Entry Name Circadian rhythm - plant
Description The circadian system is an endogenous rhythm with the period of about 24 hours to provide temporal organization of biological activity. In Arabidopsis the circadian oscillator at the core of this system is composed of the interlocked feedback loop formed by the major transcriptional factors CCA1 (circadian clock associated), LHY (late elongated hypocotyl) and TOC1 (timing of cab), a pseudo response regulator (PRR). The morning-expressed CCA1/LHY Myb transcription factors suppress TOC1 expression by binding to its promoter. Moreover, CCA1/LHY activates the expression of PRR7/9 in the morning and then PRR7/9 repress the transcription of CCA1/LHY during the rest of the day. By contrast, the evening-expressed TOC1 activates the expression of CCA1/LHY.
Class Organismal Systems; Environmental adaptationBRITE hierarchy
Pathway map Other DBs Orthology K03115 CSNK2B; casein kinase II subunit beta
K12115 ZTL; clock-associated PAS protein ZTL
K12116 FKF1; flavin-binding kelch repeat F-box protein 1
K12125 ELF3; protein EARLY FLOWERING 3
K12126 PIF3; phytochrome-interacting factor 3
K12127 TOC1, APRR1; pseudo-response regulator 1
K12128 PRR9; pseudo-response regulator 9
K12129 PRR7; pseudo-response regulator 7
K12130 PRR5; pseudo-response regulator 5
K12131 PRR3; pseudo-response regulator 3
K12133 LHY; MYB-related transcription factor LHY
K12134 CCA1; circadian clock associated 1
K12135 CO; zinc finger protein CONSTANS
K16166 PAP1, MYB75; transcription factor MYB75
K16221 TCP21, CHE; transcription factor TCP21 (protein CCA1 HIKING EXPEDITION)
K16222 CDF1; Dof zinc finger protein DOF5.5
K16223 FT; protein FLOWERING LOCUS T
K16240 SPA1_2; protein suppressor of PHYA-105 1 and protein SPA1-related 2
K16241 HY5; transcription factor HY5
K26557 SPA3_4; protein SPA1-related 3/4
Reference Authors McWatters HG, Roden LC, Staiger D.
Title Picking out parallels: plant circadian clocks in context.
Journal Reference Authors Yanovsky MJ, Kay SA.
Title Signaling networks in the plant circadian system.
Journal Reference Authors Kim L, Kircher S, Toth R, Adam E, Schafer E, Nagy F.
Title Light-induced nuclear import of phytochrome-A:GFP fusion proteins is differentially regulated in transgenic tobacco and Arabidopsis.
Journal Reference Authors Sakamoto K, Nagatani A.
Title Nuclear localization activity of phytochrome B.
Journal Reference Authors Liu XL, Covington MF, Fankhauser C, Chory J, Wagner DR.
Title ELF3 encodes a circadian clock-regulated nuclear protein that functions in an Arabidopsis PHYB signal transduction pathway.
Journal Reference Authors Zhu Y, Tepperman JM, Fairchild CD, Quail PH.
Title Phytochrome B binds with greater apparent affinity than phytochrome A to the basic helix-loop-helix factor PIF3 in a reaction requiring the PAS domain of PIF3.
Journal Reference Authors Ni M, Tepperman JM, Quail PH.
Title PIF3, a phytochrome-interacting factor necessary for normal photoinduced signal transduction, is a novel basic helix-loop-helix protein.
Journal Reference Authors Toth R, Kevei E, Hall A, Millar AJ, Nagy F, Kozma-Bognar L.
Title Circadian clock-regulated expression of phytochrome and cryptochrome genes in Arabidopsis.
Journal Reference Authors Schultz TF, Kiyosue T, Yanovsky M, Wada M, Kay SA.
Title A role for LKP2 in the circadian clock of Arabidopsis.
Journal Reference Authors Jarillo JA, Capel J, Tang RH, Yang HQ, Alonso JM, Ecker JR, Cashmore AR.
Title An Arabidopsis circadian clock component interacts with both CRY1 and phyB.
Journal Reference Authors Matsushika A, Makino S, Kojima M, Yamashino T, Mizuno T.
Title The APRR1/TOC1 quintet implicated in circadian rhythms of Arabidopsis thaliana: II. Characterization with CCA1-overexpressing plants.
Journal Reference Authors Sugano S, Andronis C, Ong MS, Green RM, Tobin EM.
Title The protein kinase CK2 is involved in regulation of circadian rhythms in Arabidopsis.
Journal Reference Authors Mas P, Devlin PF, Panda S, Kay SA.
Title Functional interaction of phytochrome B and cryptochrome 2.
Journal Reference Authors Ahmad M, Jarillo JA, Smirnova O, Cashmore AR.
Title The CRY1 blue light photoreceptor of Arabidopsis interacts with phytochrome A in vitro.
Journal Reference Authors Alabadi D, Oyama T, Yanovsky MJ, Harmon FG, Mas P, Kay SA.
Title Reciprocal regulation between TOC1 and LHY/CCA1 within the Arabidopsis circadian clock.
Journal Reference Authors Borevitz JO, Xia Y, Blount J, Dixon RA, Lamb C.
Title Activation tagging identifies a conserved MYB regulator of phenylpropanoid biosynthesis.
Journal Reference Authors Murakami-Kojima M, Nakamichi N, Yamashino T, Mizuno T.
Title The APRR3 component of the clock-associated APRR1/TOC1 quintet is phosphorylated by a novel protein kinase belonging to the WNK family, the gene for which is also transcribed rhythmically in Arabidopsis thaliana.
Journal Reference Authors Pan Y, Michael TP, Hudson ME, Kay SA, Chory J, Schuler MA
Title Cytochrome P450 monooxygenases as reporters for circadian-regulated pathways.
Journal Reference Authors Harmer SL, Hogenesch JB, Straume M, Chang HS, Han B, Zhu T, Wang X, Kreps JA, Kay SA
Title Orchestrated transcription of key pathways in Arabidopsis by the circadian clock.
Journal Reference Authors Mouradov A, Cremer F, Coupland G
Title Control of flowering time: interacting pathways as a basis for diversity.
Journal Reference Authors Chen M, Chory J, Fankhauser C
Title Light signal transduction in higher plants.
Journal Reference Authors Mas P
Title Circadian clock signaling in Arabidopsis thaliana: from gene expression to physiology and development.
Journal Reference Authors Jiao Y, Lau OS, Deng XW
Title Light-regulated transcriptional networks in higher plants.
Journal Reference Authors Turck F, Fornara F, Coupland G
Title Regulation and identity of florigen: FLOWERING LOCUS T moves center stage.
Journal Reference Authors Imaizumi T
Title Arabidopsis circadian clock and photoperiodism: time to think about location.
Journal Reference Authors McClung CR
Title A modern circadian clock in the common angiosperm ancestor of monocots and eudicots.
Journal Reference Authors Doherty CJ, Kay SA
Title Circadian control of global gene expression patterns.
Journal Reference Authors McClung CR, Gutierrez RA
Title Network news: prime time for systems biology of the plant circadian clock.
Journal Reference Authors Lu SX, Webb CJ, Knowles SM, Kim SH, Wang Z, Tobin EM
Title CCA1 and ELF3 Interact in the control of hypocotyl length and flowering time in Arabidopsis.
Journal Reference Authors Lau OS, Deng XW
Title The photomorphogenic repressors COP1 and DET1: 20 years later.
Journal Related ko00196 Photosynthesis - antenna proteins
