubiquinol oxidase subunit X [EC:7.1.1.7 ]
K00425 cydA; cytochrome bd ubiquinol oxidase subunit I [EC:7.1.1.7 ]
K00426 cydB; cytochrome bd ubiquinol oxidase subunit II [EC:7.1.1.7 ]
K01545 kdpF; potassium-transporting ATPase KdpF subunit
K01546 kdpA; potassium-transporting ATPase potassium-binding subunit
K01547 kdpB; potassium-transporting ATPase ATP-binding subunit [EC:7.2.2.6 ]
K01548 kdpC; potassium-transporting ATPase KdpC subunit
K01643 citF; citrate lyase subunit alpha / citrate CoA-transferase [EC:2.8.3.10 ]
K01644 citE; citrate lyase subunit beta / citryl-CoA lyase [EC:4.1.3.34 ]
K01646 citD; citrate lyase subunit gamma (acyl carrier protein)
K01791 wecB; UDP-N-acetylglucosamine 2-epimerase (non-hydrolysing) [EC:5.1.3.14 ]
K01991 wza, gfcE; polysaccharide biosynthesis/export protein
K02040 pstS; phosphate transport system substrate-binding protein
K02106 atoE; short-chain fatty acids transporter
K02252 comS; competence protein ComS
K02253 comX; competence protein ComX
K02279 cpaB, rcpC; pilus assembly protein CpaB
K02280 cpaC, rcpA; pilus assembly protein CpaC
K02282 cpaE, tadZ; pilus assembly protein CpaE
K02313 dnaA; chromosomal replication initiator protein
K02398 flgM; negative regulator of flagellin synthesis FlgM
K02402 flhC; flagellar transcriptional activator FlhC
K02403 flhD; flagellar transcriptional activator FlhD
K02405 fliA, whiG; RNA polymerase sigma factor FliA
K02472 wecC; UDP-N-acetyl-D-mannosaminuronic acid dehydrogenase [EC:1.1.1.336 ]
K02488 pleD; two-component system, cell cycle response regulator [EC:2.7.7.65 ]
K02489 hk1; two-component system, glycerol uptake and utilization sensor kinase [EC:2.7.13.3 ]
K02490 spo0F; two-component system, response regulator, stage 0 sporulation protein F
K02491 kinA; two-component system, sporulation sensor kinase A [EC:2.7.13.3 ]
K02556 motA; chemotaxis protein MotA
K02584 nifA; Nif-specific regulatory protein
K02650 pilA; type IV pilus assembly protein PilA
K02651 flp, pilA; pilus assembly protein Flp/PilA
K02657 pilG; twitching motility two-component system response regulator PilG
K02658 pilH; twitching motility two-component system response regulator PilH
K02659 pilI; twitching motility protein PilI
K02660 pilJ; twitching motility protein PilJ
K02661 pilK; type IV pilus assembly protein PilK
K02667 pilR, pehR; two-component system, NtrC family, response regulator PilR
K02668 pilS, pehS; two-component system, NtrC family, sensor histidine kinase PilS [EC:2.7.13.3 ]
K03092 rpoN; RNA polymerase sigma-54 factor
K03367 dltA; D-alanine--poly(phosphoribitol) ligase subunit 1 [EC:6.1.1.13 ]
K03406 mcp; methyl-accepting chemotaxis protein
K03407 cheA; two-component system, chemotaxis family, sensor kinase CheA [EC:2.7.13.3 ]
K03408 cheW; purine-binding chemotaxis protein CheW
K03412 cheB; two-component system, chemotaxis family, protein-glutamate methylesterase/glutaminase [EC:3.1.1.61 3.5.1.44 ]
K03413 cheY; two-component system, chemotaxis family, chemotaxis protein CheY
K03415 cheV; two-component system, chemotaxis family, chemotaxis protein CheV
K03532 torC; trimethylamine-N-oxide reductase (cytochrome c), cytochrome c-type subunit TorC
K03533 torD; TorA specific chaperone
K03563 csrA; carbon storage regulator
K03620 hyaC; Ni/Fe-hydrogenase 1 B-type cytochrome subunit
K03739 dltB; membrane protein involved in D-alanine export
K03740 dltD; D-alanine transfer protein
K03776 aer; aerotaxis receptor
K04751 glnB; nitrogen regulatory protein P-II 1
K05338 lrgA; holin-like protein
K05339 lrgB; holin-like protein LrgB
K05874 tsr; methyl-accepting chemotaxis protein I, serine sensor receptor
K05875 tar; methyl-accepting chemotaxis protein II, aspartate sensor receptor
K05876 trg; methyl-accepting chemotaxis protein III, ribose and galactose sensor receptor
K05877 tap; methyl-accepting chemotaxis protein IV, peptide sensor receptor
K06046 luxE; long-chain-fatty-acid---luciferin-component ligase [EC:6.2.1.19 ]
K06347 kapB; kinase-associated protein B
K06375 spo0B; stage 0 sporulation protein B (sporulation initiation phosphotransferase) [EC:2.7.-.-]
K06596 chpA; chemosensory pili system protein ChpA (sensor histidine kinase/response regulator)
K06597 chpB; chemosensory pili system protein ChpB (putative protein-glutamate methylesterase)
K06598 chpC; chemosensory pili system protein ChpC
K07165 fecR; transmembrane sensor
K07346 fimC; fimbrial chaperone protein
K07347 fimD, fimC, mrkC, htrE, cssD; outer membrane usher protein
K07636 phoR; two-component system, OmpR family, phosphate regulon sensor histidine kinase PhoR [EC:2.7.13.3 ]
K07637 phoQ; two-component system, OmpR family, sensor histidine kinase PhoQ [EC:2.7.13.3 ]
K07638 envZ; two-component system, OmpR family, osmolarity sensor histidine kinase EnvZ [EC:2.7.13.3 ]
K07639 rstB; two-component system, OmpR family, sensor histidine kinase RstB [EC:2.7.13.3 ]
K07640 cpxA; two-component system, OmpR family, sensor histidine kinase CpxA [EC:2.7.13.3 ]
K07641 creC; two-component system, OmpR family, sensor histidine kinase CreC [EC:2.7.13.3 ]
K07642 baeS, smeS; two-component system, OmpR family, sensor histidine kinase BaeS [EC:2.7.13.3 ]
K07643 basS; two-component system, OmpR family, sensor histidine kinase BasS [EC:2.7.13.3 ]
K07644 cusS, copS, silS; two-component system, OmpR family, heavy metal sensor histidine kinase CusS [EC:2.7.13.3 ]
K07645 qseC; two-component system, OmpR family, sensor histidine kinase QseC [EC:2.7.13.3 ]
K07646 kdpD; two-component system, OmpR family, sensor histidine kinase KdpD [EC:2.7.13.3 ]
K07647 torS; two-component system, OmpR family, sensor histidine kinase TorS [EC:2.7.13.3 ]
K07648 arcB; two-component system, OmpR family, aerobic respiration control sensor histidine kinase ArcB [EC:2.7.13.3 ]
K07649 tctE; two-component system, OmpR family, sensor histidine kinase TctE [EC:2.7.13.3 ]
K07650 cssS; two-component system, OmpR family, sensor histidine kinase CssS [EC:2.7.13.3 ]
K07651 resE; two-component system, OmpR family, sensor histidine kinase ResE [EC:2.7.13.3 ]
K07652 vicK; two-component system, OmpR family, sensor histidine kinase VicK [EC:2.7.13.3 ]
K07653 mprB; two-component system, OmpR family, sensor histidine kinase MprB [EC:2.7.13.3 ]
K07654 mtrB; two-component system, OmpR family, sensor histidine kinase MtrB [EC:2.7.13.3 ]
K07655 prrB; two-component system, OmpR family, sensor histidine kinase PrrB [EC:2.7.13.3 ]
K07656 trcS; two-component system, OmpR family, sensor histidine kinase TrcS [EC:2.7.13.3 ]
K07657 phoB; two-component system, OmpR family, phosphate regulon response regulator PhoB
K07658 phoB1, phoP; two-component system, OmpR family, alkaline phosphatase synthesis response regulator PhoP
K07659 ompR; two-component system, OmpR family, phosphate regulon response regulator OmpR
K07660 phoP; two-component system, OmpR family, response regulator PhoP
K07661 rstA; two-component system, OmpR family, response regulator RstA
K07662 cpxR; two-component system, OmpR family, response regulator CpxR
K07663 creB; two-component system, OmpR family, catabolic regulation response regulator CreB
K07664 baeR, smeR; two-component system, OmpR family, response regulator BaeR
K07665 cusR, copR, silR; two-component system, OmpR family, copper resistance phosphate regulon response regulator CusR
K07666 qseB; two-component system, OmpR family, response regulator QseB
K07667 kdpE; two-component system, OmpR family, KDP operon response regulator KdpE
K07668 vicR; two-component system, OmpR family, response regulator VicR
K07669 mprA; two-component system, OmpR family, response regulator MprA
K07670 mtrA; two-component system, OmpR family, response regulator MtrA
K07671 prrA; two-component system, OmpR family, response regulator PrrA
K07672 trcR; two-component system, OmpR family, response regulator TrcR
K07673 narX; two-component system, NarL family, nitrate/nitrite sensor histidine kinase NarX [EC:2.7.13.3 ]
K07674 narQ; two-component system, NarL family, nitrate/nitrite sensor histidine kinase NarQ [EC:2.7.13.3 ]
K07675 uhpB; two-component system, NarL family, sensor histidine kinase UhpB [EC:2.7.13.3 ]
K07676 rcsD; two-component system, NarL family, sensor histidine kinase RcsD [EC:2.7.13.3 ]
K07677 rcsC; two-component system, NarL family, capsular synthesis sensor histidine kinase RcsC [EC:2.7.13.3 ]
K07678 barA, gacS, varS; two-component system, NarL family, sensor histidine kinase BarA [EC:2.7.13.3 ]
K07679 evgS, bvgS; two-component system, NarL family, sensor histidine kinase EvgS [EC:2.7.13.3 ]
K07680 comP; two-component system, NarL family, sensor histidine kinase ComP [EC:2.7.13.3 ]
K07681 vraS; two-component system, NarL family, vancomycin resistance sensor histidine kinase VraS [EC:2.7.13.3 ]
K07682 devS; two-component system, NarL family, sensor histidine kinase DevS [EC:2.7.13.3 ]
K07683 nreB; two-component system, NarL family, sensor histidine kinase NreB [EC:2.7.13.3 ]
K07684 narL; two-component system, NarL family, nitrate/nitrite response regulator NarL
K07685 narP; two-component system, NarL family, nitrate/nitrite response regulator NarP
K07686 uhpA; two-component system, NarL family, uhpT operon response regulator UhpA
K07687 rcsB; two-component system, NarL family, captular synthesis response regulator RcsB
K07688 fimZ; two-component system, NarL family, response regulator, fimbrial Z protein, FimZ
K07689 uvrY, gacA, varA; two-component system, NarL family, invasion response regulator UvrY
K07690 evgA, bvgA; two-component system, NarL family, response regulator EvgA
K07691 comA; two-component system, NarL family, competent response regulator ComA
K07692 degU; two-component system, NarL family, response regulator DegU
K07693 desR; two-component system, NarL family, response regulator DesR
K07694 vraR; two-component system, NarL family, vancomycin resistance associated response regulator VraR
K07695 devR; two-component system, NarL family, response regulator DevR
K07696 nreC; two-component system, NarL family, response regulator NreC
K07697 kinB; two-component system, sporulation sensor kinase B [EC:2.7.13.3 ]
K07698 kinC; two-component system, sporulation sensor kinase C [EC:2.7.13.3 ]
K07699 spo0A; two-component system, response regulator, stage 0 sporulation protein A
K07700 dpiB, citA; two-component system, CitB family, cit operon sensor histidine kinase CitA [EC:2.7.13.3 ]
K07701 dcuS; two-component system, CitB family, sensor histidine kinase DcuS [EC:2.7.13.3 ]
K07702 dpiA, citB; two-component system, CitB family, response regulator CitB
K07703 dcuR; two-component system, CitB family, response regulator DcuR
K07704 lytS; two-component system, LytTR family, sensor histidine kinase LytS [EC:2.7.13.3 ]
K07705 lytT, lytR; two-component system, LytTR family, response regulator LytT
K07706 agrC, blpH, fsrC; two-component system, LytTR family, sensor histidine kinase AgrC [EC:2.7.13.3 ]
K07707 agrA, blpR, fsrA; two-component system, LytTR family, response regulator AgrA
K07708 glnL, ntrB; two-component system, NtrC family, nitrogen regulation sensor histidine kinase GlnL [EC:2.7.13.3 ]
K07709 zraS, hydH; two-component system, NtrC family, sensor histidine kinase HydH [EC:2.7.13.3 ]
K07710 atoS; two-component system, NtrC family, sensor histidine kinase AtoS [EC:2.7.13.3 ]
K07711 glrK, qseE; two-component system, NtrC family, sensor histidine kinase GlrK [EC:2.7.13.3 ]
K07712 glnG, ntrC; two-component system, NtrC family, nitrogen regulation response regulator GlnG
K07713 zraR, hydG; two-component system, NtrC family, response regulator HydG
K07714 atoC; two-component system, NtrC family, response regulator AtoC
K07715 glrR, qseF; two-component system, NtrC family, response regulator GlrR
K07716 pleC; two-component system, cell cycle sensor histidine kinase PleC [EC:2.7.13.3 ]
K07717 glnK; two-component system, sensor histidine kinase GlnK [EC:2.7.13.3 ]
K07718 yesM; two-component system, sensor histidine kinase YesM [EC:2.7.13.3 ]
K07719 glnL; two-component system, response regulator GlnL
K07720 yesN; two-component system, response regulator YesN
K07768 senX3; two-component system, OmpR family, sensor histidine kinase SenX3 [EC:2.7.13.3 ]
K07769 nblS, dfr, dspA, hik33; two-component system, OmpR family, sensor histidine kinase NblS [EC:2.7.13.3 ]
K07770 cssR; two-component system, OmpR family, response regulator CssR
K07771 basR; two-component system, OmpR family, response regulator BasR
K07772 torR; two-component system, OmpR family, torCAD operon response regulator TorR
K07773 arcA; two-component system, OmpR family, aerobic respiration control protein ArcA
K07774 tctD; two-component system, OmpR family, response regulator TctD
K07775 resD; two-component system, OmpR family, response regulator ResD
K07776 regX3; two-component system, OmpR family, response regulator RegX3
K07777 degS; two-component system, NarL family, sensor histidine kinase DegS [EC:2.7.13.3 ]
K07778 desK; two-component system, NarL family, sensor histidine kinase DesK [EC:2.7.13.3 ]
K07780 appY; AraC family transcriptional regulator, transcriptional regulator required for anaerobic and stationary phase induction of genes
K07781 rcsA; LuxR family transcriptional regulator, capsular biosynthesis positive transcription factor
K07782 sdiA; LuxR family transcriptional regulator, quorum-sensing system regulator SdiA
K07783 uhpC; MFS transporter, OPA family, sugar phosphate sensor protein UhpC
K07784 uhpT; MFS transporter, OPA family, hexose phosphate transport protein UhpT
K07785 nrsD, nreB; MFS transporter, NRE family, putaive nickel resistance protein
K07786 emrY; MFS transporter, DHA2 family, multidrug resistance protein
K07787 cusA, silA; copper/silver efflux system protein
K07788 mdtB; multidrug efflux pump
K07789 mdtC; multidrug efflux pump
K07790 pagO; putative membrane protein PagO
K07792 dcuB; anaerobic C4-dicarboxylate transporter DcuB
K07793 tctA; putative tricarboxylic transport membrane protein
K07794 tctB; putative tricarboxylic transport membrane protein
K07795 tctC; putative tricarboxylic transport membrane protein
K07796 cusC, silC; outer membrane protein, copper/silver efflux system
K07797 emrK; multidrug resistance protein K
K07798 cusB, silB; membrane fusion protein, copper/silver efflux system
K07799 mdtA; membrane fusion protein, multidrug efflux system
K07801 pagK; PhoPQ-activated protein
K07803 zraP; zinc resistance-associated protein
K07804 pagC; putatice virulence related protein PagC
K07805 pagD; putative membrane protein PagD
K07806 arnB, pmrH; UDP-4-amino-4-deoxy-L-arabinose-oxoglutarate aminotransferase [EC:2.6.1.87 ]
K07810 cusF; Cu(I)/Ag(I) efflux system periplasmic protein CusF
K07811 torA; trimethylamine-N-oxide reductase (cytochrome c) [EC:1.7.2.3 ]
K07813 agrB; accessory gene regulator B
K08082 algZ; two-component system, LytTR family, sensor histidine kinase AlgZ [EC:2.7.13.3 ]
K08083 algR; two-component system, LytTR family, response regulator AlgR
K08177 oxlT; MFS transporter, OFA family, oxalate/formate antiporter
K08349 fdnH; formate dehydrogenase-N, beta subunit
K08350 fdnI; formate dehydrogenase-N, gamma subunit
K08357 ttrA; tetrathionate reductase subunit A
K08358 ttrB; tetrathionate reductase subunit B
K08359 ttrC; tetrathionate reductase subunit C
K08372 pepD; putative serine protease PepD [EC:3.4.21.-]
K08475 pgtB; two-component system, NtrC family, phosphoglycerate transport system sensor histidine kinase PgtB [EC:2.7.13.3 ]
K08476 pgtA; two-component system, NtrC family, phosphoglycerate transport system response regulator PgtA
K08477 pgtE; outer membrane protease E [EC:3.4.21.-]
K08478 pgtC; phosphoglycerate transport regulatory protein PgtC
K08479 sasA; two-component system, OmpR family, clock-associated histidine kinase SasA [EC:2.7.13.3 ]
K08926 pufA; light-harvesting complex 1 alpha chain
K08927 pufB; light-harvesting complex 1 beta chain
K08928 pufL; photosynthetic reaction center L subunit
K08929 pufM; photosynthetic reaction center M subunit
K08930 pucA; light-harvesting protein B-800-850 alpha chain
K08939 pucB; light-harvesting protein B-800-850 beta chain
K09475 ompC; outer membrane pore protein C
K09476 ompF; outer membrane pore protein F
K09477 citT; citrate:succinate antiporter
K09696 natB; sodium transport system permease protein
K09697 natA; sodium transport system ATP-binding protein [EC:7.2.2.4 ]
K10001 gltI, aatJ; glutamate/aspartate transport system substrate-binding protein
K10002 gltK, aatM; glutamate/aspartate transport system permease protein
K10003 gltJ, aatQ; glutamate/aspartate transport system permease protein
K10004 gltL, aatP; glutamate/aspartate transport system ATP-binding protein [EC:7.4.2.1 ]
K10125 dctB; two-component system, NtrC family, C4-dicarboxylate transport sensor histidine kinase DctB [EC:2.7.13.3 ]
K10126 dctD; two-component system, NtrC family, C4-dicarboxylate transport response regulator DctD
K10681 saeS; two-component system, OmpR family, sensor histidine kinase SaeS [EC:2.7.13.3 ]
K10682 saeR; two-component system, OmpR family, response regulator SaeR
K10697 rpaA; two-component system, OmpR family, response regulator RpaA
K10715 rpfC; two-component system, sensor histidine kinase RpfC [EC:2.7.13.3 ]
K10850 narT; MFS transporter, NNP family, putative nitrate transporter
K10851 nreA; nitrogen regulatory protein A
K10909 luxQ; two-component system, autoinducer 2 sensor kinase/phosphatase LuxQ [EC:2.7.13.3 3.1.3.-]
K10910 luxP; autoinducer 2-binding periplasmic protein LuxP
K10911 luxU; two-component system, phosphorelay protein LuxU
K10912 luxO; two-component system, repressor protein LuxO
K10913 hapR, luxR, litR; TetR/AcrR family transcriptional regulator, hemagglutinin/protease regulatory protein
K10914 crp; CRP/FNR family transcriptional regulator, cyclic AMP receptor protein
K10916 cqsS; two-component system, CAI-1 autoinducer sensor kinase/phosphatase CqsS [EC:2.7.13.3 3.1.3.-]
K10941 flrA, fleQ, flaK; sigma-54 dependent transcriptional regulator, flagellar regulatory protein
K10942 flrB, fleS, flaL; two-component system, sensor histidine kinase FlrB [EC:2.7.13.3 ]
K10943 flrC, fleR, flaM; two-component system, response regulator FlrC
K11103 dctA; aerobic C4-dicarboxylate transport protein
K11231 SLN1; osomolarity two-component system, sensor histidine kinase SLN1 [EC:2.7.13.3 ]
K11232 YPD1; osomolarity two-component system, phosphorelay intermediate protein YPD1
K11233 SSK1; osomolarity two-component system, response regulator SSK1
K11326 nrsA, czcA; cation efflux system protein involved in nickel and cobalt tolerance
K11327 nrsB; membrane fusion protein, cation efflux system
K11328 nrsS, rppB; two-component system, OmpR family, Ni(II)-sensor and/or redox sensor kinase NrsS [EC:2.7.13.3 ]
K11329 rpaB; two-component system, OmpR family, response regulator RpaB
K11330 nrsR, rppA; two-component system, OmpR family, Ni(II)-responsive and/or redox-responsive regulator NrsR
K11331 nrsC; cation efflux system protein involved in nickel and cobalt tolerance [EC:3.2.1.17 ]
K11332 nblR; two-component system, OmpR family, response regulator NblR
K11354 cph1; two-component system, chemotaxis family, sensor kinase Cph1 [EC:2.7.13.3 ]
K11355 rcp1; two-component system, chemotaxis family, response regulator Rcp1
K11356 cikA; two-component system, sensor histidine kinase and response regulator [EC:2.7.13.3 ]
K11357 divJ; two-component system, cell cycle sensor histidine kinase DivJ [EC:2.7.13.3 ]
K11382 pgtP; MFS transporter, OPA family, phosphoglycerate transporter protein
K11383 kinB; two-component system, NtrC family, sensor histidine kinase KinB [EC:2.7.13.3 ]
K11384 algB; two-component system, NtrC family, response regulator AlgB
K11443 divK; two-component system, cell cycle response regulator DivK
K11444 wspR; two-component system, chemotaxis family, response regulator WspR [EC:2.7.7.65 ]
K11520 manS; two-component system, OmpR family, manganese sensing sensor histidine kinase [EC:2.7.13.3 ]
K11521 manR; two-component system, OmpR family, manganese sensing response regulator
K11522 pixG; two-component system, chemotaxis family, response regulator PixG
K11523 pixH; two-component system, chemotaxis family, response regulator PixH
K11524 pixI; positive phototaxis protein PixI
K11525 pixJ; methyl-accepting chemotaxis protein PixJ
K11526 pixL; two-component system, chemotaxis family, sensor histidine kinase and response regulator PixL
K11601 mntC; manganese transport system substrate-binding protein
K11602 mntB; manganese transport system permease protein
K11603 mntA; manganese transport system ATP-binding protein [EC:7.2.2.5 ]
K11614 yufL, malK; two-component system, CitB family, sensor histidine kinase MalK [EC:2.7.13.3 ]
K11615 malR; two-component system, CitB family, response regulator MalR
K11616 maeN; malate:Na+ symporter
K11617 liaS; two-component system, NarL family, sensor histidine kinase LiaS [EC:2.7.13.3 ]
K11618 liaR; two-component system, NarL family, response regulator LiaR
K11619 liaI; lia operon protein LiaI
K11620 liaH; lia operon protein LiaH
K11621 liaG; lia operon protein LiaG
K11622 liaF; lia operon protein LiaF
K11623 ydfH; two-component system, NarL family, sensor histidine kinase YdfH [EC:2.7.13.3 ]
K11624 ydfI; two-component system, NarL family, response regulator YdfI
K11625 ydfJ; membrane protein YdfJ
K11626 glnT; putative sodium/glutamine symporter
K11629 bceS; two-component system, OmpR family, bacitracin resistance sensor histidine kinase BceS [EC:2.7.13.3 ]
K11630 bceR; two-component system, OmpR family, bacitracin resistance response regulator BceR
K11631 bceA, vraD; bacitracin transport system ATP-binding protein
K11632 bceB, vraE; bacitracin transport system permease protein
K11633 yxdK; two-component system, OmpR family, sensor histidine kinase YxdK [EC:2.7.13.3 ]
K11634 yxdJ; two-component system, OmpR family, response regulator YxdJ
K11635 yxdL; putative ABC transport system ATP-binding protein
K11636 yxdM; putative ABC transport system permease protein
K11637 citS; two-component system, CitB family, sensor histidine kinase CitS [EC:2.7.13.3 ]
K11638 K11638 , citT; two-component system, CitB family, response regulator CitT
K11639 citM; Mg2+/citrate complex secondary transporter
K11640 natK; two-component system, LytTR family, sensor histidine kinase NatK [EC:2.7.13.3 ]
K11641 natR; two-component system, LytTR family, response regulator NatR
K11688 dctP, yiaO; TRAP-type transport system periplasmic protein
K11689 dctQ, yiaM; TRAP-type transport system small permease protein
K11690 dctM, yiaN; TRAP-type transport system large permease protein
K11692 K11692 , dctR; two-component system, CitB family, response regulator DctR
K11711 dctS; two-component system, LuxR family, sensor histidine kinase DctS [EC:2.7.13.3 ]
K11712 dctR; two-component system, LuxR family, response regulator DctR
K12292 comA; ATP-binding cassette, subfamily C, bacterial, competence factor transporting protein [EC:3.4.22.-]
K12293 comB; competence factor transport accessory protein ComB
K12294 comD; two-component system, LytTR family, sensor histidine kinase ComD [EC:2.7.13.3 ]
K12295 comE; two-component system, LytTR family, response regulator ComE
K12296 comX1_2; competence protein ComX
K12340 tolC, bepC, cyaE, raxC, sapF, rsaF, hasF; outer membrane protein
K12415 comC; competence-stimulating peptide
K12510 tadB; tight adherence protein B
K12511 tadC; tight adherence protein C
K12530 rtxB, fitA; ATP-binding cassette, subfamily B, bacterial RtxB
K12531 rtxE, fitC; ATP-binding cassette, subfamily B, bacterial RtxE
K12532 rtxD, fitB; membrane fusion protein, RTX toxin transport system
K13040 ttrS; two-component system, LuxR family, sensor histidine kinase TtrS [EC:2.7.13.3 ]
K13041 ttrR; two-component system, LuxR family, response regulator TtrR
K13061 rhlI, phzI, solI, cepI, tofI; acyl homoserine lactone synthase [EC:2.3.1.184 ]
K13486 wspC; chemotaxis protein methyltransferase WspC
K13487 wspA; methyl-accepting chemotaxis protein WspA
K13488 wspB; chemotaxis-related protein WspB
K13489 wspD; chemotaxis-related protein WspD
K13490 wspE; two-component system, chemotaxis family, sensor histidine kinase and response regulator WspE
K13491 wspF; two-component system, chemotaxis family, response regulator WspF [EC:3.1.1.61 ]
K13532 kinD; two-component system, sporulation sensor kinase D [EC:2.7.13.3 ]
K13533 kinE; two-component system, sporulation sensor kinase E [EC:2.7.13.3 ]
K13584 ctrA; two-component system, cell cycle response regulator CtrA
K13587 cckA; two-component system, cell cycle sensor histidine kinase and response regulator CckA [EC:2.7.13.3 ]
K13588 chpT; histidine phosphotransferase ChpT
K13589 cpdR; two-component system, cell cycle response regulator CpdR
K13598 ntrY; two-component system, NtrC family, nitrogen regulation sensor histidine kinase NtrY [EC:2.7.13.3 ]
K13599 ntrX; two-component system, NtrC family, nitrogen regulation response regulator NtrX
K13815 rpfG; two-component system, response regulator RpfG
K13991 puhA; photosynthetic reaction center H subunit
K13994 pufX; photosynthetic reaction center PufX protein
K14188 dltC; D-alanine--poly(phosphoribitol) ligase subunit 2 [EC:6.1.1.13 ]
K14205 mprF, fmtC; phosphatidylglycerol lysyltransferase [EC:2.3.2.3 ]
K14978 ssrA; two-component system, LuxR family, secretion system sensor histidine kinase SsrA
K14979 ssrB; two-component system, LuxR family, secretion system response regulator SsrB
K14980 chvG; two-component system, OmpR family, sensor histidine kinase ChvG [EC:2.7.13.3 ]
K14981 chvI; two-component system, OmpR family, response regulator ChvI
K14982 ciaH; two-component system, OmpR family, sensor histidine kinase CiaH [EC:2.7.13.3 ]
K14983 ciaR; two-component system, OmpR family, response regulator CiaR
K14986 fixL; two-component system, LuxR family, sensor kinase FixL [EC:2.7.13.3 ]
K14987 fixJ; two-component system, LuxR family, response regulator FixJ
K14988 salK; two-component system, NarL family, secretion system sensor histidine kinase SalK
K14989 salR; two-component system, NarL family, secretion system response regulator SalR
K15011 regB, regS, actS; two-component system, sensor histidine kinase RegB [EC:2.7.13.3 ]
K15012 regA, regR, actR; two-component system, response regulator RegA
K15739 vanB, vanA, vanD; D-alanine---(R)-lactate ligase [EC:6.1.2.1 ]
K15841 glmY; small regulatory RNA GlmY
K15850 luxN; two-component system, autoinducer 1 sensor kinase/phosphatase LuxN [EC:2.7.13.3 3.1.3.-]
K15851 qrr; quorum regulatory RNA Qrr
K15853 luxD; acyl transferase [EC:2.3.1.-]
K15859 SKN7; osomolarity two-component system, response regulator SKN7
K15860 ciaX; regulatory peptide CiaX
K15861 fixK; CRP/FNR family transcriptional regulator, nitrogen fixation regulation protein
K15862 ccoNO; cytochrome c oxidase cbb3-type subunit I/II [EC:7.1.1.9 ]
K16712 epsE; EPS I polysaccharide export inner membrane protein EpsE
K16713 epsF; EPS I polysaccharide export inner membrane protein EpsF
K17060 aauS; two-component system, sensor histidine kinase AauS [EC:2.7.13.3 ]
K17061 aauR; two-component system, response regulator AauR
K18072 parS; two-component system, OmpR family, sensor kinase ParS [EC:2.7.13.3 ]
K18073 parR; two-component system, OmpR family, response regulator ParR
K18093 oprD; imipenem/basic amino acid-specific outer membrane pore [EC:3.4.21.-]
K18094 mexX, amrA; membrane fusion protein, multidrug efflux system
K18095 mexY, amrB; multidrug efflux pump
K18321 smeA; membrane fusion protein, multidrug efflux system
K18322 smeB; multidrug efflux pump
K18323 smeC; outer membrane protein, multidrug efflux system
K18324 acrD; multidrug efflux pump
K18326 mdtD; MFS transporter, DHA2 family, multidrug resistance protein
K18344 vanRB, vanR, vanRD; two-component system, OmpR family, response regulator VanR
K18345 vanSB, vanS, vanSD; two-component system, OmpR family, sensor histidine kinase VanS [EC:2.7.13.3 ]
K18346 vanW; vancomycin resistance protein VanW
K18347 vanH; D-specific alpha-keto acid dehydrogenase [EC:1.1.1.-]
K18349 vanRC, vanRE, vanRG; two-component system, OmpR family, response regulator VanR
K18350 vanSC, vanSE, vanSG; two-component system, OmpR family, sensor histidine kinase VanS [EC:2.7.13.3 ]
K18351 vanSAc; two-component system, OmpR family, sensor histidine kinase VanS [EC:2.7.13.3 ]
K18352 vanRAc; two-component system, OmpR family, response regulator VanR
K18353 vanJ; vancomycin resistance protein VanJ
K18354 vanK; vancomycin resistance protein VanK
K18444 rrp1; two-component system, glycerol uptake and utilization response regulator
K18940 arlS; two-component system, OmpR family, sensor histidine kinase ArlS [EC:2.7.13.3 ]
K18941 arlR; two-component system, OmpR family, response regulator ArlR
K18986 ihk; two-component system, OmpR family, sensor kinase Ihk [EC:2.7.13.3 ]
K18987 irr; two-component system, OmpR family, response regulator Irr
K19077 graS; two-component system, OmpR family, sensor histidine kinase GraS [EC:2.7.13.3 ]
K19078 graR; two-component system, OmpR family, response regulator protein GraR
K19079 vraF; cationic antimicrobial peptide transport system ATP-binding protein
K19080 vraG; cationic antimicrobial peptide transport system permease protein
K19081 braS, bceS; two-component system, OmpR family, sensor histidine kinase BraS/BceS [EC:2.7.13.3 ]
K19082 braR, bceR; two-component system, OmpR family, response regulator protein BraR/BceR
K19083 braD, bceA; bacitracin transport system ATP-binding protein
K19084 braE, bceB; bacitracin transport system permease protein
K19609 pfeS, pirS; two-component system, OmpR family, sensor histidine kinase PfeS [EC:2.7.13.3 ]
K19610 pfeR, pirR; two-component system, OmpR family, response regulator PfeR
K19611 fepA, pfeA, iroN, pirA; ferric enterobactin receptor
K19615 fitD, mcf; insecticidal toxin
K19616 fitF; two-component system, sensor histidine kinase and response regulator FitF [EC:2.7.13.3 ]
K19617 fitH; two-component system, response regulator FitH
K19618 fitG; LysR family transcriptional regulator, activator of insecticidal toxin
K19620 phcB; extracellular factor (EF) 3-hydroxypalmitic acid methyl ester biosynthesis protein
K19621 phcS; two-component system, sensor histidine kinase PhcS [EC:2.7.13.3 ]
K19622 phcR; two-component system, response regulator PhcR
K19624 phcA; LysR family transcriptional regulator, virulence genes transcriptional regulator
K19641 hupR, hoxA; two-component system, NtrC family, response regulator HupR/HoxA
K19661 hupT, hoxJ; two-component system, NtrC family, sensor histidine kinase HupT/HoxJ [EC:2.7.13.3 ]
K19666 solR, cepR, tofR; LuxR family transcriptional regulator, quorum-sensing system regulator SolR
K19667 xpsR; transcriptional activator of eps genes
K19690 CHK1; osomolarity two-component system, sensor histidine kinase CHK1 [EC:2.7.13.3 ]
K19691 NIK1, TCSC; osomolarity two-component system, sensor histidine kinase NIK1 [EC:2.7.13.3 ]
K19692 TCSA; osomolarity two-component system, sensor histidine kinase TcsA [EC:2.7.13.3 ]
K20263 fusK; two-component system, NarL family, sensor histidine kinase FusK [EC:2.7.13.3 ]
K20264 fusR; two-component system, NarL family, response regulator FusR
K20339 agrC2; two-component system, LytTR family, sensor histidine kinase AgrC2 [EC:2.7.13.3 ]
K20340 agrA2; two-component system, LytTR family, response regulator AgrA2
K20482 nisA, spaS, epiA; lantibiotic bacteriocin
K20483 lanB, nisB, spaB, epiB; class I lanthipeptide synthase [EC:3.13.2.4 ]
K20484 lanC, nisC, spaC, epiC; class I lanthipeptide synthase [EC:3.13.2.4 ]
K20485 nisT, spaT; ATP-binding cassette, subfamily B, bacterial NisT/SpaT
K20486 nisP, epiP; lantibiotic leader peptide-processing serine protease [EC:3.4.21.-]
K20487 nisK, spaK; two-component system, OmpR family, lantibiotic biosynthesis sensor histidine kinase NisK/SpaK [EC:2.7.13.3 ]
K20488 nisR, spaR; two-component system, OmpR family, lantibiotic biosynthesis response regulator NisR/SpaR
K20489 nisI; lantibiotic immunity protein
K20490 nisF, spaF, cprA, epiF; lantibiotic transport system ATP-binding protein
K20491 nisE, spaE, cprB, epiE; lantibiotic transport system permease protein
K20492 nisG, spaG, cprC; lantibiotic transport system permease protein
K20494 epiG; lantibiotic transport system permease protein
K20552 ler; transcriptional regulator of LEE operons
K20973 sagS; two-component system, sensor histidine kinase SagS [EC:2.7.13.3 ]
K20976 hptB; histidine phosphotransfer protein HptB
K20977 hsbR; two-component system, HptB-dependent secretion and biofilm response regulator
K20978 hsbA; HptB-dependent secretion and biofilm anti anti-sigma factor
K21393 dctQM, siaT; TRAP-type transport system permease protein
K22501 appX; cytochrome bd-II ubiquinol oxidase subunit AppX [EC:7.1.1.7 ]
K23236 safA; two-component-system connector protein SafA
K23514 fecI, prhI; RNA polymerase sigma-19 factor, ECF subfamily
K23548 hupU; uptake hydrogenase small subunit
K23549 hupV; uptake hydrogenase large subunit
K23676 btsT; pyruvate/proton symporter
K25211 hptA; hexose phosphate transport regulatory protein HptA
K25212 hptS; two-component system, sensor histidine kinase HptS
K25213 hptR; two-component system, response regulator HptR
K25307 wzb, etp; low molecular weight protein-tyrosine phosphatase
K25864 mzrA; modulator protein MzrA
K27076 pprA; two-component system, NarL family, sensor histidine kinase PprA
K27077 pprB; two-component system, NarL family, response regulator PprB
K27078 cupE; spore coat protein U domain-containing protein, fimbrial subunit CupE1/2/3/6
K27079 tadD; tight adherence protein D
K27080 tadG; tight adherence protein G
K27105 dosT; two-component system, NarL family, sensor histidine kinase DosT
K27882 btsS; two-component system, LytTR family, low-concentration pyruvate sensor kinase
K27883 btsR; two-component system, LytTR family, low-concentration pyruvate response regulator
K27884 pyrS; two-component system, LytTR family, high-concentration pyruvate sensor kinase
K27885 pyrR; two-component system, LytTR family, high-concentration pyruvate response regulator
Compound C05757 (3R)-3-Hydroxydodecanoyl-[acyl-carrier protein]
C11842 N-(3-(S)-Hydroxybutyryl)homoserine lactone
C11849 3-Hydroxy-palmitic acid methyl ester
C16665 12-Methyltetradecanoic acid
C18206 cis-11-Methyl-2-dodecenoic acid
Reference Authors Yamamoto K, Hirao K, Oshima T, Aiba H, Utsumi R, Ishihama A.
Title Functional characterization in vitro of all two-component signal transduction systems from Escherichia coli.
Journal Reference Authors Abdel-Fattah WR, Chen Y, Eldakak A, Hulett FM.
Title Bacillus subtilis phosphorylated PhoP: direct activation of the E(sigma)A- and repression of the E(sigma)E-responsive phoB-PS+V promoters during pho response.
Journal Reference Authors Navarre WW, Halsey TA, Walthers D, Frye J, McClelland M, Potter JL, Kenney LJ, Gunn JS, Fang FC, Libby SJ.
Title Co-regulation of Salmonella enterica genes required for virulence and resistance to antimicrobial peptides by SlyA and PhoP/PhoQ.
Journal Reference Authors Cai SJ, Inouye M.
Title EnvZ-OmpR interaction and osmoregulation in Escherichia coli.
Journal Reference Authors Batchelor E, Walthers D, Kenney LJ, Goulian M.
Title The Escherichia coli CpxA-CpxR envelope stress response system regulates expression of the porins ompF and ompC.
Journal Reference Authors Nagakubo S, Nishino K, Hirata T, Yamaguchi A.
Title The putative response regulator BaeR stimulates multidrug resistance of Escherichia coli via a novel multidrug exporter system, MdtABC.
Journal Reference Authors Hagiwara D, Yamashino T, Mizuno T.
Title A Genome-wide view of the Escherichia coli BasS-BasR two-component system implicated in iron-responses.
Journal Reference Authors Munson GP, Lam DL, Outten FW, O'Halloran TV.
Title Identification of a copper-responsive two-component system on the chromosome of Escherichia coli K-12.
Journal Reference Authors Sperandio V, Torres AG, Kaper JB.
Title Quorum sensing Escherichia coli regulators B and C (QseBC): a novel two-component regulatory system involved in the regulation of flagella and motility by quorum sensing in E. coli.
Journal Reference Authors Epstein W.
Title The roles and regulation of potassium in bacteria.
Journal Reference Authors Ansaldi M, Simon G, Lepelletier M, Mejean V.
Title The TorR high-affinity binding site plays a key role in both torR autoregulation and torCAD operon expression in Escherichia coli.
Journal Reference Authors Malpica R, Franco B, Rodriguez C, Kwon O, Georgellis D.
Title Identification of a quinone-sensitive redox switch in the ArcB sensor kinase.
Journal Reference Authors Widenhorn KA, Somers JM, Kay WW.
Title Genetic regulation of the tricarboxylate transport operon (tctI) of Salmonella typhimurium.
Journal Reference Authors Hyyrylainen HL, Bolhuis A, Darmon E, Muukkonen L, Koski P, Vitikainen M, Sarvas M, Pragai Z, Bron S, van Dijl JM, Kontinen VP.
Title A novel two-component regulatory system in Bacillus subtilis for the survival of severe secretion stress.
Journal Reference Authors Zhang X, Hulett FM.
Title ResD signal transduction regulator of aerobic respiration in Bacillus subtilis: ctaA promoter regulation.
Journal Reference Authors Senadheera MD, Guggenheim B, Spatafora GA, Huang YC, Choi J, Hung DC, Treglown JS, Goodman SD, Ellen RP, Cvitkovitch DG.
Title A VicRK signal transduction system in Streptococcus mutans affects gtfBCD, gbpB, and ftf expression, biofilm formation, and genetic competence development.
Journal Reference Authors He H, Zahrt TC.
Title Identification and characterization of a regulatory sequence recognized by Mycobacterium tuberculosis persistence regulator MprA.
Journal Reference Authors Hutchings MI
Title Unusual two-component signal transduction pathways in the actinobacteria.
Journal Reference Authors Kramer R
Title Osmosensing and osmosignaling in Corynebacterium glutamicum.
Journal Reference Authors Eraso JM, Kaplan S.
Title Oxygen-insensitive synthesis of the photosynthetic membranes of Rhodobacter sphaeroides: a mutant histidine kinase.
Journal Reference Authors Haydel SE, Dunlap NE, Benjamin WH Jr.
Title In vitro evidence of two-component system phosphorylation between the Mycobacterium tuberculosis TrcR/TrcS proteins.
Journal Reference Authors Quisel JD, Burkholder WF, Grossman AD.
Title In vivo effects of sporulation kinases on mutant Spo0A proteins in Bacillus subtilis.
Journal Reference Authors Kaspar S, Bott M.
Title The sensor kinase CitA (DpiB) of Escherichia coli functions as a high-affinity citrate receptor.
Journal Reference Authors Janausch IG, Garcia-Moreno I, Unden G.
Title Function of DcuS from Escherichia coli as a fumarate-stimulated histidine protein kinase in vitro.
Journal Reference Authors Brunskill EW, Bayles KW.
Title Identification and molecular characterization of a putative regulatory locus that affects autolysis in Staphylococcus aureus.
Journal Reference Authors Fujimoto DF, Brunskill EW, Bayles KW.
Title Analysis of genetic elements controlling Staphylococcus aureus lrgAB expression: potential role of DNA topology in SarA regulation.
Journal Reference Authors Dufour P, Jarraud S, Vandenesch F, Greenland T, Novick RP, Bes M, Etienne J, Lina G.
Title High genetic variability of the agr locus in Staphylococcus species.
Journal Reference Authors Rabin RS, Stewart V.
Title Dual response regulators (NarL and NarP) interact with dual sensors (NarX and NarQ) to control nitrate- and nitrite-regulated gene expression in Escherichia coli K-12.
Journal Reference Authors Chiang RC, Cavicchioli R, Gunsalus RP.
Title 'Locked-on' and 'locked-off' signal transduction mutations in the periplasmic domain of the Escherichia coli NarQ and NarX sensors affect nitrate- and nitrite-dependent regulation by NarL and NarP.
Journal Reference Authors Verhamme DT, Postma PW, Crielaard W, Hellingwerf KJ.
Title Cooperativity in signal transfer through the Uhp system of Escherichia coli.
Journal Reference Authors Hagiwara D, Sugiura M, Oshima T, Mori H, Aiba H, Yamashino T, Mizuno T.
Title Genome-wide analyses revealing a signaling network of the RcsC-YojN-RcsB phosphorelay system in Escherichia coli.
Journal Reference Authors Hirakawa H, Nishino K, Yamada J, Hirata T, Yamaguchi A.
Title Beta-lactam resistance modulated by the overexpression of response regulators of two-component signal transduction systems in Escherichia coli.
Journal Reference Authors Suzuki K, Wang X, Weilbacher T, Pernestig AK, Melefors O, Georgellis D, Babitzke P, Romeo T.
Title Regulatory circuitry of the CsrA/CsrB and BarA/UvrY systems of Escherichia coli.
Journal Reference Authors Kato A, Ohnishi H, Yamamoto K, Furuta E, Tanabe H, Utsumi R.
Title Transcription of emrKY is regulated by the EvgA-EvgS two-component system in Escherichia coli K-12.
Journal Reference Authors Ansaldi M, Dubnau D.
Title Diversifying selection at the Bacillus quorum-sensing locus and determinants of modification specificity during synthesis of the ComX pheromone.
Journal Reference Authors Gabdrakhmanova L, Vishniakov I, Sharipova M, Balaban N, Kostrov S, Leshchinskaya I.
Title Salt stress induction of glutamyl endopeptidase biosynthesis in Bacillus intermedius.
Journal Reference Authors Aguilar PS, Hernandez-Arriaga AM, Cybulski LE, Erazo AC, de Mendoza D.
Title Molecular basis of thermosensing: a two-component signal transduction thermometer in Bacillus subtilis.
Journal Reference Authors Kuroda M, Kuroda H, Oshima T, Takeuchi F, Mori H, Hiramatsu K.
Title Two-component system VraSR positively modulates the regulation of cell-wall biosynthesis pathway in Staphylococcus aureus.
Journal Reference Authors Saini DK, Malhotra V, Dey D, Pant N, Das TK, Tyagi JS.
Title DevR-DevS is a bona fide two-component system of Mycobacterium tuberculosis that is hypoxia-responsive in the absence of the DNA-binding domain of DevR.
Journal Reference Authors Fedtke I, Kamps A, Krismer B, Gotz F.
Title The nitrate reductase and nitrite reductase operons and the narT gene of Staphylococcus carnosus are positively controlled by the novel two-component system NreBC.
Journal Reference Authors Shiau SP, Chen P, Reitzer LJ.
Title Effects of insertions and deletions in glnG (ntrC) of Escherichia coli on nitrogen regulator I-dependent DNA binding and transcriptional activation.
Journal Reference Authors Leonhartsberger S, Huber A, Lottspeich F, Bock A.
Title The hydH/G Genes from Escherichia coli code for a zinc and lead responsive two-component regulatory system.
Journal Reference Authors Lioliou EE, Kyriakidis DA.
Title The role of bacterial antizyme: From an inhibitory protein to AtoC transcriptional regulator.
Journal Reference Authors Yamamoto K, Ishihama A
Title Transcriptional response of Escherichia coli to external copper.
Journal Reference Authors Ashby MK, Mullineaux CW
Title Cyanobacterial ycf27 gene products regulate energy transfer from phycobilisomes to photosystems I and II.
Journal Reference Authors Lopez-Maury L, Garcia-Dominguez M, Florencio FJ, Reyes JC
Title A two-component signal transduction system involved in nickel sensing in the cyanobacterium Synechocystis sp. PCC 6803.
Journal Reference Authors Glover RT, Kriakov J, Garforth SJ, Baughn AD, Jacobs WR Jr
Title The two-component regulatory system senX3-regX3 regulates phosphate-dependent gene expression in Mycobacterium smegmatis.
Journal Reference Authors Hsiao HY, He Q, Van Waasbergen LG, Grossman AR
Title Control of photosynthetic and high-light-responsive genes by the histidine kinase DspA: negative and positive regulation and interactions between signal transduction pathways.
Journal Reference Authors Mutsuda M, Michel KP, Zhang X, Montgomery BL, Golden SS
Title Biochemical properties of CikA, an unusual phytochrome-like histidine protein kinase that resets the circadian clock in Synechococcus elongatus PCC 7942.
Journal Reference Authors Yeh KC, Wu SH, Murphy JT, Lagarias JC
Title A cyanobacterial phytochrome two-component light sensory system.
Journal Reference Authors Niu S, Jiang SQ, Hong J
Title Salmonella typhimurium pgtB mutants conferring constitutive expression of phosphoglycerate transporter pgtP independent of pgtC.
Journal Reference Authors Takai N, Nakajima M, Oyama T, Kito R, Sugita C, Sugita M, Kondo T, Iwasaki H
Title A KaiC-associating SasA-RpaA two-component regulatory system as a major circadian timing mediator in cyanobacteria.
Journal Reference Authors Janausch IG, Zientz E, Tran QH, Kroger A, Unden G
Title C4-dicarboxylate carriers and sensors in bacteria.
Journal Reference Authors Zhou YF, Nan B, Nan J, Ma Q, Panjikar S, Liang YH, Wang Y, Su XD
Title C4-dicarboxylates sensing mechanism revealed by the crystal structures of DctB sensor domain.
Journal Reference Authors Novick RP, Jiang D
Title The staphylococcal saeRS system coordinates environmental signals with agr quorum sensing.
Journal Reference Authors Leech AJ, Sprinkle A, Wood L, Wozniak DJ, Ohman DE
Title The NtrC family regulator AlgB, which controls alginate biosynthesis in mucoid Pseudomonas aeruginosa, binds directly to the algD promoter.
Journal Reference Authors Paul R, Jaeger T, Abel S, Wiederkehr I, Folcher M, Biondi EG, Laub MT, Jenal U
Title Allosteric regulation of histidine kinases by their cognate response regulator determines cell fate.
Journal Reference Authors Whitchurch CB, Leech AJ, Young MD, Kennedy D, Sargent JL, Bertrand JJ, Semmler AB, Mellick AS, Martin PR, Alm RA, Hobbs M, Beatson SA, Huang B, Nguyen L, Commolli JC, Engel JN, Darzins A, Mattick JS.
Title Characterization of a complex chemosensory signal transduction system which controls twitching motility in Pseudomonas aeruginosa.
Journal Reference Authors Yoshihara S, Ikeuchi M.
Title Phototactic motility in the unicellular cyanobacterium Synechocystis sp. PCC 6803.
Journal Reference Authors Ogawa T, Bao DH, Katoh H, Shibata M, Pakrasi HB, Bhattacharyya-Pakrasi M
Title A two-component signal transduction pathway regulates manganese homeostasis in Synechocystis 6803, a photosynthetic organism.
Journal Reference Authors Yamaguchi K, Suzuki I, Yamamoto H, Lyukevich A, Bodrova I, Los DA, Piven I, Zinchenko V, Kanehisa M, Murata N
Title A two-component Mn2+-sensing system negatively regulates expression of the mntCAB operon in Synechocystis.
Journal Reference Authors Mascher T, Zimmer SL, Smith TA, Helmann JD
Title Antibiotic-inducible promoter regulated by the cell envelope stress-sensing two-component system LiaRS of Bacillus subtilis.
Journal Reference Authors Hyyrylainen HL, Sarvas M, Kontinen VP
Title Transcriptome analysis of the secretion stress response of Bacillus subtilis.
Journal Reference Authors Serizawa M, Sekiguchi J
Title The Bacillus subtilis YdfHI two-component system regulates the transcription of ydfJ, a member of the RND superfamily.
Journal Reference Authors Ohki R, Giyanto, Tateno K, Masuyama W, Moriya S, Kobayashi K, Ogasawara N
Title The BceRS two-component regulatory system induces expression of the bacitracin transporter, BceAB, in Bacillus subtilis.
Journal Reference Authors Ogura M, Tsukahara K, Hayashi K, Tanaka T
Title The Bacillus subtilis NatK-NatR two-component system regulates expression of the natAB operon encoding an ABC transporter for sodium ion extrusion.
Journal Reference Authors Yamamoto H, Murata M, Sekiguchi J
Title The CitST two-component system regulates the expression of the Mg-citrate transporter in Bacillus subtilis.
Journal Reference Authors Satomura T, Shimura D, Asai K, Sadaie Y, Hirooka K, Fujita Y
Title Enhancement of glutamine utilization in Bacillus subtilis through the GlnK-GlnL two-component regulatory system.
Journal Reference Authors Doan T, Servant P, Tojo S, Yamaguchi H, Lerondel G, Yoshida K, Fujita Y, Aymerich S
Title The Bacillus subtilis ywkA gene encodes a malic enzyme and its transcription is activated by the YufL/YufM two-component system in response to malate.
Journal Reference Authors Tanaka K, Kobayashi K, Ogasawara N
Title The Bacillus subtilis YufLM two-component system regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium.
Journal Reference Authors Asai K, Baik SH, Kasahara Y, Moriya S, Ogasawara N
Title Regulation of the transport system for C4-dicarboxylic acids in Bacillus subtilis.
Journal Reference Authors Hamblin MJ, Shaw JG, Kelly DJ
Title Sequence analysis and interposon mutagenesis of a sensor-kinase (DctS) and response-regulator (DctR) controlling synthesis of the high-affinity C4-dicarboxylate transport system in Rhodobacter capsulatus.
Journal Reference Authors Forward JA, Behrendt MC, Wyborn NR, Cross R, Kelly DJ
Title TRAP transporters: a new family of periplasmic solute transport systems encoded by the dctPQM genes of Rhodobacter capsulatus and by homologs in diverse gram-negative bacteria.
Journal Reference Authors Martin B, Quentin Y, Fichant G, Claverys JP
Title Independent evolution of competence regulatory cascades in streptococci?
Journal Reference Authors Hensel M, Hinsley AP, Nikolaus T, Sawers G, Berks BC
Title The genetic basis of tetrathionate respiration in Salmonella typhimurium.
Journal Reference Authors Guvener ZT, Harwood CS
Title Subcellular location characteristics of the Pseudomonas aeruginosa GGDEF protein, WspR, indicate that it produces cyclic-di-GMP in response to growth on surfaces.
Journal Reference Authors Bantinaki E, Kassen R, Knight CG, Robinson Z, Spiers AJ, Rainey PB
Title Adaptive divergence in experimental populations of Pseudomonas fluorescens. III. Mutational origins of wrinkly spreader diversity.
Journal Reference Authors Jiang M, Shao W, Perego M, Hoch JA
Title Multiple histidine kinases regulate entry into stationary phase and sporulation in Bacillus subtilis.
Journal Reference Authors Jenal U
Title The role of proteolysis in the Caulobacter crescentus cell cycle and development.
Journal Reference Authors Jenal U, Galperin MY
Title Single domain response regulators: molecular switches with emerging roles in cell organization and dynamics.
Journal Reference Authors Drepper T, Wiethaus J, Giaourakis D, Gross S, Schubert B, Vogt M, Wiencek Y, McEwan AG, Masepohl B
Title Cross-talk towards the response regulator NtrC controlling nitrogen metabolism in Rhodobacter capsulatus.
Journal Reference Authors Pawlowski K, Klosse U, de Bruijn FJ
Title Characterization of a novel Azorhizobium caulinodans ORS571 two-component regulatory system, NtrY/NtrX, involved in nitrogen fixation and metabolism.
Journal Reference Authors Chatterjee S, Almeida RP, Lindow S
Title Living in two worlds: the plant and insect lifestyles of Xylella fastidiosa.
Journal Reference Authors Dow M
Title Diversification of the function of cell-to-cell signaling in regulation of virulence within plant pathogenic xanthomonads.
Journal Reference Authors Colnaghi Simionato AV, da Silva DS, Lambais MR, Carrilho E
Title Characterization of a putative Xylella fastidiosa diffusible signal factor by HRGC-EI-MS.
Journal Reference Authors Miller LD, Russell MH, Alexandre G
Title Diversity in bacterial chemotactic responses and niche adaptation.
Journal Reference Authors Eder S, Shi L, Jensen K, Yamane K, Hulett FM
Title A Bacillus subtilis secreted phosphodiesterase/alkaline phosphatase is the product of a Pho regulon gene, phoD.
Journal Related ko04011 MAPK signaling pathway - yeast
